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Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier

PHARMACEUTICS (2023)

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Article Clinical Neurology

Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease

Joseph Blommer et al.

Summary: The protein cargo of neuronal extracellular vesicles may serve as a biomarker for cognitive impairment in Parkinson's disease, with differences in alpha-synuclein, phosphorylated tau, and proteins associated with insulin signaling observed between patients with and without cognitive impairment. These findings could provide insights into the underlying pathogenic processes and improve diagnosis and prognosis of Parkinson's disease. Plasma samples from 273 participants were used in the study, and immunoassays were utilized to quantify biomarkers in plasma extracellular vesicles enriched for neuronal origin. Alpha-synuclein, phosphorylated tau, and insulin receptor substrate-1 phosphorylated tyrosine showed diagnostic classification contributions between groups, indicating that both alpha-synuclein and tau pathologies, along with impaired insulin signaling, may underlie Parkinson's disease with cognitive impairment. Plasma neuronal extracellular vesicles biomarkers may inform cognitive prognosis in Parkinson's disease.

BRAIN (2023)

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Review Immunology

Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders

Marlies Burgelman et al.

Summary: The complement system is involved in neuroinflammatory disorders like Alzheimer's disease and multiple sclerosis. Measuring complement levels in biofluids could potentially serve as a biomarker for these diseases. Extracellular vesicles (EVs) that contain complement proteins may provide a platform to improve the diagnostic power of these proteins.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Biology

An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer

Richard J. Lobb et al.

Summary: Despite advancements in therapy, lung cancer remains a leading cause of cancer-related death globally. Non-small cell lung cancer (NSCLC) patients have a low five-year survival rate and current staging methods may not accurately predict outcomes. Epithelial-to-mesenchymal transition (EMT) and associated protein changes in extracellular vesicles may serve as prognostic markers in NSCLC patients, enabling personalized treatment decisions.

COMMUNICATIONS BIOLOGY (2023)

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Review Cardiac & Cardiovascular Systems

Extracellular vesicles and atherosclerotic peripheral arterial disease

Paul A. Brown et al.

Summary: Atherogenesis is a complex process involving chronic inflammation and the participation of various cell types and molecules. Extracellular vesicles play a crucial role in this process, contributing to monocyte transmigration, foam cell formation, smooth muscle cell proliferation and migration, leukocyte transmigration, and thrombosis. Peripheral arterial disease, a common type of peripheral vascular disease, is characterized by impaired blood supply due to atherosclerosis. Elevated levels of extracellular vesicles have been found in patients with peripheral arterial disease and are implicated in the development of atherosclerosis. However, extracellular vesicles also have the potential to deliver cargo with atheroprotective effects, offering opportunities for therapeutic angiogenesis in the management of peripheral arterial disease.

CARDIOVASCULAR PATHOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer

Cristina Villa del Campo et al.

Summary: Researchers investigated the signaling of epicardial EVs to promote cardiomyocyte proliferation in infarcted mouse hearts and a human myocardial injury model. Deep RNA-sequencing revealed conserved miRs in exosomes derived from mouse and human epicardium, and the combination of these miRs replicated the therapeutic effects of promoting cardiomyocyte proliferation.

CARDIOVASCULAR RESEARCH (2022)

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Article Chemistry, Multidisciplinary

A novel phage display based platform for exosome diversity characterization

Domenico Maisano et al.

Summary: This study presents an innovative approach to identify, isolate, and characterize disease-related exosomes based on their antigenic reactivities. The strategy can be immediately applied to any disease involving exosomes. The identification of specific markers and their association with exosome subtypes, along with the engineering of target-guided exosome-like particles, could be crucial for the effective clinical adoption of exosomes.

NANOSCALE (2022)

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Article Surgery

Liver Transplantation Outcomes From Controlled Circulatory Death Donors SCS vs in situ NRP vs ex situ NMP

Rohit Gaurav et al.

Summary: NRP and NMP were associated with better early liver function compared to SCS, whereas NRP was associated with superior preservation of the biliary system.

ANNALS OF SURGERY (2022)

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Article Engineering, Biomedical

Pharmacological testing of therapeutics using normothermic machine perfusion: A pilot study of 2,4-dinitrophenol delivery to steatotic human livers

Samuel J. Tingle et al.

