4.7 Article

Safety in Rats of a Novel Nasal Spray Formulation for the Prevention of Airborne Viral Infections

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Environmental Sciences

The size and culturability of patient-generated SARS-CoV-2 aerosol

Joshua L. Santarpia et al.

Summary: The study found evidence of viral replication in submicron aerosol samples from COVID-19 patients, further confirming the potential for airborne transmission of COVID-19. Therefore, it emphasizes the importance of using efficient respiratory protection in healthcare and public settings to limit transmission.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2022)

Article Biochemistry & Molecular Biology

Drug-Free Nasal Spray as a Barrier against SARS-CoV-2 and Its Delta Variant: In Vitro Study of Safety and Efficacy in Human Nasal Airway Epithelia

Fabio Fais et al.

Summary: This study tested the safety and efficacy of a newly developed nasal spray, AM-301, against SARS-CoV-2 and its Delta variant using an in vitro 3D model of the human nasal airway epithelium. The results showed that AM-301 was safe and significantly reduced viral replication. The study suggests that AM-301 has the potential to be effective against a broad range of airborne viruses and allergens.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

(+)-Usnic acid and its salts, inhibitors of SARS-CoV-2, identified by using in silico methods and in vitro assay

Eunseok Oh et al.

Summary: This study investigates the inhibitors of SARS-CoV-2 protein targets and identifies (+)-usnic acid as a potential treatment for COVID-19. In vitro experiments show that (+)-usnic acid exhibits antiviral activity and enhanced efficacy against SARS-CoV-2 variants. The study suggests that (+)-usnic acid has the potential to be developed as a COVID-19 treatment.

SCIENTIFIC REPORTS (2022)

Article Virology

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial.

Damian Balmforth et al.

Summary: This study evaluates the efficacy and safety of a test agent as a prophylaxis against SARS-CoV-2 infection in high-risk healthcare workers. The results show that the test agent significantly reduces SARS-CoV-2 infection compared to placebo and leads to fewer clinical symptoms in the test group. Additionally, the test agent is found to be safe and well tolerated.

JOURNAL OF CLINICAL VIROLOGY (2022)

Article Virology

(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

Aleksandr S. Filimonov et al.

Summary: A series of usnic acid derivatives were synthesized and tested for their antiviral activity against SARS-CoV-2 virus. Specific derivatives showed high activity against different strains of the virus. The study also revealed that the derivatives bind to the surface glycoprotein of the virus and provided insights into the possible antiviral mechanism.

VIRUSES-BASEL (2022)

Review Toxicology

Toxicity of Usnic Acid: A Narrative Review

Nicoletta Croce et al.

Summary: Usnic acid is a naturally occurring compound found in lichens, with various biological activities. It has been used as a traditional medicine and a weight loss product, but was withdrawn from the market due to severe hepatotoxicity. Studies on the toxicology, genotoxicity, mutagenesis, and teratogenicity of usnic acid have been reviewed, as well as research on its topical use and efforts to enhance its pharmacological activity and reduce toxicity.

JOURNAL OF TOXICOLOGY (2022)

Article Multidisciplinary Sciences

Impact of urban structure on infectious disease spreading

Javier Aguilar et al.

Summary: The organization of urban flows has a significant impact on disease spreading and the effectiveness of mitigation strategies. Hierarchical cities are more vulnerable to rapid spread but have better response to mobility restrictions, while sprawled cities have slower spread but weaker response to restrictions.

SCIENTIFIC REPORTS (2022)

Review Plant Sciences

Usnic acid: from an ancient lichen derivative to promising biological and nanotechnology applications

D. C. S. Macedo et al.

Summary: Usnic acid, a compound of natural origin, has various pharmacological activities, but it is also toxic. Research is utilizing nanotechnology to overcome obstacles in its pharmacological application and enhance therapeutic efficacy.

PHYTOCHEMISTRY REVIEWS (2021)

Article Chemistry, Physical

Phospholipids dock SARS-CoV-2 spike protein via hydrophobic interactions: a minimal in-silico study of lecithin nasal spray therapy

Muhammad Nawaz Qaisrani et al.

Summary: Research shows strong binding capability of lecithin to the receptor-binding domain of SARS-CoV-2, mainly driven by hydrophobic interactions involving the non-polar tails, accompanied by dewetting of the receptor-binding motif, potentially playing a crucial role in antiviral activity.

EUROPEAN PHYSICAL JOURNAL E (2021)

Article Virology

Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread

Kirsten Bentley et al.

Summary: The study found that HPMC powder nasal sprays have the ability to inhibit SARS-CoV-2 infection and release primarily by forming a physical passive barrier. The addition of wild garlic can provide additional antiviral properties in some formulations.

VIRUSES-BASEL (2021)

Article Chemistry, Multidisciplinary

Formulation of a Composite Nasal Spray Enabling Enhanced Surface Coverage and Prophylaxis of SARS-COV-2

Richard J. A. Moakes et al.

Summary: Airborne pathogens, particularly in the nasal region, pose significant risks for transmission and infection. This study reports on a nasal formulation targeting SARS-CoV-2, showing strong anti-viral properties. The spray system can prevent SARS-CoV-2 infection in Vero cells by encapsulating and inactivating the virus within a polymeric coating in the respiratory pathways.

