☆ 4.7 Review

Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery

PHARMACEUTICS (2023)

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Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model

Mahsa Mobahat et al.

Summary: This study successfully enhanced the penetration of curcumin through the blood brain barrier into the brain by fabricating nanoformulated curcumin loaded exosomes. The new formulation improved the anti-Parkinsonism effects of curcumin, including suppressing alpha-synuclein aggregation and rescuing neuronal cell death.

CELL AND TISSUE BANKING (2023)

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Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders

Jie Wu et al.

Summary: This review discusses the application of extracellular vesicles (EVs) in the treatment of brain disorders and the new strategies for bioengineering EVs. It provides detailed descriptions of the properties and biogenesis of different subtypes of EVs, and compares EVs with other brain-targeted nanocarriers.

NANO RESEARCH (2023)

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Ronnie H. Fang et al.

Summary: Cell membrane-coated nanoparticles (CNPs) are emerging nanocarriers that have the potential to improve cancer therapy by overcoming limitations of traditional nanoparticles. CNPs, consisting of a synthetic nanoparticulate core surrounded by a layer of naturally derived cell membranes, offer improved biocompatibility, immune evasion, and tumor targeting. They have been used for drug delivery, phototherapy, and immunotherapy.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Review Chemistry, Multidisciplinary

Review: Milk Small Extracellular Vesicles for Use in the Delivery of Therapeutics

Javaria Munir et al.

Summary: Small extracellular vesicles (sEVs, exosomes) in milk have scalable production, protect cargo, can be absorbed and cross barriers, do not affect organ function or elicit immune responses, can be loaded with therapeutic cargo, and have potential for drug delivery.

PHARMACEUTICAL RESEARCH (2023)

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Article Cell & Tissue Engineering

Stem Cell-derived Extracellular Vesicles : A Promising Nano Delivery Platform to the Brain?

Yuying Guo et al.

Summary: This review briefly presents current brain drug delivery strategies and the application of nanocarriers, specifically EVs. EVs, as naturally derived nanoscale vesicles, have been extensively studied in drug delivery due to their superior properties. The cellular origin of EVs affects their properties, and stem cell-derived EVs have shown promise as drug carriers. However, there are still challenges in the clinical application of EVs as drug carriers.

STEM CELL REVIEWS AND REPORTS (2023)

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Review Chemistry, Physical

Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders

Jie Wu et al.

Summary: This review explores the potential applications of extracellular vesicles (EVs) as novel nanocarriers for brain disorders. By bioengineering EVs, their properties have been improved in terms of encapsulation efficiency, targeting capability, and controlled drug release. A systematic comparison between EVs and other brain-targeted nanocarriers is presented, along with the discussion of current challenges and future perspectives of EVs.

NANO RESEARCH (2023)

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Article Nanoscience & Nanotechnology

Visualization of Acute Inflammation through a Macrophage-Camouflaged Afterglow Nanocomplex

Xiu Wang et al.

Summary: The study introduces a Trojan horse strategy using a macrophage-camouflaged afterglow nanocomplex to visualize acute inflammation, showing excellent recognition ability in different models and potential for inflammatory detection and treatments.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles

Tian Tian et al.

Summary: The delivery of therapeutic agents to glioblastoma (GBM) is hindered by the blood-brain barrier and immune suppressive microenvironment. This study demonstrates that modifying the surface of extracellular vesicles (EVs) with a brain-tumor-targeting peptide and using bursts of radiation can enhance EV delivery to GBM. Furthermore, loading EVs with small interfering RNA against programmed cell death ligand-1 (PD-L1) reverses radiation-stimulated PD-L1 expression and recruits tumor-associated myeloid cells, leading to improved therapeutic effects. These findings provide a new EV-based strategy for GBM immune checkpoint therapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma

Tingting Wu et al.

Summary: Sonodynamic therapy (SDT) is a promising cancer treatment modality for glioblastoma (GBM) due to its high tissue penetration and minimal damage to normal tissues. However, the blood-brain barrier (BBB) and hypoxic microenvironment present challenges to SDT efficiency. In this study, a biodegradable nanoplatform (CSI@Ex-A) was developed, which could effectively penetrate the BBB and target cancer cells. The nanoplatform releases hydrogen peroxide (H2O2) and oxygen (O-2) to relieve tumor hypoxia, thereby enhancing the efficacy of SDT.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Engineered extracellular vesicles encapsulated Bryostatin-1 as therapy for neuroinflammation

Wen-Cheng Wu et al.

Summary: This study developed a novel therapeutic strategy for local drug delivery using extracellular vesicles derived from neural stem cells. The results showed that this method could effectively deliver drugs to the central nervous system and ameliorate the development of neuroinflammatory diseases.