Summary: This study demonstrates the ability of normothermic machine perfusion (NMP) as a platform for pharmacological testing. Using 25 hours of NMP on human livers, the researchers showed that a drug called 2,4-dinitrophenol (DNP) was rapidly eliminated by the ex vivo liver, resulting in only transient drug effects. This highlights the importance of assessing pharmacokinetics when delivering therapeutics during NMP, especially for organs involved in drug elimination. Rigorous pharmacological testing is needed to unlock the potential of NMP as a clinical drug-delivery platform.

ARTIFICIAL ORGANS (2022)

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Article Engineering, Biomedical

Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia-reperfusion injury by transferring mitochondria to modulate the formation of neutrophil extracellular traps

Tongyu Lu et al.

Summary: This study shows that mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) can reduce neutrophil extracellular traps (NETs) formation in liver tissue, improve mitochondrial function in neutrophils, and have therapeutic potential for liver ischemia-reperfusion injury (IRI).

BIOMATERIALS (2022)

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Review Biochemistry & Molecular Biology

Circulating cell-specific extracellular vesicles as biomarkers for the diagnosis and monitoring of chronic liver diseases

Lauren A. Newman et al.

Summary: This study summarizes the contribution of extracellular vesicles (EVs) to normal liver function and chronic liver diseases. It explores the use of circulating EV biomarkers for monitoring disease status and treatment response. Emerging technologies for selectively isolating and analyzing circulating EVs derived only from hepatic cells show promise for biomarker platforms in chronic liver diseases.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Cardiac & Cardiovascular Systems

MicroRNA Expression Profiles of Epicardial Adipose Tissue-Derived Exosomes in Patients with Coronary Atherosclerosis

Jinxing Liu et al.

Summary: This study aimed to establish miRNA expression profiles of epicardial adipose tissue-derived exosomes in patients with coronary atherosclerosis. The results showed differential expression of miRNAs in coronary artery disease patients, suggesting their potential involvement in cell survival, apoptosis, proliferation, and differentiation.

REVIEWS IN CARDIOVASCULAR MEDICINE (2022)

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Article Biology

Extracellular Vesicles Derived from Mesenchymal Stromal Cells Delivered during Hypothermic Oxygenated Machine Perfusion Repair Ischemic/Reperfusion Damage of Kidneys from Extended Criteria Donors

Teresa Rampino et al.

Summary: This study explores the use of hypothermic oxygenated perfusion (HOPE) combined with extracellular vesicles (EV) derived from mesenchymal stromal cells as a new strategy for organ preservation. The results show that EV delivery during HOPE can effectively reduce ischemic damage, prevent reoxygenation-dependent injury, and improve transplant outcomes. This study is significant in increasing the donor pool and improving transplantation success.

BIOLOGY-BASEL (2022)

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Article Cell & Tissue Engineering

Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway

Xiaolong Liu et al.

Summary: Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles can enhance corneal epithelial wound healing by inhibiting PTEN through miR-21 transfer and activating the PI3K/Akt signaling pathway, promoting epithelial cell proliferation and migration.

STEM CELLS INTERNATIONAL (2022)

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Review Cell Biology

The Fatal Circle of NETs and NET-Associated DAMPs Contributing to Organ Dysfunction

Helena Block et al.

Summary: The innate immune system acts as the first line of defense against invading pathogens or sterile injuries. Neutrophils play a crucial role in fighting infection and healing injuries, with the release of neutrophil extracellular traps (NETs) being an important mechanism. Recent studies have shown that NETs can have detrimental effects in certain diseases.

CELLS (2022)

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Review Neurosciences

Extracellular vesicles through the blood-brain barrier: a review

Hector M. Ramos-Zaldivar et al.

Summary: Extracellular vesicles (EVs) are non-replicative particles released from cells. The mechanism of bidirectional EVs transport across the blood-brain barrier (BBB) is poorly understood. Current research lacks direct visualization of EVs transcytosis through the BBB in mammals, with most studies relying on in vitro models that do not consider the combined effect of all cellular layers constituting the BBB. Further research using in vitro and in vivo methodologies is needed to clarify these issues.

FLUIDS AND BARRIERS OF THE CNS (2022)

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Article Multidisciplinary Sciences

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Jorge Sanz-Ros et al.

