☆ 4.6 Review

Traditional Chinese medicine inhibits PD-1/PD-L1 axis to sensitize cancer immunotherapy: a literature review

FRONTIERS IN ONCOLOGY (2023)

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Article Oncology

The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses

Jaemoo Chun et al.

Summary: By combining phytochemical, transcriptomic, and experimental analyses, the study identified the potential target of active compounds in Inula helenium and demonstrated that the sesquiterpene lactone-rich fraction of I. helenium (SFIH) enhances the antitumor effect of anti-PD-1 antibody in colorectal cancer. The combination therapy increased the proportion of cytotoxic T lymphocytes and M1-like macrophages, and activated immune-related pathways to a greater extent than monotherapy.

CANCERS (2023)

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Article Pharmacology & Pharmacy

Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFicB activity

Shang-Lang Huang et al.

Summary: Our study identified the upregulation of the NFicB signaling pathway in paclitaxel-resistant ovarian cancer cells and found that SNIP1 may be involved in regulating NFicB activity. Curcumin upregulated SNIP1 expression, leading to the downregulation of pro-survival genes and the inhibition of NFicB activity. Furthermore, we demonstrated that SNIP1 enhanced NFicB protein degradation, thereby suppressing NFicB/p65 acetylation and protein stability. These findings provide insights into the mechanism of curcumin in reducing paclitaxel resistance and inducing apoptosis in ovarian cancer cells.

BIOCHEMICAL PHARMACOLOGY (2023)

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Review Integrative & Complementary Medicine

Successful treatment of immune-related lichenoid dermatitis by Weiling decoction in a patient with non-small cell lung cancer: A case report and review of literature

Ying Liu et al.

Summary: This article reports a case of successful alleviation of immune-induced lichenoid dermatitis in a patient with sqNSCLC using modified Weiling decoction. The study indicates that Weiling decoction may be an effective and safe complementary or alternative approach for the treatment of cutaneous irAEs.

EXPLORE-THE JOURNAL OF SCIENCE AND HEALING (2023)

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Review Immunology

CD8+ T cell exhaustion in anti-tumour immunity: The new insights for cancer immunotherapy

Yijin Huang et al.

Summary: CD8(+) T cells play a crucial role in anti-tumour immunity, but their exhaustion, induced by long-term antigen exposure and regulated by cytokines, affects their anti-tumour activity. This review focuses on the biology of exhausted CD8(+) T cells, including differentiation pathways, cellular characteristics, and signaling pathways involved in exhaustion, and discusses how this knowledge can be applied to tumor immunotherapy.

IMMUNOLOGY (2023)

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Article Chemistry, Medicinal

Curcumin suppressed the proliferation and apoptosis of HPV-positive cervical cancer cells by directly targeting the E6 protein

Xingyu Zhao et al.

Summary: This study found that curcumin, an active ingredient in turmeric, can inhibit the survival and induce apoptosis of human papillomavirus (HPV)-related cervical cancer cells. It also demonstrated that curcumin can inhibit the invasion and migration ability of cervical cancer cells and regulate the expression of E6.

PHYTOTHERAPY RESEARCH (2023)

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Article Oncology

Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma

Yuqing Xie et al.

Summary: This study used network pharmacology to identify the key drugs in the Yangyin Fuzheng Jiedu prescription (YFJP) and investigate their therapeutic effects on hepatocellular carcinoma (HCC). The results showed that the Fuzheng prescription (FZP) of YFJP exhibited significant anti-tumor effects and improved immune response in H22 tumor-bearing mice. Network pharmacology and experimental validation identified PIK3CA, TP53, MAPK1, MAPK3, and EGFR as the key targets of FZP in HCC treatment. FZP was found to alleviate T cell exhaustion and improve the immunosuppressive microenvironment through HCC-related signaling pathways and biological processes.

CANCER MEDICINE (2023)

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Article Biochemical Research Methods

Neobavaisoflavone Demonstrates Valid Anti-tumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3

Xueding Cai et al.

Summary: The results of this study indicate that neobavaisoflavone (NBIF) can reduce the proliferation and migration of non-small-cell lung cancer cells, as well as induce apoptosis. The anti-cancer efficacy of NBIF may be attributed to the inhibition of the STAT3 signaling pathway, as well as the modulation of apoptosis-related proteins.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2022)

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Review Biochemistry & Molecular Biology

Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review

Qianqian Li et al.

