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The 3Ds of Growing Kidney Organoids: Advances in Nephron Development, Disease Modeling, and Drug Screening

CELLS (2023)

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Article Urology & Nephrology

Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking

Aude Dorison et al.

Summary: NPHS2 variants are the most common cause of steroid-resistant nephrotic syndrome in children. This study used induced pluripotent stem cell lines to investigate the effects of NPHS2 variants on the expression and subcellular localization of PODOCIN protein, and found that different variants resulted in distinct intracellular localization of PODOCIN, providing insight into the pathobiology of NPHS2 variants.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2023)

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Review Physiology

How Many Cell Types Are in the Kidney and What Do They Do?

Michael S. Balzer et al.

Summary: The kidney plays a crucial role in maintaining electrolyte, water, and acid-base balance, regulating blood pressure, and eliminating waste compounds. Different specialized cell types in the kidney work together to ensure its proper function. With the advancement of single-cell technologies, we now have new opportunities to classify kidney cells and understand their functions.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

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Review Cell Biology

Kidney organoids: current knowledge and future directions

Niloofar Khoshdel-Rad et al.

Summary: In recent years, significant progress has been made in creating in vitro kidney models, such as kidney organoids. These organoids exhibit similar cell types, morphology, and function as native kidney tissue, and they can be used for drug screening, disease modeling, and regenerative medicine applications.

CELL AND TISSUE RESEARCH (2022)

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Article Cell & Tissue Engineering

Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

Rosemarie Ungricht et al.

Summary: Human organoids provide valuable insights into proliferation, lineage specification, and 3D tissue development. In this study, a genome-wide CRISPR screen was conducted in induced pluripotent stem cell (iPSC)-derived kidney organoids, resulting in a complex and high-quality dataset. The findings shed light on various aspects of biology, ranging from early development to adult epithelial morphogenesis. The dataset not only enhances mesoderm induction and identifies kidney disease genes, but also confirms genetic anomalies and provides a list of potential ciliopathy-related genes.

CELL STEM CELL (2022)

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Article Cell & Tissue Engineering

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jitske Jansen et al.

Summary: The study found that SARS-CoV-2 can directly infect kidney cells, leading to cell injury and fibrosis, causing kidney failure. Inhibitors can alleviate the infection.

CELL STEM CELL (2022)

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Review Urology & Nephrology

Tissue Culture Models of AKI: From Tubule Cells to Human Kidney Organoids

Julie Bejoy et al.

Summary: AKI affects millions of people worldwide each year, but regenerative therapies are still not available. Human kidney tissue culture systems and human pluripotent stem cells offer new approaches to studying AKI mechanisms and developing new therapeutics.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Review Urology & Nephrology

Regrow or Repair: An Update on Potential Regenerative Therapies for the Kidney

Melissa H. Little et al.

Summary: This article reviews the changes in our understanding of kidney development, disease, repair, and regeneration over the past fifteen years, and envisions the future of kidney regeneration and repair for the next fifteen years.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Transplantation

An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease International

Roman-Ulrich Mueller et al.

Summary: Approval of tolvaptan for ADPKD has transformed patient care and shifted focus from general measures to targeting disease-specific mechanisms. Evidence-based approaches are crucial due to long-term nature of treatment and potential side effects.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Multidisciplinary Sciences

Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma

Shunsuke Tanigawa et al.

Summary: Researchers have successfully induced renal stromal progenitors from mouse pluripotent stem cells (PSCs) and generated completely PSC-derived organoids that reproduce complex kidney structure. By understanding the molecular features of the renal stromal lineage, they established an in vitro induction protocol for stromal progenitors (SPs) from mouse PSCs. Assembling induced SPs with differentially induced parenchymal progenitors resulted in organoids that replicated the complex kidney structure.

NATURE COMMUNICATIONS (2022)

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Article Genetics & Heredity

DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets

Sean B. Wilson et al.

Summary: This study developed an unbiased tool (DevKidCC) for accurately classifying cell identities in kidney organoids and comparing different single-cell datasets. By applying this tool, differences in the relative proportions of cell types between kidney organoids generated using different protocols can be identified, leading to improvements in kidney organoid generation methods.

GENOME MEDICINE (2022)

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Article Developmental Biology

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Jitske Jansen et al.

Summary: Using organoid podocytes as a model, this study investigated idiopathic nephrotic syndrome and found that repaired organoids exhibited improved functionality, providing a valuable tool for disease modeling and therapy development.

DEVELOPMENT (2022)

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Editorial Material Urology & Nephrology

Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium

Bilal A. Naved et al.

