Optimal Frequency of Hepatitis C Virus (HCV) RNA Testing for Detection of Acute HCV Infection Among At-risk People With Human Immunodeficiency Virus: A Multicenter Study

Article Immunology

Low Spontaneous Clearance Rates of Recently Acquired Hepatitis C Virus in Human Immunodeficiency Virus-Positive Men Who Have Sex With Men (PROBE-C Study)

Malte B. Monin et al.

Summary: This study analyzed the spontaneous clearance rates and predictors of spontaneous clearance in recently acquired hepatitis C virus (HCV) infections among HIV-positive men who have sex with men (MSM). The findings showed that spontaneous clearance is infrequent in this population, highlighting the importance of early antiviral treatment.

CLINICAL INFECTIOUS DISEASES (2023)

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Article Immunology

Hepatitis C microelimination among people living with HIV in Taiwan

Guan-Jhou Chen et al.

Summary: To achieve the WHO goal of HCV elimination, Taiwan implemented a free direct-acting antiviral treatment program. The study found significant declines in the prevalence and incidence of HCV viremia among PLWH with the expansion of the DAA treatment program, but the proportion of HCV reinfections continued to increase.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

Risk of hepatitis C reinfection following successful therapy among people living with HIV: a global systematic review, meta-analysis, and meta-regression

Samira Hosseini-Hooshyar et al.

Lancet HIV (2022)

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Article Microbiology

Three-Stage Pooled Plasma Hepatitis C Virus RNA Testing for the Identification of Acute HCV Infections in At-Risk Populations

Hsin-Yun Sun et al.

Summary: The study evaluated the performance and cost reductions of a pooled plasma HCV RNA testing strategy and found that it can effectively identify acute HCV infections in high-risk populations, with a significant reduction in testing costs.

MICROBIOLOGY SPECTRUM (2022)

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Review Gastroenterology & Hepatology

Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis

Fengyi Jin et al.

Summary: A global systematic review and meta-analysis showed that the prevalence of HCV among men who have sex with men is high, with the highest rates in Africa and Southeast Asia. HIV-positive MSM have a significantly higher HCV prevalence compared to HIV-negative MSM, and the burden of HCV varies considerably by region.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Microbiology

Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data

Gonche Danesh et al.

Summary: The ongoing HCV epidemic among MSMs in Lyon, France is significantly different from previous non-MSM epidemics, with a much shorter doubling time. This has important practical implications for HCV control and highlights the additional information provided by virus genomics in public health.

PLOS PATHOGENS (2021)

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Article Immunology