Summary: Platycodonis Radix (Jiegeng), the dried root of Platycodon grandiflorum, is a traditional herb used for the treatment of cough, phlegm, sore throat, pulmonary and respiratory diseases. Its main active ingredient, Platycodin D, has shown various biological activities, such as analgesic, expectorant, anti-tumor, etc., making it a potential candidate for drug research.

CURRENT DRUG METABOLISM (2022)

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Article Integrative & Complementary Medicine

Therapeutic Effect of Catgut Implantation at Acupoint in a Mouse Model of Hepatocellular Carcinoma by Suppressing Immune Escape

Shi-Hua Xu et al.

Summary: The study demonstrates that catgut implantation at acupoint (CIAA) treatment has therapeutic effects on hepatocellular carcinoma (HCC) by inhibiting immune escape and deactivating the AKT pathway.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Oncology

Evidence of immunogenic cancer cell death induced by honey-processed Astragalus polysaccharides in vitro and in vivo

Xinrui Sha et al.

Summary: Honey-processed Astragalus exhibits anti-tumor effects by inducing tumor cell apoptosis, increasing the expression of immunogenic cell death-related molecules, and modulating immune cell activity.

EXPERIMENTAL CELL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

A Critical YAP in Malignancy of HCC Is Regulated by Evodiamine

Un-Jung Yun et al.

Summary: Liver cancer is often diagnosed in the late stage due to its few early symptoms. Sorafenib, the only FDA-approved first-line anticancer drug for advanced HCC, has limited use due to resistance. Therefore, developing new drugs is crucial for customized treatment. Studies have shown that Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) is associated with metastasis and progression of liver cancer. This study found that evodiamine can inhibit YAP and reduce cell growth of HCC, demonstrating its potential as an effective anticancer drug for HCC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Gastroenterology & Hepatology

Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Jumin Huang et al.

Summary: This study demonstrated that the combination of GPs and alpha PD-1 mAb enhanced the antitumor response by modulating gut microbiota. The GPs increased microbial metabolites and reshaped gut microbiota towards responders, sensitizing non-small cell lung cancer patients to anti-PD-1 immunotherapy. Additionally, gut microbiota could serve as a novel biomarker to predict the response to anti-PD-1 immunotherapy.

GUT (2022)

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Article Oncology

Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer

Yihua Xu et al.

Summary: Obesity increases the risk of colorectal cancer, and DFB can inhibit tumor growth by modulating the immune system, especially in conjunction with anti-PD-1 treatment.

CANCER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Chemosensitization of U-87 MG Glioblastoma Cells by Neobavaisoflavone towards Doxorubicin and Etoposide

Mateusz Maszczyk et al.

Summary: Glioblastoma is a type of glioma with high mortality rates and resistance to treatment. Research suggests that neobavaisoflavone may enhance the pro-apoptotic activity of chemotherapeutic drugs like etoposide and doxorubicin in glioblastoma cells, indicating potential chemosensitizing properties of this isoflavone.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Chemistry, Medicinal

Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19)

Elahe Aleebrahim-Dehkordi et al.

Summary: Polysaccharides, including Astragalus polysaccharides (APS), are attracting attention for their non-toxic, biodegradable, and biocompatible properties, making them suitable candidates for pharmaceutical formulations and new drug development. APS have great potential for drug applications, with studies showing antiviral and anti-inflammatory activities, as well as stimulation of cytokine secretion. This natural and inexpensive source has promising prospects for controlling COVID-19 infection.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Andrographolide suppresses non-small-cell lung cancer progression through induction of autophagy and antitumor immune response

Xuan-Run Wang et al.

Summary: Andrographolide (AD) in the treatment of non-small-cell lung cancer (NSCLC) involves regulating autophagy and PD-L1 expression, inhibiting tumour growth by suppressing JAK2/STAT3 signaling and P62-dependent selective autophagy.

PHARMACOLOGICAL RESEARCH (2022)

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Article Plant Sciences

Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling

Yu Zhang et al.

Summary: The study aimed to investigate the regulatory mechanism of CFF-1 on PD-L1/PD-1-mediated tumor immune escape. The results showed that CFF-1 can inhibit tumor growth and lung metastasis by suppressing the PD-1/PD-L1 pathway and improving T lymphocyte immune response.