Summary: Acute kidney injury is a serious global health issue with millions of individuals affected and significant mortality rates. The (Re)Building a Kidney (RBK) consortium is focused on studying endogenous kidney repair mechanisms and generating new kidney tissue. This review provides an update on RBK studies of nephron repair and addresses important questions regarding the cellular sources and drivers of repair. Additionally, it highlights the importance of RBK in promoting the development of therapeutics and provides a guide to their open access data hub.

KIDNEY INTERNATIONAL (2022)

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Article Cell Biology

Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair

Navin Gupta et al.

Summary: Kidneys have the capacity for intrinsic repair, but when overwhelmed, incomplete repair can lead to chronic kidney disease. Limited treatments exist due to the limited predictivity of animal studies. This study used kidney organoids to identify genes and pathways involved in intrinsic repair and discovered a potential therapeutic candidate that can prevent the progression of chronic kidney disease.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia

Nelly M. Cruz et al.

Summary: Human pluripotent stem cells edited via CRISPR can be used to model and reveal underlying mechanisms of ciliopathy phenotypes.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Multidisciplinary Sciences

Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity

M. L. Lawrence et al.

Summary: Advances in regenerative medicine have allowed the construction of organoids, including renal organoids, which can be used as screening tools with the HMOX1 reporter, potentially applicable to other stem-cell-derived organs and tissues.

ISCIENCE (2022)

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Article Cell & Tissue Engineering

A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

Tracy Tran et al.

Summary: Human pluripotent stem-cell-derived organoids have been modified to generate thousands of similar kidney organoids, which can be used for modeling human kidney development and disease. The models have been used to study polycystic kidney disease and identify compounds that can block cyst formation. Scaling and further development of this platform will greatly enhance its capabilities for kidney disease modeling and high-throughput drug screening.

CELL STEM CELL (2022)

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Article Cell Biology

Kidney organoid research: current status and applications

Olena Trush et al.

Summary: Organoids derived from human-induced pluripotent stem cells have become an indispensable tool in studying kidney development, modeling kidney diseases and infections, and advancing drug development and personalized medicine. This review provides an update on the recent advancements in kidney organoid induction, their advantages, limitations, and current applications in modeling kidney injuries, screening kidney diseases, and understanding cell interactions within the organoids.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

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What can we learn from kidney organoids?

Aude Dorison et al.

KIDNEY INTERNATIONAL (2022)

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Review Urology & Nephrology

Principles of human and mouse nephron development

Jack Schnell et al.

Summary: Understanding the mechanisms of kidney development is crucial for studying congenital anomalies and developing genetic diagnostic tools. Studies have identified signaling pathways that regulate the development of nephron progenitor and precursor cells, and cross-species comparisons have enhanced our understanding of the common and unique features of kidney development. Furthermore, insights into cellular movements and patterning mechanisms have provided important clues for understanding kidney diseases. In addition, advances in technology have allowed the creation of kidney organoids in vitro, providing a blueprint for the formation of correctly patterned nephrons. Comparisons between human and mouse kidney development have also aided our understanding, as well as single-cell omics and high-resolution imaging techniques.

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Developmental genetics with model organisms

Uwe Irion et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Kidney organoids: a pioneering model for kidney diseases

Murat Tekguc et al.

Summary: The kidney is an important organ that plays a crucial role in regulating bodily fluid and electrolyte balance. Traditional research methods are unable to fully replicate complex human kidney diseases. However, advancements in directed differentiation of induced pluripotent stem cells and biofabrication techniques have allowed the generation of patient-specific 3D kidney organoids and the construction of vascularized kidney tissues. Gene editing technology can also be used to minimize immune rejection in kidney transplant recipients.

TRANSLATIONAL RESEARCH (2022)

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Article Cell & Tissue Engineering

Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease

Julie Bejoy et al.

Summary: This study successfully derived podocytes from human-induced pluripotent stem cells using a accelerated 12-day protocol. The derived podocytes showed comparable marker expression and morphology to longer cultured podocytes. These podocytes can be used for modeling diabetic kidney disease.

STEM CELL RESEARCH & THERAPY (2022)

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Article Genetics & Heredity

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease

Yaoxian Xu et al.

Summary: Adult kidney organoids, known as tubuloids, are derived from a distinct CD24(+) epithelial subpopulation and can be used to model autosomal dominant polycystic kidney disease (ADPKD) and study drug response. The study found similarities in gene expression between gene-edited tubuloids and ADPKD patients' tissue, demonstrating the potential of tubuloids in ADPKD disease modeling. Additionally, the approved drug for ADPKD, tolvaptan, was found to have a significant effect on cyst size in tubuloids but not in pluripotent stem cell-derived models.

