☆ 4.6 Review

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy

FRONTIERS IN ONCOLOGY (2023)

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The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy

Hanwen Zhang et al.

Summary: In recent decades, adoptive cellular therapy has shown remarkable efficacy in treating relapsed/refractory or late-stage malignancies. However, the effectiveness of FDA-approved T-cell therapies is limited by cellular exhaustion and senescence in hematologic malignancies and solid tumor patients. Researchers are addressing these obstacles by focusing on the manufacturing process of effector T cells, including engineering approaches and ex vivo expansion strategies. This review highlights current small-molecule strategies to enhance T-cell expansion, persistence, and functionality, and proposes novel vasoactive intestinal peptide receptor antagonists (VIPR-ANT) peptides as emerging candidates to enhance cell-based immunotherapy.

FRONTIERS IN IMMUNOLOGY (2023)

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TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

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Summary: T cell engineering has revolutionized cancer immunotherapy. Chimeric antigen receptor T cells have shown great efficacy in treating B cell malignancies, while T cells expressing engineered T cell receptors (TCR-T cells) offer a promising therapeutic alternative for solid tumors. This review summarizes clinical results and methods for identifying and optimizing TCR candidates, discusses challenges such as toxicity assessment and resistance mechanisms, and highlights future directions in the field.

SCIENCE ADVANCES (2023)

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Editorial Material Oncology

Manufacture of adoptive cell therapies at academic cancer centers: scientific, safety and regulatory challenges

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ANNALS OF ONCOLOGY (2022)

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Review Medicine, Research & Experimental

The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer

Hajar Alemohammad et al.

Summary: The growth and development of cancer are directly correlated to the suppression of the immune system, with immune checkpoints playing a key role in inhibiting anti-tumor immune responses. Up-regulation of inhibitory immune checkpoints on immune cells during tumor progression suppresses anti-tumor immune responses and promotes immune escape. Targeting inhibitory immune checkpoints through antibodies or miRNAs is a promising therapeutic strategy, and immune checkpoint inhibitors have shown favorable results in enhancing immune cell-induced antitumor responses.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

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BLOOD (2022)

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FDA approval of Immunocore's first-in-class TCR therapeutic broadens depth of the T cell engager platform

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Medicine, General & Internal

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

Hussein A. Tawbi et al.

Summary: LAG-3 and PD-1 are two distinct inhibitory immune checkpoints that contribute to T-cell exhaustion. The combination of relatlimab and nivolumab has been shown to be safe and effective in previously treated melanoma patients, and this study aimed to evaluate its safety and activity in previously untreated melanoma patients. The results demonstrated that the combination therapy provided a greater benefit in terms of progression-free survival compared to nivolumab alone, without any new safety signals.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Oncology

Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment

Juha P. Vayrynen et al.

Summary: This study developed a multiplexed immunofluorescence assay coupled with digital image analysis and machine learning to identify different lymphocytic populations in colorectal cancer. The study found that T cells were more abundant than NK and NKT-like cells in colorectal cancer. NK cells expressed high levels of a cytotoxic marker and were located closer to tumor cells, while T and NKT-like cells expressing the marker were enriched in cells closer to tumor cells. Higher densities of T and NKT-like cells were associated with longer cancer-specific survival, as well as higher densities of GZMB(+) and FCGR3A(+) NK cells and closer proximity of T and NKT-like cells to tumor cells.

CANCER IMMUNOLOGY RESEARCH (2022)

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Review Immunology

Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer

An-Ping Shi et al.

Summary: LAG3 is a promising immune checkpoint that inhibits the immune microenvironment and promotes tumor growth, next to PD-1 and CTLA-4. The interaction mechanism between LAG3 and FGL1, as well as their intracellular signals, remains unclear. LAG3/FGL1 activity is associated with immune cell infiltration, proliferation, and secretion. IMP321 and relatlimab are potential monoclonal antibodies targeting LAG3 in melanoma.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Virus-like Particles as Preventive and Therapeutic Cancer Vaccines

Anna Lucia Tornesello et al.

Summary: Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the structure of native viruses. They are able to efficiently activate the immune response and hold promise for the development of vaccines against infectious diseases and cancers. VLP-based vaccine formulations have the advantage of incorporating multiple antigens and can be modified without affecting their structure or antigenicity.

VACCINES (2022)

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Macrophage-Based Combination Therapies as a New Strategy for Cancer Immunotherapy

Lin Tian et al.

Summary: This article discusses the importance of reversing the immunosuppressive state of tumor microenvironments, transforming M2 tumor-associated macrophages into M1 type, and utilizing macrophage-based cell therapies in cancer immunotherapy research.

KIDNEY DISEASES (2022)

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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer

Hanna Elomaa et al.

Summary: This study evaluated the prognostic significance of tumour cell-T cell co-localisation and T cell densities in colorectal cancer patients. The findings showed that high T cell proximity score was associated with longer cancer-specific survival, indicating the potential of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.

BRITISH JOURNAL OF CANCER (2022)

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An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors

Jitka Fucikova et al.

Summary: This study found that patients with highly infiltrated, hot EOCs benefit from chemotherapy, whereas women with cold EOCs may require DC-based vaccination for better clinical responses.

CLINICAL CANCER RESEARCH (2022)

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Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer

Kwang-Hyeok Kim et al.

Summary: Lung cancer is a major cause of cancer-related deaths, with small cell lung cancer (SCLC) accounting for a significant portion. Overexpression of c-Kit is a characteristic of SCLC. This study found that the antibody-drug conjugate 4C9-DM1 shows potential as a therapeutic agent for SCLC, as it efficiently induces apoptosis and inhibits tumor growth. Combination treatment with other drugs further enhances its anti-tumor effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer

Diego de Miguel-Perez et al.