Summary: This study found that treatment of old animals with ADSC-sEVs derived from young animals can improve various parameters associated with aging and reduce frailty. This treatment induces proregenerative effects and reduces oxidative stress, inflammation, and senescence in muscle and kidney. Additionally, tissue epigenetic age decreases and metabolome shifts to a youth-like pattern after this treatment.

SCIENCE ADVANCES (2022)

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Article Multidisciplinary Sciences

Extracellular vesicle fusion visualized by cryo-electron microscopy

Mattia I. Morandi et al.

Summary: This study developed an in vitro biophysical assay to investigate membrane fusion of extracellular vesicles (EVs) and benchmarked it against viral fusion. The results showed that EVs and retroviruses can fuse with liposomes in a pH- and protein-dependent manner, and the stages of membrane fusion were directly visualized using cryo-electron tomography. In addition, the study found that EVs remain fusogenic after acidification and reneutralization, which is different from most retroviruses.

PNAS NEXUS (2022)

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Article Surgery

Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation

Emily R. Thompson et al.

Summary: Ex vivo normothermic machine perfusion (NMP) of donor kidneys provides a platform for direct delivery of cellular therapeutics, such as Multipotent Adult Progenitor Cells (MAPC(R)), to optimize organ quality prior to transplantation. This study demonstrated improved urine output, decreased injury biomarker expression, and regulation of inflammatory factors in MAPC-treated kidneys during NMP, suggesting a promising strategy for organ reconditioning before transplantation.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Cytokine absorption during human kidney perfusion reduces delayed graft function-associated inflammatory gene signature

John R. Ferdinand et al.

Summary: The study found that cold storage led to a global reduction in gene expression, while normothermic machine perfusion (NMP) could upregulate oxidative phosphorylation genes, but also potentially increase the expression of immune and inflammatory pathway genes. Organs with prolonged delayed graft function (DGF) showed higher levels of inflammatory gene expression, and the use of a hemoadsorber could potentially attenuate this and increase OXPHOS pathway genes.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Chemistry, Medicinal

Extracellular Vesicles in Skin Wound Healing

Deimante Narauskaite et al.

Summary: Extracellular vesicles (EVs) play a crucial role in wound healing and potential therapeutic interventions. In addition to their natural healing capacity, EVs can be engineered to carry specific cargo for targeted pharmaceutical purposes, making them a promising treatment modality.

PHARMACEUTICALS (2021)

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Article Chemistry, Multidisciplinary

Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers

Jelle Penders et al.

Summary: The study focuses on extracellular vesicles (EVs) and introduces a high-throughput label-free EV analysis method for cancer diagnosis and monitoring, eliminating interpreter bias. By developing a dedicated device and using dimensional reduction analysis (DRA), a convenient and comprehensive approach for comparing multiple EV spectra is demonstrated. The study shows the high sensitivity and specificity of the dedicated SPARTA system in differentiating cancer and noncancer EVs, and its consistent predictive ability across multiple EV isolations.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Flow Cytometry Analysis of Circulating Extracellular Vesicle Subtypes from Fresh Peripheral Blood Samples

Marco Marchisio et al.

Summary: The study optimized a procedure using PFC to identify and separate circulating EVs from different cell origins, with the use of LCD staining being essential for PFC detection and sorting of EVs from fresh body fluids.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma

Chisaki Ikeda et al.

Summary: This study isolated EVs from human bile using EDEG and performed proteomic analysis, identifying Claudin-3 as a useful biomarker for CCA. The diagnostic accuracy was high with AUC 0.945 and sensitivity and specificity of 87.5%.

SCIENTIFIC REPORTS (2021)

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Article Clinical Neurology

Exosomal miRNA as peripheral biomarkers in Parkinson's disease and progressive supranuclear palsy: A pilot study

Ida Manna et al.

Summary: This study demonstrated the potential of exosomal miRNAs as biomarkers to differentiate between Parkinson's disease and Progressive Supranuclear Paralysis, with specific miRNAs like miR-21-3p, miR-22-3p, miR-223-5p, miR-425-5p, miR-21-3p, and miR-199a-5p showing promise in accurate discrimination. The classifier consisting of six exosomal miRNAs had high diagnostic sensitivity and specificity in distinguishing PSP from PD.