NANOSCALE (2022)

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Article Cell Biology

Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours

Xiaoyu Yu et al.

Summary: This study investigated the effects of extracellular vesicle-mediated delivery of circDYM on MDD treatment. The results showed that RVG-circDYM-EVs were successfully delivered to the brain and alleviated depressive-like behaviors induced by CUS. Moreover, it was found that RVG-circDYM-EVs inhibited microglial activation, BBB leakiness, peripheral immune cells infiltration, and attenuated astrocyte dysfunction through the decreased expression of downstream target genes, suggesting its potential for clinical applications.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Chemistry, Multidisciplinary

Engineered Nanoerythrocytes Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia

Na Yin et al.

Summary: Reprogramming microglia from classical M1 to alternative M2 through induction of HO-1, Notch1/Hes1/Stat3 signaling, and inhibition of NF-kappa B p65 translocation provides a promising therapeutic strategy for central nervous system disorders.

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Biomimetic neutrophil and macrophage dual membrane-coated nanoplatform with orchestrated tumor-microenvironment responsive capability promotes therapeutic efficacy against glioma

Ying Yin et al.

Summary: This study presents an effective approach for treating malignant glioma based on neutrophil-macrophage hybrid membrane coating nanotechnology. The biomimetic nanoparticle can overcome the blood-brain barrier and target glioma, showing high therapeutic efficacy.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Oncology

Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy

Qi Zhan et al.

Summary: The study demonstrated that combination therapy using blood exosomes (Exos) as carriers can regulate the energy metabolism of glioblastoma (GBM) for personalized treatment. Exos co-loaded cytoplasmic phospholipase A2 siRNA (sicPLA2) and metformin, delivering them across the blood-brain barrier to GBM tissue. In a PDX GBM model, systemic administration of Exos-Met/sicPLA2 reduced tumor growth and prolonged survival.

NEURO-ONCOLOGY (2022)

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Article Food Science & Technology

Momordica charantia-derived extracellular vesicles-like nanovesicles inhibited glioma proliferation, migration, and invasion by regulating the PI3K/AKT signaling pathway

Bin Wang et al.

Summary: Momordica.charantia-derived extracellular vesicles-like nanovesicles (MCELNs) have the potential to treat glioma by inhibiting cell proliferation and migration, and may be associated with the PI3K/AKT pathway.

JOURNAL OF FUNCTIONAL FOODS (2022)

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Article Chemistry, Multidisciplinary

Biomimetic Lipopolysaccharide-Free Bacterial Outer Membrane-Functionalized Nanoparticles for Brain-Targeted Drug Delivery

Haiyan Chen et al.

Summary: This study proposes a biomimetic nanoparticle that utilizes the BBB invasion ability of Escherichia coli K1 (EC-K1) outer membrane for brain-targeted drug delivery. The nanoparticles penetrate the BBB through the transcellular vesicle transport pathway, which is mediated by the interactions between outer membrane protein A and gp96 on BBB endothelial cells. This nanoengineering strategy provides the loaded drugs with prolonged circulation, intracranial interstitial distribution, and extremely high biocompatibility. The study also reveals the potential of delivering therapeutics to treat gp96-overexpressing intracranial malignancies.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy

Boyan Li et al.

Summary: A novel composite therapeutic platform combining magnetic nanoparticles and engineered exosomes is proposed for GBM treatment, aiming to improve the penetration through the blood-brain barrier and enhance tumor targeting ability for effective ferroptosis therapy.

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Article Chemistry, Multidisciplinary

Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy

Shaobo Shan et al.

Summary: This study developed a nano drug delivery system based on functionalized macrophage exosomes, which could efficiently deliver drugs and gene therapeutics for targeted therapy of DIPG tumor cells, resulting in prolonged survival of patients.

ADVANCED SCIENCE (2022)

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Article Cell Biology

Tumour-derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour-homing and intracellular freeway transportation

Xin Zhou et al.

Summary: This study successfully isolated TDEV membranes from hepatocellular carcinoma cells and fabricated innovative TDEV membrane hybrid lipid nanovesicles (LEVs) for precise delivery to tumors and efficient siRNA transfection. The LEVs, equipped with 'homing' targeting ability, showed improved siRNA delivery efficiency compared to liposomes. In animal experiments, siRNA loaded LEVs demonstrated enhanced antitumor efficacy in hepatocellular carcinoma tumors.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Materials Science, Multidisciplinary

Multi-functional platelet membrane-camouflaged nanoparticles reduce neuronal apoptosis and regulate microglial phenotype during ischemic injury

Chaoyue Zhao et al.

