Regulatory factors involved in Th17/Treg cell balance of immune thrombocytopenia

Immune thrombocytopenia is a common heterogeneous autoimmune disease that is characterized by decreasing peripheral blood platelet counts and increasing risk of bleeding. Studies have shown that an imbalance between T helper 17 (Th17) and Regulatory T (Treg) cells differentiated from CD4+T-cells is a key factor influencing the development and pathogenesis of immune thrombocytopenia. Th17 cells promote the development of chronic inflammatory disorders and induce autoimmune diseases, whereas Treg cells regu-late immune homeostasis and prevent autoimmune diseases. Several regulators affecting the production and maintenance of these cells are also essential for proper regulation of Th17/Treg balance; these regulatory fac-tors include cell surface proteins, miRNAs, and cytokine signaling. In this review, we focus on the function and role of balance between Th17 and Treg cells in immune thrombocytopenia, the regulatory factors, and therapeutic goals of this balance in immune thrombocytopenia.(c) 2023 Elsevier Masson SAS. All rights reserved.

Automated summary

Immune thrombocytopenia is a common autoimmune disease characterized by low platelet counts and increased bleeding risk. The imbalance between Th17 and Treg cells, derived from CD4+ T-cells, plays a key role in its development and pathogenesis. Th17 cells promote chronic inflammatory disorders and autoimmune diseases, while Treg cells regulate immune homeostasis and prevent autoimmune diseases. Various regulators, including cell surface proteins, miRNAs, and cytokine signaling, are essential for maintaining the Th17/Treg balance in immune thrombocytopenia. This review focuses on the function and role of this balance, as well as the therapeutic goals.