PARKINSONISM & RELATED DISORDERS (2021)

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Article Multidisciplinary Sciences

Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands

Allison Kupsco et al.

Summary: Human milk extracellular vesicles (EVs) containing microRNAs (miRNAs) play a critical role in infant cognitive, immune, and cardiometabolic functions. The expression of many top-cluster human milk EV-miRNAs is highly correlated, and they are involved in pathways related to the endocrine system, cellular community, neurodevelopment, and cancers. Further studies are needed to elucidate the determinants of human milk EV-miRNAs and their impact on health outcomes.

SCIENTIFIC REPORTS (2021)

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Review Cell Biology

Extracellular vesicles in pancreatic cancer progression and therapies

Chao-Hui Chang et al.

Summary: Pancreatic cancer is a leading cause of cancer-related deaths worldwide due to delayed diagnosis and limited treatments. Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers, with extracellular vesicles playing a crucial role in regulating tumor growth and metastasis. Understanding the factors in EVs derived from pancreatic ductal adenocarcinoma can provide insights into potential early diagnosis and therapeutic strategies against this deadly cancer.

CELL DEATH & DISEASE (2021)

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Review Immunology

The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders

Mengrou Lu et al.

Summary: Extracellular vesicles play important roles in autoimmune diseases, both in disease pathogenesis and as potential treatments. Understanding the link between cellular stress and EV biogenesis and intercellular trafficking is crucial for advancing our understanding of autoimmune diseases. EVs derived from various cell types contain a wide range of molecules and have diverse physiological effects, showing promise as potential treatments for autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs

Christina Bogensperger et al.

Summary: Transplantation is limited by the shortage of healthy donor organs, but ex situ machine perfusion has the potential to expand the donor pool. Mesenchymal stem cells are considered as a tool with the potential to improve organs, but clinical benefits have not been conclusively demonstrated.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Urology & Nephrology

Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury

Seonghun Kim et al.

Summary: Ischemia-reperfusion injury is a major cause of acute kidney injury, and immune responses play a significant role in this process. Treatment with Exo-srI kappa B can reduce post-ischemic damage in mice by decreasing NF-kappa B activity and modulating immune cell populations.

KIDNEY INTERNATIONAL (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Surgery

Human liver stem cell-derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia

Nicola De Stefano et al.

Summary: HLSC-EV treatment during normothermic machine perfusion (NMP) effectively reduces liver injury, enhances liver metabolism, and promotes regeneration in a donor after circulatory death (DCD) model with prolonged warm ischemia.

TRANSPLANT INTERNATIONAL (2021)

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Article Biotechnology & Applied Microbiology

Tetraspanins are unevenly distributed across single extracellular vesicles and bias sensitivity to multiplexed cancer biomarkers

Rachel R. Mizenko et al.

Summary: The study revealed distinct patterns in tetraspanin expression of EVs from different sources, with flow cytometry measurements showing some inconsistencies. Non-specific tetraspanin capture can bias multiplexed tetraspanin profiles, impacting diagnostic sensitivity for tumor-associated EV surface markers. The findings provide insights into protein expression heterogeneity of EVs, informing better EV capture and detection platforms for diagnostic or downstream use.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Oncology

The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma

Yi-Te Lee et al.

Summary: Extracellular vesicles (EVs) play a crucial role in regulating the progression of hepatocellular carcinoma (HCC) and are considered promising biomarkers for early detection. Studies have shown their involvement in mediating disease progression and efforts have been made to efficiently isolate EVs for clinical applications.

CANCERS (2021)

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Article Cell Biology

Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses

Christina F. Budden et al.

Summary: The text explains that activation of inflammasomes can lead to inflammation and immune pathology, but EVs released by inflammasome-activated cells also contain specific RNA, which can induce interferon beta in bystander cells to suppress NLRP3 inflammasome responses.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia

Rafael Sanchez-Sanchez et al.

Summary: Extracellular vesicles derived from mesenchymal stromal cells (MSCs) and containing miR-4732-3p microRNA show potential for cardioprotection, with miR-4732-3p being regulated by hypoxia and exerting protective actions against ischemic insult.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Surgery

OPTN/SRTR 2018 Annual Data Report: Kidney

A. Hart et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Article Surgery

Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis

Naoya Yamada et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Review Medicine, General & Internal

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Gertrude J. Nieuwenhuijs-Moeke et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing

Yue Zhang et al.

