☆ 4.7 Review

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

PHARMACEUTICS (2023)

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Review Chemistry, Medicinal

5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy

Anai A. Valencia-Lazcano et al.

Summary: This study reviews the applications of 5-Fluorouracil (5-FU) as an anticancer drug for various types of cancers. Different approaches, such as nanoparticles loaded with 5-FU, co-delivery systems with other drugs, have been described to overcome the limitations of 5-FU therapy. This review provides the latest progress on 5-FU-loaded nanocarriers and their potential as an advanced tool for cancer therapy.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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Review Pharmacology & Pharmacy

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Summary: The EPR effect is crucial for anticancer nanomedicine design, but its efficacy varies depending on factors such as vascular mediators, tumor blood flow, and physicochemical properties of nanomedicines. Restoring obstructed tumor blood flow and improving tumor vascular permeability are key strategies for overcoming barriers to the EPR effect.

EXPERT OPINION ON DRUG DELIVERY (2022)

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Review Oncology

Lack of consensus identifies important areas for future clinical research: Advanced Prostate Cancer Consensus Conference (APCCC) 2019 findings

Ursula M. Vogl et al.

Summary: This article discusses the lack of consensus on clinical management issues in advanced prostate cancer addressed at the Advanced Prostate Cancer Consensus Conference. By reviewing ongoing clinical trials, it is found that many unresolved questions remain. The article emphasizes that the lack of consensus indicates gaps in existing evidence and calls for robust clinical trials to fill these gaps.

EUROPEAN JOURNAL OF CANCER (2022)

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Article Chemistry, Inorganic & Nuclear

Hierarchical MOF-on-MOF Architecture for pH/GSH-Controlled Drug Delivery and Fe-Based Chemodynamic Therapy

Weishu Ni et al.

Summary: Chemotherapy is an important and effective clinical treatment for cancer, but precise controlled release and targeted therapy are challenging. Drug carriers have emerged as a solution to these problems. This study utilized the MOF-on-MOF strategy to develop a core-shell-structured nanomaterial capable of pH and GSH dual-responsive controlled drug release. Additionally, the nanomaterial exhibited peroxidase-like catalytic activity and significant inhibitory effects on cancer cells.

INORGANIC CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application

Marzieh Sajadi Bami et al.

Summary: This review examines recent studies on pH-responsive drug delivery systems (DDS) synthesis, properties, mechanisms, and applications. pH-sensitive DDSs deliver drugs at the precise time required by the disease's pathophysiology, improving therapeutic effectiveness and patient compliance. pH-sensitive polymer systems combined with nanotechnology offer a promising alternative to traditional targeting systems, addressing challenges such as non-specific tissue distribution, decreased drug effectiveness, and systemic side effects.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Understanding the Biological Interactions of pH-Swellable Nanoparticles

Sarah S. Kermaniyan et al.

Summary: pH-responsive nanoparticles have attracted attention for their potential in inducing release at low pH. This study investigates the impact of pH-swellable nanoparticles on biological interactions, particularly endosomal escape. The results suggest limitations with the proton-sponge effect and pH-induced swelling mechanism for inducing endosomal escape.

MACROMOLECULAR BIOSCIENCE (2022)

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Article Pharmacology & Pharmacy

PEGylated versus Non-PEGylated pH-Sensitive Liposomes: New Insights from a Comparative Antitumor Activity Study

Shirleide Santos Nunes et al.

Summary: PEGylated liposomes are widely studied as drug delivery systems, but their interaction with cells may be hindered by the addition of PEG. This study compared the characteristics and drug delivery capabilities of PEGylated and non-PEGylated liposomes. The results showed that non-PEGylated liposomes had better cellular uptake and were more effective in controlling tumor growth.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review

Mihad Ibrahim et al.

Summary: Doxorubicin, a widely used anticancer drug, can be encapsulated in nanoparticles to achieve localized and controlled delivery, reducing toxicity to healthy cells.

PHARMACEUTICS (2022)

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Review Chemistry, Physical

The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger of Stimuli-Responsive Drug Delivery Systems

Xiaodong Jing et al.

Summary: The tumor microenvironment contains abnormal biochemical indicators that accelerate tumor heterogeneity. However, these indicators also provide opportunities for designing intelligent drug delivery systems, potentially improving the effectiveness of chemotherapy and reducing side effects.

SMALL METHODS (2022)

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Review Pharmacology & Pharmacy

New generation of viral nanoparticles for targeted drug delivery in cancer therapy

Nikta Alvandi et al.

Summary: This article discusses the potential and applications of using viral-like particles (VLPs) for nanoscale engineering, including drug delivery and disease detection. VLPs have advantages such as small size, high stability, and large-scale production, making them suitable for various medical fields.