Summary: This study evaluated the use of extracellular vesicle PD-L1 expression as a biomarker for predicting durable treatment response and survival in non-small cell lung cancer (NSCLC) patients receiving immune-checkpoint inhibitors (ICIs). The results showed that an increase in extracellular vesicle PD-L1 was observed in non-responders compared to responders and was an independent biomarker for shorter progression-free survival and overall survival. In contrast, tissue PD-L1 expression, the commonly used biomarker, was not predictive for durable response or survival.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Tiragolumab plus atezolizumab versus placebo plus atezolizumab as a first-line treatment for PD-L1-selected non-small-cell lung cancer (CITYSCAPE): primary and follow-up analyses of a randomised, double-blind, phase 2 study

Byoung Chul Cho et al.

Summary: The combination of tiragolumab and atezolizumab showed promising efficacy and safety as first-line treatment for NSCLC, with improved objective response rate and progression-free survival compared to placebo plus atezolizumab.

LANCET ONCOLOGY (2022)

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Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment

Ying Li et al.

Summary: Pancreatic cancer interacts closely with the tumor microenvironment, and extracellular vesicles play a key role in this interaction. Understanding the selective packaging and mechanistic impact of these vesicles is important for understanding cancer biology. This review summarizes recent findings on the interactions between pancreatic cancer and stromal cells, as well as the mechanisms involved in immune response and chemoresistance. It also identifies extracellular vesicles as potential diagnostic biomarkers and therapeutic targets for pancreatic cancer.

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Recent Advances in Solid Tumor CAR-T Cell Therapy: Driving Tumor Cells From Hero to Zero?

Pouya Safarzadeh Kozani et al.

Summary: CAR-T cells have revolutionized cancer treatment for hematologic malignancies, but face challenges in solid tumors due to heterogeneous antigen expression and immunosuppressive tumor microenvironments. Strategies such as boosting vaccines and novel implementations are explored to enhance CAR-T tumoricidal capacity and trigger endogenous antitumor responses.

FRONTIERS IN IMMUNOLOGY (2022)

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Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer

Naohiko Akimoto et al.

Summary: Immature desmoplastic reaction and myxoid stroma are associated with lower densities of immune cells in the colorectal tumor microenvironment, which may influence cancer survival.

FRONTIERS IN IMMUNOLOGY (2022)

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Dual Relationship Between Stromal Cells and Immune Cells in the Tumor Microenvironment

Jeong-Yeon Mun et al.

Summary: The tumor microenvironment (TME) consists of tumor cells, stromal cells, and immune cells. Understanding the interactions between these cellular components is crucial for precise therapeutic approaches in cancer treatment.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Escaping Death: How Cancer Cells and Infected Cells Resist Cell-Mediated Cytotoxicity

Karoliina Tuomela et al.

Summary: Cytotoxic lymphocytes play a critical role in immune defense, but malignant and infected cells have ways to evade cell-mediated killing. Understanding these evasion mechanisms is important for medical interventions.

FRONTIERS IN IMMUNOLOGY (2022)

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Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy

Pauline Gilson et al.

Summary: Malignant tumors exhibit high levels of heterogeneity at both molecular and phenotypic levels, which poses challenges for patient management. This heterogeneity exists between patients and even within a single patient over space and time. Current treatment decision-making often only considers the molecular characteristics of a limited tumor tissue sample, without taking into account the complexity and continuous evolution of bulk tumors. This review explores the extent of tumor heterogeneity, focusing on intra-tumor heterogeneity (ITH), and discusses the mechanisms that promote and sustain this diversity in cancers. The clinical implications of ITH in the management of cancer patients are summarized, along with discussions on current approaches to adequately appreciate ITH.

CANCERS (2022)

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Review Oncology

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Xiaocui Liu et al.

Summary: This article summarizes the regulation of miRNA/lncRNA on the differentiation, expansion, and immunosuppressive function of tumor MDSCs in the tumor microenvironment. The regulatory mechanisms of exosomal miRNA/lncRNA on tumor MDSCs are discussed, and the interaction of miRNA/lncRNA in modulating tumor MDSCs is also explored.

FRONTIERS IN ONCOLOGY (2022)

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Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer

Alba Navarro-Ocon et al.

Summary: Breast cancer is the most common type of malignancy among women worldwide, but clinical response to immunotherapy is often below expectations due to immune escape mechanisms. Nanomedicine presents an opportunity to enhance the efficacy of cancer immunotherapy and overcome tumor immune escape.

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Review Immunology

EGFR-Based Targeted Therapy for Colorectal Cancer-Promises and Challenges

Balakarthikeyan Janani et al.

Summary: Colorectal carcinoma is a common and lethal form of cancer, with a high rate of metastasis. Targeted nanotherapy, particularly targeting EGFR, has the potential to improve surgical control and reduce tumor-related mortality. Antibodies conjugated with drug-loaded carriers can increase drug effectiveness and quantity delivered to the target site.

VACCINES (2022)

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Epi-immunotherapy for cancers: rationales of epi-drugs in combination with immunotherapy and advances in clinical trials

Yang Xu et al.

Summary: This review discusses the rationale behind incorporating epigenetic therapy into immunotherapy, known as epi-immunotherapy. It provides an update on current clinical trials in hematological and solid malignancies and outlines future challenges and strategies in the field of cancer epi-immunotherapy.