Summary: Cerebral ischemic injury is a significant factor in the prognosis of acute ischemic stroke (AIS). This study explores the use of platelet membrane-coated nanoparticles to deliver miRNA-Let-7c for targeted regulation of neurons and microglia in the ischemic injury area. The results suggest that this strategy could be an effective gene delivery system and a potential treatment for ischemic injury.

APPLIED MATERIALS TODAY (2022)

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Review Pharmacology & Pharmacy

Cell-based drug delivery systems and their in vivo fate

Liuxin Yang et al.

Summary: Cell-based drug delivery systems have gained attention for their unique biological properties and self-powered functions. They exhibit excellent biocompatibility, low immunogenicity, long circulation time, tissue-homing characteristics, and the ability to cross biological barriers. Various cells have been explored as functional vectors for loading and delivering therapeutic payloads, showing potential for disease treatment. The fate of these cell-based drug delivery systems in vivo depends on biological properties, loaded drugs, physiological and pathological circumstances, and the body's response.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Biophysics

Tumor-derived exosomes reversing TMZ resistance by synergistic drug delivery for glioma-targeting treatment

Ruoning Wang et al.

Summary: This study proposes a new strategy for glioma treatment by using reassembly exosomes to carry drugs, which have good ability to cross the blood-brain barrier and tumor-targeting accumulation, overcoming drug resistance and triggering immune response.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Chemistry, Multidisciplinary

Engineered Macrophage-Membrane-Coated Nanoparticles with Enhanced PD-1 Expression Induce Immunomodulation for a Synergistic and Targeted Antiglioblastoma Activity

Tieying Yin et al.

Summary: This article reports an engineered macrophage-membrane-coated nanoplatform with enhanced programmed cell death-1 (PD-1) expression, which can efficiently traverse the blood-brain barrier and accumulate nanoparticles at the tumor site, thereby enhancing the effectiveness of immune checkpoint blockade therapy.

NANO LETTERS (2022)

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Review Biotechnology & Applied Microbiology

A mini-review: Advances in plant-derived extracellular vesicles as nano-delivery systems for tumour therapy

Ying Zhu et al.

Summary: This paper reviews the application of plant-derived extracellular vesicles and their nano-derivatives as nano-delivery systems in tumor therapy, illustrating their great application potential.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

Guihong Lu et al.

Summary: The use of cancer cell-membrane encapsulated nanoparticles for targeted therapy in lactate-high cancer cells shows promising results in reducing tumorigenesis in glioblastoma.

NATURE COMMUNICATIONS (2022)

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Review Pharmacology & Pharmacy

A Historical Review of Brain Drug Delivery

William M. Pardridge

Summary: This article reviews the history of brain drug delivery and discusses different technologies and methods. Due to the restricted transport across the blood-brain barrier, FDA-approved drugs for the central nervous system are generally limited to lipid-soluble small molecules.

PHARMACEUTICS (2022)

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Article Cell Biology

Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides

Zhanchi Zhu et al.

Summary: The study demonstrates that engineered sEVs can effectively treat glioma by crossing the blood-brain barrier and specifically targeting brain tumors. The high targeting efficiency of these dual-modified sEVs for BBB and glioma was confirmed in vitro and in animal models.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Chemistry, Multidisciplinary

Brain-Targeting Metastatic Tumor Cell Membrane Cloaked Biomimetic Nanomedicines Mediate Potent Chemodynamic and RNAi Combinational Therapy of Glioblastoma

Dongya Zhang et al.

Summary: This paper develops a brain-targeting metastatic tumor cell membrane cloaked biomimetic nanomedicine for combinational GBM therapy. The nanomedicine induces cascade chemodynamic and RNA interference (RNAi) to effectively treat GBM. The results demonstrate efficient blood brain barrier (BBB) penetration and promising potential in GBM treatment.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Biotechnology & Applied Microbiology

Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design

Haoyue Song et al.

Summary: This review comprehensively summarizes the potential and challenges of natural endogenous extracellular vesicles (EVs) in precision medicine drug delivery systems. The strategies to improve targeting specificity, such as nanoengineering techniques to modify source cells and EVs surfaces, as well as auxiliary strategies to change the external environment, are discussed. The lack of a gold standard for assessing targeting efficiency in contemporary issues is also highlighted.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Overcoming the blood-brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

Ksenia Mitusova et al.

Summary: Despite the broad development of nanotechnological approaches for cancer diagnosis and therapy, there has been no significant progress in the treatment of brain tumors. The key challenge lies in finding therapeutic molecules that can cross the blood-brain barrier and effectively target brain tumors. Various methods and nanocarriers have been explored, but clinical translations have been lacking. Understanding the mechanisms of blood-brain barrier penetration and developing advanced drug delivery platforms are crucial for the development of effective therapy against brain tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

Xiao Liu et al.

