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Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

PHARMACEUTICS (2023)

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Article Chemistry, Physical

Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages

Mengran Guo et al.

Summary: Nanoparticles decorated with folic acid were developed for the oral treatment of atherosclerosis. These nanoparticles effectively targeted lesional macrophages in aortic plaques and significantly reduced aortic lesion, plaque, and necrotic core areas after three months of oral administration. This study provides a promising approach for the treatment of atherosclerosis.

NANO RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer's Disease by Regulating Sirt1/miRNA-134/GSK3β Expression

Omayma A. R. Abozaid et al.

Summary: The study found that resveratrol-selenium nanoparticles (RSV-SeNPs) can improve oxidative stress and inflammation, alleviate neurochemical deficits and promote neurite outgrowth in an Alzheimer's disease model.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Article Nutrition & Dietetics

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease

Giuseppe Caruso et al.

Summary: Cognitive impairment is a significant public health problem associated with normal aging and neurodegenerative disorders. Dietary polyphenols, particularly phenolic acids, play an important role in healthy aging and the prevention of cognitive decline.

NUTRIENTS (2022)

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Review Immunology

Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis

Qi Jiang et al.

Summary: Inflammasome is a cellular complex involved in the innate inflammatory response, and its excessive or abnormal activation has been implicated in various diseases. In rheumatoid arthritis, inflammasome activation plays a key role in immune dysregulation and joint inflammation. This review summarizes recent research on inflammasome activation and its effector mechanisms in the pathogenesis of rheumatoid arthritis, as well as potential therapeutic strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Materials Science, Multidisciplinary

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

V. Chandrakala et al.

Summary: Nanotechnology has attracted considerable research attention in recent years due to its outstanding properties. The application of metallic nanoparticles, especially in medicine, offers significant advances in drug delivery systems and diagnostics. Green synthesis is an emerging method with economic and environmental benefits.

EMERGENT MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Resveratrol Triggered the Quick Self-Assembly of Gallic Acid into Therapeutic Hydrogels for Healing of Bacterially Infected Wounds

Xin-Chuang Wang et al.

Summary: This study reports a new method of triggering the self-assembly of gallic acid into fibrous hydrogels by adding a small amount of resveratrol. These hydrogels show excellent colloid stability, slow release, and biocompatibility, and demonstrate high antibacterial effects and wound healing capabilities in vivo.

BIOMACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Psoriasis and Systemic Inflammatory Disorders

Tomoko Tashiro et al.

Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Molecular Pharmacology of Inflammation Resolution in Atherosclerosis

Stanislav Kotlyarov et al.

Summary: Atherosclerosis is a significant problem in modern medicine, characterized by an imbalance between inflammation activation and its control mechanisms. The resolution of inflammation is impaired in atherosclerosis, and specialized pro-resolving mediators (SPMs), derived from lipids, play a crucial role in the regulation of inflammation resolution. These substances have important physiological implications and studying their potential pharmacological effects on inflammation resolution is of interest.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Agriculture, Multidisciplinary

Biopolymer nanoparticles: a strategy to enhance stability, bioavailability, and biological effects of phenolic compounds as functional ingredients

Daniela Nishimoto-Sauceda et al.

Summary: Phenolic compounds are abundant in nature and are increasingly being used in various industries as functional ingredients, such as the food industry. However, their beneficial properties are limited by factors like chemical instability and poor water solubility, prompting researchers to explore how nanotechnology can improve their stability and bioavailability.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

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Article Chemistry, Medicinal

Caffeic Acid Phenethyl Ester Loaded Electrospun Nanofibers for Wound Dressing Application

Secil Kaya et al.

Summary: This study investigates the physicochemical and biological properties of caffeic acid phenethyl ester (CAPE) molecule loaded onto poly(lactic-co-glycolic acid) (PLGA) nanofibers for the first time. The results demonstrate that CAPE-loaded PLGA membranes exhibit strong antimicrobial activity against various strains and have good biocompatibility and wound healing properties on human fibroblast cells.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Chemistry, Multidisciplinary

Supramolecular Vector/Drug Coassemblies of Polyglycerol Dendrons and Rutin Enhance the pH Response

Zhijun Guo et al.