CANCER COMMUNICATIONS (2022)

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Immunosuppressive Signaling Pathways as Targeted Cancer Therapies

Botle Precious Setlai et al.

Summary: Immune response is crucial for patient prognosis and response to cancer treatment. Tumors evade immune surveillance by altering antigen processing pathways and the tumor microenvironment. This review highlights the molecular signaling pathways involved in immune suppression and how cancer cells manipulate antigen processing to escape immune surveillance. Additionally, the review explores the potential use of these pathways in precision medicine and understanding drug resistance.

BIOMEDICINES (2022)

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Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade

Kevin Chih-Yang Huang et al.

Summary: This study demonstrates that engineering mesenchymal stem cells (MSCs) to express specific anti-cancer genes can enhance the sensitivity of radiotherapy in colorectal cancer patients. This novel therapeutic strategy not only improves the effectiveness of radiotherapy, but also remodels the tumor microenvironment, making it more suitable for immunotherapy.

CELL DEATH & DISEASE (2022)

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Review Immunology

N-Glycosylation and Inflammation; the Not-So-Sweet Relation

Barbara Radovani et al.

Summary: Chronic inflammation is a key feature of many inflammatory diseases, and changes in N-glycosylation play an important role in inflammation. Proinflammatory cytokines can alter the pathways involved in N-glycan synthesis and the expression of relevant enzymes, affecting immune cell functions and signal transduction. Understanding inflammation-induced N-glycosylation changes is crucial for elucidating disease mechanisms.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness

Valentina Bova et al.

Summary: This study focuses on the efficacy and enhancement of adenosine receptor antagonists in anti-cancer immunotherapy, arguing that the accumulation of adenosine in the tumor microenvironment is the cause of its tumor-protective effect.

CANCERS (2022)

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Small molecule inhibitors targeting the cancers

Gui-Hong Liu et al.

Summary: Compared with traditional therapies, targeted therapy has advantages in cancer treatment, but still faces obstacles. This article reviews the application of small molecule inhibitors in cancer treatment, discusses approved drugs and pivotal drug candidates in clinical trials, and explores strategies to overcome resistance and combination therapies.

MEDCOMM (2022)

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Review Oncology

Immune Checkpoint Inhibitors in Cancer Therapy

Yavar Shiravand et al.

Summary: The discovery of immune checkpoint proteins has revolutionized cancer immunotherapy, leading to the successful utilization of targeted monoclonal antibodies in various cancer patients. However, not all patients respond favorably to these drugs, emphasizing the need for biomarkers to predict treatment responses.

CURRENT ONCOLOGY (2022)

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Review Immunology

CAR T Cell Immunotherapy Beyond Haematological Malignancy

Cedric Hupperetz et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy has shown remarkable potential in treating hematological malignancies, but its application in solid tumors faces challenges such as antigen heterogeneity and the immunosuppressive tumor microenvironment. Additionally, CAR T cell therapy holds promise in infectious diseases and autoimmune diseases.

IMMUNE NETWORK (2022)

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Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome

Xiaozhou Wang et al.

Summary: Cell death and inflammation are closely linked during mastitis caused by Staphylococcus aureus. Bovine mammary epithelial cells respond to S. aureus by NLRP3 inflammasome activation, leading to cell apoptosis and pyroptosis. This cell death process is associated with caspase-1 activation.

VETERINARY RESEARCH (2022)

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Article Gastroenterology & Hepatology

Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer

Dmitrij Ostroumov et al.

Summary: Our study identified TIGIT as a key marker of T-cell exhaustion in liver cancer, showing it to be more reliable than PD-1 in identifying exhausted CD8 T cells. Targeting TIGIT in combination with PD-1 inhibition synergistically inhibited liver cancer growth in mice, and the expression of TIGIT on tumor-infiltrating CD8 T cells in patient samples was validated.

HEPATOLOGY (2021)

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Article Hematology

Lenalidomide Exposure at Time of CAR T-Cells Expansion Enhances Response of Refractory/Relapsed Aggressive Large B-Cell Lymphomas

Jean Lemoine et al.

BLOOD (2021)

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Review Oncology

Critical role of mTOR in regulating aerobic glycolysis in carcinogenesis (Review)

Hui Fan et al.

Summary: mTOR plays a crucial role in regulating various biological processes, especially energy metabolism, and could be a potential target for cancer therapy. Understanding the complex mechanisms by which mTOR regulates glycolysis is essential for developing drugs targeting molecules associated with mTOR and glycolysis to provide strategies for clinical cancer treatment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

Yao Wang et al.

Summary: The study demonstrates that pre-treatment of CAR T cells with a DNA methyltransferase inhibitor enhances anti-tumor activities, cytokine production, and proliferation, allowing for effective eradication of tumors at low doses and improved response to tumor rechallenge.

NATURE COMMUNICATIONS (2021)

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Review Immunology

LAG3's Enigmatic Mechanism of Action

Colin G. Graydon et al.

Summary: This review outlines the importance of LAG3 as an immune checkpoint in cancer, infectious diseases, and autoimmunity, while also highlighting the gaps in understanding its biology, regulation, and mechanisms of action. Further research is needed to fully elucidate the role of LAG3 in disease and explore its potential as a target for therapeutic interventions.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression

Jesse D. Armitage et al.

Summary: The complex and heterogeneous nature of the tumor microenvironment, including various immune, stromal, vascular, and tumor cells, contributes to the resistance of some cancers to immunotherapy. Fine-tuning the immunosuppressive features of the TME, rather than completely eliminating them, may lead to a more comprehensive and balanced anti-tumor response.

