Global Pull Incentives for Better Antibacterials: The UK Leads the Way

Article Economics

Can the UK 'Netflix' Payment Model Boost the Antibacterial Pipeline?

Colm Leonard et al.

Summary: The issue of antimicrobial resistance (AMR) is a global concern that requires immediate attention. A comprehensive one-health approach across various sectors is needed to address the overuse of antibacterials and improve infection prevention and control measures. Additionally, there is a need for a stronger pipeline of new antibacterials as the current one is inadequate. The UK has implemented a unique funding arrangement for two antibacterials that delinks reimbursement from sales volume, providing a pull incentive based on the added value to the healthcare system.

APPLIED HEALTH ECONOMICS AND HEALTH POLICY (2023)

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Editorial Material Infectious Diseases

The antibiotic subscription model: fostering innovation or repackaging old drugs?

Rebecca E. Glover et al.

LANCET MICROBE (2023)

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Article Immunology

An Analysis of Antibacterial Drug Development Trends in the United States, 1980-2019

Nidhi Dheman et al.

Summary: The longitudinal analysis of investigational new drug applications for new, systemic antibacterial drugs from 1980 to 2019 showed fluctuations in the number of applications, success rates, and development times over the past three decades. The majority of active new drug programs in development as of 2019 come from established drug classes, with most being sponsored by small pharmaceutical companies.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Health Care Sciences & Services

Estimating The Appropriate Size Of Global Pull Incentives For Antibacterial Medicines

Kevin Outterson

Summary: This article discusses the commercial challenges faced by antibacterials, proposes policy initiatives for pull incentives, and estimates the global incentives required to create a functional market. The model indicates that strengthening pull incentives will have a positive impact on the global revenue stream for innovative antibacterials.

HEALTH AFFAIRS (2021)

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Article Public, Environmental & Occupational Health