JOURNAL OF DRUG TARGETING (2022)

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Article Polymer Science

pH-Responsive Nanocarriers in Cancer Therapy

Nour M. AlSawaftah et al.

Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.

POLYMERS (2022)

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Review Biotechnology & Applied Microbiology

Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research

Yan Hu et al.

Summary: This article reviews the subtype of extracellular vesicles (EVs) called microparticles (MPs), which function as delivery vectors for bioactive antitumor compounds. MPs, with their unique antitumor functionalities, have gained interest for their potential use in therapeutic vaccines and direct antitumor agents. The mechanisms underlying MP biogenesis, factors that influence MP production, properties of MP membranes, size, composition, and isolation methods are discussed. Additionally, the applications, mechanisms of action, and main hurdles for MP use in cancer management are introduced.

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Review Pharmacology & Pharmacy

Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges

Tore Skotland et al.

Summary: The paper discusses the development and application of nanoparticles and extracellular vesicles for therapeutic delivery or imaging. It explores the methods and challenges involved in studying their biodistribution, metabolism, and excretion, often through the use of radioactive isotopes or fluorescent molecules. The importance of evaluating the behavior of labeled and unlabeled products in the body and considering the association of labels with the products during analysis is emphasized. Additionally, the advantages and disadvantages of different imaging modalities for whole-body biodistribution are compared, and methods for estimating the amount of labeled product in harvested organs and tissue are described.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Pharmacology & Pharmacy

A facile method for anti-cancer drug encapsulation into polymersomes with a core-satellite structure

Hongchao Xu et al.

Summary: Polymersomes have been successfully used as drug carriers in this study, with a unique core-satellite structure that facilitates sustained drug release. They exhibit superior anticancer abilities compared to liposomal formulations, and can inhibit the expression of drug transport proteins. Polymersomes are a promising alternative to liposomes for drug delivery.

DRUG DELIVERY (2022)

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Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

Ivan Zelepukin et al.

Summary: Tumour microenvironment poses a challenge to effective treatment of solid tumours and metastatic nodes. This study introduces a novel drug delivery concept, FlaRE, which involves rapid release of drug-loaded nanocarriers within blood vessels to achieve targeted tissue permeation.

NATURE COMMUNICATIONS (2022)

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Review Chemistry, Multidisciplinary

Preparation and application of pH-responsive drug delivery systems

Haitao Ding et al.

Summary: Microenvironment-responsive drug delivery systems (DDSs) achieve targeted drug delivery and improve drug efficacy by responding to specific pH conditions in diseased tissues. Various synthetic approaches have been developed to prepare pH-sensitive DDSs, including the introduction of pH-sensitive chemical bonds or groups. Different nano DDSs, such as liposomes, micelles, hydrogels, dendritic macromolecules, and organic-inorganic hybrid nanoparticles, can respond to pH variations. These pH-sensitive DDSs have been applied in research on anticancer therapy and the diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Trends in advanced oral drug delivery system for curcumin: A systematic review

Suchiwa Pan-On et al.

Summary: Although curcumin has health benefits, its clinical application is limited by its poor solubility and stability. Nanocarrier-based drug delivery systems (NDS) are effective in improving curcumin's physicochemical and pharmacological effects. This study reviewed evidence of lipid and polymer-based NDS for oral delivery of curcumin. Most studies found that NDS increased curcumin absorption compared to free curcumin.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

A pH-Responsive Cluster Metal-Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect

Ruoyu Cheng et al.

Summary: A pH-responsive targeting strategy using solid lipid nanoshell coated zeolitic imidazolate framework nanoparticles loaded with apilimod was developed to enhance accumulation in tumors, activate the tumor microenvironment, and increase survival rate in mice.

ADVANCED MATERIALS (2022)

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Electrical Characterization of Micron-Sized Chambers Used as a Depot for Drug Delivery

Ahsan Noor Khan et al.

Summary: Implantable drug delivery devices have become an essential platform for treating chronic diseases that require enhanced and localized drug concentrations. This article presents micrometer-sized chambers fabricated using a patterned film base for array formation. These microchambers, made from a polylactic acid matrix and modified with conducting species, show potential for thermal therapy and drug delivery in response to electromagnetic radiations.

IEEE SENSORS JOURNAL (2022)

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Article Biochemistry & Molecular Biology

pH-Responsive Drug Delivery and Imaging Study of Hybrid Mesoporous Silica Nanoparticles

Zhongtao Li et al.

Summary: A pH-responsive and imaging nanocarriers system using mesoporous silica nanoparticles (MSNs) doped with gadolinium (Gd) was developed. The system showed pH-responsiveness and high biocompatibility, and the T1 contrast was significantly enhanced by Gd, making it a promising system for cancer diagnosis and treatment.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow

Roman Verkhovskii et al.