Summary: This study used engineering technology to generate T7 peptide-decorated exosomes, which efficiently deliver chemotherapy drugs to GBM cells, enhance chemosensitivity, and reverse therapeutic resistance.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Medicinal

Hybrid Membrane-Derived Nanoparticles for Isoliquiritin Enhanced Glioma Therapy

Wenwan Shi et al.

Summary: Due to the obstruction and heterogeneity of the blood-brain barrier, the clinical treatment of glioma has been extremely difficult. In this study, researchers established a nanoscale hybrid membrane-derived system composed of erythrocytes and tumor cells, aiming to enhance the solubility and targeting of isoliquiritigenin (ISL) for glioma therapy. The results showed that the hybrid membrane-derived nanoparticles significantly increased the solubility and antitumor effect of ISL, and further investigations revealed the mechanism of action of the ISL-loaded nanoparticles on tumor cells.

PHARMACEUTICALS (2022)

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Article Biochemistry & Molecular Biology

Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects

Xiaojun Wang et al.

Summary: The researchers successfully developed M1-like macrophage-derived extracellular vesicles (M1EVs) for the treatment of glioblastoma multiforme (GBM). These M1EVs achieved synergistic immunomodulation, chemiexcited photodynamic therapy (CDT), and hypoxia-activated chemotherapy in GBM, leading to a potent therapeutic effect. The results demonstrated the excellent efficacy of CCA-M1EVs against GBM in cell-derived and patient-derived xenograft models.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Nanoscience & Nanotechnology

Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas

Sheng Wang et al.

Summary: A macrophage loaded with a photothermal nanoprobe was developed to cross the blood-brain barrier and accumulate into deep gliomas for multimodal imaging and guided surgery purposes. This nanoplatform shows promise for achieving accurate diagnosis, imaging-guided surgery, and effective photothermal therapy for gliomas.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

Tingting Xiao et al.

Summary: The study introduces a multifunctional polymer nanogel camouflaged with macrophage membranes for MR imaging-guided chemotherapy of glioma. The nanogel exhibits dual pH and redox-responsive release profiles, enhancing chemotherapy/CDT efficacy.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

Lishuai Feng et al.

Summary: This study introduces a neutrophil-like cell-membrane-coated mesoporous Prussian blue nanozyme, which improves the delivery of the nanozyme to the damaged brain for noninvasive active-targeting therapy in ischemic stroke. The long-term therapeutic efficacy of this nanozyme in ischemic stroke is demonstrated, with a detailed mechanism involving uptake by microglia leading to beneficial effects like microglia polarization, reduced recruitment of neutrophils, decreased neuron apoptosis, and neural cell proliferation. This strategy offers an approach for nanozyme therapy in brain diseases.

ACS NANO (2021)

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Review Biochemistry & Molecular Biology

Cell death due to electroporation - A review

Tina Batista Napotnik et al.

Summary: Exposure of cells to high voltage electric pulses can transiently increase membrane permeability through electroporation. Electroporation can be reversible and used in gene transfer and drug delivery, but may also lead to irreversible electroporation causing cell death. Understanding the mechanisms of cell death and membrane repair after electroporation is crucial for optimizing and developing new techniques in medicine, biotechnology, and food technology.

BIOELECTROCHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Wenbo Niu et al.

Summary: By patching doxorubicin-loaded heparin-based nanoparticles onto natural grapefruit extracellular vesicles, biomimetic EV-DNs can efficiently penetrate the blood brain barrier and blood-(brain tumor) barrier, achieving effective drug delivery and enhanced antiglioma efficacy.

NANO LETTERS (2021)

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Review Biochemistry & Molecular Biology

Application of Mesenchymal Stem Cells in Targeted Delivery to the Brain: Potential and Challenges of the Extracellular Vesicle-Based Approach for Brain Tumor Treatment

Anh Duy Do et al.

Summary: Treating brain tumors is challenging due to the blood-brain barrier, which limits therapeutic access. Mesenchymal stem cells can be engineered to release extracellular vesicles with healing effects, providing a cell-free approach for targeting tumors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Engineering, Biomedical

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

Maxime Ayer et al.

Summary: This study demonstrates the feasibility of using activated effector/memory CD4(+) helper T cells as carriers for delivering polymer nanoparticles across the blood-brain barrier. In vitro and in vivo experiments confirm the ability of these cells to transport nanoparticles across the barrier, showing the potential for brain delivery in allogeneic hosts.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Endocrinology & Metabolism

Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA

Chao Li et al.

