A Bundle of the Top 10 OPAT Publications in 2022

Article Pharmacology & Pharmacy

Evaluation of Opportunities for Oral Antibiotic Therapy in Bone and Joint Infections

Hita Bhagat et al.

Summary: Based on this study, most patients treated with outpatient parenteral antimicrobial therapy (OPAT) for bone and joint infections (BJIs) could have been treated with oral antibiotics, leading to cost savings.

ANNALS OF PHARMACOTHERAPY (2023)

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Article Infectious Diseases

Safety of prolonged outpatient courses of intravenous antibiotics: a prospective cohort study

Sarah Browning et al.

Summary: The demand for outpatient parenteral antimicrobial therapy (OPAT) has increased, and the noninferiority of an early switch to oral therapy has been demonstrated. This 10-year study found a low incidence of major adverse events during long courses of intravenous antibiotics, with the peak occurring in the second week.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Infectious Diseases

Outpatient parenteral antimicrobial therapy (OPAT) in the UK: findings from the BSAC National Outcomes Registry (2015-19)

Mark Gilchrist et al.

Summary: This study analyzed data collected by the BSAC OPAT National Outcomes Registry from 2015 to 2019 and demonstrated the safety, breadth, and complexity of modern UK OPAT practice. Future research should focus on infection- and service-specific quality indicators.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Article Pharmacology & Pharmacy

Risk factors for readmission among patients receiving outpatient parenteral antimicrobial therapy: a retrospective cohort study

Sabrine Douiyeb et al.

Summary: Home treatment with intravenous antimicrobial therapy in the Netherlands is a relatively new concept, and patients receiving this treatment are still at risk of readmission. Receiving aminoglycosides or vancomycin treatment and having a prosthetic infection are independent risk factors associated with readmission.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2022)

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Article Immunology

Outpatient Versus Inpatient Intravenous Antimicrobial Therapy: A Population-Based Observational Cohort Study of Adverse Events and Costs

John A. Staples et al.

Summary: The outpatient parenteral antimicrobial therapy has a similar prevalence of adverse events but significantly lower costs compared to inpatient therapy.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Short- versus standard-course intravenous antibiotics for peri-prosthetic joint infections managed with debridement and implant retention: a randomised pilot trial using a desirability of outcome ranking (DOOR) endpoint

Laurens Manning et al.

Summary: This study investigated the optimal duration of intravenous antibiotics for peri-prosthetic joint infection (PJI). The findings suggest that shorter courses of IV antibiotics may be appropriate for selected patients with PJI managed with debridement and implant retention (DAIR). However, further confirmation is needed due to the small sample size and the data's alignment with other international trials.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2022)

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Article Immunology

A Bundle of the Top 10 OPAT Publications in 2021

Christina G. Rivera et al.

Summary: As outpatient parenteral antimicrobial therapy (OPAT) becomes more common, it may be challenging to keep up with recent publications. A group of multidisciplinary OPAT clinicians reviewed and ranked all OPAT publications published in 2021. This article provides a high-level summary of the top 10 OPAT manuscripts voted in 2021.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Immunology

Implementation of IV Push Antibiotics for Outpatients During a National Fluid Shortage Following Hurricane Maria

Kruti J. Yagnik et al.

Summary: This study investigates the impact of using an IV syringe bolus push as a nursing method during an IV fluid shortage. The results show that IV syringe bolus push can reduce hospital stay, increase patient satisfaction, save costs, without compromising safety or efficacy.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Clinical Efficacy and Safety of Vancomycin Continuous Infusion in Patients Treated at Home in an Outpatient Parenteral Antimicrobial Therapy Program

Lore Thijs et al.

Summary: This study reports the safety and efficacy of a structured vOPAT program implemented in a university hospital. The findings demonstrate that this program provides safe and effective ambulatory treatment of patients with vancomycin in continuous infusion, with high patient satisfaction.

ANTIBIOTICS-BASEL (2022)

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Article Emergency Medicine

Outpatient parenteral antibiotic therapy (OPAT) and inpatient treatment strategies for emergency department patients with cellulitis: a cost analysis

Krishan Yadav et al.

Summary: This study compares the cost of different OPAT strategies for cellulitis patients and finds that a dedicated OPAT clinic for cellulitis patients is more expensive than the return to ED strategy, but still more cost-effective than hospital admission.

CANADIAN JOURNAL OF EMERGENCY MEDICINE (2022)

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Article Immunology

Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria

Juan M. Pericas et al.

Summary: This study investigated whether more liberal criteria for outpatient parenteral antibiotic treatment (OPAT) in infective endocarditis (IE) can be safely used. The results showed that patients who did not fulfill OPAT-GAMES criteria had higher rates of readmission, but there were no significant differences in mortality and recurrences.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Emergency Medicine

The effects of ceftriaxone by intravenous push on adverse drug reactions in the emergency department

Abdulkareem Agunbiade et al.

Summary: The study examined adverse reactions to ceftriaxone administered via intravenous push, and found a low rate of adverse reactions with only one case confirmed. The demonstrated safety of IVP administration suggests potential benefits for ED efficiency and cost savings warranting further research.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Pharmacology & Pharmacy

Intravenous push versus intravenous piggyback beta-lactams for the empiric management of gram-negative bacteremia

Kassandra Marsh et al.

Summary: The study found that there were no significant differences in clinical response between using intravenous push (IVP) and intravenous piggyback (IVPB) administration of cefepime (FEP) and meropenem (MEM) for treating Gram-negative bacteria infections. This form of administration may be considered as a fluid conservation strategy during shortages.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2021)

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Article Pharmacology & Pharmacy

High-Dose Daptomycin Is Well Tolerated via 2-Minute IV Push Administration

Christian M. Gill et al.

Summary: This study evaluated the safety of administering high-dose daptomycin via a 2-minute intravenous push compared to traditional 30-minute intravenous piggyback infusion. The results showed infusion-related reactions occurred in 1% of patients regardless of infusion method, indicating comparable safety between the two methods of administration. This practice may be beneficial during fluid shortages and in outpatient settings.

HOSPITAL PHARMACY (2021)

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Editorial Material Pharmacology & Pharmacy