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Pharmacology & Pharmacy
Rik P. M. Moonen et al.
Summary: The study monitored iron oxide contrast agent uptake in mouse atherosclerotic plaques using quantitative T-2-mapping MRI, finding an inverse relationship between T-2 values and iron levels in the plaque.
Article
Pharmacology & Pharmacy
Carlos Caro et al.
Summary: The study reported the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone, demonstrating their potential applications in multimodal imaging and photothermal therapy. Experimental results showed excellent efficiency in killing glioblastoma cells and reliable pharmacokinetics and biodistribution in animal models. Additionally, the study confirmed the limitations of intravenous administration for tumor targeting, suggesting intratumoral administration for therapeutic applications.
Article
Pharmacology & Pharmacy
Antoine D'Hollander et al.
Summary: The use of synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for cell labeling and tracking showed high contrast in both MRI and CT imaging. These nanoparticles accumulated in the liver and spleen after injection, leading to significant MRI contrast enhancement. Furthermore, the cell accumulation in the lungs after injection of SAF-NP-labeled cells was detectable using CT but not MRI. SAF-NPs are efficient agents for complementary MRI- and CT-based cell tracking, particularly useful in applications where visualization of particles and cells in all organs is needed.
Review
Pharmacology & Pharmacy
Clara Correa-Paz et al.
Summary: Ischemic stroke, caused by blood flow interruption and neuronal death, is a major disability cause in developed countries. Therapeutic methods have limitations, but nanotechnology has emerged as a promising tool to improve treatment efficacy, with the use of nanoparticles for contrast agents or drug carriers being common approaches.
Article
Pharmacology & Pharmacy
Lukasz Kalkowski et al.
Summary: Cell therapy holds promise for treating CNS disorders, but faces challenges in translation due to ineffective delivery methods. The intrathecal route of administration is attractive for global diseases like stroke or ALS, but precision and efficacy remain a challenge. Hydrogels and contrast agents have been introduced to improve delivery outcomes.
Article
Pharmacology & Pharmacy
Ander Egimendia et al.
Summary: Ex vivo models using multimodal imaging and myelin-targeting liposomes show potential for quantifying myelin content in organotypic cultures. MRI can successfully image brain tissue sections with good contrast, while myelin-targeting liposomes allow for semiquantitative detection by fluorescence. Fine tuning of the probe is necessary to improve specificity when using lipid-based systems.
Article
Pharmacology & Pharmacy
Nuria Arias-Ramos et al.
Summary: Conjugated polymer nanoparticles (CPNs) have shown excellent properties such as high fluorescence brightness, high absorption coefficients, and good stability in water and physiological medium, making them suitable for biomedical applications. In this study, CPNs were modified by incorporating metal oxide magnetic cores, allowing in vivo monitoring using MRI and intravital fluorescence. The biocompatible IONP-doped CPNs showed good performance in tumor cells and organs, with no adverse effects on photodynamic therapy (PDT) cytotoxicity.