Summary: A promising approach to targeted drug delivery is the remote control of magnetically sensitive objects using an external magnetic field source. This method can assist in the accumulation of magnetic carriers in the affected area for local drug delivery and provides magnetic nanoparticles for various applications. Despite some existing research, further studies are needed to fully understand the potential of magnetically controlled drug delivery.

MOLECULES (2022)

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Review Polymer Science

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

Stefan Morarasu et al.

Summary: This scoping review aimed to map current protocols for pH functionalization of nanoparticles (NPs) and analyze the outcomes of drug-loaded pH-functionalized NPs (pH-NPs) in tumoral tissue. The results indicated that pH-NPs can improve drug delivery and enhance antitumoral effects.

GELS (2022)

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Article Oncology

Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

Sibi Raj et al.

Summary: Nanotechnology offers a promising approach for cancer diagnosis and treatment, providing specific and efficient drug delivery to target tissues while minimizing side effects. Various types of nanocarriers are being studied for potential use in cancer therapy.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Oncology

Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Eunus S. Ali et al.

Summary: Nanotechnology is reshaping healthcare strategies with a tremendous impact, especially in the fields of medical diagnostics and drug delivery, offering potential for improved effectiveness and sustainability in treating diseases like cancer. The application of nano-level elements can reduce drug toxicities and enhance drug delivery efficiency.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Biochemical Research Methods

Inorganic Porous Nanoparticles for Drug Delivery in Antitumoral Therapy

Jorge Parra-Nieto et al.

Summary: The use of porous inorganic nanoparticles in oncology for delivering chemotherapeutic agents shows great potential by utilizing specific targeting moieties to achieve selective uptake in malignant cells and controlled drug release, benefiting from their excellent cargo capacity, biocompatibility, and precise control over drug release behavior.

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Article Chemistry, Multidisciplinary

Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration

Jinjin Wang et al.

Summary: The inadequate concentration of drugs at the site of action due to poor physicochemical properties and multi-stage biological barriers can lead to side effects. The rapid development of nanoscale drug delivery systems offers a way to overcome multi-stage biological barriers. However, poor understanding of biological barriers remains a bottleneck for the development of NDDS.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Engineering, Biomedical

Stimuli-Responsive Biomaterials: Scaffolds for Stem Cell Control

Amy Gelmi et al.

Summary: Engineering biomaterials can recreate the microenvironmental and endogenous cues affecting stem cell fate in an ex vivo environment, providing temporal and spatial cues to stem cells through responsive to exogenous stimulation. These stimuli-responsive biomaterials have versatile applications in studying stem cell responses and cellular manipulation, with promising potential for future personalized tissue engineering and organoid models.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Nanoscience & Nanotechnology

Remotely Activated Nanoparticles for Anticancer Therapy

Luisa Racca et al.

Summary: This review emphasizes the importance of remotely activated nanoparticles for anticancer purposes, discussing their active synergy with physical inputs and providing examples and mechanisms of action. Clinical trials involving remotely triggered nanoparticles are also examined in detail.

NANO-MICRO LETTERS (2021)

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Article Chemistry, Physical

Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies

Palanivel Sathishkumar et al.

Summary: In this study, a zinc oxide-quercetin nanocomposite was developed as a smart nano-drug delivery system. The release kinetics showed faster release of quercetin in acidic conditions, with specific interactions between quercetin and zinc oxide identified. The nanocomposite demonstrated effective inhibition of breast cancer cells and high biocompatibility.

APPLIED SURFACE SCIENCE (2021)

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Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

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Article Engineering, Environmental

Bioinspired metal-organic frameworks mediated efficient delivery of siRNA for cancer therapy

Yanfen Zhang et al.

Summary: siRNA has emerged as a powerful tool in gene therapy, but its fragile properties and low efficiency have compromised its therapeutic effect. MOFs have high binding affinity, but their short circulation lifetime and lack of specificity hinder their application in cancer therapy. The fabrication of CAMEL nanoparticles has successfully enabled targeted delivery of siRNA to knockdown tumor genes.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Medicinal

Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches

Eisa Kaveh Vernousfaderani et al.

Summary: Phytochemicals, particularly resveratrol, exhibit a wide range of beneficial effects including anti-inflammatory, neuroprotective, antioxidant, and cancer prevention and treatment properties. Resveratrol shows promising outcomes in colorectal cancer treatment through various vital molecules and cancer signaling pathways.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

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Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Nanoscience & Nanotechnology

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Yuanyuan Jin et al.

Summary: Nanobiomaterials show great promise in the treatment of ALF, enhancing drug bioavailability and increasing therapeutic agent accumulation in the liver for more effective treatment. Additionally, stimuli-responsive, optical, or magnetic nanomaterials offer potential in therapeutical, diagnostic, and imaging applications in ALF.