Summary: The study demonstrates that small extracellular vesicles derived from rat cerebral endothelial cells (CEC-sEVs) in combination with tissue plasminogen activator (tPA) have a positive effect on treating cerebral large vessel occlusion, reducing infarct volume, increasing recanalization, improving cerebral blood flow, and reducing blood-brain barrier leakage. This treatment also effectively suppresses a network of microRNAs and proteins that mediate thrombosis, coagulation, and inflammation.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Article Chemistry, Multidisciplinary

Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer

Yongho Jang et al.

Summary: In this study, tumor-derived reassembled exosome (R-Exo) was used both as a drug delivery carrier and an immunostimulatory agent for cancer therapy. By loading chlorin e6 photosensitizer into R-Exo, it retained its original size and membrane proteins for targeting tumor cells. The modified exosomes were able to generate reactive oxygen species and increase cytokine release from immune cells, showing their potential as an immunotherapeutic agent.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Engineered Microglia Potentiate the Action of Drugs against Glioma Through Extracellular Vesicles and Tunneling Nanotubes

Yitian Du et al.

Summary: This study demonstrated the use of engineered microglia as transport vectors to deliver paclitaxel for the treatment of glioma. Engineered microglia can cross the BBB, migrate towards gliomas, and transfer cargo to glioma cells. Extracellular vesicles and tunneling nanotubes were found to play unique roles in cargo transportation between microglia and glioma cells.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Exosome-Coated 10B Carbon Dots for Precise Boron Neutron Capture Therapy in a Mouse Model of Glioma In Situ

Juan Li et al.

Summary: Novel boron-containing carbon dots (BCDs) were designed and prepared for boron neutron capture therapy (BNCT), encapsulated in exosomes (Exos) from macrophages to form BCD-Exos, achieving excellent therapeutic effects on brain glioma in mice models with 100% survival rate. Adjusted biodistribution of boron, enhanced T/N ratios, and precise match between boron and neutron exposure at the tumor site in vivo with fluorescence imaging of BCD-Exos contributed to the success of the treatment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery

Wenyan Hao et al.

Summary: The study successfully developed a cell membrane-based chemoimmunotherapy delivery vehicle for anti-glioma therapy through different modes. The nanosuspension could target cancer cells through homotypic-targeting mechanism and induce immune response by mimicking dendritic cell membrane characteristics.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

Yi Xing et al.

Summary: Extracellular vesicles (EVs) act as natural nanocarriers and intercellular messengers, playing a crucial role in cell communication, while macrophage-derived EVs may have significant implications in the development of chronic inflammatory diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Novel Roles of Small Extracellular Vesicles in Regulating the Quiescence and Proliferation of Neural Stem Cells

Jingtian Zhang et al.

Summary: The quiescence of neural stem cells is crucial for avoiding exhaustion and sustaining neurogenesis in the adult brain. Exosomes, small extracellular vesicles, have been found to play a role in regulating the maintenance and transition of NSC quiescence. Proteomic analysis of exosome protein cargos from different states of NSCs revealed fluctuations and functional clusters in protein translation and vesicular transport, highlighting the involvement of exosomes in regulating NSC quiescence.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

Wenxiu He et al.

Summary: The study presents a novel biomimetic nanoplatform designed to enhance drug delivery to cerebral ischemic lesions, demonstrating superior neuroprotective effects.

NANO LETTERS (2021)

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Article Chemistry, Physical

Enhanced treatment for cerebral ischemia-reperfusion injury of puerarin loading liposomes through neutrophils-mediated targeted delivery

Wei Liu et al.

Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.

NANO RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies

Yulian Wang et al.

Summary: The study explores the potential of using small apoptotic bodies from brain metastatic cancer cells as carriers for brain-targeted drug delivery, showing high delivery efficiency. By combining anti-TNF-alpha antisense oligonucleotide with sABs, successful enhancement of brain delivery efficiency is achieved. This research provides a new strategy for the treatment of brain diseases.

ADVANCED SCIENCE (2021)

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Article Robotics

Dual-responsive biohybrid neutrobots for active target delivery

Hongyue Zhang et al.

Summary: Neutrophil-based microrobots, constructed by phagocytosis of drug-loaded magnetic nanogels enveloped in Escherichia coli membrane, exhibit controllable intravascular movement and can autonomously aggregate in the brain by positive chemotactic motion along the gradient of inflammatory factors. These dual-responsive neutrobots show promise for targeted drug delivery to inhibit tumor cell proliferation compared to traditional drug injection, leveraging the biological characteristics of natural neutrophils that artificial microrobots cannot replicate.

SCIENCE ROBOTICS (2021)

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Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison

Jun-Yong Wu et al.

