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The emerging role of neutrophil extracellular traps in cancer: from lab to ward

FRONTIERS IN ONCOLOGY (2023)

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Article Oncology

Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma

Xi Zhan et al.

Summary: This study investigates the role of neutrophil extracellular traps (NETs) in HBV-related hepatocarcinogenesis and their clinical significance. The researchers found that HBV infection correlated with elevated levels of NETs in HCC patients. They also identified the mechanism by which HBV induces NETs formation through the RAGE/TLR4-ROS signaling pathway. NETs were found to facilitate the growth and metastasis of HCC, and circulating NETs showed potential as a biomarker for predicting extrahepatic metastasis in HBV-related HCC.

CANCER COMMUNICATIONS (2023)

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Article Chemistry, Multidisciplinary

Localized Degradation of Neutrophil Extracellular Traps by Photoregulated Enzyme Delivery for Cancer Immunotherapy and Metastasis Suppression

Jiayuan Chen et al.

Summary: The study found that photoregulated release of DNase I can disrupt NETs, increase the contact between immune cytotoxic cells and tumor cells, enhance the therapeutic efficacy of tumor immunotherapy, and prevent tumor metastasis. This method of photoregulated release of DNase I represents a translational route for immune-mediated tumor regression and metastasis inhibition.

ACS NANO (2022)

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Article Oncology

Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer

Antonia M. Stehr et al.

Summary: Neutrophil extracellular traps (NETs), released by neutrophils, have been found in colorectal cancer (CRC) tissues and are associated with disease progression. This study used high-resolution microscopy to detect citrullinated NETs in colon cancer tissues and found that citrullinated NETs were significantly associated with high tumour grades and lymph node metastasis. In vitro experiments also showed that purified NETs induced filopodia formation and cell motility in CRC cell lines, indicating their potential contribution to CRC metastasis.

JOURNAL OF PATHOLOGY (2022)

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Article Multidisciplinary Sciences

Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications

Xiang Xia et al.

Summary: Postoperative abdominal infectious complications are associated with metastasis in gastric cancer, and the release of neutrophil extracellular traps (NETs) by neutrophils can facilitate the extravasation and metastasis formation of gastric cancer cells.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Neutrophil Extracellular Traps Facilitate A549 Cell Invasion an Migration in a Macrophage-Maintained Inflammatory Microenvironment

Lemeng Zhang et al.

Summary: This study explores the relationship between neutrophil extracellular traps (NETs) and the inflammatory microenvironment in lung cancer. It found that NETs can promote lung cancer cell invasion and migration, partly dependent on macrophages.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Oncology

Neutrophil Extracellular Traps Are Increased in Chronic Myeloid Leukemia and Are Differentially Affected by Tyrosine Kinase Inhibitors

Alona Telerman et al.

Summary: Neutrophil extracellular traps (NETs) are increased in chronic myeloid leukemia (CML) and certain drugs used to treat CML (tyrosine kinase inhibitors-TKIs) further increase NET formation, suggesting a possible link between CML, TKIs, and vascular toxicity.

CANCERS (2022)

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Article Cell Biology

Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype

Daniel Guimaraes-Bastos et al.

Summary: Evidence suggests that EVs produced by melanoma cells can modulate the phenotype and function of neutrophils, driving them towards a pro-tumor (N2) polarization and promoting tumor progression.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Oncology

Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress

J. Cedervall et al.

Summary: This study investigates the role of neutrophil extracellular traps (NETs) in myocardial inflammation and tissue damage in treatment-naive cancer patients. The findings suggest that NETs contribute to inflammation and myocardial stress during malignancy, and removing NETs may prevent cardiac inflammation and dysfunction in cancer patients.

ONCOIMMUNOLOGY (2022)

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Article Oncology

Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells

Ze-Zhou Jiang et al.

Summary: Neutrophil extracellular traps (NETs) formation is increased in human hepatocellular carcinoma (HCC) tumor tissues, promoting cancer cell migration and facilitating tumor metastasis. Inhibiting NETs can suppress tumor metastasis in HCC, with the levels of NETs-releasing neutrophils being negatively correlated with patient survival.

ONCOIMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps

Zhicheng Zeng et al.

Summary: This study reveals the crucial role of HAO1-mediated oxalate metabolism in the formation and metastasis of cancer-induced lung PMN. Oxalate accumulation promotes neutrophil extracellular trap formation and activates the MAPK signaling pathway, facilitating the growth of metastatic cancer cells in the lung. Inhibition of HAO1 effectively reduces lung metastasis.

