☆ 4.7 Review

Extracellular Vesicle-Based Drug Delivery Systems for Head and Neck Squamous Cell Carcinoma: A Systematic Review

PHARMACEUTICS (2023)

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Summary: The pathophysiology of allergic rhinitis (AR) is not well understood, and extracellular vesicles (EVs) may provide important information about this disease. Recent research has focused on the potential use of EVs as biomarkers, vaccines, or drug delivery systems for AR. This review provides an up-to-date overview of the literature on EVs in AR, highlighting their potential clinical significance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Oncology

HPV+ HNSCC-derived exosomal miR-9-5p inhibits TGF-beta signaling-mediated fibroblast phenotypic transformation through NOX4

Bozhi Wang et al.

Summary: HPV-positive HNSCC patients have a better prognosis due to fewer infiltrated CAFs in the tumor microenvironment. Exosomal miR-9-5p derived from HPV-positive HNSCC cells inhibits fibroblast phenotypic transformation via decreasing NOX4 expression and ROS levels, affecting the TGF-beta signaling pathway and prognosis.

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Domenico Maisano et al.

Summary: This study presents an innovative approach to identify, isolate, and characterize disease-related exosomes based on their antigenic reactivities. The strategy can be immediately applied to any disease involving exosomes. The identification of specific markers and their association with exosome subtypes, along with the engineering of target-guided exosome-like particles, could be crucial for the effective clinical adoption of exosomes.

NANOSCALE (2022)

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Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

Xiwei Wang et al.

Summary: This study demonstrates that gamma delta-T cell-derived exosomes synergize with radiotherapy to control nasopharyngeal carcinoma (NPC) by overcoming radioresistance of NPC cancer stem cells (CSCs). Additionally, gamma delta-T-Exos preserve their tumor-killing and T cell-promoting activities in the immunosuppressive NPC microenvironment.

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Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration

Yue Kang et al.

Summary: In this study, we designed and synthesized an exosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, which enhanced osteogenic, angiogenic and anti-inflammatory capabilities simultaneously. The composite scaffold promoted in vitro osteogenesis and angiogenesis, as well as in vivo new bone formation and osseointegration.

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In vitro experimental study on the formation of microRNA-34a loaded exosomes and their inhibitory effect in oral squamous cell carcinoma

Wei Deng et al.

Summary: This study explored the use of exosomes as carriers for loading microRNA-34a and treating oral squamous cell carcinoma. The results showed that loading microRNA-34a into exosomes and delivering them into HN6 cells significantly inhibited cell proliferation, migration, and invasion. This provides a new delivery method for microRNA-34a and a potential approach for oral cancer treatment.

CELL CYCLE (2022)

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Letter Oncology

DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer

Yao Jiang et al.

Summary: Despite the successful use of molecular targeted therapy and immunotherapy, only a small subset of patients can benefit from these treatments. Chemotherapy remains the main treatment for most tumors, but its non-selective effects on healthy tissues and developing resistance are major obstacles. In this study, a new conjugate called DTX-P7 was developed, which specifically targeted and inhibited tumor growth in non-small cell lung cancer. DTX-P7 induced unfolded protein response and subsequent apoptosis, effectively killing the dormant cancer stem cells. Therefore, DTX-P7 shows promise as a potential anticancer therapeutic.

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Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Panpan Liu et al.

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Yu-Jeong Choi et al.

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BIOMED RESEARCH INTERNATIONAL (2022)

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Review Biochemistry & Molecular Biology

Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma

Ting Li et al.

Summary: This review highlights the potential of exosomes as biomarkers and therapeutic targets for head and neck squamous cell carcinoma (HNSCC), discussing their biological mechanisms and recent clinical application.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Oncology

Unraveling molecular mechanisms of head and neck cancer

Antra et al.

Summary: Head and neck squamous cell carcinomas (HNSCC) pose major challenges in treatment due to their heterogeneity, late-stage diagnosis, and high recurrence rate. Current biomarkers for diagnosis and prognosis of HNSCC mainly rely on smoking as the major risk factor. This review focuses on the differential environment and gene mutations of HNSCC in Indian patients who consume smokeless tobacco. It reveals frequent mutations in genes involved in DNA repair, cell proliferation, cell death, metastasis, lymphocyte proliferation, cell-cell adhesion, miRNA processing, and inflammatory responses in Indian HNSCC patients.

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Summary: In this study, Cabazitaxel (CZT) loaded chitosan-alginate based (CSA) nanoparticles with dual targeting functions were developed. The nanoparticles were able to target both folate receptor and epidermal growth factor receptor (EGFR). The results showed enhanced cellular uptake, improved anticancer efficacy, and better safety of the dual receptor-targeted CSA nanoparticles.

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Karolina Dzaman et al.

Summary: This review examines the role of exosomes in chronic rhinosinusitis (CRS) and their potential applications. The findings suggest that exosomal biomarkers have promising clinical utility in the diagnosis and prognosis of CRS patients, and may also contribute to the identification of novel therapeutic targets. Furthermore, exosomes can serve as excellent materials for studying noninvasive proteomic alterations, which is important for the development of personalized medicine.