PEERJ (2020)

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Article Cell Biology

Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage

Sim Lai Tung et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Medicine, General & Internal

Urinary Extracellular Vesicles as Biomarkers of Kidney Disease: From Diagnostics to Therapeutics

In O. Sun et al.

DIAGNOSTICS (2020)

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Article Immunology

The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion

Richard W. Laing et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

MicroRNA-206 antagomiR-enriched extracellular vesicles attenuate lung ischemia-reperfusion injury through CXCL1 regulation in alveolar epithelial cells

Jun Cai et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Article Cell Biology

Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas

Eva Hulstaert et al.

CELL REPORTS (2020)

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Review Biochemistry & Molecular Biology

Immunocapture-based ELISA to characterize and quantify exosomes in both cell culture supernatants and body fluids

Mariantonia Logozzi et al.

EXTRACELLULAR VESICLES (2020)

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Article Oncology

Extracellular vesicles from young women's breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Kimberly R. Jordan et al.

BREAST CANCER RESEARCH (2020)

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Article Cell Biology

Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control

Joana Maia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Oncology

The evolving translational potential of small extracellular vesicles in cancer

Andreas Moller et al.

NATURE REVIEWS CANCER (2020)

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Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

CELL (2019)

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Article Multidisciplinary Sciences

Microvesicles from cerebrospinal fluid of patients with Alzheimer's disease display reduced concentrations of tau and APP protein

Philipp Spitzer et al.

SCIENTIFIC REPORTS (2019)

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Article Pharmacology & Pharmacy

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

Ji wei Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Cell Biology

Exosomes from human-bone-marrow-derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR-199a-3p

Gongmin Zhu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Cell Biology

Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView

Daniel Bachurski et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Biochemistry & Molecular Biology

Human keratinocyte-derived microvesicle miRNA-21 promotes skin wound healing in diabetic rats through facilitating fibroblast function and angiogenesis

Qian Li et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Cell Biology

Immature dendritic cells derived exosomes promotes immune tolerance by regulating T cell differentiation in renal transplantation

Xin-Lu Pang et al.

AGING-US (2019)

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Article Nanoscience & Nanotechnology

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

Hongxiang Wei et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Cell Biology

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis

Kaitlin Clark et al.

CELLS (2019)

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Article Biochemistry & Molecular Biology

BMSCs protect against renal ischemia-reperfusion injury by secreting exosomes loaded with miR-199a-5p that target BIP to inhibit endoplasmic reticulum stress at the very early reperfusion stages

Chenyang Wang et al.

FASEB JOURNAL (2019)

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Article Gastroenterology & Hepatology

Survival advantage for patients accepting the offer of a circulatory death liver transplant

Rhiannon Taylor et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Article Cell Biology

Quality of extracellular vesicle images by transmission electron microscopy is operator and protocol dependent

L. G. Rikkert et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Review Biochemistry & Molecular Biology

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Daniel E. Murphy et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis

Seock-Won Youn et al.

ANTIOXIDANTS (2019)

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Article Surgery

Observations on the ex situ perfusion of livers for transplantation

Christopher J. E. Watson et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

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Article Engineering, Biomedical

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian Tian et al.

BIOMATERIALS (2018)

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Article Cardiac & Cardiovascular Systems

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A

Lucio Barile et al.

CARDIOVASCULAR RESEARCH (2018)

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Article Cell Biology

Exosomes Derived from Dendritic Cells Attenuate Liver Injury by Modulating the Balance of Treg and Th17 Cells After Ischemia Reperfusion

Lei Zheng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Cardiac & Cardiovascular Systems

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction

Xavier Loyer et al.

CIRCULATION RESEARCH (2018)

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Article Gastroenterology & Hepatology

Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans

Xiaojiaoyang Li et al.

HEPATOLOGY (2018)

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Investigation of the phosphatidylserine binding properties of the lipid biosensor, Lactadherin C2 (LactC2), in different membrane environments

Kathryn Del Vecchio et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2018)

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The biology of extracellular microvesicles

Alanna E. Sedgwick et al.

