☆ 4.7 Article

Ultrasonic Microbubble Cavitation Deliver Gal-3 shRNA to Inhibit Myocardial Fibrosis after Myocardial Infarction

PHARMACEUTICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Fani Vlachou et al.

Summary: Galectin-3 plays a role in promoting cardiac adverse remodeling, inflammation, and failure by affecting functions of cardiac fibroblasts and macrophages. This study suggests that Galectin-3 is a valid intervention target for treating heart failure and associated comorbidities.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Angiogenesis after acute myocardial infarction

Xuekun Wu et al.

Summary: The translation describes how acute myocardial infarction causes damage to the coronary microcirculation, leading to vascular disintegration and capillary rarefication in the infarct region. Tissue repair after MI involves robust angiogenic response and interactions among various cell types through secreted proteins and receptors. Macrophages and fibroblasts have emerged as major drivers of the angiogenic response after MI, while understanding the mechanism of infarct angiogenesis creates therapeutic opportunities.

CARDIOVASCULAR RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The therapeutic potential of galectin-3 inhibition in fibrotic disease

R. J. Slack et al.

Summary: Galectin-3, a beta-galactoside-binding mammalian lectin, plays a crucial role in regulating cellular signaling by prolonging retention time or retarding lateral movement of cell surface receptors in the plasma membrane. It is involved in various cellular functions such as diffusion, compartmentalization, endocytosis, and the functionality of membrane receptors, and has been shown to be pro-fibrotic in multiple models of organ fibrosis. Additionally, there has been a significant increase in scientific literature investigating the role of Galectin-3 in fibrotic diseases and the clinical development of new Galectin-3 inhibitors over the past decade.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

Mengrui Liu et al.

Summary: Cardiac fibrosis is a major challenge in heart diseases, with myoFbs playing a key role in the fibrotic process. The lack of clear mechanisms and specific targets poses challenges for treatment strategies.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Small Endogeneous Peptide Mitigates Myocardial Remodeling in a Mouse Model of Cardioselective Galectin-3 Overexpression

Swati D. Sonkawade et al.

Summary: The study demonstrated that cardioselective Gal3 overexpression leads to cardiac inflammation and fibrosis, ultimately resulting in cardiac dysfunction. Pharmacological inhibition of Gal3 can reduce inflammation and fibrosis, providing protective effects against cardiac dysfunction.

CIRCULATION-HEART FAILURE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

Emily S. Lau et al.

Summary: In this trial, higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, but treatment with modified citrus pectin did not change collagen markers. Further investigation is needed for the effect of Gal-3 inhibition among individuals with heart failure.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiac monocytes and macrophages after myocardial infarction

Claire Peet et al.

CARDIOVASCULAR RESEARCH (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

Naga Chalasani et al.

GASTROENTEROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

UTMD inhibit EMT of breast cancer through the ROS/miR-200c/ZEB1 axis

Dandan Shi et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway

Geng-Rui Xu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Engineering, Biomedical

Antagomir-155 Attenuates Acute Cardiac Rejection Using Ultrasound Targeted Microbubbles Destruction

Luyang Yi et al.

ADVANCED HEALTHCARE MATERIALS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

Yoko Endo-Takahashi et al.

PHARMACEUTICS (2020)

添加到收藏夹

Article Engineering, Biomedical

Targeted galectin-7 inhibition with ultrasound microbubble targeted gene therapy as a sole therapy to prevent acute rejection following heart transplantation in a Rodent model

Zhuo Wang et al.

BIOMATERIALS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Galectin-3 in Cardiovascular Diseases

Valeria Blanda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

添加到收藏夹

Review Geriatrics & Gerontology

Roles of Biomarkers in Myocardial Fibrosis

Yuejia Ding et al.

AGING AND DISEASE (2020)

添加到收藏夹

Article Physiology

Perindopril and a Galectin-3 Inhibitor Improve Ischemic Heart Failure in Rabbits by Reducing Gal-3 Expression and Myocardial Fibrosis

Sha Li et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Biomechanical assessment of remote and postinfarction scar remodeling following myocardial infarction

Mihaela Rusu et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Ultrasound and Microbubble-targeted Delivery of a microRNA Inhibitor to the Heart Suppresses Cardiac Hypertrophy and Preserves Cardiac Function

Jonathan A. Kopechek et al.

THERANOSTICS (2019)

添加到收藏夹

Article Materials Science, Biomaterials

Improving acute cardiac transplantation rejection therapy using ultrasound-targeted FK506-loaded microbubbles in rats

Jie Liu et al.

BIOMATERIALS SCIENCE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Galectins as Molecular Targets for Therapeutic Intervention

Ruud P. M. Dings et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Myocardial Interstitial Fibrosis in Heart Failure Biological and Translational Perspectives

Arantxa Gonzalez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Extracellular matrix remodeling and cardiac fibrosis

Li Li et al.

MATRIX BIOLOGY (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update

Navin Suthahar et al.

THERANOSTICS (2018)

添加到收藏夹

Review Respiratory System

The present and future role of ultrasound targeted microbubble destruction in preclinical studies of cardiac gene therapy

Lijun Qian et al.

JOURNAL OF THORACIC DISEASE (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia-reperfusion injury

Guo-Qing Du et al.

BASIC RESEARCH IN CARDIOLOGY (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction

Li Zhang et al.

THERANOSTICS (2017)

添加到收藏夹

Article Pathology

Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis

Olga Frunza et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Biological Basis for Cardiac Repair After Myocardial Infarction From Inflammation to Fibrosis

Sumanth D. Prabhu et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiac Fibrosis The Fibroblast Awakens

Joshua G. Travers et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Nucleic acid delivery with microbubbles and ultrasound

Joshua J. Rychak et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Genetic and Pharmacological Inhibition of Galectin-3 Prevents Cardiac Remodeling by Interfering With Myocardial Fibrogenesis

Lili Yu et al.

CIRCULATION-HEART FAILURE (2013)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.