Summary: The study compared Exos and BNVs for brain tumor drug delivery, finding that BNVs derived from brain-derived endothelial cells are a promising alternative with higher yield and similar drug-loading capacity to natural exosomes. Despite different mechanisms, BNV/DOX showed similar therapeutic effects to Exo/DOX in inhibiting the progression of glioblastoma, with minimal systemic toxicity. The findings suggest that autologous BNVs are an effective alternative to Exos for brain tumor nanomedicine.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Multidisciplinary

Biomimetic and cell-based nanocarriers-New strategies for brain tumor targeting

D. Mendanha et al.

Summary: In the last two decades, significant advances in the treatment of the most common and malignant types of brain tumors have not been achieved, primarily due to difficulties in drug delivery to the central nervous system and associated severe side effects. Research on cell-based nanocarriers is exploring the potential for crossing biological barriers and targeting brain tumors with higher selectivity, offering new hope for safe and effective treatments.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Artificial exosomes for translational nanomedicine

Yong-Jiang Li et al.

Summary: Artificial exosomes, produced through nanobiotechnology, have emerged as effective drug delivery carriers and include various types such as nanovesicles, exosome-mimetic, and hybrid exosomes. These artificial exosomes offer solutions to overcome limitations of natural exosomes and are considered powerful alternatives for drug delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Cell Biology

Extracellular vesicles in the development of organ-specific metastasis

Fumihiko Urabe et al.

Summary: Distant organ metastasis, orchestrated by complex biological interactions, is a fundamental feature of malignant tumors. Extracellular vesicles (EVs) play a critical role in mediating tumor-host cell interactions, controlling organ-specific infiltration, adaptation, and colonization at the secondary site.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits

Yi-An Chen et al.

Summary: The study evaluated the therapeutic performance of MSC-exosomes in AD, showing that they could reduce Aβ expression, restore the expression of neuronal memory/synaptic plasticity-related genes, improve brain glucose metabolism and cognitive function in AD transgenic mice.

BIOMEDICINES (2021)

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Article Materials Science, Multidisciplinary

Targeted Photoacoustic Imaging of Brain Tumor Mediated by Neutrophils Engineered with Lipid-Based Molecular Probe

Xingang Liu et al.

Summary: The study developed a lipid-decorated molecular photoacoustic contrast agent TFML, which effectively labeled live neutrophils for targeted brain tumor imaging in mice glioblastoma multiforme detection. This approach presents a promising prospect for neutrophil-based nanotherapeutics research.

ACS MATERIALS LETTERS (2021)

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Article Chemistry, Multidisciplinary

Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

Chao Li et al.

Summary: This biomimetic nanomedicine utilizes macrophage-disguised manganese dioxide nanospheres loaded with fingolimod to target the damaged brain in ischemic stroke, reducing oxidative stress, promoting microglial transition, and ultimately enhancing neuronal survival. This new strategy offers a multitargeted combined treatment approach for ischemic stroke.

ADVANCED SCIENCE (2021)

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Article Medicine, Research & Experimental

Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy

Jianbing Du et al.

Summary: This study successfully designed an exosome-based platform to deliver ferroptosis inducer and photosensitizer into liver cancer cells, inducing cell death significantly while minimizing toxicity to the liver and kidney.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia

Tian Tian et al.

Summary: Ischemic stroke is a major cause of death and anti-inflammatory strategies are promising for reducing brain injury during reperfusion. Stem cell-derived extracellular vesicles (EVs) have emerged as therapeutic agents for immune modulation. By attaching targeting ligands onto EVs using a recombinant fusion protein, researchers were able to deliver anti-inflammatory EVs to the ischemic brain, showing promising results in suppressing inflammation.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles

Aixue Li et al.

Summary: Nanotechnology provides synthetic carriers for cancer drug delivery, while cell-derived biomimetic vehicles based on the concept of 'mimicking nature' offer low immunogenicity, long circulation time, and targeting ability. Cell membrane-coated carriers and extracellular vesicles are two widely used cell-based biomimetic materials in targeted cancer therapy, but they also face future challenges and development prospects.

DRUG DELIVERY (2021)

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Review Pharmacology & Pharmacy

The blood-brain barrier: Physiology and strategies for drug delivery

Rucha Pandit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Camouflaging Nanoparticles with Brain Metastatic Tumor Cell Membranes: A New Strategy to Traverse Blood-Brain Barrier for Imaging and Therapy of Brain Tumors

Caixia Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

Gyeungyun Kim et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Clinical Neurology

The global burden of neurological disorders: translating evidence into policy

Valery L. Feigin et al.

LANCET NEUROLOGY (2020)

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Review Biotechnology & Applied Microbiology

Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing

Antonio Casado-Diaz et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Cell Biology

Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy

Hong-Xu Chen et al.