ONCOGENE (2022)

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Article Multidisciplinary Sciences

Neutrophils activated by membrane attack complexes increase the permeability of melanoma blood vessels

Xiaobo Liu et al.

Summary: The microenvironment of malignant melanomas plays a crucial role in the infiltration and vascular dissemination of immune and cancer cells. In this study, we found that the complement system is activated in melanoma patients and murine melanomas. Complement-derived C5a recruits neutrophils, and activated neutrophils release neutrophil extracellular traps (NETs), which open the endothelial barrier and facilitate the entrance of melanoma cells into circulation. Inhibition of neutrophil activation could prevent vascular intravasation of melanoma cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Gastroenterology & Hepatology

Neutrophil extracellular traps participate in the development of cancer-associated thrombosis in patients with gastric cancer

Jia-Cheng Li et al.

Summary: This study found that GC patients are likely to form NETs, and the formation of NETs is associated with thrombosis. NETs can induce a hypercoagulable state in platelets and endothelial cells through various mechanisms, thereby increasing the risk of VTE. These results suggest that NETs may be potential therapeutic targets in the prevention and treatment of VTE in GC patients.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Review Oncology

Drug Resistance in Colorectal Cancer: From Mechanism to Clinic

Qianyu Wang et al.

Summary: Chemotherapy, radiotherapy and molecularly targeted therapy have shown promising results in improving prognosis of colorectal cancer patients. Immunotherapy, especially immune checkpoint inhibitors, has also significantly enhanced patient outcomes. However, drug resistance remains a major challenge, with mechanisms including aberrant anti-tumor drug metabolism, transportation, target, cell death pathways, carcinogenic signals, compensation feedback loop signal pathways, and tumor immune microenvironment playing crucial roles. Further research into these mechanisms may lead to potential therapeutic interventions.

CANCERS (2022)

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Article Oncology

A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

Hui Deng et al.

Summary: PAD4 plays a critical role in neutrophil migration in cancer, and targeting PAD4 with a small molecule inhibitor can suppress tumor growth and metastasis and enhance the efficacy of immune checkpoint blockade therapy.

CANCER RESEARCH (2022)

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Article Multidisciplinary Sciences

Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation

Qiqi Tang et al.

Summary: Our study reveals a novel mechanism for de novo cholesterol biosynthesis in regulating CCDC25 expression, NETs formation, and breast cancer metastasis. Targeting cholesterol biosynthesis may be a promising therapeutic strategy for treating breast cancer metastasis.

SCIENTIFIC REPORTS (2022)

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Article Oncology

Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis

Hongjun Zhang et al.

Summary: Ivermectin (IVM) is identified as a potential therapeutic approach for melanoma cancer metastasis by inhibiting neutrophil extracellular traps (NETs) formation and modulating immune cell infiltration. The mechanism involves the targeting of pyroptotic driver gasdermin D (GSDMD) and suppression of GSDMD oligomerization essential for NETs formation.

FRONTIERS IN ONCOLOGY (2022)

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Article Immunology

Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway

Yong Wang et al.

Summary: Neutrophil extracellular traps (NETs) produced in the tumour microenvironment (TME) promote non-small cell lung cancer (NSCLC) metastasis by activating the NF-kappa B/NOD-like receptor protein 3 (NLRP3) pathway and inducing epithelial to mesenchymal transition (EMT). Downregulation of MIR503HG expression by NETs facilitates EMT and enhances NSCLC cell invasion and migration. Targeting NET formation may be a potential therapeutic strategy for treating NSCLC metastasis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

Yansen Xiao et al.

Summary: The study reveals that tumor-secreted protease CTSC promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.

CANCER CELL (2021)

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Article Oncology

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

Hiroki Kajioka et al.

Summary: Surgery is the primary curative treatment for pancreatic cancer, but postsurgical recurrence is common. Inflammation caused by surgery, neutrophils, and neutrophil extracellular traps (NETs) play important roles in cancer metastasis. Targeting NETs with thrombomodulin may be a novel strategy to improve surgical outcomes for pancreatic cancer patients.

CANCER LETTERS (2021)

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Article Medicine, General & Internal

Telomerase-positive circulating tumor cells are associated with poor prognosis via a neutrophil-mediated inflammatory immune environment in glioma

Wen Zhang et al.

Summary: The study found that telomerase-positive circulating tumor cells can predict poor prognosis in patients with glioma, correlating with neutrophil activation. RNA sequencing results showed that postoperative CTCs were positively correlated with innate immune responses, but negatively correlated with cytotoxic response.

