相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Update on the Development of MNK Inhibitors as Therapeutic Agents
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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Inhibitory effects of Tomivosertib in acute myeloid leukemia
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Oncotarget (2021)
Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products
Iksen et al.
MOLECULES (2021)
MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression
William Yang et al.
ONCOGENE (2020)
Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer
Celia Pinto-Diez et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Phosphorylation of the mRNA cap-binding protein eIF4E and cancer
Xiaotong Yang et al.
CELLULAR SIGNALLING (2020)
Update 2020: Management of Non-Small Cell Lung Cancer
Mariam Alexander et al.
LUNG (2020)
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
Senthilmurugan Ramalingam et al.
CANCERS (2019)
New oncologic emergencies: What is there to know about inmunotherapy and its potential side effects?
Arantzazu Barquin-Garcia et al.
EUROPEAN JOURNAL OF INTERNAL MEDICINE (2019)
Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia
Michael Steurer et al.
HAEMATOLOGICA (2019)
Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a] pyridine]-1',5'-dione derivatives as Mnk inhibitors
Ahmed M. Abdelaziz et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ
Qianyu Guo et al.
CANCER RESEARCH (2019)
Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold
Xin Jin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Overview of current systemic management of EGFR-mutant NSCLC
W. -H. Hsu et al.
ANNALS OF ONCOLOGY (2018)
XIAP Regulation by MNK Links MAPK and NF kappa B Signaling to Determine an Aggressive Breast Cancer Phenotype
Myron K. Evans et al.
CANCER RESEARCH (2018)
The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth
Vidya P. Ramamurthy et al.
FEBS JOURNAL (2018)
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Siegfried H. Reich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils
Nathaniel Robichaud et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer
Celia Pinto-Díez et al.
Oncotarget (2018)
MAP Kinase-Interacting Kinase 1 Promotes Proliferation and Invasion of Hepatocellular Carcinoma and Is an Unfavorable Prognostic Biomarker
Xujing Wang et al.
MEDICAL SCIENCE MONITOR (2018)
Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
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MOLECULES (2018)
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Jiehua Zhou et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
Yao Zhan et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
Shuye Tian et al.
ONCOTARGET (2017)
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer
Zhihua Guo et al.
SCIENTIFIC REPORTS (2017)
Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer
S. Hou et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2017)
BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity
Susann Santag et al.
CANCER LETTERS (2017)
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Antonio Rossi et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2016)
Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion
Andrew K. Kwegyir-Afful et al.
FEBS JOURNAL (2016)
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway
Qiuyuan Wen et al.
ONCOTARGET (2016)
Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells
Eva M. Garcia-Recio et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2016)
From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research
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PLOS ONE (2016)
The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding
James E. Beggs et al.
BIOCHEMICAL JOURNAL (2015)
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
N. Robichaud et al.
ONCOGENE (2015)
Oncogenic roles of EMT-inducing transcription factors
Alain Puisieux et al.
NATURE CELL BIOLOGY (2014)
First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines
Senthilmurugan Ramalingam et al.
ONCOTARGET (2014)
Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation
Avraham Maimon et al.
CELL REPORTS (2014)
Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
H. Zhang et al.
ONCOGENE (2011)
The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
Matthew J. Wheater et al.
CANCER BIOLOGY & THERAPY (2010)
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading
Kathrin S. Zeller et al.
CELLULAR SIGNALLING (2010)
Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction
Mayya Shveygert et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Luc Furic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A Gene-Alteration Profile of Human Lung Cancer Cell Lines
Raquel Blanco et al.
HUMAN MUTATION (2009)
Dose Escalation Methods in Phase I Cancer Clinical Trials
Christophe Le Tourneau et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)
Expression profiling of integrins in lung cancer cells
Linlang Guo et al.
PATHOLOGY RESEARCH AND PRACTICE (2009)
The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor α
Maria Buxade et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Dissecting eIF4E action in tumorigenesis
Hans-Guido Wendel et al.
GENES & DEVELOPMENT (2007)
A parallel phase I/II clinical trial design for combination therapies
Xuelin Huang et al.
BIOMETRICS (2007)
Controlling gene expression through RNA regulons - The role of the eukaryotic translation initiation factor eIF4E
Biljana Culjkovic et al.
CELL CYCLE (2007)
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b
Ana O'Loghlen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Regulation of sprouty stability by Mnk1-dependent phosphorylation
J DaSilva et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
EWM Ng et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
The Mnks are novel components in the control of TNFα biosynthesis and phosphorylate and regulate hnRNP A1
M Buxadé et al.
IMMUNITY (2005)
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
T Ueda et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1
A O'Loghlen et al.
EXPERIMENTAL CELL RESEARCH (2004)
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases
Y Hefner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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