CELL DEATH & DISEASE (2020)

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Article Biotechnology & Applied Microbiology

Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer's disease

Chunhong Gao et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Medicine, Research & Experimental

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease

Cang Chen et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Oncology

The Antitumor Effect of Gene-Engineered Exosomes in the Treatment of Brain Metastasis of Breast Cancer

Minchen Liu et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

Guanjun Deng et al.

ACS NANO (2020)

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Article Biotechnology & Applied Microbiology

Trojan horse monocyte-mediated delivery of conjugated polymer nanoparticles for improved photodynamic therapy of glioblastoma

Luis E. Ibarra et al.

NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment

Tao Zheng et al.

NANO-MICRO LETTERS (2020)

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Article Multidisciplinary Sciences

Targeted exosome coating gene-chem nanocomplex as nanoscavenger for clearing α-synuclein and immune activation of Parkinson's disease

Linying Liu et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Regulating Interactions Between Targeted Nanocarriers and Mononuclear Phagocyte System via an Esomeprazole-Based Preconditioning Strategy

Zakia Belhadj et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Oncology

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases

Costas D. Arvanitis et al.

NATURE REVIEWS CANCER (2020)

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Article Pharmacology & Pharmacy

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

Yao Qi et al.

DRUG DELIVERY (2020)

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Article Chemistry, Multidisciplinary

Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

Qingwei Zhu et al.

ADVANCED SCIENCE (2019)

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Review Pharmacology & Pharmacy

Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application

Qing Xia et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Article Nanoscience & Nanotechnology

Cell-Penetrating Peptide-Functionalized Persistent Luminescence Nanoparticles for Tracking J774A.1 Macrophages Homing to Inflamed Tissues

Li-Jian Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Nathan D. Donahue et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Geriatrics & Gerontology

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease

Guo-hong Cui et al.

IMMUNITY & AGEING (2019)

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Article Chemistry, Multidisciplinary

Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells

Junning Ma et al.

SMALL (2019)

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Article Engineering, Biomedical

Scaffolds biomimicking macrophages for a glioblastoma NIR-Ib imaging guided photothermal therapeutic strategy by crossing Blood-Brain Barrier

Jiazheng Lai et al.

BIOMATERIALS (2019)

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Article Biotechnology & Applied Microbiology

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

Maria Izco et al.

MOLECULAR THERAPY (2019)

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Article Multidisciplinary Sciences

Accessing neuroinflammation sites: Monocyte/neutrophil-mediated drug delivery for cerebral ischemia

Jia Hou et al.

SCIENCE ADVANCES (2019)

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Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

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Article Biotechnology & Applied Microbiology

RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors

Fernanda Pohl-Guimaraes et al.

MOLECULAR THERAPY (2019)

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Review Chemistry, Multidisciplinary

Recent Advances in Cell Membrane-Camouflaged Nanoparticles for Cancer Phototherapy

Xu Zhen et al.

SMALL (2019)

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Review Cell & Tissue Engineering

Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases

Xiao Sun et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Biotechnology & Applied Microbiology

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications

Federica Marinaro et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Hao Wang et al.

NANOSCALE (2019)

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Article Engineering, Biomedical

Cell-Based Drug Delivery and Use of Nano- and Microcarriers for Cell Functionalization

Alexander S. Timin et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Cell Membrane Coating Nanotechnology

Ronnie H. Fang et al.

ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian Tian et al.

BIOMATERIALS (2018)

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Article Engineering, Biomedical

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Gang Jia et al.

BIOMATERIALS (2018)

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Review Oncology

Exosomes in cancer development and clinical applications

Yu-Ling Tai et al.

CANCER SCIENCE (2018)

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Review Chemistry, Multidisciplinary

New Technologies for Analysis of Extracellular Vesicles

Huilin Shao et al.

CHEMICAL REVIEWS (2018)

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Review Biochemistry & Molecular Biology

Role of extracellular vesicles in glioma progression

Claudia Quezada et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Monocyte-mediated chemotherapy drug delivery in glioblastoma

Chao Wang et al.

NANOMEDICINE (2018)

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Article Multidisciplinary Sciences

Efficient RNA drug delivery using red blood cell extracellular vesicles

Waqas Muhammad Usman et al.

NATURE COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Myelin-specific T cells carry and release magnetite PGLA-PEG COOH nanoparticles in the mouse central nervous system

M. M. D'Elios et al.

RSC ADVANCES (2018)

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Article Medicine, Research & Experimental

Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells

Xinyi Jiang et al.

THERANOSTICS (2018)

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Review Medicine, Research & Experimental

Current Strategies for Brain Drug Delivery

Xiaowei Dong

THERANOSTICS (2018)

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Review Immunology

Therapeutic Prospects of extracellular vesicles in Cancer Treatment

Daria S. Chulpanova et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

Mengke Qu et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Multidisciplinary Sciences

Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression

Zhefeng Li et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Meiying Wu et al.

