Unexpected Increase in Invasive Group a Streptococcal Infections in Children After Respiratory Viruses Outbreak in France: A 15-Year Time-Series Analysis

Article Infectious Diseases

Increase in invasive group A streptococcal infection notifications, England, 2022

Rebecca Guy et al.

Summary: There has been an increase in invasive group A streptococcal (iGAS) infection and associated deaths, especially in children, exceeding seasonally expected levels in England (772 notifications reported in weeks 37 to 48 in 2022). Diagnoses of iGAS infection from lower respiratory tract specimens in children under 15 years increased to 28% in November 2022. Medical practitioners have been alerted to the exceptional rise in incidence, including unusual numbers of children presenting with pulmonary empyema.

EUROSURVEILLANCE (2023)

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Article Infectious Diseases

Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022

Brechje de Gier et al.

Summary: A significant increase in the number of invasive Streptococcus pyogenes infections among children aged 0-5 years was observed in the Netherlands in 2022 compared to pre-COVID-19 years. Out of 42 cases in this age group, seven had varicella zoster infections and nine were fatal. This increase is not linked to a specific emm type. Vigilance for clinical deterioration as a sign of iGAS is important in young children, especially those with varicella zoster infection.

EUROSURVEILLANCE (2023)

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Article Medicine, General & Internal

The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study

Ron Dagan et al.

Summary: The COVID-19 pandemic has had a significant impact on pneumonia and pneumococcal disease-associated viruses (PDA-viruses) in young children. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are the main contributors to childhood pneumonia and pneumococcal disease. This finding is important for prevention and treatment strategies.

EBIOMEDICINE (2023)

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Article Medicine, General & Internal

Association of Nonpharmaceutical Interventions During the COVID-19 Pandemic With Invasive Pneumococcal Disease, Pneumococcal Carriage, and Respiratory Viral Infections Among Children in France

Alexis Rybak et al.

Summary: This study examined the impact of nonpharmaceutical interventions implemented during the COVID-19 pandemic on the incidence of invasive pneumococcal disease (IPD) in France. The results showed that the decrease in IPD incidence was associated with decreased viral infection cases, rather than changes in pneumococcal carriage rate.

JAMA NETWORK OPEN (2022)

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Review Infectious Diseases

Pediatric Infectious Disease Group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap?

Robert Cohen et al.

Summary: The COVID-19 pandemic has reduced the incidence of many viral and bacterial infections in children, leading to a positive short-term effect of preventing healthcare system overload. However, the reduced exposure to pathogens and vaccination rates may result in a potential immunity debt and increase the risk of future epidemics when non-pharmaceutical interventions are lifted.

INFECTIOUS DISEASES NOW (2021)

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Article Infectious Diseases