PHYTOMEDICINE (2022)

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Article Oncology

PD-L1 expressed from tumor cells promotes tumor growth and invasion in lung cancer via modulating TGF-β1/SMAD4 expression

Ming-Jenn Chen et al.

Summary: The expression of PD-L1 is associated with human papillomavirus and epidermal growth factor receptor mutation in lung cancer, and it promotes tumor growth and invasiveness through the ERK-C/EBP β-TLR4-NF-κB cascade, leading to decreased expression of transforming growth factor and SMAD4.

THORACIC CANCER (2022)

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Article Pharmacology & Pharmacy

Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment

Ruijie Yang et al.

Summary: It has been discovered that Platycodon grandiflorum (PG) can reduce the expression of PD-1 on the surface of CD8(+) T cells, exerting anti-tumor effects in non-small cell lung cancer (NSCLC). PG has the potential to modulate T cells and suppress tumors. By reducing the secretion of VEGF-A regulated by the level of P-STAT3 in tumor cells, PG regulates the expression of PD-1 on the surface of CD8(+) T cells.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Jieyao Ma et al.

Summary: UHPLC-HRMS is a technique that combines the advantages of UHPLC and HRMS, and has been widely used for quality control of traditional Chinese medicines. It enables efficient structure identification, quantitative determination, fingerprint analysis, and elucidation of mechanisms of action.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Impact of gallic acid on tumor suppression: Modulation of redox homeostasis and purinergic response in in vitro and a preclinical glioblastoma model

Nathalia Stark Pedra et al.

Summary: This study investigated the potential therapeutic effect of gallic acid (GA) on glioblastoma (GBM). The results demonstrated that GA had selective anti-glioma activity in vitro without inducing cytotoxicity in astrocytes. In vivo, GA reduced tumor volume and prevented oxidative damage caused by the tumor.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Article Biotechnology & Applied Microbiology

Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway

Yuhe Lei et al.

Summary: This study used a network pharmacology-based approach to identify the active compounds and targets of Evodiae fructus (EF) against prostate cancer. Experimental results showed that Evodiamine is the active compound responsible for inhibiting proliferation and migration of DU145 cells through the PI3K/AKT/NF-kappa B signaling pathway. This suggests that Evodiamine may be a potential lead drug for treating prostate cancer.

DISEASE MARKERS (2022)

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Article Integrative & Complementary Medicine

Grain-Sized Moxibustion Heightens the AntiTumor Effect of Cyclophosphamide in Hepa1-6 Bearing Mice

Tao Zhu et al.

Summary: The study demonstrates that grain-sized moxibustion can synergize with cyclophosphamide (CTX) to enhance its antitumor effect and alleviate its toxic and side effects. Grain-sized moxibustion not only inhibits the growth of liver cancer, but also down-regulates the expression of proliferation genes Ki67 and PCNA, inhibiting the proliferation ability of tumor cells and improving CTX-induced toxicity.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Oncology

Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy

Biaolong Deng et al.

Summary: This study identifies gallic acid as a compound that promotes the instability of T-reg cells, thereby enhancing the efficacy of immune checkpoint blockade (ICB) therapy in cancer treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Medicine, Research & Experimental

Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer

Shuying Dai et al.

Summary: This study investigated the potential immunomodulatory effect of the aqueous extract of Taxus chinensis var. mairei (AETC) in the treatment of non-small cell lung cancer (NSCLC). The results showed that AETC could downregulate CD47 levels, enhance immune response against NSCLC, and inhibit tumor growth by promoting macrophage-mediated tumor cell phagocytosis and activating CD8(+) T cells. These findings suggest that AETC could be a promising alternative or adjuvant therapy for lung cancer.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Oncology

Single-Cell Analysis Reveals a CD4+ T-cell Cluster That Correlates with PD-1 Blockade Efficacy

Hiroshi Kagamu et al.

Summary: CD4(+) T-cell immunity is essential in antitumor immune responses. A new CD4(+) T-cell metacluster associated with the efficacy of PD-1 blockade therapy has been identified, which can predict the progression-free survival and overall survival of lung cancer patients after PD-1 blockade therapy.