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Concept: A randomised multicentre trial of first line chemotherapy comparing three weekly cabazitaxel versus weekly paclitaxel in HER2 negative metastatic breast cancer

Amit Bahl et al.

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BREAST (2022)

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Oral squamous cell carcinoma-clinical characteristics, treatment, and outcomes in a single institution retrospective cohort study

Wojciech Kazmierczak et al.

Summary: This study analyzed the data of patients treated for malignant tumors of the oral cavity to assess the influence of risk factors on survival in patients with squamous cell carcinoma of the oral cavity. The study found that age over 65 did not significantly influence survival. The location of the tumor also had an impact on the outcome, with better outcomes observed in the anterior two thirds of the tongue and worse outcomes in the retromandibular triangle area. Higher degrees of local and regional advancement and higher stage were associated with worse outcomes. Positive surgical margins did not affect treatment results, and delayed reporting of symptoms did not worsen the outcome.

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Ari J. Rosenberg et al.

Summary: The treatment of locoregionally advanced head and neck squamous cell carcinoma typically involves a multidisciplinary approach, but there has been recent discussion on de-escalation strategies. Research has focused on how to minimize toxicity while maintaining good treatment outcomes. While there are ongoing de-escalation trials, there is still controversy surrounding patient selection and de-escalation strategies.

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HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2021)

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Effect of stroma on the behavior of temoporfin-loaded lipid nanovesicles inside the stroma-rich head and neck carcinoma spheroids

Ilya Yakavets et al.

Summary: The presence of stromal components significantly influences the uptake of nanoparticles, while the penetration and photodynamic therapy efficacy are less affected. Among the three lipid-based nanoformulations, mTHPC-EVs showed superior cellular uptake and photodynamic efficiency due to their high loading capacity. The results of this study enhance our understanding of how stromal components impact the delivery of nanoparticles to tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Yutaro Kase et al.

Summary: Exosomes, engineered to contain therapeutic agents, have shown potential in attenuating the oncogenic activity of human cancer cells. Specifically targeting oral squamous cell carcinoma (OSCC) with engineered exosomes (octExosomes) loaded with siRNA has demonstrated significant tumor-suppressive effects both in vitro and in vivo, providing a valuable tool for inhibiting tumor cells.

SCIENTIFIC REPORTS (2021)

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Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, Research & Experimental

MiR-155 Inhibitor-Laden Exosomes Reverse Resistance to Cisplatin in a 3D Tumor Spheroid and Xenograft Model of Oral Cancer

Adil Ali Sayyed et al.

Summary: The study demonstrates that miR-155 inhibitor-loaded exosomes show therapeutic potential in reversing cisplatin resistance in oral cancer by upregulating FOXO3a, inducing epithelial-to-mesenchymal transition, and inhibiting stem cell-like properties. This provides a novel alternative therapeutic strategy for refractory oral cancer patients.

MOLECULAR PHARMACEUTICS (2021)

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Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Shayna Sharma et al.

Summary: EVs can serve as natural carriers for drug delivery, and their fusion with engineered nanostructures has been proposed to enhance drug loading and achieve site-specific delivery. Challenges such as isolation, heterogeneity, coexistence with biomolecules, and lack of targeted delivery have limited the potential of EVs.

SMALL (2021)

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Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

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Summary: The study demonstrates that extracellular vesicles from milk can be absorbed in mice and detected in multiple organs. Orally administered milk-derived extracellular vesicles have a context specific role in promoting or suppressing primary tumor growth and metastasis in mouse models.

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Nanoscale biomimetic nano system for the co-delivery of SNS032 and tumor necrosis factor related apoptosis inducing ligand to enhance therapeutic efficacy in oral squamous cell carcinoma cell line SCC25

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Summary: SNS032 and TRAIL have shown synergistic effects in cancer treatment, and a biomimetic nano system using gelatin exosomes to deliver them has been proven effective in inhibiting oral squamous cell carcinoma cells through multiple signaling pathways. The combination of MSCT-EXO/G-SNS032 has a satisfactory synergistic action and could provide a new idea for the treatment of multidrug-resistant tumors.

MATERIALS EXPRESS (2021)

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Bitter melon derived extracellular vesicles enhance the therapeutic effects and reduce the drug resistance of 5-fluorouracil on oral squamous cell carcinoma

Meng Yang et al.

Summary: Bitter melon-derived extracellular vesicles (BMEVs) demonstrated significant therapeutic efficacy against oral squamous cell carcinoma (OSCC) and reduced drug resistance. The study provides evidence for the development of PDEVs-enhanced therapy for cancer treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Karishma Singh et al.

Summary: Exosomes are nano-sized extracellular vesicles that serve as a communication system between cells and show promise in various human diseases. Due to their natural heterogeneity, there is a need to separate them into distinct subpopulations for full interrogation of exosome biology before clinical translation. Various technologies and advancements are being explored for better isolation and characterization of exosome subpopulations in clinical practices.

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Oded Cohen et al.