NANO-MICRO LETTERS (2021)

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Article Chemistry, Physical

A new pH-sensitive CS/Zn-MOF@GO ternary hybrid compound as a biofriendly and implantable platform for prolonged 5-Fluorouracil delivery to human breast cancer cells

Malihe Pooresmaeil et al.

Summary: This study investigated and compared the capabilities of different types of chitosan microspheres as anticancer drug carriers, with the CS/Zn-MOF@GO ternary hybrid microspheres showing potential advantages such as higher drug loading capacity and a pH-sensitive sustained release pattern. The experimental results demonstrated that these microspheres have good biocompatibility and therapeutic efficacy against tumor cells.

JOURNAL OF ALLOYS AND COMPOUNDS (2021)

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Article Chemistry, Physical

Prussian Blue modified Metal Organic Frameworks for imaging guided synergetic tumor therapy with hypoxia modulation

Haiqing Gao et al.

Summary: A hybrid material UIO-66-NH2/PB with good photo-thermal performance was synthesized for synergetic tumor therapy and hypoxia modulation through the generation of free radicals. The material demonstrated excellent anti-cancer effects by killing cancer cells and improving tumor hypoxia with the help of center dot OH generation.

JOURNAL OF ALLOYS AND COMPOUNDS (2021)

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Article Materials Science, Biomaterials

Tumor microenvironment responsive VEGF-antibody functionalized pH sensitive liposomes of docetaxel for augmented breast cancer therapy

Sanyog Jain et al.

Summary: The VEGF antibody functionalized PEGylated pH sensitive liposomes (VEGF-PEG-pH-Lipo-DTX) showed enhanced cellular uptake and cytotoxicity in MCF-7 cell line, as well as anti-angiogenic potential in HUVECs stimulated by VEGF. The pharmacokinetic profile of VEGF-PEG-pH-Lipo-DTX demonstrated improved half-life, AUC, and mean residence time compared to the marketed formulation Taxotere (R), leading to a significant reduction in tumor burden in breast cancer treatment.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Oncology

Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field

Fernanda Andrade et al.

Summary: Cancer remains the second leading cause of death globally, with the major obstacles in treatment being chemotherapy side effects and drug resistance. Research is ongoing to develop new formulations for localized drug delivery at tumor sites to improve treatment outcomes. Stimuli-responsive hydrogels, such as pH-, light-, ionic strength-, and magnetic-responsive hydrogels, show promising results in the localized control and treatment of cancer.

CANCERS (2021)

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Article Multidisciplinary Sciences

Effects of hypoxia and nanocarrier size on pH-responsive nano-delivery system to solid tumors

M. Soltani et al.

Summary: A comprehensive mathematical model is proposed in this study to investigate the impact of pH-responsive nanocarriers on cancer cell death, where smaller nanocarriers are more effective and capable of deeper penetration into tumor tissues, although the presence of hypoxic regions in tumors reduces drug penetration depth.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Novel pH-responsive nanohybrid for simultaneous delivery of doxorubicin and paclitaxel: an in-silico insight

Ehsan Alimohammadi et al.

Summary: This study investigated the effect of a novel copolymer on drug delivery through molecular dynamics simulation and quantum calculations. The results showed significant improvements in drug release in cancerous tissues and enhanced biocompatibility in healthy tissues. Repeat simulations confirmed the findings from a similar study, suggesting that the copolymer can be a promising candidate for smart drug delivery systems.

BMC CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells

Bing-bing Zhang et al.

Summary: Nanomedicine using dual-pH-responsive nanoparticles coated with polyacrylic acid and pH-sensitive lipid for synergistic delivery of arsenic trioxide and paclitaxel showed significant synergistic effects in cancer treatment. The nanoparticles exhibited enhanced drug release in cells and deeper penetration into tumors through a tumor priming effect.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Pharmacology & Pharmacy

Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

Natalia A. D'Angelo et al.

Summary: This study reviews the literature from the past 10 years on the encapsulation of curcumin (CUR) in nanostructured systems, highlighting its use and ability in cancer therapy. The findings show that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System

Roman Verkhovskii et al.

Summary: Drug carriers based on polyelectrolyte microcapsules controlled by an external magnetic field show promise as a drug delivery system. However, the impact of capsule parameters on their behavior in vivo remains unclear. This study demonstrates how microcapsules of different sizes interact with vital organs, blood cells, and magnetic fields, affecting circulation time, cytotoxicity, and hemotoxicity. Small capsules circulate longer without affecting blood cells, while larger capsules are quickly filtered, inhibit macrophage proliferation, and cause hemolysis depending on concentration. These findings suggest potential strategies to optimize microcapsule parameters for efficient drug delivery without adverse effects on blood flow or cells.

PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Polymeric micelles in cancer therapy: State of the art

Balaram Ghosh et al.

Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.

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Article Materials Science, Multidisciplinary

A method of drug delivery to tumors based on rapidly biodegradable drug-loaded containers

Bogdan Parakhonskiy et al.

Summary: Encapsulation of anticancer drugs in nanocontainers can enhance drug uptake in tumors, while a new drug delivery concept involving passive accumulation in tumor vasculature and controlled release of small-molecule payload shows improved therapeutic efficacy.

APPLIED MATERIALS TODAY (2021)

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Letter Oncology

Ultrasound-guided percutaneous metal-organic frameworks based codelivery system of doxorubicin/acetazolamide for hepatocellular carcinoma therapy

Ziwei Jing et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Materials Science, Multidisciplinary

Curcumin: Modern Applications for a Versatile Additive

Florentina Monica Raduly et al.

Summary: Curcumin, extracted from the root of Curcuma longa, has been intensively researched for its antifungal, antiviral, and antibacterial properties. It has found applications in both food quality and medical fields. This review paper discusses the various formulations of curcumin, such as (nano)emulsions, (nano)particles, or (nano)composites, for different purposes and conditions of use.

COATINGS (2021)

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Advances in pH-responsive drug delivery systems

Yongxu Mu et al.

OpenNano (2021)

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Article Biochemistry & Molecular Biology

Cu (II)-porphyrin metal-organic framework/graphene oxide: synthesis, characterization, and application as a pH-responsive drug carrier for breast cancer treatment

Zahra Gharehdaghi et al.

Summary: A new multifunctional nanocomposite CuG, consisting of Cu-TCPP MOF supported on GO nanosheets, was successfully fabricated for efficient drug loading and smart pH-responsive release in chemotherapy. In vitro experiments showed minimal cytotoxicity on normal cells and significant cancer cell-killing ability, indicating the potential for further biomedical investigations.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system

Saeid Moghassemi et al.

Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

Sikhumbuzo Charles Kunene et al.

Summary: The study formulated thermo-and pH-dependent doxorubicin (DOX) carriers based on magnetic graphene nanosheets (MGNSs) for targeting liver cancer cells. The carriers showed high biocompatibility and non-toxicity, with enhanced efficacy of drug release under applied magnetic field (AMF) and efficient cellular intake into cancer cells, indicating a high potential for cancer cell suppression.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

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Article Chemistry, Medicinal

pH-Sensitive PEGylated Liposomal Silybin: Synthesis, In Vitro and In Vivo Anti-Tumor Evaluation

Fatemeh Gheybi et al.

Summary: The study developed a TAT peptide-modified pH-sensitive liposome that enhanced cellular association and cytotoxicity, showing potential therapeutic effects on breast tumors. However, in vivo studies found that TAT as a targeting ligand decreased the therapeutic efficacy of the formulation.

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Challenges towards Targeted Drug Delivery in Cancer Nanomedicines

Muhammad Nadeem Hafeez et al.

Summary: Despite thirty years of development in cancer nanomedicine, there are still serious disadvantages that need to be addressed. Future directions may involve focusing on personalized treatment and designing multifunctional targeted nano-drug delivery systems for enhanced therapeutic effects.

PROCESSES (2021)

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Review Engineering, Electrical & Electronic

Wireless on-demand drug delivery

Seyed M. Mirvakili et al.

Summary: This review examines the development of wireless on-demand drug delivery systems triggered by electric fields, magnetic fields, or electromagnetic radiation, discussing the working mechanisms, applications, advantages, and limitations of these systems. The article also provides design guidelines and key metrics for evaluating the practicality of different smart drug delivery systems.

NATURE ELECTRONICS (2021)

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Dual functions of pH-sensitive cation Zr-MOF for 5-Fu: large drug-loading capacity and high-sensitivity fluorescence detection

Xi-Yu Sun et al.

Summary: A promising drug carrier UiO-67-CDC-(CH3)(2) with good drug loading capacity and fluorescence detection properties was successfully synthesized. The material exhibited effective release of 5-Fu in simulated blood environment, providing a new direction for drug delivery applications.

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Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses

Eiji Yuba et al.

Summary: In this study, a novel pH-sensitive polyamidoamine dendron-based lipid was synthesized for the preparation of liposomes for precise endosome delivery. The pH-sensitive dendron lipid-based liposomes demonstrated the ability to release water-soluble molecules under weakly acidic conditions, specifically targeting endosomes for content release. These liposomes showed potential efficacy for cancer immunotherapy by inducing tumor regression and specific T cell proliferation.

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Article Chemistry, Physical

Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Rui Xu et al.