CELLS (2021)

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Article Oncology

HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer

Yiwei Huang et al.

Summary: The study reveals that TGF-beta plays a dual role in regulating glycolysis and cell proliferation in non-small cell lung cancer. HIF-1 alpha is identified as a critical factor in this process, potentially serving as a biomarker or therapeutic target for TGF-beta mediated cancer progression. The research findings provide insight into the metabolic reprogramming mechanisms in tumor cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao et al.

Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.

MOLECULAR CANCER (2021)

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Review Genetics & Heredity

Novel Approaches to Epigenetic Therapies: From Drug Combinations to Epigenetic Editing

Aleksandra Majchrzak-Celinska et al.

Summary: Cancer treatment is increasingly utilizing epigenetic drugs, with challenges including overcoming drug resistance and expanding therapeutic options.

GENES (2021)

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Review Immunology

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Karthik Dhatchinamoorthy et al.

Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Achieving clinical success with BET inhibitors as anti-cancer agents

Tatiana Shorstova et al.

Summary: Transcriptional upregulation of oncogenes drives tumor progression, and targeting BET proteins with inhibitors has shown promise in suppressing oncogenic networks in tumors. Understanding the biology of BET proteins, designing better BET inhibitors, and incorporating BET inhibitors into combination therapies can enhance their efficacy in clinical settings.

BRITISH JOURNAL OF CANCER (2021)

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Review Immunology

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Liyang Fei et al.

Summary: CCR2 is predominantly expressed by monocytes/macrophages with proinflammatory functions, and targeting CCR2 has been investigated as a strategy to modify the tumor microenvironment and enhance anti-tumor immunity. In addition to blocking chemotaxis of suppressive myeloid cells, CCR2 signaling has underappreciated effects on myeloid cell survival and function polarization. T cells also express CCR2, and targeting CCR2 is shown to favor the anti-tumor arm of immune responses by affecting tissue homing of Treg cells and enhancing Treg functional potency.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Next generation of immune checkpoint inhibitors and beyond

Julian A. Marin-Acevedo et al.

Summary: The immune system plays a crucial role in defending against cancer, but tumor cells can evade immune recognition. Immunotherapy enhances host immune response to combat tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Editorial Material Multidisciplinary Sciences

Recruiting T cells in cancer immunotherapy

Kathryn E. Yost et al.

SCIENCE (2021)

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Article Oncology

Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology

Akira Yokoi et al.

Summary: This review summarizes recent studies on EVs from the perspective of EV heterogeneity and highlights their role in various steps from oncogenic to metastatic processes. Recognizing EV subtypes is crucial for identifying pathways affected by EVs and targeting specific subtypes in therapeutic approaches or liquid biopsies.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Oncology

The role of exosomal PD-L1 in tumor immunotherapy

Jing Wang et al.

Summary: Exosomes play crucial roles in tumor progression by facilitating cell signaling and immune evasion. Anti-PD-1 / PD-L1 antibodies can restore T cell activity. Exosomal PD-L1 may serve as a potential target for therapy and biomarker for liquid biopsy.

TRANSLATIONAL ONCOLOGY (2021)

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Review Immunology

Role of Epigenetic Regulation in Plasticity of Tumor Immune Microenvironment

Yunkai Yang et al.

Summary: The tumor immune microenvironment (TIME) is crucial in the development, progression, and immune escape of various cancers. Epigenetic alterations can reprogram immune cells in TIME, while the gut microbiome can also influence colorectal cancer and extraintestinal tumors. Tumors are heterogeneous diseases regulated by genetics and epigenetics.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Neoantigen: A New Breakthrough in Tumor Immunotherapy

Zheying Zhang et al.

Summary: Cancer immunotherapy enhances the body's immune response to target and eliminate cancer cells, with a focus on the emerging approach of tumor neoantigens. Studies have shown the relationship between neoantigens and T cell recognition of cancer cells, highlighting the potential of vaccines developed against these specific antigens in clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Depleting Tumor Cells Expressing Immune Checkpoint Ligands-A New Approach to Combat Cancer

Fabrizio Marcucci et al.

Summary: Targeting ICPMLs with antibody drugs may be a useful tool for cancer therapy, and ICIs play a significant role in the treatment of malignant tumors.

CELLS (2021)

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Review Cell Biology

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Mithunah Krishnamoorthy et al.

Summary: Myeloid cells can transform into myeloid-derived suppressor cells during cancer progression or chronic inflammation, inhibiting anti-tumor immunity. Overcoming the suppression caused by MDSCs is a major obstacle in cancer immunotherapy, highlighting the importance of understanding the mechanisms behind how MDSCs promote tumor growth for improving and developing new therapies.

CELLS (2021)

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Article Oncology

Endogenous Retroviral-K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma

Veronika Weyerer et al.

Summary: The study found that ERV-K env protein expression was highest in ccRCC, with the strongest significant membrane expression compared to other RCC subtypes. High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease-specific survival.

FRONTIERS IN ONCOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in breast cancer therapeutics

Kamal S. Saini et al.

Summary: Advanced breast cancer remains incurable, but there have been promising developments in the use of ADCs and ICIs for patients. Combining newer ADCs and ICIs for different subtypes of breast cancer shows potential synergy in improving treatment outcomes. The development of next-generation ADCs, rational combination strategies with ICIs, and the use of immune biomarkers could significantly enhance the outlook for patients with refractory aBC.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Review Biochemistry & Molecular Biology

Adenosine and Inflammation: Here, There and Everywhere

Silvia Pasquini et al.