TRAFFIC (2018)

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Article Cell Biology

Plasma exosomes induced by remote ischaemic preconditioning attenuate myocardial ischaemia/reperfusion injury by transferring miR-24

Wen Minghua et al.

CELL DEATH & DISEASE (2018)

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Article Multidisciplinary Sciences

Regulatory T cell-derived extracellular vesicles modify dendritic cell function

Sim L. Tung et al.

SCIENTIFIC REPORTS (2018)

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Article Medicine, Research & Experimental

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Stella Cosenza et al.

THERANOSTICS (2018)

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Review Medicine, General & Internal

Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond

Hailin Zhao et al.

EBIOMEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Induced Pluripotent Stem Cell (iPSC)-Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs

Marta Adamiak et al.

CIRCULATION RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

Sander A. A. Kooijmans et al.

NANOSCALE (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell & Tissue Engineering

Exosomes Derived From Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

Jie Ma et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Pharmacology & Pharmacy

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

Chonlada Charoenviriyakul et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Biochemistry & Molecular Biology

A direct-imaging cryo-EM study of shedding extracellular vesicles from leukemic monocytes

Na'ama Koiffman et al.

JOURNAL OF STRUCTURAL BIOLOGY (2017)

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Article Rheumatology

The process defines the product: what really matters in biosimilar design and production?

Arnold G. Vulto et al.

RHEUMATOLOGY (2017)

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Article Cell Biology

Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis

Xiaodong Yuan et al.

CELL DEATH & DISEASE (2017)

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Article Multidisciplinary Sciences

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

Ikuhiko Nakase et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

Sistiana Aiello et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies

Maria G. Amorim et al.

SCIENTIFIC REPORTS (2017)

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Article Respiratory System

Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Matthew L. Stone et al.

RESPIRATORY RESEARCH (2017)

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Article Cell Biology

Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways

Liang Liu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Article Cell Biology

Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway

Yingdong Du et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Article Engineering, Biomedical

Extracellular matrix-derived extracellular vesicles promote cardiomyocyte growth and electrical activity in engineered cardiac atria

Minae An et al.

BIOMATERIALS (2017)

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Article Cardiac & Cardiovascular Systems

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Teresa M. Ribeiro-Rodrigues et al.

CARDIOVASCULAR RESEARCH (2017)

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Article Cardiac & Cardiovascular Systems

Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular Postconditioning

Geoffrey de Couto et al.

CIRCULATION (2017)

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Article Biotechnology & Applied Microbiology

Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles

Divya B. Patel et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2017)

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Article Chemistry, Analytical

Multispectral Optical Tweezers for Biochemical Fingerprinting of CD9-Positive Exosome Subpopulations

Randy P. Carney et al.

ANALYTICAL CHEMISTRY (2017)

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Article Cardiac & Cardiovascular Systems

Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb

Prabhu Mathiyalagan et al.

CIRCULATION RESEARCH (2017)

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Article Immunology

Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury

Karla Drommelschmidt et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Review Pharmacology & Pharmacy

Extracellular vesicles for drug delivery

Pieter Vader et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Surgery

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

W. G. Land et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

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Article Chemistry, Multidisciplinary

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

S. A. A. Kooijmans et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Cardiac & Cardiovascular Systems

Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure

Anais Kervadec et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

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Article Cardiac & Cardiovascular Systems

Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction

Haibo Liu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

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Article Urology & Nephrology

Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury

Jose L. Vinas et al.

KIDNEY INTERNATIONAL (2016)

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Review Neurosciences

Extracellular vesicles round off communication in the nervous system

Vivian Budnik et al.

NATURE REVIEWS NEUROSCIENCE (2016)

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Article Orthopedics

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

S. Zhang et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

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Article Multidisciplinary Sciences

Surface Phosphatidylserine Is Responsible for the Internalization on Microvesicles Derived from Hypoxia-Induced Human Bone Marrow Mesenchymal Stem Cells into Human Endothelial Cells

Xiaojuan Wei et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Yunhao Qin et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

Ben Ma et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Sander A. A. Kooijmans et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Article Cardiac & Cardiovascular Systems

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

Mohsin Khan et al.