BMC MEDICINE (2021)

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Article Cell Biology

Role of Sciellin in gallbladder cancer proliferation and formation of neutrophil extracellular traps

Yang Li et al.

Summary: This study identified that Sciellin (SCEL) is upregulated in gallbladder cancer, associated with advanced stages and poor prognosis, and plays a role in promoting cell proliferation and inducing thrombosis through interaction with EGFR and stimulation of IL-8 production.

CELL DEATH & DISEASE (2021)

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Article Oncology

Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread

Zhenzi Peng et al.

Summary: Aged neutrophils, characterized by CXCR4(hi)CD62L(lo) phenotype, accumulate in cancer metastasis and promote tumor migration and metastasis through increased release of metastasis-promoting factors. Adoptive transfer of aged neutrophils enhances cancer cell metastasis to the liver, predominantly mediated by neutrophil extracellular traps. Targeting aged neutrophil clearance and homeostasis may be effective in reducing cancer metastasis.

ONCOIMMUNOLOGY (2021)

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Article Oncology

Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress

Jinghua Ren et al.

Summary: Surgical trauma activates platelets and neutrophils, facilitating tumor cell distant metastasis. Platelet activation under surgical stress enhances the formation of platelet-tumor cell aggregates, aiding in their entrapment by neutrophil extracellular traps (NET).

CANCER RESEARCH (2021)

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Article Engineering, Biomedical

A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellular traps (NETs)-mediated collective tumor invasion

Vikram Surendran et al.

Summary: Neutrophils play dual roles in tumors, with the potential to both promote and limit tumor growth. Studying the interaction between neutrophils and tumor cells can provide insights into tumor progression. In this study, a novel microfluidic device was used to demonstrate that neutrophils respond to growing tumor spheroids by forming neutrophil extracellular traps (NETs), which stimulate tumor cells to collectively invade the surrounding matrix. This location-dictated mechanism of NETosis suggests a new avenue for anti-tumor therapeutics research.

BIOFABRICATION (2021)

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Article Multidisciplinary Sciences

Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth

Hafsa Munir et al.

Summary: The study reveals that cancer-associated fibroblasts (CAF) induce the formation of neutrophil extracellular traps (NET) within tumors and systemically in the blood and bone marrow. These tumor-induced NETs are driven by a ROS-mediated pathway dependent on CAF-derived Amyloid beta peptide. Inhibition of NETosis skews neutrophils to an anti-tumor phenotype, while t-NETs enhance CAF activation.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

Zhiyuan Zheng et al.

Summary: The study reveals that C3 protein in lung mesenchymal stromal cells promotes breast cancer cell metastasis to the lungs by facilitating neutrophil recruitment and the formation of neutrophil extracellular traps. The induction of C3 expression by Th2 cytokines and its dependency on STAT6 play a crucial role in this process.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment

Christof Kaltenmeier et al.

Summary: NETs in the tumor microenvironment promote an immunosuppressive environment by inducing exhaustion and dysfunction of infiltrating T cells, leading to tumor growth. Targeting NETs or PD-L1 with DNAse or anti-PD-L1 during surgery can diminish tumor growth and enhance T cell function in the TME, suggesting a novel strategy to sustain immune competence.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial-mesenchymal transition

Tong Zhu et al.

Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Oncology

Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis

Chenghui Yang et al.

Summary: Naged, a subset of neutrophils, plays a crucial role in premetastatic niche formation during breast cancer metastasis. It is characterized by distinct cell markers and morphological features, and is maintained by the key transcription factor SIRT1 for their function in promoting tumor metastasis through mitochondria-dependent NETs formation. Therapeutic interventions targeting the SIRT1-Naged-NETs axis show promise for reducing breast cancer lung metastasis.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

Neutrophils Extracellular Traps Inhibition Improves PD-1 Blockade Immunotherapy in Colorectal Cancer

Hongji Zhang et al.

Summary: Despite significant advances in immune checkpoint blockade therapy for advanced cancer, targeting the tumor immune microenvironment remains a critical approach to improve efficacy. Combination therapy using DNase I and PD-1 antibody shows superior efficacy over single-agent treatment in colorectal cancer. The resistance to anti-PD-1 blockade can be reversed by targeting neutrophil extracellular traps with DNase I, indicating a novel strategy for overcoming immunotherapy resistance in advanced cancer.

CANCERS (2021)

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Article Multidisciplinary Sciences

Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

Surashri Shinde-Jadhav et al.

Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.

NATURE COMMUNICATIONS (2021)

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Article Oncology

The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target

Xiangqian Guan et al.

Summary: This study revealed that the release of NETs is increased in HCC patients, especially those with portal vein tumor thrombosis. The presence of NETs in HCC tumor tissues is closely associated with a poor prognosis. Functionally, co-culture of HCC neutrophils enhances the invasion ability of HCC cells through NETs formation, while neutrophils from healthy donors inhibit invasion ability. Mechanistic investigations showed that HCC cells-derived cytokine IL-8 triggers NADPH oxidase-dependent NETs formation, promoting HCC metastasis in vitro and in vivo.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Article Hematology

Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation

Camila Meirelles S. Silva et al.

Summary: Research has shown that inhibition of the pore-forming protein GSDMD can reduce the formation of NETs during sepsis, thereby decreasing multiple organ dysfunction and sepsis lethality. This suggests that GSDMD could be a therapeutic target for improving sepsis treatment.

BLOOD (2021)

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Article Oncology

NF-κB and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis

Baoling Zhu et al.

Summary: Aberrant activation of NF-kappa B and formation of neutrophil extracellular traps (NETs) are associated with breast cancer progression. This study shows that there is a positive feedback loop between NF-kappa B and NETs, facilitating breast tumor progression and metastasis. Inhibition of NET formation or NF-kappa B activation may offer an effective therapeutic approach for treating breast cancer.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Oncology

Lipopolysaccharides increase the risk of colorectal cancer recurrence and metastasis due to the induction of neutrophil extracellular traps after curative resection

Wei-Wei Wang et al.

Summary: The study demonstrates that LPS-induced formation of NETs promotes the development and metastasis of colorectal cancer, involving the TLR9 and mitogen-activated protein kinase signaling pathway.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Review Oncology

Neutrophil extracellular traps in cancer: not only catching microbes

Livia Ronchetti et al.

Summary: Neutrophils are essential in immune defense, but their aberrant activation leading to NETosis in cancer has been associated with increased disease progression and complications. NETosis biomarkers could potentially help in selecting cancer patients for immunotherapy treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Gastroenterology & Hepatology

Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

Han Wang et al.

Summary: The study shows an increased number of Tregs in NASH-HCC, and depleting Tregs can inhibit the initiation and progression of HCC. There is a positive correlation between increased NETs and hepatic Tregs levels, and NETs promote Treg activity through metabolic reprogramming, linking innate and adaptive immunity. Therapies targeting NETs and Treg interactions may offer a potential strategy for preventing HCC in NASH patients.

JOURNAL OF HEPATOLOGY (2021)

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Article Oncology

Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL-8

Carlos E. de Andrea et al.

Summary: NETs are present in various human solid tumors and are associated with IL-8 protein expression and CD8(+) T-cell density in the tumor microenvironment. There is individual variation in NET density across different cancer types, with a positive correlation with IL-8 and a trend towards a negative association with CD8(+) TILs.

JOURNAL OF PATHOLOGY (2021)

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Article Multidisciplinary Sciences

DNAse-dependent, NET-independent pathway of thrombus formation in vivo

Estelle Carminita et al.

Summary: The research indicates that neutrophils rather than NETs are involved in thrombus formation after laser-induced injury. Treatment with DNase-I leads to hydrolysis of ATP and ADP, generating adenosine and inhibiting thrombus formation in vivo.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma

Robin Zenlander et al.

Summary: Plasma markers of NET formation were found to be elevated in liver cirrhosis and hepatocellular carcinoma patients, correlating to the degree of liver dysfunction. Levels of H3Cit-DNA were highest in cirrhosis patients, and Child-Pugh and MELD scores positively correlated with MPO-DNA and H3Cit-DNA levels.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence

Bin Yan et al.

Summary: The study demonstrated that stromal NET density is an independent prognostic factor for recurrence-free survival in cervical cancer patients. Patients with high NET density showed a higher risk of recurrence in every stage, and combining NETs with the TNM staging system may enhance prognostic stratification for cervical cancer.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, Research & Experimental

DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis

Jenying Deng et al.

Summary: The study reveals that DDR1 activation in cancer cells induced by collagen is a major stimulus for the production of CXCL5, leading to the recruitment of TANs and formation of NETs, promoting cancer cell invasion and metastasis in PDAC. Furthermore, the collagen-induced CXCL5 production is mediated by a DDR1/PKC theta/SYK/NF-kappa B signaling cascade.