Summary: A coassembly strategy for a supramolecular vector/drug was proposed, which uses biocompatible molecules to achieve pH-responsive and sustained release functions. The self-assembling behaviors of the components and the functions of the vector/drug were characterized. The results demonstrate that this coassembly method is a simple and effective approach.

LANGMUIR (2022)

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Review Immunology

Advancement of nanomedicines in chronic inflammatory disorders

Vikas Jogpal et al.

Summary: Chronic inflammatory diseases pose a threat to human health, and traditional medicine using natural products may offer therapeutic benefits. Nanoparticles, as a new drug delivery device, can enhance drug efficacy and bioavailability. Nanoparticles play an important role in the treatment of various inflammatory diseases.

INFLAMMOPHARMACOLOGY (2022)

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Review Medicine, General & Internal

Chronic Inflammation in Obesity and Cancer Cachexia

Rosa Divella et al.

Summary: Chronic inflammation is associated with obesity, metabolic diseases, and increased cancer risk. Elevated levels of pro-inflammatory cytokines, such as adipocytokines, are found in chronic metabolic diseases. Cytokines and inflammatory mediators play a significant role in tumorigenesis. Cachexia is linked to a dysregulation of metabolic pathways.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Pharmacology & Pharmacy

Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition

Dan Chen et al.

Summary: Thrombosis in both macrovasculature and microvasculature is a major cause of cardiovascular diseases. This study explores the potential of protein disulfide isomerase (PDI) inhibitors as antithrombotics. The research focuses on the utilization of rutin-loaded lipid-based nano-formulation (NanoR) to improve the solubility and efficacy of rutin. The results demonstrate that NanoR exhibits enhanced antithrombotic activity and specificity, making it a promising treatment option.

DRUG DELIVERY (2022)

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Review Rheumatology

A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: A literature systematic review

Arash Karimi et al.

Summary: This systematic review summarizes the effects of resveratrol supplementation on complications of rheumatoid arthritis (RA). The review suggests that resveratrol supplementation may have beneficial effects on RA complications by reducing inflammation and oxidative stress, modulating the immune response, and down-regulating the expression of genes related to inflammatory pathways. However, due to the limited number of human studies, further clinical trials are warranted.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2022)

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Review Immunology

Impact of Chronic Inflammation in Psoriasis on Bone Metabolism

Anja Saalbach et al.

Summary: Psoriasis is a chronic inflammatory disease associated with various comorbidities and has been linked to cardiovascular diseases. However, recent evidence suggests that it also impacts the development of osteoporosis. Routine bone metabolism examination is crucial for psoriatic patients to prevent long-term consequences.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Apigenin-Mn(II) loaded hyaluronic acid nanoparticles for ulcerative colitis therapy in mice

Feng Lv et al.

Summary: This study proposes a novel nanoparticle for the treatment of ulcerative colitis with promising results. The nanoparticle repairs the intestinal barrier and improves damaged colon tissue.

FRONTIERS IN CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases

Shih-Chun Yang et al.

Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model

Nancy Nabil Shahin et al.

Summary: The study prepared a CAPE-loaded nanoliposomal formulation which significantly improved the efficacy of CAPE for acute pancreatitis management, displaying superior antioxidant, anti-inflammatory, and anti-apoptotic effects.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease

Weronika Frak et al.

Summary: Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system, with atherosclerosis as its underlying cause. CVDs are the leading cause of morbidity and mortality globally, creating a significant public health concern. This review summarizes the pathophysiological implications of CVDs, focusing on coronary artery disease and atherosclerosis. Inflammatory factors and genetic risk factors have been identified in association with CVDs.

BIOMEDICINES (2022)

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Article Nutrition & Dietetics

Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis

Mengguo Han et al.

Summary: EGCG nanoparticles effectively alleviate symptoms and reduce inflammation in atopic dermatitis by inhibiting necroptosis.

FRONTIERS IN NUTRITION (2022)

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Article Chemistry, Multidisciplinary

Caffeic Acid Modified Nanomicelles Inhibit Articular Cartilage Deterioration and Reduce Disease Severity in Experimental Inflammatory Arthritis

Akshay Vyawahare et al.

