4.6 Review

Perioperative intravenous lidocaine for postoperative pain in patients undergoing breast surgery: a meta-analysis with trial sequential analysis of randomized controlled trials

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Review Anesthesiology

Perioperative Intravenous Lidocaine Infusion for Postoperative Analgesia in Patients Undergoing Surgery of the Spine: Systematic Review and Meta-Analysis

Ana Licina et al.

Summary: Perioperative intravenous lidocaine infusion effectively reduces pain, decreases opioid consumption, and shortens hospital stay for patients undergoing spinal surgery. The treatment is more significant in adult patients, with positive effects also seen in pediatric patients.

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Effect of intravenous lidocaine infusion on perioperative cellular immunity and the quality of postoperative recovery in breast cancer patients: a randomized controlled trial

Qingfeng Wei et al.

Summary: The study found that continuous intravenous pumping of lidocaine during the perioperative period has little effect on immune function in breast cancer patients and promotes postoperative recovery.

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Effect of intravenous lidocaine on chronic postoperative pain in patients undergoing breast cancer surgery: a prospective, double-blind, randomized, placebo-controlled clinical trial

Ming Xia et al.

Summary: This study suggests that perioperative intravenous lidocaine infusion can reduce the incidence of chronic postoperative pain in breast cancer patients and is effective in relieving acute postoperative pain.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Effect of intravenous lidocaine on chronic postoperative pain in patients undergoing breast cancer surgery: a prospective, double-blind, randomized, placebo-controlled clinical trial

Ming Xia et al.

Summary: The study found that perioperative intravenous lidocaine infusion significantly reduces the incidence of chronic postoperative pain in breast cancer patients and effectively relieves acute postoperative pain.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

Article Anesthesiology

A pilot multicentre randomised controlled trial of lidocaine infusion in women undergoing breast cancer surgery

A. J. Toner et al.

Summary: The pilot study demonstrated that peri-operative lidocaine infusion in breast cancer surgery patients is safe, effective, and feasible, with high protocol adherence and successful long-term data capture. The trial design was in accordance with expert guidance, overcoming previous limitations and providing valuable insights for planning a larger-scale trial.

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Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

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The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety

I. Foo et al.

Summary: The use of intravenous lidocaine in peri-operative pain management should be considered carefully due to its potential benefits and risks, especially for patients with comorbidities. Proper approval from hospital medication governance systems and informed consent from patients are crucial before utilizing this 'high-risk' medicine. Dosage recommendations and timing of administration in relation to other local anesthetic interventions should also be strictly followed.

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Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review

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The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

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Acute and Persistent Postoperative Pain after Breast Surgery

Karamarie Fecho et al.

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Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

Jorn Wetterslev et al.

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Risk factors for chronic pain following breast cancer surgery: A prospective study

Ellen L. Poleshuck et al.

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JPT Higgins et al.

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