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Review Materials Science, Biomaterials

pH-Sensitive nanogels for drug delivery in cancer therapy

Zhen Li et al.

Summary: Nanogels are considered ideal drug carriers for cancer treatment due to their high stability, water content, and drug loading capacities. pH-sensitive nanogels, which utilize the lower pH value in tumor tissue, have shown potential for more precise drug delivery and release in cancer treatment.

BIOMATERIALS SCIENCE (2021)

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A novel pH-responsive Fe-MOF system for enhanced cancer treatment mediated by the Fenton reaction

Senlin Wang et al.

Summary: By modifying a new pH-responsive nanoreactor with the cationic polymer MV-PAH, drug delivery was notably enhanced in the weak acid environment of tumor cells, showing advanced anti-cancer effects.

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Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal-organic frameworks nanoparticles on breast cancer

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Article Nanoscience & Nanotechnology

Dual pH-Responsive Hydrogel Actuator for Lipophilic Drug Delivery

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ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Engineering, Biomedical

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BIOMATERIALS (2020)

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Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy

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CARBOHYDRATE POLYMERS (2020)

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Thiazole-containing compounds as therapeutic targets for cancer therapy

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Charge-reversal nanocarriers: An emerging paradigm for smart cancer nanomedicine

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JOURNAL OF CONTROLLED RELEASE (2020)

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The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Article Biophysics

pH-responsive cationic liposome for endosomal escape mediated drug delivery

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COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Effect of Systemic Polyelectrolyte Microcapsule Administration on the Blood Flow Dynamics of Vital Organs

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A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Imaging small molecule-induced endosomal escape of siRNA

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Stealth Coating of Nanoparticles in Drug-Delivery Systems

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NANOMATERIALS (2020)

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Current Trends in Drug Delivery System of Curcumin and its Therapeutic Applications

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MINI-REVIEWS IN MEDICINAL CHEMISTRY (2020)

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Zn-MOF-74 as pH-Responsive Drug-Delivery System of Arsenic Trioxide

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CHEMNANOMAT (2020)

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Article Nanoscience & Nanotechnology

Tuning Composition of Polymer and Porous Silicon Composite Nanoparticles for Early Endosome Escape of Anti-microRNA Peptide Nucleic Acids

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PEGMA-modified bimetallic NiCo Prussian blue analogue doped with Tb(III) ions: Efficiently pH-responsive and controlled release system for anticancer drug

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CHEMICAL ENGINEERING JOURNAL (2020)

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A multifunctional MOF-based nanohybrid as injectable implant platform for drug synergistic oral cancer therapy

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CHEMICAL ENGINEERING JOURNAL (2020)

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CANCERS (2020)

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Article Pharmacology & Pharmacy

In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer

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Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: Review of the Literature and Perspectives of Clinical Research

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Hyaluronic acid-drug conjugate modified core-shell MOFs as pH responsive nanoplatform for multimodal therapy of glioblastoma

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Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy

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8-Hydroxyquinoline functionalized covalent organic framework as a pH sensitive carrier for drug delivery

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Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

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Natural tripeptide capped pH-sensitive gold nanoparticles for efficacious doxorubicin delivery both in vitro and in vivo

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NANOSCALE (2020)

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MOF nanoparticles with encapsulated dihydroartemisinin as a controlled drug delivery system for enhanced cancer therapy and mechanism analysis

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pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer

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Article Chemistry, Multidisciplinary

Cancer cell membrane-camouflaged MOF nanoparticles for a potent dihydroartemisinin-based hepatocellular carcinoma therapy

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RSC ADVANCES (2020)

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Heterodimers made of metal-organic frameworks and upconversion nanoparticles for bioimaging and pH-responsive dual-drug delivery

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JOURNAL OF MATERIALS CHEMISTRY B (2020)

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pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

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COMMUNICATIONS BIOLOGY (2020)

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Stimuli-responsive nanoscale drug delivery systems for cancer therapy

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JOURNAL OF DRUG TARGETING (2019)

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Synthesis of Imatinib-loaded chitosan-modified magnetic nanoparticles as an anti-cancer agent for pH responsive targeted drug delivery

Zahra Karimi Ghezeli et al.

APPLIED ORGANOMETALLIC CHEMISTRY (2019)

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Treg programming and therapeutic reprogramming in cancer

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IMMUNOLOGY (2019)

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Magneto-ultrasonic heating with nanoparticles

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Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

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PLOS ONE (2019)

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Article Chemistry, Analytical

Facile preparation of metal organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment

Kai Dong et al.

TALANTA (2019)

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pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy

Mousumi Kundu et al.