JCI INSIGHT (2021)

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Article Oncology

Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Sheri A. C. McDowell et al.

Summary: Quail and colleagues demonstrate that obesity leads to impairment of vascular integrity through neutrophil-dependent mechanisms, facilitating breast cancer metastasis to the lungs. Targetable mechanisms underlying cancer progression in the obese population are revealed.

NATURE CANCER (2021)

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Article Hematology

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

Yohei Hisada et al.

HAEMATOLOGICA (2020)

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Article Oncology

Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer

Monica M. Rivera-Franco et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

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Article Oncology

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Sarah Greene et al.

CLINICAL CANCER RESEARCH (2020)

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Article Oncology

Neutrophil extracellular traps promote liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer-associated fibroblasts

Shin Takesue et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2020)

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Article Oncology

Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

Lu-Yu Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Cell Biology

Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

Anquan Shang et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Immunology

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Alvaro Teijeira et al.

IMMUNITY (2020)

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Article Cell Biology

Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis by inhibiting ROS-PAD4 pathway

Jie Zeng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Immunology

Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma

Roni F. Rayes et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Hematology

Phosphatidylserine-exposing blood cells, microparticles and neutrophil extracellular traps increase procoagulant activity in patients with pancreatic cancer

Muxin Yu et al.

THROMBOSIS RESEARCH (2020)

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Article Oncology

Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis

Lai Shi et al.

MOLECULAR CANCER RESEARCH (2020)

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Article Oncology

Diagnostic, Therapeutic Predictive, and Prognostic Value of Neutrophil Extracellular Traps in Patients With Gastric Adenocarcinoma

Yiyin Zhang et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Multidisciplinary Sciences

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Linbin Yang et al.

NATURE (2020)

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Article Immunology

Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

Yu Zhang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Oncology

Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps

Marina Li et al.

CANCERS (2020)

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Review Oncology

Neutrophil diversity and plasticity in tumour progression and therapy

Sebastien Jaillon et al.

NATURE REVIEWS CANCER (2020)

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Article Immunology

Heparin induces neutrophil elastase-dependent vital and lytic NET formation

Patrick M. Lelliott et al.

INTERNATIONAL IMMUNOLOGY (2020)

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Article Oncology

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis

Caijun Zha et al.

CANCER BIOLOGY & MEDICINE (2020)

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Article Oncology

IL-8 mediates a positive loop connecting increased neutrophil extracellular traps (NETs) and colorectal cancer liver metastasis

Luyu Yang et al.

JOURNAL OF CANCER (2020)

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Article Immunology

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment

Kangkang Liu et al.

CLINICAL IMMUNOLOGY (2019)

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Article Oncology

Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps

Yan Li et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2019)

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Article Oncology

Multi-institutional analysis of the prognostic significance of postoperative complications after curative resection for gastric cancer

Mitsuro Kanda et al.

CANCER MEDICINE (2019)

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Article Oncology

DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth

Jennifer L. Miller-Ocuin et al.

ONCOIMMUNOLOGY (2019)

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Article Oncology

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth

Hamza O. Yazdani et al.

CANCER RESEARCH (2019)

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Article Immunology

IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model

Taina Gomes et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Neutrophil Extracellular Traps Induced by IL8 Promote Diffuse Large B-cell Lymphoma Progression via the TLR9 Signaling

Man Nie et al.

CLINICAL CANCER RESEARCH (2019)

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Article Immunology

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

WonJae Lee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Medicine, Research & Experimental

Primary tumors induce neutrophil extracellular traps with targetable metastasis-promoting effects

Roni F. Rayes et al.

JCI INSIGHT (2019)

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Article Oncology

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

Brian A. Boone et al.

BMC CANCER (2018)

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Article Gastroenterology & Hepatology

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis

Dirk J. van der Windt et al.

HEPATOLOGY (2018)

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Review Oncology

Targeting the tumour stroma to improve cancer therapy

Kenneth C. Valkenburg et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Gastroenterology & Hepatology

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system

Masaki Honda et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Multidisciplinary Sciences

Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)

Rihito Kanamaru et al.

SCIENTIFIC REPORTS (2018)

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Review Oncology

Role of platelets and platelet receptors in cancer metastasis

Martin Schlesinger

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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Jean Albrengues et al.

SCIENCE (2018)

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Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Oncology

Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?

Olga A. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Oncology

Neutrophil extracellular traps sequester circulating tumor cells via 1-integrin mediated interactions

Sara Najmeh et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Pharmacology & Pharmacy

Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps

Angelo A. Manfredi et al.