NATURE GENETICS (2022)

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Review Urology & Nephrology

Regulation of nephron progenitor cell lifespan and nephron endowment

Alison J. Perl et al.

Summary: Low nephron number is a risk factor for the development of hypertension, chronic kidney disease, and kidney failure. This review discusses the mechanisms that regulate nephrogenesis and the timing of nephrogenesis cessation, with a focus on environmental and intrinsic pathways that may enhance nephron endowment in susceptible individuals.

NATURE REVIEWS NEPHROLOGY (2022)

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Article Multidisciplinary Sciences

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

Jessica M. Vanslambrouck et al.

Summary: Enhanced specification of metanephric nephron progenitors results in improved development of proximal nephrons with better functionality and distinct cell types. This improvement enhances the study of proximal tubular diseases, drug responses, and viral interactions.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Jeffrey O. Aceves et al.

Summary: This study presents a method for creating a perfusable 3D proximal tubule model that exhibits improved drug uptake. The model shows upregulation of transporters and increased lactate dehydrogenase release when exposed to nephrotoxic substances. This platform holds promise for personalized kidney-on-chip models for drug screening and disease modeling.

SCIENTIFIC REPORTS (2022)

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Editorial Material Cell Biology

Editorial overview: How to generate and maintain organs-organoids, regeneration, and beyond

Ophir D. Klein et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

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Article Urology & Nephrology

Human kidney organoids produce functional renin

Anusha S. Shankar et al.

Summary: This study used human induced pluripotent stem cell-derived kidney organoids as a model to investigate the role of renin and the renin-angiotensin system in the kidney, demonstrating the expression of renin in kidney organoids and providing insights into their endocrine potential.

KIDNEY INTERNATIONAL (2021)

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Article Cell & Tissue Engineering

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden et al.

Summary: Distinct progenitors contribute to the nephrons versus the ureteric epithelium during kidney development. The distal nephron segment alone displays significant in vitro plasticity and can adopt a ureteric epithelial tip identity when isolated and cultured in defined conditions. Cultures harboring loss-of-function mutations in PKHD1 recapitulate the cystic phenotype associated with autosomal recessive polycystic kidney disease.

CELL STEM CELL (2021)

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Article Developmental Biology

Returning to kidney development to deliver synthetic kidneys

Melissa H. Little

Summary: Progress has been made in generating kidney tissue from stem cells, but the limited scale, incomplete cellular complexity, and functional immaturity suggest we are still far from the goal of transplantable synthetic kidneys.

DEVELOPMENTAL BIOLOGY (2021)

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Article Chemistry, Physical

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

Kynan T. Lawlor et al.

Summary: The study demonstrates the use of extrusion-based three-dimensional cellular bioprinting to rapidly and efficiently generate kidney organoids with highly reproducible cell number and viability. This technology not only improves throughput and quality control in organoid production, but also facilitates precise control of structure, enhancing the in vitro and in vivo applications of stem cell-derived human kidney tissue.

NATURE MATERIALS (2021)

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Article Urology & Nephrology

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney

Amin Abedini et al.

Summary: Microscopic analysis of urine sediment is commonly used in nephrology for diagnostic purposes. Single-cell transcriptomic analysis revealed that almost all kidney cell types can be identified in urine, with subject-specific and relatively stable cell-type composition. Urinary cells show similarities in gene expression with kidney and bladder cells.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Biochemical Research Methods

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

Linda Gijzen et al.

Summary: The study focuses on establishing tubuloid cultures from tissue and urine, generating three-dimensional tubular structures in a perfused microfluidic multi-chip platform. Advanced in vitro kidney models are crucial for studying renal physiology and diseases, with tubuloids providing a realistic recapitulation of tubular function for various disease studies. Integrating tubuloids into an organ-on-a-chip system allows for a more physiological representation of the kidney tubule, enhancing the complexity of the in vitro model with donor-specific properties.

NATURE PROTOCOLS (2021)

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Article Developmental Biology

Vascular deficiencies in renal organoids and ex vivo kidney organogenesis

Anne R. Ryan et al.

Summary: Kidney organoids offer a promising model system to study vascular-nephron interactions, but face unique challenges in establishing and maintaining a vascular network when grown ex vivo.

DEVELOPMENTAL BIOLOGY (2021)

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Article Urology & Nephrology

Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis

Lydia Djenoune et al.