Summary: Adenosine, an ubiquitous endogenous modulator, interacts with four subtypes of adenosine receptors to maintain cellular and tissue homeostasis. It plays a crucial role in modulating inflammation, and targeting its receptors or regulating its extracellular concentration shows promising therapeutic strategies for various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors

Apostolia-Maria Tsimberidou et al.

Summary: TCR-based adoptive therapy uses genetically modified lymphocytes to target specific tumor markers, but faces challenges with TCR product manufacturing, patient selection, and preparation for lymphodepletion. Overcoming these challenges and developing next-generation strategies are crucial for improving the efficacy and safety of TCR-based therapies. Optimization of technology for TCR product generation and patient monitoring for adverse events is necessary.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Letter Oncology

Dasatinib enhances anti-leukemia efficacy of chimeric antigen receptor T cells by inhibiting cell differentiation and exhaustion

Hao Zhang et al.

Summary: Dasatinib has shown promising results in preventing or reversing differentiation and exhaustion of CAR-T cells, significantly enhancing therapeutic efficacy and in vivo persistence.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Immunology

Repositioning TH cell polarization from single cytokines to complex help

Selma Tuzlak et al.

Summary: Three decades ago, the description of helper T cell polarization led to a dramatic growth in the T cell universe, with new subsets emerging. Categorizing T helper cells based on the help they provide offers a better understanding of their complexity and diversity.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

Kyoesti Tahkola et al.

Summary: The study found that high-level stromal HA accumulation is associated with poor disease-specific survival and overall survival in pancreatic ductal adenocarcinoma (PDAC), as well as low immune cell score (ICS).

SCIENTIFIC REPORTS (2021)

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Review Immunology

Cancer Immunotherapies: From Efficacy to Resistance Mechanisms - Not Only Checkpoint Matters

Shuyue Wang et al.

Summary: The effectiveness of immunotherapy in different cancer patients varies significantly, with many patients struggling to achieve meaningful therapeutic benefits, which may be attributed to factors such as tumor heterogeneity, the immune microenvironment, and treatment history.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

Yin-Qiao Liu et al.

Summary: Desmosomes, intercellular adhesion complexes, play paradoxical roles in tumor suppression and promotion in the context of head and neck cancer, with abnormal expression of desmosomal components being associated with tumor progression and poor survival. The signaling functions of desmosomes in regulating cancer cell behavior offer valuable insights for HNC diagnosis and therapeutics development.

BIOMOLECULES (2021)

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Review Oncology

The landscape of bispecific T cell engager in cancer treatment

Shujie Zhou et al.

Summary: T cell-based immunotherapies have revolutionized cancer treatment, but limited T-cell infiltration in tumor sites remains a major issue. BiTE therapy, a promising approach using bispecific antibodies to induce tumor lysis, has shown impressive efficacy in B cell malignancies but faces resistance mechanisms such as antigen loss and immune checkpoints upregulation. This highlights the need for modifying antibody constructs and developing combination strategies to enhance efficacy and reduce toxicity, particularly in solid tumors where response to BiTE therapy is poor.

BIOMARKER RESEARCH (2021)

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Review Health Care Sciences & Services

Interrogating Epigenome toward Personalized Approach in Cutaneous Melanoma

Elena-Georgiana Dobre et al.

Summary: Epigenetic alterations play a crucial role in the pathogenesis of cutaneous melanoma, offering potential diagnostic, prognostic, and therapeutic benefits. Understanding how aberrant DNA methylation and histone modifications impact disease development is key, as it may lead to the identification of therapeutic targets for drug resistance prevention.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Oncology

The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification

Jessica Jou et al.

Summary: Therapeutic cancer vaccines aim to create and enhance tumor-specific T-cell responses, but face challenges in achieving success. Researchers are exploring various strategies to overcome immunosuppressive mechanisms in the tumor microenvironment, improve vaccine delivery platforms, and utilize combination therapies.

CLINICAL CANCER RESEARCH (2021)

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Article Immunology

Combined evaluation of the expression status of CD155 and TIGIT plays an important role in the prognosis of LUAD (lung adenocarcinoma)

Yu Sun et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Biotechnology & Applied Microbiology

'Off-the-shelf' allogeneic CAR T cells: development and challenges

S. Depil et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Review Pharmacology & Pharmacy

Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges

Yoshinobu Takakura et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2020)

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Article Immunology

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

Jean-Christophe Beltra et al.

IMMUNITY (2020)

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Article Oncology

Phase II study of the oral HIF-2α inhibitor MK-6482 for Von Hippel-Lindau disease–associated renal cell carcinoma.

Eric Jonasch et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

Jenny H. Lee et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Myeloid Cell-Derived Arginase in Cancer Immune Response

Tomasz M. Grzywa et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

Alyssa Vito et al.

CELLS (2020)

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Review Oncology

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Shing Yau Tam et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Cell Biology

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

Joshua D. Webster et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Immunology

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression

Reem Saleh et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies

Shin Foong Ngiow et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Cancer Stem Cell Plasticity - A Deadly Deal

Archana P. Thankamony et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Review Cell Biology

Metabolic Modulation of Immunity: A New Concept in Cancer Immunotherapy

Luana Guerra et al.

CELL REPORTS (2020)

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Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Oncology

TIGIT in cancer immunotherapy

Joe-Marc Chauvin et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Oncology

Extracellular Vesicles as Biomarkers in Cancer Immunotherapy

Matthen Mathew et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

Xueke Shi et al.