PHARMACOLOGICAL RESEARCH (2017)

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Article Oncology

Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice

Jessica Cedervall et al.

ONCOIMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis

Ana C. Leal et al.

SCIENTIFIC REPORTS (2017)

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Article Cardiac & Cardiovascular Systems

Neutrophil extracellular traps are increased in cancer patients but does not associate with venous thrombosis

Rahmi Oklu et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2017)

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Article Oncology

Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2-Negative Metastatic Breast Cancer

Anne F. Schott et al.

CLINICAL CANCER RESEARCH (2017)

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Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

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Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy

Indu R. Ramachandran et al.

CANCER LETTERS (2016)

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Article Oncology

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

Samer Tohme et al.

CANCER RESEARCH (2016)

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Article Cell Biology

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Juwon Park et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Review Immunology

How Neutrophil Extracellular Traps Become Visible

Nicole de Buhr et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

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Time to Surgery and Breast Cancer Survival in the United States

Richard J. Bleicher et al.

JAMA ONCOLOGY (2016)

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Targeting metastasis

Patricia S. Steeg

NATURE REVIEWS CANCER (2016)

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Review Oncology

Neutrophils in cancer: neutral no more

Seth B. Coffelt et al.

NATURE REVIEWS CANCER (2016)

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Article Oncology

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

Jessica Cedervall et al.

CANCER RESEARCH (2015)

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Article Multidisciplinary Sciences

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis et al.

NATURE CHEMICAL BIOLOGY (2015)

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Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Siu Ling Wong et al.

NATURE MEDICINE (2015)

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Prognostic Significance of Complications after Curative Surgery for Gastric Cancer

Takeshi Kubota et al.

ANNALS OF SURGICAL ONCOLOGY (2014)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Article Hematology

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

Alexander S. Savchenko et al.

BLOOD (2014)

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Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery

Daniel J. y McIlroy et al.

JOURNAL OF CRITICAL CARE (2014)

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Review Oncology

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

James Harper et al.

SEMINARS IN CANCER BIOLOGY (2014)

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Review Hematology

NETosis: how vital is it?

Bryan G. Yipp et al.

BLOOD (2013)

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Article Immunology

Surgery and stress promote cancer metastasis: New outlooks on perioperative mediating mechanisms and immune involvement

Elad Neeman et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

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Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

Jonathan Cools-Lartigue et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Immunology

An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans

Angel S. Byrd et al.

JOURNAL OF IMMUNOLOGY (2013)

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Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

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Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

Bryan G. Yipp et al.

NATURE MEDICINE (2012)

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Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

Melanie Demers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Classification, Functions, and Clinical Relevance of Extracellular Vesicles

Edwin van der Pol et al.

PHARMACOLOGICAL REVIEWS (2012)

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Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Contribution of platelets to tumour metastasis

Laurie J. Gay et al.

NATURE REVIEWS CANCER (2011)

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Review Immunology

Neutrophils in the activation and regulation of innate and adaptive immunity

Alberto Mantovani et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Cell Biology

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Venizelos Papayannopoulos et al.

JOURNAL OF CELL BIOLOGY (2010)

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Article Immunology

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

Florian H. Pilsczek et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Extracellular DNA traps promote thrombosis

Tobias A. Fuchs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Hematology

Emerging risk stratification approaches to cancer-associated thrombosis: risk factors, biomarkers and a risk score

Gregory C. Connolly et al.

THROMBOSIS RESEARCH (2010)

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Article Oncology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

Zvi G. Fridlender et al.

CANCER CELL (2009)

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Article Biochemistry & Molecular Biology

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

S. Yousefi et al.

CELL DEATH AND DIFFERENTIATION (2009)

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Review Oncology

Microenvironmental regulation of metastasis

Johanna A. Joyce et al.

NATURE REVIEWS CANCER (2009)

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Article Immunology

IL-8 as antibody therapeutic target in inflammatory diseases: Reduction of clinical activity in palmoplantar pustulosis

Lone Skov et al.

JOURNAL OF IMMUNOLOGY (2008)

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Review Oncology

Cancer-associated thrombosis

Jeffrey I. Zwicker et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2007)

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Novel cell death program leads to neutrophil extracellular traps

Tobias A. Fuchs et al.

JOURNAL OF CELL BIOLOGY (2007)

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Cancer metastasis:: Building a framework

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CELL (2006)

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Neutrophil extracellular traps kill bacteria

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SCIENCE (2004)

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