CANCER RESEARCH (2022)

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Article Immunology

Neobavaisoflavone inhibits antitumor immunosuppression via myeloid-derived suppressor cells

Jufeng Guo et al.

Summary: Neobavaisoflavone (Neo) has been found to inhibit the expansion and suppressive function of MDSCs, leading to the inhibition of tumor growth and metastasis. Additionally, Neo enhances the efficacy of anti-PD-1 treatment. This study highlights the potential of Neo as a therapeutic strategy against cancer.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy

Weidong Qi et al.

Summary: This review explores the biological activities of quercetin, including its antioxidant and antibacterial properties, intervention effects on pesticide poisoning, detoxification process, and its potential in reducing mycotoxin toxicity. The harmful effects of heavy metal poisoning on quercetin application are also evaluated. This review provides valuable insights for the clinical application of quercetin.

MOLECULES (2022)

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Review Chemistry, Multidisciplinary

Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances

Yaolei Li et al.

Summary: Traditional Chinese medicine (TCM) plays a crucial role in major public health events, with its complex chemical composition posing challenges for research. This paper provides a comprehensive review of existing approaches and technologies, as well as future prospects for the study of Chinese medicine formula. The essence of TCM should be preserved while pursuing innovation in the field.

ARABIAN JOURNAL OF CHEMISTRY (2022)

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Review Oncology

A comprehensive review of SHP2 and its role in cancer

Moges Dessale Asmamaw et al.

Summary: This article comprehensively reviews the regulatory mechanisms, substrates and binding partners, biological functions, roles in human cancers, and different classes of small molecule inhibitors target this oncoprotein in cancer, providing insights into the potential of SHP2 as a promising anticancer drug target.

CELLULAR ONCOLOGY (2022)

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Article Pharmacology & Pharmacy

Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification

Junjie Pan et al.

Summary: This study aimed to investigate the molecular mechanisms through which the Qingfei Jiedu decoction (QFJDD) regulates PD-L1 expression in lung adenocarcinoma (LUAD). The results showed that QFJDD downregulates PD-L1 expression and increases CD8(+)PD-1(+)T% via regulating HIF-1, EGFR, JUN and NF kappa B signaling pathways. QFJDD may be a potential treatment option for LUAD.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Immunology

Research advance of natural products in tumor immunotherapy

Jin-Ling Huo et al.

Summary: Cancer immunotherapy is a promising approach for treating tumors, but its effectiveness is limited to certain types of tumors. Natural products have been found to improve immune function by remodeling the tumor immunosuppressive microenvironment, providing an alternative method to enhance cancer immunotherapy. The discovery of new potential modulators from natural products holds great potential for guiding tumor treatment.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Endocrinology & Metabolism

Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora

Jiayue Liu et al.

Summary: This study found that HRP, APS, and HRP+APS can improve the intestinal flora of AFLD model mice, alleviate liver injury, and maintain normal intestinal function to a certain extent.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Biochemistry & Molecular Biology

Induction of Apoptosis and Effect on the FAK/AKT/mTOR Signal Pathway by Evodiamine in Gastric Cancer Cells

Ji Yeong Yang et al.

Summary: Evodiamine, isolated from Evodia rutaecarpa, exhibits cytotoxicity and promotes apoptosis in gastric cancer cells through the regulation of apoptosis-related proteins and the suppression of the FAK/AKT/mTOR signal pathway.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Keywords: AGE, , , Clinical efficacy, Inflammatory factors

Weiwei Zhang et al.

Summary: This study demonstrated the clinical efficacy of Gegen Qinlian Decoction combined with a Chinese herbal hot package in the treatment of acute gastroenteritis (AGE). The treatment effectively improved clinical symptoms and reduced inflammation in patients.

CELLULAR AND MOLECULAR BIOLOGY (2022)

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Article Endocrinology & Metabolism

Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src

Pei Cheng et al.

Summary: Evodiamine exhibits antitumor activity in prostate cancer by targeting Src to inhibit AR transcriptional activity.

ENDOCRINE (2022)

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Article Oncology

Oxymatrine reduces expression of programmed death-ligand 1 by promoting DNA demethylation in colorectal cancer cells

S. Hua et al.

Summary: The natural alkaloid oxymatrine suppresses viability and reduces PD-L1 expression in interferon gamma-stimulated colorectal cancer cells through enhanced DNA demethylation, suggesting its potential as an epigenetic modulatory agent for immunotherapy against CRC via PD-1/PD-L1 blockade.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights

Sandeep Kumar et al.