BIOMOLECULES (2020)

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Review Biology

CAR-expressing NK cells for cancer therapy: a new hope

Jufeng Xia (Shunichi Arai) et al.

BIOSCIENCE TRENDS (2020)

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Letter Oncology

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

Li Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Oncology

Turning Cold into Hot: Firing up the Tumor Microenvironment

Qianqian Duan et al.

TRENDS IN CANCER (2020)

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Review Oncology

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Daniela Bruni et al.

NATURE REVIEWS CANCER (2020)

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Review Oncology

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

Gerta Hoxhaj et al.

NATURE REVIEWS CANCER (2020)

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Article Oncology

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation

Lan Wu et al.

NATURE CANCER (2020)

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Article Immunology

The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function

Stalin Chellappa et al.

JOURNAL OF IMMUNOLOGY (2019)

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Review Immunology

Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

Abdullah Al Emran et al.

TRENDS IN IMMUNOLOGY (2019)

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Article Oncology

Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells

Shengmeng Di et al.

FRONTIERS IN ONCOLOGY (2019)

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Review Oncology

Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks

Andreia Peixoto et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Cell Biology

Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma

Pramod Mallikarjuna et al.

CELL CYCLE (2019)

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Review Cell Biology

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale et al.

CELL METABOLISM (2019)

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Review Immunology

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

Selena Vigano et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Kyle B. Lupo et al.

CANCERS (2019)

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Review Gastroenterology & Hepatology

Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance

Anne E. Tuomisto et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Immunology

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Lea Monteran et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling

Dan Wang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Oncology

The Diverse Contributions of Fucose Linkages in Cancer

Tyler S. Keeley et al.

CANCERS (2019)

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Review Biochemistry & Molecular Biology

A2B Adenosine Receptor and Cancer

Zhan-Guo Gao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Oncology

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Lipid order and charge protect killer T cells from accidental death

Jesse A. Rudd-Schmidt et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Immunology

Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor

Elisa Ruffo et al.

SEMINARS IN IMMUNOLOGY (2019)

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Review Immunology

Support of Tumor Endothelial Cells by Chemokine Receptors

Nicole Salazar et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Yuan Cheng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Review Biochemistry & Molecular Biology

Metazoan MicroRNAs

David P. Bartel

CELL (2018)

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Review Oncology

Next generation of immune checkpoint therapy in cancer: new developments and challenges

Julian A. Marin-Acevedo et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Biochemical Research Methods

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming

Qingran Li et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

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Article Biochemistry & Molecular Biology

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Nikolaos Zacharakis et al.

NATURE MEDICINE (2018)

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Review Medicine, General & Internal

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

Andrew P. Feinberg

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Pharmacology & Pharmacy

Combining Immunotherapy and Radiotherapy for Cancer Treatment Current Challenges and Future Directions

Yifan Wang et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Pharmacology & Pharmacy

Poly(Ethylene Glycol)-Polylactide Micelles for Cancer Therapy

Jixue Wang et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Alteration of the Antitumor immune Response by Cancer-Associated Fibroblasts

Linda Ziani et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations

Judith A. Seidel et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics

Karie Runcie et al.

MOLECULAR MEDICINE (2018)

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Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

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Review Chemistry, Physical

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

Hua Wang et al.

NATURE MATERIALS (2018)

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Article Multidisciplinary Sciences

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Constantinos Alexandrou et al.

SCIENTIFIC REPORTS (2018)

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Review Biotechnology & Applied Microbiology

TIM-3, a promising target for cancer immunotherapy

Yayi He et al.

ONCOTARGETS AND THERAPY (2018)

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Article Immunology

Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation

Elisabeth Mueller et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Glycans as Key Checkpoints of T Cell Activity and Function

Marcia S. Pereira et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cell Biology

Mechanism of Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors and a Potential Treatment Strategy

Tatsuya Nagano et al.

CELLS (2018)

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Article Immunology

The tumour glyco-code as a novel immune checkpoint for immunotherapy

Ernesto Rodriguez et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Hematology

CTLA-4: a moving target in immunotherapy

Behzad Rowshanravan et al.

BLOOD (2018)

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Review Biotechnology & Applied Microbiology

Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development

Kevin Dzobo et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms involved in dendritic cell dysfunction in cancer

Michael Tang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Review Oncology

Cancer stem cells: A product of clonal evolution?

Gustav van Niekerk et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Immunology

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

Giada Mondanelli et al.

IMMUNITY (2017)

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Review Immunology

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3

Murali Janakiram et al.

IMMUNOLOGICAL REVIEWS (2017)

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Review Immunology

LAG3 (CD223) as a cancer immunotherapy target

Lawrence P. Andrews et al.

IMMUNOLOGICAL REVIEWS (2017)

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Review Biochemistry & Molecular Biology

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

Wenwen Du et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Intra-tumor heterogeneity from a cancer stem cell perspective

Pramudita R. Prasetyanti et al.

MOLECULAR CANCER (2017)

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Review Oncology

Determinants of metastatic competency in colorectal cancer

Daniele V. F. Tauriello et al.

MOLECULAR ONCOLOGY (2017)

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Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Review Biochemistry & Molecular Biology

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Krzysztof M. Zak et al.

STRUCTURE (2017)

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Article Multidisciplinary Sciences

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

Martin Lauss et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

CDK8 Kinase Activity Promotes Glycolysis

Matthew D. Galbraith et al.

CELL REPORTS (2017)

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Article Cell Biology

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

Daniel Zingg et al.