Summary: Exosomes derived from mesenchymal stem cells (MSC-exo) show superior tumor accumulation and penetration abilities compared to exosomes from the A431 squamous cell carcinoma line (A431-exo), as demonstrated in a study using gold nanoparticle labeling and computed tomography imaging in tumor-bearing mice. This suggests that MSC-exo may be a more effective option for tumor-targeted therapy.

BIOMATERIALS SCIENCE (2021)

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Exosome-mediated delivery of gene vectors for gene therapy

Li Duan et al.

Summary: Gene vectors deliver genetic materials or gene editing devices into cells for therapeutic protein production or gene correction, but barriers like cell membrane and degradation necessitate carriers for clinical gene therapy. Exosomes, engineered to encapsulate and deliver nucleic acids, and their fusion with liposomes increase loading capacity and maintain targeting capability, showing promise for future gene delivery applications in therapy.

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Sang-Han Lee et al.

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WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

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miRNA-200c mediates mono-butyl phthalate-disrupted steroidogenesis by targeting vimentin in Leydig tumor cells and murine adrenocortical tumor cells

Hongchao Lu et al.

TOXICOLOGY LETTERS (2016)

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Article Biotechnology & Applied Microbiology

The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis

Yadong Wang et al.

ONCOTARGETS AND THERAPY (2016)

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Review Cell & Tissue Engineering

Illuminating the physiology of extracellular vesicles

Hongyoon Choi et al.

STEM CELL RESEARCH & THERAPY (2016)

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Article Multidisciplinary Sciences

MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features

Ruma Dey Ghosh et al.

SCIENTIFIC REPORTS (2016)

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Review Cell Biology

Biogenesis and Function of T Cell-Derived Exosomes

Leandro N. Ventimiglia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

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Review Pharmacology & Pharmacy

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Edgar Perez-Herrero et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Article Chemistry, Multidisciplinary

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Tyson Smyth et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Multidisciplinary Sciences

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

Charles P. Lai et al.

NATURE COMMUNICATIONS (2015)

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Article Multidisciplinary Sciences

Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma

Longmei Cai et al.

NATURE COMMUNICATIONS (2015)

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Review Oncology

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Xiang-Jun Tang et al.

ONCOTARGET (2015)

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Article Oncology

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

Stefania Raimondo et al.

ONCOTARGET (2015)

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Review Anatomy & Morphology

Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature

Daniel Martinez Saez et al.

CELLS TISSUES ORGANS (2015)

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Article Dentistry, Oral Surgery & Medicine

Altered levels of miR-21, miR-125b-2*, miR-138, miR-155, miR-184, and miR-205 in oral squamous cell carcinoma and association with clinicopathological characteristics

Mayakannan Manikandan et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2015)

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Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Chemistry, Multidisciplinary

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Charles P. Lai et al.

ACS NANO (2014)

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Review Pathology

MicroRNAs in Cancer

Gianpiero Di Leva et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 (2014)

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Article Oncology

Large-scale expansion of γδ T cells and peptide-specific cytotoxic T cells using zoledronate for adoptive immunotherapy

Toshiaki Yoshikawa et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Review Biochemistry & Molecular Biology

Current methods for the isolation of extracellular vesicles

Fatemeh Momen-Heravi et al.

BIOLOGICAL CHEMISTRY (2013)

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Article Cell Biology

Dynamics of exosome internalization and trafficking

Tian Tian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

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Article Oncology

Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients With Locally Advanced Larynx Cancer

Arlene A. Forastiere et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Oncology

miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling

Yong Chen et al.

MOLECULAR MEDICINE REPORTS (2013)

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Article Cell & Tissue Engineering

MicroRNA-200C and-150 Play an Important Role in Endothelial Cell Differentiation and Vasculogenesis by Targeting Transcription Repressor ZEB1

Zhenling Luo et al.

STEM CELLS (2013)

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Editorial Material Oncology

NK cell-released exosomes Natural nanobullets against tumors

Stefano Fais

ONCOIMMUNOLOGY (2013)

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Article Oncology

MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3

Bing Feng et al.

CANCER (2012)

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Article Biochemistry & Molecular Biology

Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs

Taketoshi Hata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

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Article Oncology

A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

Qunzhou Zhang et al.

CANCER LETTERS (2010)

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Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon et al.

IMMUNITY (2010)

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Review Medicine, Research & Experimental

MicroRNAs in Cancer

Ramiro Garzon et al.

ANNUAL REVIEW OF MEDICINE (2009)

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Review Biochemistry & Molecular Biology

MicroRNA Profiling and Head and Neck Cancer

Xiqiang Liu et al.

COMPARATIVE AND FUNCTIONAL GENOMICS (2009)

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Article Oncology

HPV Prophylactic Vaccines and the Potential Prevention of Noncervical Cancers in Both Men and Women

Maura L. Gillison et al.

CANCER (2008)

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Article Oncology

Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue

Thian-Sze Wong et al.

CLINICAL CANCER RESEARCH (2008)

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Article Biochemical Research Methods

Engineering tumors with 3D scaffolds

Claudia Fischbach et al.

NATURE METHODS (2007)

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