Summary: The study found that the combination of 9AA and CA conjugated nanomicelles (9AA-NMs) can inhibit inflammation and alleviate symptoms of rheumatoid arthritis, such as joint damage, bone erosion, and swelling. The therapeutic effect is likely due to the simultaneous inhibition of NF-kappa B by 9AA and the suppression of HIF-1 alpha by NR4A1 activation. This combined treatment significantly enhances the therapeutic efficacy of 9AA-NMs and reduces the severity of inflammatory arthritis.

ACS NANO (2022)

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Review Pharmacology & Pharmacy

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery

Yirui Li et al.

Summary: Protein nanocarriers are valuable tools for drug delivery, with advantages of self-assembly, biocompatibility, and biodegradability. Modular design and functionalization are key for their therapeutic applications.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Food Science & Technology

Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health

Han Tao et al.

Summary: This review provides a comprehensive overview of flavonoids in vegetables, including their types, distribution, health-promoting effects, metabolic pathways, and applied metabolic engineering. It also introduces breakthroughs in multi-omics approaches and genome-editing technologies related to flavonoid metabolism in vegetables. Dietary suggestions for human health based on the composition and content of flavonoids in different vegetables are also provided.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Article Pharmacology & Pharmacy

Rutin and selenium nanoparticles protected against STZ-induced diabetic nephropathy in rats through downregulating Jak-2/Stat3 pathway and upregulating Nrf-2/HO-1 pathway

Randa A. Zaghloul et al.

Summary: This study investigated the inhibitory effects of Rutin and Selenium nanoparticles on the Stat3 pathway in diabetic nephropathy. The results showed that the combination of Rutin and Selenium nanoparticles had a potential renoprotective effect. The study suggests that Rutin and Selenium nanoparticles may alleviate inflammation and kidney damage by modulating the Nrf-2/HO-1 and Jak-2/Stat3 pathways.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Resveratrol and resveratrol nano-delivery systems in the treatment of inflammatory bowel disease

Vemana Gowd et al.

Summary: Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation in the digestive tract. The exact cause of IBD is unknown, and current treatments using synthetic drugs and monoclonal antibodies have limitations. Resveratrol, a natural polyphenol, has been shown to have therapeutic effects against IBD by targeting multiple molecular pathways. However, its therapeutic application is hindered by its low water solubility and limited bioavailability. Encapsulation and controlled release of resveratrol using different carriers have emerged as a promising strategy to overcome these limitations.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Review Pharmacology & Pharmacy

Nano-Formulation Based Intravesical Drug Delivery Systems: An Overview of Versatile Approaches to Improve Urinary Bladder Diseases

Muhammad Sarfraz et al.

Summary: Intravesical drug delivery is a direct approach for treating bladder diseases with site-specific drug action. However, there are limitations such as washout of drugs and poor permeability. Nanomaterial-based delivery systems are being used to enhance drug penetration and retention in the bladder, improving treatment efficacy.

PHARMACEUTICS (2022)

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Article Biotechnology & Applied Microbiology

Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation

Yiming Wang et al.

Summary: EGCG-Se NP shows superior neuroprotective effect in spinal cord injury (SCI) through scavenging reactive oxygen species (ROS) and attenuating inflammation, making it a promising and effective treatment option.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Polymer Science

In Vivo Effect of Resveratrol-Cellulose Aerogel Drug Delivery System to Relieve Inflammation on Sports Osteoarthritis

Ningxin Cui et al.

Summary: Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) drug delivery system has potential application for the treatment of sports osteoarthritis.

GELS (2022)

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Article Materials Science, Biomaterials

Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing

Yiyang Hou et al.

Summary: Diabetic wound healing is a challenging clinical issue that requires a wound dressing with balanced functionality. In this study, a composite hydrogel (GAK) was developed to promote diabetic wound healing, showing superior adhesion, stability, swelling properties, and antibacterial activity.

BIOMATERIALS ADVANCES (2022)

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Article Medicine, Research & Experimental

Oral Delivery of β-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis

Naisarg Pujara et al.

Summary: Resveratrol complexation with BLG enhances its solubility and stability, leading to improved anti-inflammatory activity in a mouse model of IBD. This study highlights the potential of biocompatible nanomaterials for oral delivery of poorly soluble anti-inflammatory agents.

MOLECULAR PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells

Khushbu Priyadarshi et al.