CELL REPORTS (2017)

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Article Oncology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Susanne M. Steggerda et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

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Article Multidisciplinary Sciences

The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis

Pingping Hu et al.

SCIENTIFIC REPORTS (2017)

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Review Pharmacology & Pharmacy

Structural features of subtype-selective EP receptor modulators

Tijana Markovic et al.

DRUG DISCOVERY TODAY (2017)

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Review Oncology

Tumor endothelial cells accelerate tumor metastasis

Nako Maishi et al.

CANCER SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Tumor evolution: Linear, branching, neutral or punctuated?

Alexander Davis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

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Review Oncology

MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer

Lingling Guo et al.

TUMOR BIOLOGY (2016)

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Article Oncology

Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

Sandeep K. Singhal et al.

ONCOTARGET (2016)

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Article Oncology

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Shuhei Ito et al.

ANNALS OF SURGICAL ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

Qods Lahmar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

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Article Hematology

T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Syed Abbas Ali et al.

BLOOD (2016)

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Article Oncology

The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition

Priti S. Hegde et al.

CLINICAL CANCER RESEARCH (2016)

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Review Biochemistry & Molecular Biology

How do tumor cells respond to HDAC inhibition?

Andrea Newbold et al.

FEBS JOURNAL (2016)

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Review Immunology

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

Ana C. Anderson et al.

IMMUNITY (2016)

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Article Cell Biology

RAS isoforms and mutations in cancer at a glance

G. Aaron Hobbs et al.

JOURNAL OF CELL SCIENCE (2016)

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Article Medicine, Research & Experimental

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

Yuki Kagoya et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Oncology

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

Maria Pia Abruzzese et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

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Review Cell Biology

The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation

Drenka Trivanovic et al.

MEDIATORS OF INFLAMMATION (2016)

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Review Nanoscience & Nanotechnology

Nanomedicine applied to translational oncology: A future perspective on cancer treatment

Lisa Bregoli et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Multidisciplinary Sciences

PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda et al.

NATURE (2016)

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Review Biotechnology & Applied Microbiology

Cancer Stem Cell Hypothesis for Therapeutic Innovation in Clinical Oncology? Taking the Root Out, Not Chopping the Leaf

Kevin Dzobo et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2016)

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Article Oncology

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

Maurizio Perdicchio et al.

ONCOTARGET (2016)

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Article Oncology

Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells

Sofia R. Gameiro et al.

ONCOTARGET (2016)

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Article Cell Biology

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

Tianli Xia et al.

CELL REPORTS (2016)

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Review Oncology

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nissim Hay

NATURE REVIEWS CANCER (2016)

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Review Oncology

Tumor-associated stromal cells as key contributors to the tumor microenvironment

Karen M. Bussard et al.

BREAST CANCER RESEARCH (2016)

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Review Oncology

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

S. J. Thomas et al.

BRITISH JOURNAL OF CANCER (2015)

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Article Biochemistry & Molecular Biology

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

David Roulois et al.

CELL (2015)

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Review Medicine, Research & Experimental

Therapeutic cancer vaccines

Cornelis J. M. Melief et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Review Medicine, Research & Experimental

From mice to humans: developments in cancer immunoediting

Michele W. L. Teng et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Oncology

Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus-Targeted Tumor-Infiltrating T Cells

Sanja Stevanovic et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Review Chemistry, Multidisciplinary

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

Andreas Wicki et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Multidisciplinary Sciences

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Stefani Spranger et al.

NATURE (2015)

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Article Oncology

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

Lotte Spel et al.

ONCOTARGET (2015)

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Article Cell Biology

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Leticia Corrales et al.

CELL REPORTS (2015)

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Article Oncology

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

Alisha Holtzhausen et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Oncology

Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody

Ross Stewart et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Oncology

Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells

Benjamin Boyerinas et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Oncology

cu Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction

Ravikumar Muthuswamy et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2015)

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Review Immunology

Molecular and cellular insights into T cell exhaustion

E. John Wherry et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Immunology

Regulation of tumour necrosis factor signalling: live or let die

Dirk Brenner et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Cell Biology

Biogenesis and secretion of exosomes

Joanna Kowal et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

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Review Biochemistry & Molecular Biology

Deregulation of cell signaling in cancer

Filippo G. Giancotti

FEBS LETTERS (2014)

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Article Immunology

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Liufu Deng et al.

IMMUNITY (2014)

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Article Oncology

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)

David Hoskin et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Immunology

Role of TGF-β Signaling in Generation of CD39+CD73+ Myeloid Cells in Tumors

Sergey V. Ryzhov et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Matthew M. Gubin et al.

NATURE (2014)

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Article Biochemistry & Molecular Biology

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Antonella Sistigu et al.

NATURE MEDICINE (2014)

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Article Oncology

Are natural killer cells superior CAR drivers?

Hans Klingemann

ONCOIMMUNOLOGY (2014)

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Article Oncology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

Encouse B. Golden et al.

ONCOIMMUNOLOGY (2014)

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Review Oncology

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Kamal S. Saini et al.

CANCER TREATMENT REVIEWS (2013)

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Article Oncology

Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies

Michal J. Besser et al.

CLINICAL CANCER RESEARCH (2013)

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Article Cell Biology

The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling

Christopher James Ferrante et al.

INFLAMMATION (2013)

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Review Immunology

Tumor-altered dendritic cell function: implications for anti-tumor immunity

Kristian M. Hargadon

FRONTIERS IN IMMUNOLOGY (2013)

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Article Oncology

TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

Kaori Sakuishi et al.