JOURNAL OF ADVANCED RESEARCH (2019)

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Review Pharmacology & Pharmacy

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

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PHARMACEUTICS (2019)

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Nanoscale Metal-Organic-Frameworks Coated by Biodegradable Organosilica for pH and Redox Dual Responsive Drug Release and High-Performance Anticancer Therapy

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Biochemistry & Molecular Biology

Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles

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BIOCHIMIE (2019)

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A review of magnet systems for targeted drug delivery

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JOURNAL OF CONTROLLED RELEASE (2019)

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An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

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JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)

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Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

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CANCERS (2019)

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Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Drug Loaded Nanoparticles of Metal-Organic Frameworks with High Colloidal Stability for Anticancer Application

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Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Size-Tunable Assemblies Based on Ferrocene-Containing DNA Polymers for Spatially Uniform Penetration

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CHEM (2019)

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Regulatory T Cells Tailored with pH-Responsive Liposomes Shape an I mmuno-Antitumor Milieu against Tumors

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

Passive and Active Drug Targeting: Role of Nanocarriers in Rational Design of Anticancer Formulations

Ram P. Das et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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The emergence of drug resistance to targeted cancer therapies: Clinical evidence

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DRUG RESISTANCE UPDATES (2019)

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Article Biochemistry & Molecular Biology

Ecofriendly one pot fabrication of methyl gallate@ZIF-L nanoscale hybrid as pH responsive drug delivery system for lung cancer therapy

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PROCESS BIOCHEMISTRY (2019)

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Article Medicine, Research & Experimental

Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model

Juliana de Oliveira Silva et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Nanoscience & Nanotechnology

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

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NATURE NANOTECHNOLOGY (2019)

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Article Materials Science, Biomaterials

Crystal-Seeded Growth of pH-Responsive Metal-Organic Frameworks for Enhancing Encapsulation, Stability, and Bioactivity of Hydrophobicity Compounds

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Article Chemistry, Physical

O2-Loaded pH-Responsive Multifunctional Nanodrug Carrier for Overcoming Hypoxia and Highly Efficient Chemo-Photodynamic Cancer Therapy

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CHEMISTRY OF MATERIALS (2019)

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Article Engineering, Biomedical

Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy

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BIOMATERIALS (2019)

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Article Engineering, Environmental

Tailored synthesis of hollow MOF/polydopamine Janus nanoparticles for synergistic multi-drug chemo-photothermal therapy

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CHEMICAL ENGINEERING JOURNAL (2019)

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Article Chemistry, Physical

Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

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JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Review Biochemistry & Molecular Biology

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Houliang Tang et al.

MOLECULES (2019)

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Review Chemistry, Multidisciplinary

Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release

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JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

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NANOSCALE (2019)

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Peptide ligand-mediated targeted drug delivery of nanomedicines

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BIOMATERIALS SCIENCE (2019)

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A tumor microenvironment responsive biodegradable CaCO3/MnO2- based nanoplatform for the enhanced photodynamic therapy and improved PD-L1 immunotherapy

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THERANOSTICS (2019)

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Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update

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BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

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A γ-cyclodextrin-based metal-organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

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NANOSCALE (2019)

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Article Nanoscience & Nanotechnology

Overcoming Multidrug Resistance by Codelivery of MDR1-Targeting siRNA and Doxorubicin Using EphA10-Mediated pH-Sensitive Lipoplexes: In Vitro and In Vivo Evaluation

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Keratin-Templated Synthesis of Metallic Oxide Nanoparticles as MRI Contrast Agents and Drug Carriers

Yan Li et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors

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ACS NANO (2018)

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Article Engineering, Biomedical

Estrone-modified pH-sensitive glycol chitosan nanoparticles for drug delivery in breast cancer

Huan Yang et al.

ACTA BIOMATERIALIA (2018)

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Review Cell Biology

Tetrazolium salts and formazan products in Cell Biology: Viability assessment, fluorescence imaging, and labeling perspectives

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ACTA HISTOCHEMICA (2018)

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Article Biochemistry & Molecular Biology

Importance of Encapsulation Stability of Nanocarriers with High Drug Loading Capacity for Increasing in Vivo Therapeutic Efficacy

L. Palanikumar et al.

BIOMACROMOLECULES (2018)

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Article Chemistry, Medicinal

Hollow Mesoporous Silica@Metal-Organic Framework and Applications for pH-Responsive Drug Delivery

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CHEMMEDCHEM (2018)

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Article Chemistry, Inorganic & Nuclear

A protein@metal-organic framework nanocomposite for pH-triggered anticancer drug delivery

Zuozhong Liang et al.

DALTON TRANSACTIONS (2018)

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Article Pharmacology & Pharmacy

Eph A10-modified pH-sensitive liposomes loaded with novel triphenylphosphine-docetaxel conjugate possess hierarchical targetability and sufficient antitumor effect both in vitro and in vivo

Jiulong Zhang et al.

DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Curcumin-lipoic acid conjugate as a promising anticancer agent on the surface of gold-iron oxide nanocomposites: A pH-sensitive targeted drug delivery system for brain cancer theranostics

Milad Ghorbani et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Pharmacology & Pharmacy

Co-delivery of doxorubicin and imatinib by pH sensitive cleavable PEGylated nanoliposomes with folate-mediated targeting to overcome multidrug resistance

Yan Chen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation

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PHARMACEUTICAL RESEARCH (2018)

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Article Chemistry, Inorganic & Nuclear

A Biocompatible Zinc(II)-based Metal-organic Framework for pH Responsive Drug Delivery and Anti-Lung Cancer Activity

Yong Cai et al.

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE (2018)

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Review Multidisciplinary Sciences

Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum et al.

NATURE COMMUNICATIONS (2018)

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Review Chemistry, Multidisciplinary

Manipulating extracellular tumour pH: an effective target for cancer therapy

Guanyu Hao et al.

RSC ADVANCES (2018)

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Article Nanoscience & Nanotechnology

Metal-Organic Framework-Based Nanoplatform for Intracellular Environment-Responsive Endo/Lysosomal Escape and Enhanced Cancer Therapy

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Materials Science, Biomaterials

FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

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BIOMATERIALS SCIENCE (2018)

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Chitosan Immobilization on Bio-MOF Nanostructures: A Biocompatible pH-Responsive Nanocarrier for Doxorubicin Release on MCF-7 Cell Lines of Human Breast Cancer

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INORGANIC CHEMISTRY (2018)

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Article Multidisciplinary Sciences

Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

Prashant Dogra et al.

NATURE COMMUNICATIONS (2018)

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Review Nanoscience & Nanotechnology

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Linlin Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

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NATURE REVIEWS DRUG DISCOVERY (2017)

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Article Materials Science, Biomaterials

Hyaluronic-Acid-Based pH-Sensitive Nanogels for Tumor-Targeted Drug Delivery

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Materials Science, Biomaterials

Hyaluronic-Acid-Based pH-Sensitive Nanogels for Tumor-Targeted Drug Delivery

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Biochemistry & Molecular Biology

Importance of Evaluating Dynamic Encapsulation Stability of Amphiphilic Assemblies in Serum

Bin Liu et al.

BIOMACROMOLECULES (2017)

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Review Oncology

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

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CANCER AND METASTASIS REVIEWS (2017)

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Review Chemistry, Multidisciplinary

Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems

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CHEMICAL SOCIETY REVIEWS (2017)

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MOF-Mediated Destruction of Cancer Using the Cell's Own Hydrogen Peroxide

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical Enhanced Radiotherapy

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Postsynthetic Modification of ZIF-90 for Potential Targeted Codelivery of Two Anticancer Drugs

Feng-Ming Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Multidisciplinary

A Drug-Self-Gated Mesoporous Antitumor Nanoplatform Based on pH-Sensitive Dynamic Covalent Bond

Xiaowei Zeng et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Nanoscience & Nanotechnology

Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers

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WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2016)

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Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis

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ANALYTICAL BIOCHEMISTRY (2016)

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Review Engineering, Biomedical

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Manju Kanamala et al.

BIOMATERIALS (2016)

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Review Pharmacology & Pharmacy

Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications

Anisha A. D'souza et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

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Review Chemistry, Multidisciplinary

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

F. Danhier

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

One-pot Synthesis of Metal Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Article Polymer Science

pH-Sensitive nanogates based on poly(L-histidine) for controlled drug release from mesoporous silica nanoparticles

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POLYMER CHEMISTRY (2016)

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Article Multidisciplinary Sciences

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

Edward A. Sykes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Pharmacology & Pharmacy

Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications

Irina I. Vlasova et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

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Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Review Oncology

Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3

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ONCOTARGET (2016)

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Analysis of nanoparticle delivery to tumours

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NATURE REVIEWS MATERIALS (2016)

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Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles

Alexandra Rodzinski et al.

SCIENTIFIC REPORTS (2016)

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Article Chemistry, Physical

Selective adsorption of cationic dyes by UiO-66-NH2

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APPLIED SURFACE SCIENCE (2015)

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Article Engineering, Biomedical

Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior

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BIOMATERIALS (2015)

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Review Chemistry, Multidisciplinary

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

Ulrich Laechelt et al.

CHEMICAL REVIEWS (2015)

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Review Pharmacology & Pharmacy

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

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Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment

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Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths

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Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo

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Size-controlled hydroxyapatite nanoparticles as self-organized organic-in organic composite materials

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Dose optimization of a doxorubicin prodrug (HMR 1826) in isolated perfused human lungs:: Low tumor pH promotes prodrug activation by β-glucuronidase

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