Summary: The study focused on improving the efficacy of anti-cancer drugs by conjugating Gallic acid with PAMAM dendrimers. This conjugate showed increased activity in inhibiting cell proliferation, restricting cancer cell migration, and inducing apoptotic cell death.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Nanoscience & Nanotechnology

Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota

Changjiang Li et al.

Summary: A Res-selenium-peptide nanocomposite was developed to improve cognitive dysfunction in AD model mice by reducing Aβ aggregation, inhibiting Aβ deposition, decreasing oxidative stress and inflammation, and alleviating gut microbiota disorder.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Pharmacology & Pharmacy

Phytophospholipid Complex of Caffeic Acid: Development, In vitro Characterization, and In Vivo Investigation of Antihyperlipidemic and Hepatoprotective Action in Rats

Shubhada Mangrulkar et al.

Summary: The study developed a novel CA-Phospholipon(R) 90H complex that significantly improved the solubility and release rate of CA, leading to a substantial increase in oral bioavailability. This promising formulation demonstrated potential antihyperlipidemic and hepatoprotective activities.

AAPS PHARMSCITECH (2021)

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Review Pharmacology & Pharmacy

Encapsulation of phenolic compounds with liposomal improvement in the cosmetic industry

Alejandra Figueroa-Robles et al.

Summary: Phenolic compounds, secondary metabolites in plants, exhibit antioxidant and anti-inflammatory properties. Encapsulation in liposomes prevents rapid degradation and enhances bioavailability and solubility.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Chemistry, Applied

Encapsulation of phenolic compounds within nano/microemulsion systems: A review

Farhad Garavand et al.

Summary: Phenolic compounds have health-promoting attributes and are of great interest in the food, pharmaceutical, and nutraceutical industries. However, their limited use is mainly due to poor water dispersibility and instability, requiring encapsulation with nanocarriers. Both microemulsions and nanoemulsions have been proven as suitable vehicles for encapsulating and protecting phenolics, potentially expanding their applications in foods, supplements, and pharmaceuticals.

FOOD CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Nanophytosomes for enhancement of rutin efficacy in oral administration for diabetes treatment in streptozotocin-induced diabetic rats

Sajed Amjadi et al.

Summary: Encapsulation of rutin into nanophytosomes showed enhanced therapeutic effects in diabetic rats by controlling hyperglycemia and hyperlipidemia, regulating liver marker enzymes, improving antioxidant defenses, and alleviating diabetic complications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems

Daniela Placha et al.

Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.

PHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Shweta Devi et al.

Summary: Neurodegenerative disorders such as PD, AD, ALS, and HD are of great concern due to the lack of effective therapy and increasing number of cases. Small molecules like flavonoids have potential in reducing cellular stress and have gained attention for their antioxidant, anti-inflammatory, and anti-apoptotic properties. Further research is needed to uncover the mechanisms behind the protective effects of flavonoids against cellular stress response in neurodegenerative disorders.

BIOMEDICINES (2021)

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Review Chemistry, Medicinal

The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products

Ren-Xiao Wang et al.

Summary: Chronic inflammation is a long-term immune response to harmful stimuli, implicated in the development of various diseases. Targeting inflammation presents new opportunities for treatment, and natural products show therapeutic potential for diseases associated with chronic inflammation.

CHEMMEDCHEM (2021)

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Review Food Science & Technology

Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review

Kizhakkeppurath Kumaran Ajeeshkumar et al.

Summary: Liposomes play a significant role in encapsulation of various bioactive compounds, improving core stability and promoting effective application in functional food and nutraceuticals. Combining traditional and emerging methods has resulted in stable liposome formulations for industrial applications, enhancing the stability, delivery, and bioavailability of bioactive compounds in functional food systems and nutraceuticals.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2021)

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Article Chemistry, Medicinal

A rutin nanocrystal gel as an effective dermal delivery system for enhanced anti-photoaging application

Jing Li et al.

Summary: In this study, a novel freeze-dried rutin nanocrystal was developed to enhance the saturation solubility of rutin, and further formulated into a targeted rutin nanocrystal gel for improved transdermal delivery efficiency. The results demonstrated that the rutin nanocrystal gel significantly enhanced the permeated amounts of rutin on mice and effectively prevented skin photoaging and tissue damage induced by UV irradiation. This study validated that the nanocrystal gel was an ideal carrier for the epidermal application of rutin, providing a valuable platform for enhancing the transdermal bioavailability of insoluble drugs.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2021)

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Review Biochemistry & Molecular Biology

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

Juan Huang et al.

Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, involve progressive loss of neurons and are common in the elderly. Excessive microglial activation leading to neuroinflammation is closely linked to the onset and progression of these diseases. Natural products like resveratrol show therapeutic potential in modulating microglial polarization and controlling neuroinflammation in the treatment of NDs.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials

Farzaneh Fallahi et al.

Summary: Inflammatory bowel diseases may result from mutations in genes encoding for innate immunity, requiring multi-targeted treatment options. Curcumin, a natural compound known for its anti-inflammatory and immunomodulatory properties, has shown therapeutic potential against IBDs in both preclinical and clinical studies. Clinical trials have demonstrated the efficacy of curcumin in different dosages, and improvements in oral bioavailability and absorption through nanotechnology may enhance its effectiveness for IBD treatment.

MOLECULAR IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Metallic nanoparticles as drug delivery system for the treatment of cancer

Neha Desai et al.

Summary: Metallic nanoparticles show promise in cancer therapy by targeting tumor cells through mechanistic pathways, offering high specificity and efficiency. Recent advancements in nanotechnology highlight their potential for more effective cancer treatment.

EXPERT OPINION ON DRUG DELIVERY (2021)

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Article Chemistry, Multidisciplinary

Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity

Yujiao Zu et al.

Summary: Research shows targeted nanoparticle delivery of browning agents could induce differentiation of adipose stromal cells into beige adipocytes, leading to decreased fat mass, improved glucose metabolism, and reduced inflammation, providing a transformative technology in combating obesity and its comorbidities.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Naringin as Sustained Delivery Nanoparticles Ameliorates the Anti-inflammatory Activity in a Freund's Complete Adjuvant-Induced Arthritis Model

Sangeeta Mohanty et al.

Summary: The study introduces polymeric nanoparticles of Naringin (NAR) to enhance its oral efficiency, with improved absorption and bioavailability. Physicochemical properties were evaluated, in vitro and ex vivo studies were conducted to show potential anti-arthritic effects, and the optimized nanoformulation demonstrated sustained action and reduced arthritic inflammation compared to free NAR.

ACS OMEGA (2021)

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Article Chemistry, Medicinal

The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial

Zohre Bateni et al.

Summary: This study demonstrated that supplementation with nano-micelle curcumin significantly reduced serum triglyceride levels and HOMA-beta in MetS patients. However, there were no significant differences in other anthropometric measurements, blood pressure, and lipid profile variables at the end of the study.

PHYTOTHERAPY RESEARCH (2021)

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Review Pharmacology & Pharmacy

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

Adhimoolam Karthikeyan et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the small intestine and colon, including ulcerative colitis (UC) and Crohn's disease (CD), which are major factors for the development of colon cancer. Current treatments involve synthetic drugs and monoclonal antibodies with side effects and high relapse rates. Recent studies suggest that curcumin derived from turmeric may be a potential therapeutic agent for IBD, effectively reducing clinical relapse in patients.

PHARMACEUTICS (2021)

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Article Engineering, Environmental

Polyoxometalate nanoclusters: A potential preventative and therapeutic drug for inflammatory bowel disease

Jingguo Wang et al.

Summary: This study discovered that tungsten-based polyoxometalate nanoclusters may serve as a potential medicine for treating IBD by scavenging reactive oxygen species, showing promising results in a mouse model.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Recent strategies in nanodelivery systems for natural products: a review

Giulia Vanti

Summary: Nanocarriers made of polymer or lipid constituents can improve the application of natural products in drug discovery by enhancing bioavailability and therapeutic efficacy. These nanosystems offer potential advantages in terms of increased stability and solubility, reduced adverse effects and toxicity.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Article Pharmacology & Pharmacy

Synthesis of naringenin loaded lipid based nanocarriers and their in-vivo therapeutic potential in a rheumatoid arthritis model

Adil Munir et al.