CIRCULATION RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

Yingjie Wang et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Article Cell Biology

Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism

Felix Jansen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Gastroenterology & Hepatology

Analysis of Ischemia/Reperfusion Injury in Time-Zero Biopsies Predicts Liver Allograft Outcomes

Jason M. Ali et al.

LIVER TRANSPLANTATION (2015)

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Article Multidisciplinary Sciences

CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

Simon J. F. Harper et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

Georgia K. Atkin-Smith et al.

NATURE COMMUNICATIONS (2015)

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Article Multidisciplinary Sciences

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Yuchen Liu et al.

SCIENTIFIC REPORTS (2015)

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Article Multidisciplinary Sciences

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

Alanna E. Sedgwick et al.

SCIENTIFIC REPORTS (2015)

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Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Cell Biology

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Cell Biology

Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

Takafumi Imai et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Article Cardiac & Cardiovascular Systems

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

Lucio Barile et al.

CARDIOVASCULAR RESEARCH (2014)

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Article Clinical Neurology

Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice

J. Mark Cooper et al.

MOVEMENT DISORDERS (2014)

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Article Multidisciplinary Sciences

Unexpected link between an antibiotic, pannexin channels and apoptosis

Ivan K. H. Poon et al.

NATURE (2014)

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Review Transplantation

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

Claudio Ponticelli

NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)

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Article Rheumatology

Exosomes from IL-1 beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes

Tomohiro Kato et al.

ARTHRITIS RESEARCH & THERAPY (2014)

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Article Hematology

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

Bas W. M. van Balkom et al.

BLOOD (2013)

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Article Immunology

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function

Lesley Ann Smyth et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Review Gastroenterology & Hepatology

Ischaemia-reperfusion injury, in liver transplantation-from bench to bedside

Yuan Zhai et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)

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Article Cell Biology

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Pathology

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

Dolores Di Vizio et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

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Review Cell Biology

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

Crislyn D'Souza-Schorey et al.

GENES & DEVELOPMENT (2012)

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Article Cell Biology

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

Maria Francesca Baietti et al.

NATURE CELL BIOLOGY (2012)

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Article Multidisciplinary Sciences

Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury

Stefania Bruno et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

Xiao Li et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

Ke Tang et al.

NATURE COMMUNICATIONS (2012)

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Article Cell Biology

Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells

Michael Romio et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

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Article Cell Biology

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

Guillaume van Niel et al.

DEVELOPMENTAL CELL (2011)

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Article Surgery

Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats

Xiaojun Yang et al.

JOURNAL OF SURGICAL RESEARCH (2011)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Article Cell & Tissue Engineering

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

Leo Timmers et al.

STEM CELL RESEARCH (2011)

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Article Cell Biology

Microvesicles: mediators of extracellular communication during cancer progression

Vandhana Muralidharan-Chari et al.

JOURNAL OF CELL SCIENCE (2010)

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Article Multidisciplinary Sciences

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Thomas Wollert et al.

NATURE (2010)

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Article Cell & Tissue Engineering

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Ruenn Chai Lai et al.

STEM CELL RESEARCH (2010)

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Article Biochemistry & Molecular Biology

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Vandhana Muralidharan-Chari et al.

CURRENT BIOLOGY (2009)

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Article Multidisciplinary Sciences

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

Jae W. Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Cell Biology

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

Sonja I. Buschow et al.

TRAFFIC (2009)

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Article Immunology

Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor

Sarah C. Saunderson et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Cell Biology

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Johan Skog et al.

NATURE CELL BIOLOGY (2008)

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Article Biotechnology & Applied Microbiology

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

Leo Timmers et al.

Stem Cell Research (2008)

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Article Immunology

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Silvia Deaglio et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

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Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

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Article Cell Biology

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

David K. Moss et al.

JOURNAL OF CELL SCIENCE (2006)

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Article Cell Biology

Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells

JD Lane et al.

JOURNAL OF CELL SCIENCE (2005)

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Article Hematology

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

E Segura et al.

BLOOD (2005)

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Article Immunology

A2A adenosine receptor induction inhibits IFN-γ production in murine CD4+ T cells

CM Lappas et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

AA Mangi et al.

NATURE MEDICINE (2003)

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Article Gastroenterology & Hepatology

Role of NF-κB on liver cold ischemia-reperfusion injury

Y Takahashi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)

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