NATURE COMMUNICATIONS (2018)

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Review Anatomy & Morphology

Neural Progenitor Cell Terminology

Veronica Martinez-Cerdeno et al.

FRONTIERS IN NEUROANATOMY (2018)

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Review Medicine, General & Internal

Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders

Andrew Vogel et al.

EBIOMEDICINE (2018)

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Article Pharmacology & Pharmacy

Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy

Liang Pang et al.

DRUG DELIVERY (2018)

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Article Chemistry, Multidisciplinary

Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma

Wen-Chia Huang et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Nanoscience & Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

Jingwei Xue et al.

NATURE NANOTECHNOLOGY (2017)

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Review Cell & Tissue Engineering

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

Donald G. Phinney et al.

STEM CELLS (2017)

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Article Medicine, Research & Experimental

Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles

Chun Zhang et al.

THERANOSTICS (2017)

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Review Cell Biology

Biological roles and potential applications of immune cell-derived extracellular vesicles

Chuan Wen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Pharmacology & Pharmacy

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin

Farrukh Aqil et al.

AAPS JOURNAL (2017)

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Article Engineering, Biomedical

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Dongfen Yuan et al.

BIOMATERIALS (2017)

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Article Oncology

Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma

Zhihong Chen et al.

CANCER RESEARCH (2017)

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Article Chemistry, Multidisciplinary

A Dual-Functional Persistently Luminescent Nanocomposite Enables Engineering of Mesenchymal Stem Cells for Homing and Gene Therapy of Glioblastoma

Shu-Qi Wu et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

Haiqiang Cao et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

Brian P. Mead et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Neurosciences

The role of microglia and macrophages in glioma maintenance and progression

Dolores Hambardzumyan et al.

NATURE NEUROSCIENCE (2016)

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Review Chemistry, Multidisciplinary

Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy

Jingxing Si et al.

SMALL (2016)

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Article Oncology

Exploiting macrophages as targeted carrier to guide nanoparticles into glioma

Liang Pang et al.

ONCOTARGET (2016)

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Review Biotechnology & Applied Microbiology

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Sweta Rani et al.

MOLECULAR THERAPY (2015)

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Article Cell Biology

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

Wenchao Zhou et al.

NATURE CELL BIOLOGY (2015)

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Article Chemistry, Multidisciplinary

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

Tianzhi Yang et al.

PHARMACEUTICAL RESEARCH (2015)

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Review Chemistry, Physical

Imaging macrophages with nanoparticles

Ralph Weissleder et al.

NATURE MATERIALS (2014)

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Article Multidisciplinary Sciences

EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

Hongsheng Miao et al.

PLOS ONE (2014)

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Review Immunology

From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation

Paola Italiani et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Engineering, Biomedical

Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery

Xinglu Huang et al.

BIOMATERIALS (2013)

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Article Cell & Tissue Engineering

Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use

Marianne Z. Metz et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

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Review Immunology

T-cell trafficking in the central nervous system

Federica Sallusto et al.

IMMUNOLOGICAL REVIEWS (2012)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor-α-Activated Endothelial Cells Via Both Leukocyte-Like and Novel Mechanisms

Grace S. L. Teo et al.

STEM CELLS (2012)

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Review Immunology

Capture, crawl, cross: the T cell code to breach the blood-brain barriers

Britta Engelhardt et al.

TRENDS IN IMMUNOLOGY (2012)

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Article Oncology

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

Qing Chen et al.

CANCER CELL (2011)

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Review Pharmacology & Pharmacy

Cell-mediated drug delivery

Elena V. Batrakova et al.

EXPERT OPINION ON DRUG DELIVERY (2011)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Article Multidisciplinary Sciences

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Che-Ming J. Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Biochemical Research Methods

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8

GG Wang et al.

NATURE METHODS (2006)

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Review Neurosciences

Astrocyte-endothelial interactions at the blood-brain barrier

NJ Abbott et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Article Cell & Tissue Engineering

Efficient transfection of embryonic and adult stem cells

U Lakshmipathy et al.

STEM CELLS (2004)

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Review Oncology

New aspects of natural-killer-cell surveillance and therapy of cancer

MJ Smyth et al.

NATURE REVIEWS CANCER (2002)

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Article Endocrinology & Metabolism

Recruitment of neutrophils across the blood-brain barrier: The role of E- and P-selectins

M Bernardes-Silva et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

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Article Multidisciplinary Sciences

Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas

KS Aboody et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Multidisciplinary Sciences

Role of CD47 as a marker of self on red blood cells

PA Oldenborg et al.

SCIENCE (2000)

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