Summary: The crucial role of host immunity in clinical cancer management is highlighted, emphasizing the importance of therapies that can enhance tumor cell death and bolster host immunity. The impact of the tumor microenvironment on CD8+ T cell exhaustion and survival is discussed, along with potential strategies for restoring CD8+ T cell effector function through immunotherapy.

DRUG DISCOVERY TODAY (2021)

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Review Oncology

Combination strategies to maximize the benefits of cancer immunotherapy

Shaoming Zhu et al.

Summary: This review discusses the relationship between cancer immune response and resistance mechanisms to immunotherapy, as well as provides a comprehensive overview of the latest clinical status and FDA-approved combination therapies. It also covers therapies targeting cytokines, immunotherapy, virotherapy, innate immune modifiers, and cancer vaccines, as well as insights from the 2020 China Immuno-Oncology Workshop.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Chemistry, Medicinal

Quercetin inhibiting the PD-1/PD-L1 interaction for immune-enhancing cancer chemopreventive agent

Lei Jing et al.

Summary: Quercetin dihydrate can inhibit the interaction of PD-1/PD-L1, enhance the killing activity of T cells on cancer cells, and exhibit anti-tumor effects in mouse experiments.

PHYTOTHERAPY RESEARCH (2021)

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Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway

Reza Mirzaei et al.

Summary: The study identified a population of cells coexpressing PD-1 and BTIC marker within the human glioblastoma microenvironment, with tumor-intrinsic PD-1 promoting proliferation and self-renewal of BTICs independently of PD-L1. Additionally, BTIC-intrinsic PD-1 accelerated intracranial tumor growth in mice lacking T and B cells, indicating a nonimmune resistance mechanism to PD-1 or PD-L1-blocking therapies in patients with glioblastoma.

SCIENCE ADVANCES (2021)

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Article Oncology

Concomitant inhibition of B7-H3 and PD-L1 expression by a novel and synthetic microRNA delivers potent antitumor activities in colorectal tumor models

Fanyi Meng et al.

Summary: The study found that the miR-34 and miR-449 families share a common seed region, but different members have varying effects on the expression of B7-H3 and PD-L1. By modifying the non-seed region of miR-34a, synthetic microRNA analogs like NS-MX3 were created, with NS-MX3 exhibiting the strongest inhibition on B7-H3 and PD-L1 expression.

INVESTIGATIONAL NEW DRUGS (2021)

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Article Oncology

Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma

Zhe Deng et al.

Summary: SYPs inhibit immune escape and enhance chemosensitization in HCC by simultaneously inhibiting HIF-1 alpha and PD-L1, thus suppressing the growth of subcutaneous xenograft HCC tumors.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Review Immunology

Neoantigen: A New Breakthrough in Tumor Immunotherapy

Zheying Zhang et al.

Summary: Cancer immunotherapy enhances the body's immune response to target and eliminate cancer cells, with a focus on the emerging approach of tumor neoantigens. Studies have shown the relationship between neoantigens and T cell recognition of cancer cells, highlighting the potential of vaccines developed against these specific antigens in clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro

Gaochenxi Zhang et al.

Summary: The study revealed that the aqueous extract of Taxus chinensis var. mairei (TC) has potential anti-tumor effects in promoting apoptosis in non-small cell lung cancer (NSCLC) cells via the ATF3-Hippo-YAP pathway. AETC showed minimal inhibitory effects on normal cells and mice, indicating its potential as a promising adjuvant for NSCLC therapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Guiqing Ding et al.

Summary: The study demonstrates that Astragalus polysaccharides can modulate the immune function in tumor-bearing mice by remodeling the gut microbiota, particularly by reducing the number of myeloid-derived suppressor cells. Results from 16S rRNA analysis show that APS significantly regulates various microorganisms, with changes in abundance related to the increase of metabolites that promote tumor growth.

CANCER SCIENCE (2021)

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Article Plant Sciences

The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer

Lihua Liu et al.

