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Article
Biochemistry & Molecular Biology
Chong-Chao Zhong et al.
Summary: Oxidative stress and autophagy are involved in copper-induced lipid deposition, and Nrf2 plays a crucial role in this process, regulating lipid metabolism and lipogenesis. Additionally, oxidative stress promotes Nrf2 recruitment to the PPAR gamma promoter, leading to target gene transcription and subsequent lipogenesis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Yicheng Jiang et al.
Summary: Recent studies have shown that imbalanced copper homeostasis can affect tumor growth, causing irreversible damage. Copper can induce various forms of cell death, such as apoptosis and autophagy, through mechanisms involving reactive oxygen species accumulation, proteasome inhibition, and antiangiogenesis. This review highlights the antitumor mechanisms of copper, the development of biomaterials and nanotechnology incorporating copper, and the clinical applications of novel copper complexes.
Article
Psychology, Multidisciplinary
Dustin Fife
Summary: The human visual processing system can interpret large amounts of data quickly, but there is a lack of graphics in scientific literature that may unintentionally bias perception. The underuse and misuse of graphics may be due to the difficulty in producing sound graphs with existing software. flexplot, an R package, aims to simplify and automate graphical decision-making, making it easy for users to visualize various statistical models in combination with statistical modeling.
PSYCHOLOGICAL METHODS
(2022)
Article
Oncology
T. Powles et al.
ANNALS OF ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Paul A. Cobine et al.
Summary: Tsvetkov et al. (2022) identified a novel form of cell death caused by targeted accumulation of Cu in mitochondria, which leads to aggregation of lipoylated TCA cycle enzymes through direct Cu binding.
Review
Biochemistry & Molecular Biology
Valentina Oliveri
Summary: Conventional cancer therapies face challenges due to off-target effects, leading to the need for new therapeutic agents with increased selectivity, reduced side effects, and the ability to overcome cancer cell resistance targeting cancer stem cells. Some copper ionophores show promise in inducing cuproptosis in cancer cells with greater selectivity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Eva J. Ge et al.
Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.
NATURE REVIEWS CANCER
(2022)
Letter
Medicine, General & Internal
H. Jakubowski
Summary: What is Klevay's opinion in the Letter to the Editor?
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vinit C. Shanbhag et al.
Summary: Over the past 25 years, significant progress has been made in identifying and characterizing proteins that regulate the uptake, intracellular trafficking and export of copper. While copper is essential for growth and development in humans and other mammals, it is also a limiting nutrient for cancer cell growth and proliferation. Oral copper chelators have been shown to have anti-neoplastic and anti-metastatic effects in animals and humans.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Liyang Cui et al.
Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.
NATURE BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Imran Khan et al.
Summary: Programmed cell death (PCD) has been a major research interest in the past three decades. Initially, apoptosis was considered the only mechanistic pathway for PCD, but now other important pathways such as necroptosis have been discovered, which are crucial for understanding the cellular processes behind different pathological conditions. Additionally, research on triggering necroptosis in cancer cells to induce cell death and overcome chemoresistance is being discussed.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Paul A. Cobine et al.
Summary: Mitochondria accumulate copper through MCF proteins for the maturation of copper enzymes, involving transporters like Pic2 and SLC25A3. Copper and copper proteins play essential roles in regulating cellular copper balance and inter-organ communication, while matrix copper may also have a role in novel cell death pathway cuproptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Bryce Blades et al.
Summary: The complex and inverse relationship between copper and lipid metabolism has implications for diseases involving dyslipidemia. Understanding these pathways may provide druggable targets for therapeutic intervention. Tissue-specific roles of the copper regulatory protein ATP7B further elucidate the association between copper and lipid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Cell Biology
Svetlana Lutsenko
Summary: Copper homeostasis is crucial for the development and function of organisms, with misbalance leading to serious pathologies. Mammalian Cu(I) transporters play a key role in regulating intracellular copper fluxes, with various regulatory proteins contributing to the dynamic and cell-specific nature of the copper transport networks. The comparison of copper transport mechanisms in the liver and intestine highlights the distinct composition and regulatory responses of their transporters to changing copper levels.
JOURNAL OF CELL SCIENCE
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Pharmacology & Pharmacy
Hanshu Yuan et al.