ONCOIMMUNOLOGY (2013)

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Article Immunology

Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

Aharon Kessel et al.

AUTOIMMUNITY REVIEWS (2012)

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Review Oncology

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

Michael Platten et al.

CANCER RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Cancer Epigenetics: From Mechanism to Therapy

Mark A. Dawson et al.

CELL (2012)

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Review Pharmacology & Pharmacy

Theranostic applications of nanoparticles in cancer

Naveed Ahmed et al.

DRUG DISCOVERY TODAY (2012)

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Review Immunology

Regulation of Immune Responses by Prostaglandin E-2

Pawel Kalinski

JOURNAL OF IMMUNOLOGY (2012)

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Article Immunology

Mice completely lacking immunoproteasomes show major changes in antigen presentation

Eleanor Z. Kincaid et al.

NATURE IMMUNOLOGY (2012)

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Article Medicine, General & Internal

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Medicine, General & Internal

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Multidisciplinary Sciences

Cell Elasticity Determines Macrophage Function

Naimish R. Patel et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Eric T. Clambey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Cell Biology

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

Janis M. Taube et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Review Immunology

CD73: a potent suppressor of antitumor immune responses

Paul. A. Beavis et al.

TRENDS IN IMMUNOLOGY (2012)

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Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Review Cell Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Article Hematology

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Qing Zhou et al.

BLOOD (2011)

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Article Oncology

Matrix Metalloproteinse-2 Conditions Human Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12-and OX40L-Dependent Pathway

Emmanuelle Godefroy et al.

CANCER CELL (2011)

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Article Oncology

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

Beatrice Dirat et al.

CANCER RESEARCH (2011)

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Review Biochemistry & Molecular Biology

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

P. N. Kelly et al.

CELL DEATH AND DIFFERENTIATION (2011)

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Article Immunology

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

Mark S. Diamond et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Review Genetics & Heredity

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Eric Huntzinger et al.

NATURE REVIEWS GENETICS (2011)

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Article Biochemistry & Molecular Biology

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+ Regulatory T Cells

Magis Mandapathil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Genetics & Heredity

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Ryan D. Morin et al.

NATURE GENETICS (2010)

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Review Cell Biology

PIK3CA mutations in human solid tumors Role in sensitivity to various therapeutic approaches

Giovanni Ligresti et al.

CELL CYCLE (2009)

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Article Oncology

Induction of myeloid-derived suppressor cells by tumor exosomes

Xiaoyu Xiang et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Review Immunology

Death receptor signal transducers: nodes of coordination in immune signaling networks

Nicholas S. Wilson et al.

NATURE IMMUNOLOGY (2009)

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Review Immunology

Membrane vesicles as conveyors of immune responses

Clotilde Thery et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Pharmacology & Pharmacy

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells

F. Condorelli et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

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Article Oncology

Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer

Amy J. French et al.

CLINICAL CANCER RESEARCH (2008)

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Article Biochemistry & Molecular Biology

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

Tõnis Org et al.

EMBO REPORTS (2008)

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Review Immunology

Protein-glycan interactions in the control of innate and adaptive immune responses

Yvette van Kooyk et al.

NATURE IMMUNOLOGY (2008)

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Review Medicine, General & Internal

Gastrointestinal stromal tumour

Brian P. Rubin et al.

LANCET (2007)

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Article Oncology

Colon cancer cell-derived tumor necrosis factor-α mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway

Karin Zins et al.

CANCER RESEARCH (2007)

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Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

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Review Oncology

Polycomb silencers control cell fate, development and cancer

Anke Sparmann et al.

NATURE REVIEWS CANCER (2006)

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Article Immunology

Human NK cell education by inhibitory receptors for MHC class I

Nicolas Anfossi et al.

IMMUNITY (2006)

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Article Oncology

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

IM Bachmann et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

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Review Immunology

Monocyte and macrophage heterogeneity

S Gordon et al.

NATURE REVIEWS IMMUNOLOGY (2005)

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Article Immunology

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

DH Munn et al.

IMMUNITY (2005)

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Article Biochemistry & Molecular Biology

Inhibition of interleukin-12 p40 transcription and NF-κB activation by nitric oxide in murine macrophages and dendritic cells

HB Xiong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Review Oncology

Guilty as charged: B-RAF is a human oncogene

MJ Garnett et al.

CANCER CELL (2004)

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Article Oncology

Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses

PC Rodriguez et al.

CANCER RESEARCH (2004)

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Review Pharmacology & Pharmacy

Inhibition of MHC II gene transcription by nitric oxide and antioxidants

O Harari et al.

CURRENT PHARMACEUTICAL DESIGN (2004)

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Article Immunology

Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients

JC Lee et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Cell Biology

L-arginine modulates CD3ξ expression and T cell function in activated human T lymphocytes

AH Zea et al.

CELLULAR IMMUNOLOGY (2004)

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Article Oncology

Akt stimulates aerobic glycolysis in cancer cells

RL Elstrom et al.

CANCER RESEARCH (2004)

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Article Multidisciplinary Sciences

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

GQ Phan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Cell Biology

Frequency and genetic basis of MHC, beta-2-microglobulin and MEMO-1 loss of heterozygosity in sporadic breast cancer

CRE McEvoy et al.

TISSUE ANTIGENS (2002)

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Article Oncology

Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas:: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

I Maleno et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2002)

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Article Immunology

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase

G Frumento et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

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Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

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Article Cell Biology

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

K Gottlob et al.

GENES & DEVELOPMENT (2001)

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