Summary: This study aimed to enhance the therapeutic potential of natural flavonoids in rheumatoid arthritis treatment by using lipid-based nanocarriers. The results showed that NAR-loaded lipid nanocarriers had superior anti-inflammatory effects compared to sole NAR, with SL carriers being the most effective.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity

Guangshuai Zhang et al.

Summary: The study aimed to improve the therapeutic efficacy of naringenin by formulating it into nanocrystals, showing promising results in enhancing bioavailability, cellular uptake, and rheumatoid arthritis treatment.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Omega-3-and Resveratrol-Loaded Lipid Nanosystems for Potential Use as Topical Formulations in Autoimmune, Inflammatory, and Cancerous Skin Diseases

Ana R. Caldas et al.

Summary: By encapsulating Omega 3 and Resveratrol in different lipid nanosystems, this study overcame the stability and skin permeation limitations, demonstrating the potential application value of using these two systems in a semi-solid base for autoimmune, inflammatory, and cancerous skin diseases.

PHARMACEUTICS (2021)

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Review Plant Sciences

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Anastasia Kyriakoudi et al.

Summary: Plant-derived phytochemicals have proven biological activity but face challenges such as low stability and poor solubility. Various delivery systems have been developed to enhance the stability and solubility of these compounds, delivering them efficiently to target tissues for biological activity and human health promotion.

PLANTS-BASEL (2021)

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Article Engineering, Biomedical

Rutin-Loaded Nanovesicles for Improved Stability and Enhanced Topical Efficacy of Natural Compound

Maria Chiara Cristiano et al.

Summary: The study aimed to optimize ethosomes for the delivery of rutin, resulting in improved stability and efficacy for both antioxidant and anti-inflammatory effects. Through encapsulation into nanosystems, enhanced photostability of rutin was achieved, leading to promising results in in vitro and in vivo studies for potential use in skin diseases.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

Phenolic compounds: current industrial applications, limitations and future challenges

Bianca R. Albuquerque et al.

Summary: Phenolic compounds are natural bioactive molecules mainly found in plant tissues, with interesting bioactivities such as antioxidant, antimicrobial, anti-inflammatory, and antiproliferative activities. Despite their potential applicability in various industries, there are still issues that need to be addressed, including improving bioavailability and stability through sustainable extraction and refinement technologies. This review focuses on recent advances in the applications of phenolic compounds in different technological and medicinal areas, as well as techniques to enhance their sustainable resourcing, stability, and bioavailability.

FOOD & FUNCTION (2021)

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Article Pharmacology & Pharmacy

Formulation and evaluation of rutin-loaded solid lipid nanoparticles for the treatment of brain tumor

Sureshbabu Ram Kumar Pandian et al.

Summary: This study successfully formulated Rutin-encapsulated solid lipid nanoparticles (SLNs) for effective brain delivery across the blood-brain barrier. The in vivo biodistribution results showed high distribution of Rutin in the brain, while molecular docking and dynamic simulation demonstrated its stable binding with EGFR receptor.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Polymer Science

Targeting keratinocyte hyperproliferation, inflammation, oxidative species and microbial infection by biological macromolecule-based chitosan nanoparticle-mediated gallic acid-rutin combination for the treatment of psoriasis

Amarjeet Shandil et al.

POLYMER BULLETIN (2020)

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Article Engineering, Biomedical

In situ forming and reactive oxygen species-scavenging gelatin hydrogels for enhancing wound healing efficacy

Phuong Le Thi et al.

ACTA BIOMATERIALIA (2020)

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Protective role of poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol against isoproterenol-induced myocardial infarction

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Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice

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Nano-formulated curcumin accelerates acute wound healing through Dkk-1-mediated fibroblast mobilization and MCP-1-mediated anti-inflammation

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PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice

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Multiple Functions of D-α-Tocopherol Polyethylene Glycol 1000 Succinate (TPGS) as Curcumin Nanoparticle Stabilizer: In Vivo Kinetic Profile and Anti-Ulcerative Colitis Analysis in Animal Model

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Review Chemistry, Medicinal

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

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Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease

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Polymeric In Situ Hydrogel Implant of Epigallocatechin Gallate (EGCG) for Prolonged and Improved Antihyperlipidemic and Anti-Obesity Activity: Preparation and Characterization

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Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet-1 Peptide To Reduce Amyloid-β Aggregation and Cytotoxicity

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Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes

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