Necrotizing Soft Tissue Infections in South Australia: A 15-Year Review

Necrotizing soft tissue infections (NSTIs) are associated with high morbidity and mortality. We retrospectively examined the impact of empiric antimicrobials coupled with early surgery on mortality in NSTI. Early surgery independently reduced 30-day mortality (odds ratio, .16; 95% confidence interval, .05-.51; P < .001) that was not further augmented by empiric antimicrobial choice.

Automated summary

This study retrospectively analyzed the effect of early surgery combined with empiric antimicrobials on mortality in necrotizing soft tissue infections (NSTIs). The results showed that early surgery independently reduced 30-day mortality, and the choice of empiric antimicrobials did not further enhance this effect.