Summary: Ferroptosis is a recently defined form of programmed cell death that is distinct due to its iron dependency and accumulation of lipid hydroperoxides. It can be regulated by various cellular variables and is potentially linked to degenerative diseases and acute injury scenarios. Additionally, ferroptosis may have significance in tumor-suppression and cancer therapy as a proposed target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiffany Tsang et al.
Review
Biochemistry & Molecular Biology
Paulina Wigner et al.
Summary: Bladder cancer is a dangerous disease, with men being at higher risk and risk factors including chemical exposure and genetic factors. Studies suggest that inflammation, oxidative stress, and angiogenesis disorders may promote the development of bladder cancer, and gene polymorphisms may affect the risk of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yi Xiao et al.
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Microbiology
Yuan Ping Li et al.
Summary: Competition drives evolution, with toxic metals and metalloids exerting selective pressure on life, leading to the evolution of resistance mechanisms in microorganisms. Microorganisms exploit antimicrobial metals to gain competitive advantage, which in turn drives the evolution of resistance mechanisms against these metals and metalloids.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Review
Oncology
Lisha Li et al.
Summary: Pyroptosis is a type of programmed cell death that can activate the immune system to kill cancer cells, yet it may also promote tumor development by changing the immune microenvironment.
Review
Biochemistry & Molecular Biology
May T. Maung et al.
Summary: Copper is an essential micronutrient for human health, involved in critical metabolic reactions and signaling pathways. Maintaining copper balance and transport is crucial for proper cellular function and overall health. Copper plays a dual role in cancer, both promoting tumor growth and inducing oxidative stress in cancer cells, and is also involved in cancer treatment as a component of drugs and regulator of drug sensitivity.
Review
Biochemistry & Molecular Biology
Beata Tarnacka et al.
Summary: Copper, manganese, and iron are essential elements for appropriate brain development and function, but their imbalance can lead to various neurological conditions. This review focuses on neurological disorders associated with excess copper, iron, and manganese, and discusses the diagnosis and potential treatment of these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Reid Loveless et al.
Summary: Pyroptosis, a lytic and inflammatory programmed cell death pathway, has shown potential in addressing tumor resistance to apoptosis and the immunosuppressive tumor microenvironment by inducing a robust inflammatory response and marked tumor regression. Gasdermin proteins mediate pyroptosis and facilitate immune cell activation and infiltration, but aberrant pyroptosis may also contribute to tumor progression by upregulating gasdermin proteins in certain cancers. Harnessing pyroptosis as a tool in anticancer strategies shows promise in novel interventions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Engineering, Biomedical
Muyue Yang et al.
Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.
BIOACTIVE MATERIALS
(2021)
Review
Medicine, General & Internal
Jakub Dobruch et al.
Summary: Bladder cancer diagnosis and management have entered a new era, with advancements in technology and new discoveries leading to a decrease in mortality rates. New agents for patients with BCG failure have been approved, and alternative approaches are being developed to improve treatment success rates.
MEDICINA-LITHUANIA
(2021)
Article
Multidisciplinary Sciences
Tianzhi Wu et al.
Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.
Review
Oncology
Linda Tran et al.
Summary: Recent developments in bladder cancer research have focused on identifying mutated genes, understanding cellular aspects, and advancing non-invasive diagnostic methods. Immune checkpoint inhibitor therapeutics have shown significant therapeutic impact, providing patients with better monitoring options and hope for prolonged survival.
NATURE REVIEWS CANCER
(2021)
Review
Oncology
Xu Lei et al.
Article
Cell Biology
Lingyun Liu et al.
Review
Cell Biology
Sammy Bedoui et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Cell Biology
Yilin Yan et al.
Article
Biotechnology & Applied Microbiology
Yao Ma et al.
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Immunology
Shigekazu Nagata et al.
NATURE REVIEWS IMMUNOLOGY
(2017)
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Biochemical Research Methods
Aaron M. Newman et al.
Article
Biochemistry & Molecular Biology
Matthew E. Ritchie et al.
NUCLEIC ACIDS RESEARCH
(2015)
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Multidisciplinary Sciences
Paul Geeleher et al.
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Biochemical Research Methods
Jeffrey T. Leek et al.
Article
Urology & Nephrology
Peter C. Black et al.
JOURNAL OF UROLOGY
(2011)
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Biochemical Research Methods
Matthew D. Wilkerson et al.
Article
Computer Science, Interdisciplinary Applications
Jerome Friedman et al.
JOURNAL OF STATISTICAL SOFTWARE
(2010)