Summary: The study evaluated the immune-modulating effects of Curcumin in HNSCC, finding that it decreased the expression of inhibitory IC ligands and restored the functional ability of cytotoxic T cells. Additionally, Curcumin increased T-cell proliferation and effector cytokines, and decreased the expression of suppressive IC receptors and their ligands in the TME, suggesting reinvigoration of exhausted T cells. These results provide a rationale for combining Curcumin with conventional targeted therapy or ICB to treat patients with HNSCC.

PHYTOMEDICINE (2021)

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Article Oncology

Moxibustion for treating cancer-related fatigue: A multicenter, assessor-blinded, randomized controlled clinical trial

Kyungsun Han et al.

Summary: The study confirmed the efficacy and safety of moxibustion for CRF compared to usual care, and it also found a prolonged treatment effect during the 4 weeks of follow-up period.

CANCER MEDICINE (2021)

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Review Immunology

CD8+ T Cell Exhaustion in Cancer

Joseph S. Dolina et al.

Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

Dandan Wang et al.

Summary: The study isolated and studied a polysaccharide from Panax ginseng, finding that it exhibits significant intestinal anti-inflammatory activity by modulating gut microbiota structure and restoring autophagic function to suppress inflammation.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment

I-Ying Kuo et al.

Summary: Rab37 regulates IL-6 secretion in macrophages to induce M2 polarization, promoting PD-1 expression in CD8(+) T cells. Tumors with high stromal Rab37 and IL-6 levels are associated with immunotherapeutic resistance and poor prognosis in lung cancer patients.

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CD47/SIRPα pathway mediates cancer immune escape and immunotherapy

Xiao Jia et al.

Summary: Immune evasion of cancer cells is mediated by the SIRPα-CD47 axis, but blocking the CD47-SIRPα interaction can enhance phagocytic clearance of cancer cells, activate immune responses, promote antigen presentation, and ultimately activate antitumor immune responses.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Oncology

Double-edged effects of interferons on the regulation of cancer-immunity cycle

Xiao Zhang et al.

Summary: Interferons have a dual effect on cancer immune response, with both anti-cancer and immune escape-promoting effects. They regulate each step of the cancer immunity cycle, contributing to our understanding of the mechanisms of IFNs in regulating cancer immunity. Recent studies have highlighted the critical roles of IFNs in the success of cancer therapy strategies.

ONCOIMMUNOLOGY (2021)

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Review Medicine, Research & Experimental

Antitumor effects of immunity-enhancing traditional Chinese medicine

Yeshu Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Immunology

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

Jackson G. Egen et al.

IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Molecular mechanisms associated with macrophage activation by Rhizoma Atractylodis Macrocephalae polysaccharides

Wei Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Medicine, Research & Experimental

Evidence for acupoint catgut embedding treatment and TRPV1 gene deletion increasing weight control in murine model

Chanya Inprasit et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Daixi Ren et al.

MOLECULAR CANCER (2020)

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Modified Bu-zhong-yi-qi decoction synergies with 5 fluorouracile to inhibits gastric cancer progress via PD-1/PD-L1-dependent T cell immunization

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Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

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Mechanisms of immune escape in the cancer immune cycle

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Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion

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Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis

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Tumor-associated macrophages induce PD-L1 expression in gastric cancer cells through IL-6 and TNF-α signaling

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A guide to cancer immunotherapy: from T cell basic science to clinical practice

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Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment

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The Effectiveness of Acupoint Catgut Embedding Therapy for Abdominal Obesity: A Systematic Review and Meta-Analysis

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Moxibustion as a Therapy for Breast Cancer-Related Lymphedema in Female Adults: A Preliminary Randomized Controlled Trial

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The opposing roles of CD4+ T cells in anti-tumour immunity

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Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

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Immunoadjuvant activity in mice of polysaccharides isolated from the leaves of Panax ginseng CA Meyer

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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

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Cancer immunotherapy using checkpoint blockade

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CD4+ T cell help in cancer immunology and immunotherapy

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Cross-talk between TNF-alpha and IFN-gamma signaling in induction of B7-H1 expression in hepatocellular carcinoma cells

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Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells

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Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

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MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas

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Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

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PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation

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Classification of current anticancer immunotherapies

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ONCOTARGET (2014)

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Oncology Meets Immunology: The Cancer-Immunity Cycle

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Cancer immunotherapy - revisited

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The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

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Inhibitory B7-family molecules in the tumour microenvironment

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