ADVANCED MATERIALS (2021)

Article Chemistry, Physical

Screening of cryptogamic secondary metabolites as putative inhibitors of SARS-CoV-2 main protease and ribosomal binding domain of spike glycoprotein by molecular docking and molecular dynamics approaches

G. Prateeksha et al.

Summary: The study aims to identify potential inhibitors of SARS-CoV-2 through computational evaluation of cryptogamic secondary metabolites. Some metabolites were found to potentially block the virus's major targets, showing promise as inhibitors.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Multidisciplinary Sciences

Airborne transmission of respiratory viruses

Chia C. Wang et al.

Summary: The COVID-19 pandemic has exposed critical knowledge gaps in our understanding of traditional respiratory virus transmission pathways, highlighting the need for updates. Improved understanding of aerosol transmission through studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection calls for a reassessment of major transmission pathways for other respiratory viruses, enabling better control measures to reduce airborne transmission.

SCIENCE (2021)

Article Biology

How did we get here: what are droplets and aerosols and how far do they go? A historical perspective on the transmission of respiratory infectious diseases

K. Randall et al.

Summary: The COVID-19 pandemic has revealed gaps in our understanding of airborne virus transmission, leading to confusion in public health policies and messaging. Current recommendations are based on inconsistent principles requiring better collaboration and integration of scientific research for effective public health policies.

INTERFACE FOCUS (2021)

Article Health Care Sciences & Services

Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data

Martin P. Grobusch et al.

Summary: The study evaluated travel-related illness encountered at EuroTravNet clinics between 1998 and 2018, finding an increase in ill travellers over the years. Despite this, regions of exposure remained stable. Diseases like falciparum malaria, rabies, and influenza showed varying trends over the years.

LANCET REGIONAL HEALTH-EUROPE (2021)

Article Public, Environmental & Occupational Health

Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak — United States, December 31, 2019–February 4, 2020

Anita Patel et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Article Virology

Seasonality of Respiratory Viral Infections

Miyu Moriyama et al.

ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020 (2020)

Article Construction & Building Technology

Short-range airborne route dominates exposure of respiratory infection during close contact

Wenzhao Chen et al.

BUILDING AND ENVIRONMENT (2020)

Article Pharmacology & Pharmacy

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2

Pablo F. Garrido et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Biochemistry & Molecular Biology

Inclusion complex with β-cyclodextrin is a key determining factor for the cardioprotection induced by usnic acid

Peligris Henrique dos Santos et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Article Public, Environmental & Occupational Health

The Impact of Climate Change on Vaccine-Preventable Diseases: Insights From Current Research and New Directions

Ayesha S. Mahmud et al.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2020)

Review Multidisciplinary Sciences

Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence

Linsey C. Marr et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2019)

Article Public, Environmental & Occupational Health

Economic Impact of the 2015 MERS Outbreak on the Republic of Korea's Tourism-Related Industries

Heesoo Joo et al.

HEALTH SECURITY (2019)

Article Multidisciplinary Sciences

Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community

Jing Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Immunology

Economic burden of seasonal influenza in the United States

Wayan C. W. S. Putri et al.

VACCINE (2018)

Review Respiratory System

Methyl-cellulose powder for prevention and management of nasal symptoms

Todor A. Popov et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2017)

Review Chemistry, Multidisciplinary

Review: A History of Cyclodextrins

Gregorio Crini

CHEMICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

Water Soluble Usnic Acid-Polyacrylamide Complexes with Enhanced Antimicrobial Activity against Staphylococcus epidermidis

Iolanda Francolini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Chemistry, Physical

Solubility of (+)-Usnic Acid in Water, Ethanol, Acetone, Ethyl Acetate and n-Hexane

Ju-qing Jin et al.

JOURNAL OF SOLUTION CHEMISTRY (2013)

Article Chemistry, Medicinal

Anti-viral activity of (-)- and (+)-usnic acids and their derivatives against influenza virus A(H1N1)2009

Dmitriy N. Sokolov et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Infectious Diseases

Membrane-damaging potential of natural L-(-)-usnic acid in Staphylococcus aureus

V. K. Gupta et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2012)

Review Infectious Diseases

The first influenza pandemic of the new millennium

Gabriele Neumann et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2011)

Article Health Care Sciences & Services

The economic impact of SARS: How does the reality match the predictions?

Marcus Richard Keogh-Brown et al.

HEALTH POLICY (2008)

Article

Review of Usnic Acid andUsnea BarbataToxicity

LEI GUO et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2008)

Article Pharmacology & Pharmacy

The current state of serum biomarkers of hepatotoxicity

Josef Ozer et al.

TOXICOLOGY (2008)

Review Food Science & Technology

Safety assessment of hydroxypropyl methylcellulose as a food ingredient

George A. Burdock

FOOD AND CHEMICAL TOXICOLOGY (2007)

Article Medicine, General & Internal

Evidence of airborne transmission of the severe acute respiratory syndrome virus

ITS Yu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Infectious Diseases

Severe acute respiratory syndrome

JT Wang et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2004)