期刊
PROCESSES
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pr11030870
关键词
chitosan; iron(III); deferoxamine; nanoparticles; antibacterial activity; toxicity
In this study, chitosan/Fe(III)/deferoxamine nanoparticles were prepared with a unimodal size distribution. These nanoparticles exhibited outstanding antibacterial activity in vitro and in vivo, surpassing that of commercial antibiotics ampicillin and gentamicin. Additionally, the nanoparticles were found to be non-toxic. The introduction of iron ions into the chitosan matrix increased the ability of the nanoparticles to disrupt the integrity of microorganism membranes, and the incorporation of deferoxamine greatly enhanced their membrane destruction effect.
In this study, we prepared chitosan/Fe(III)/deferoxamine nanoparticles with unimodal size distribution (hydrodynamic diameter ca. 250 nm, zeta potential ca. 32 mV). The elaborated nanoparticles are characterized by outstanding in vitro and in vivo antibacterial activity, which exceeds even that of commercial antibiotics ampicillin and gentamicin. Moreover, the nanoparticles are non-toxic. We found that the introduction of iron ions into the chitosan matrix increases the ability of the resulting nanoparticles to disrupt the integrity of the membranes of microorganisms in comparison with pure chitosan. The introduction of deferoxamine into the obtained nanoparticles sharply expands their effect of destruction the bacterial membrane. The obtained antibacterial nanoparticles are promising for further preclinical studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据