Summary: The study reveals the presence of cell-autonomous calcium signaling in podocyte development, which is a conserved mechanism in different species. Calcium signaling is released from endoplasmic reticulum stores and plays a critical role in podocyte morphology and foot process formation.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Cell & Tissue Engineering

Promoting Maturation of Human Pluripotent Stem Cell-Derived Renal Microtissue by Incorporation of Endothelial and Mesenchymal Cells

Niloofar Khoshdel-Rad et al.

Summary: A new differentiation protocol using IDE1 was established for efficient generation of renal precursors, replacing expensive activin A. Furthermore, coculture of endothelial and mesenchymal cells increased maturation of 3D renal structures, resulting in greater maturity compared to precursors cultured alone. Ex ovo transplantation induced further maturation in the constructs, showing potential for high-throughput drug screening and nephrotoxicology studies.

STEM CELLS AND DEVELOPMENT (2021)

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Article Engineering, Biomedical

Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition

Thomas Geuens et al.

Summary: Differentiated kidney organoids from induced pluripotent stem cells show potential in treating kidney diseases, but overcoming flaws in their cellular composition, extracellular composition, and developmental plateau is crucial for their clinical translation. A proteomic analysis revealed increased expression of specific collagen types in kidney organoids cultured for a prolonged time, indicative of renal fibrosis. Encapsulating the organoids in a thiol-ene cross-linked alginate hydrogel for four days reduced abnormal collagen expression and maintained organoid structural morphology, bringing kidney organoids closer to clinical application.

BIOMATERIALS (2021)

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Article Cell Biology

Spatial transcriptional mapping of the human nephrogenic program

Nils O. Lindstrom et al.

Summary: Researchers spatially resolved a stereotypical process of nephron progenitor generation and constructed three-dimensional protein maps using data-driven approaches to predict interactions within and between nephron cell types. Single-cell RNA sequencing and network mining identified developmental disease genes and predicted interesting targets. This spatially resolved nephrogenic program will enhance efforts in understanding kidney development and disease as well as in generating new kidney structures.

DEVELOPMENTAL CELL (2021)

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Article Multidisciplinary Sciences

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors

Zipeng Zeng et al.

Summary: Researchers have developed a model to study the collecting duct system in kidneys by generating organoids from ureteric bud (UB) progenitor cells derived from mouse and human primary tissues, as well as from hESC and hiPSC, showing potential for modeling congenital anomalies of the kidney and urinary tract.

NATURE COMMUNICATIONS (2021)

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Rapid target validation in a Cas9-inducible hiPSC derived kidney model

Yasaman Shamshirgaran et al.

Summary: Recent technologies allow for the development of new human disease models, with kidney organoids providing greater cellular complexity, but current genetic manipulation methods are time and labor consuming.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing

Wei-Yang Chen et al.

Summary: Kidneys play a critical role in eliminating drugs and metabolites, filtering waste, and maintaining fluid and electrolyte balance. Innovative three-dimensional in vitro cell culture models like organoids and microphysiological systems have been developed to replicate nephron function, improving efficacy, safety, and toxicity evaluation of new drugs and environmental exposures.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Physiology

Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases

Valeriia Y. Vasileva et al.

Summary: PKD is a severe genetic disorder characterized by the formation and growth of fluid-filled cysts in the kidney. Current research focuses on understanding fundamental mechanisms like the PC1/PC2 pathways and metabolic factors that influence disease progression. While there are no treatments for ARPKD, the FDA-approved drug tolvaptan has limited effects on ADPKD symptoms.

FRONTIERS IN PHYSIOLOGY (2021)

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The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids

Verena Waehle et al.

Summary: Researchers have developed a human kidney organoid model that reveals how deletion of WT1 during organoid development leads to overgrowth of kidney progenitor cells, halting their progression at a pre-epithelialized cell state and recapitulating transcriptional changes seen in a subgroup of Wilms tumor patients with ectopic myogenesis. They also found that propagation of WT1 mutant cells requires an untransformed microenvironment.

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PEDIATRIC NEPHROLOGY (2020)

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Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

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In Vivo Assessment of Size-Selective Glomerular Sieving in Transplanted Human Induced Pluripotent Stem Cell?Derived Kidney Organoids

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A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells

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Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids

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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

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Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling

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3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening

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Three-Dimensional Renal Organoids from Whole Kidney Cells: Generation, Optimization, and Potential Application in Nephrotoxicology In Vitro

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Evaluation of cisplatin-induced injury in human kidney organoids

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Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells

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Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

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Article Multidisciplinary Sciences

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

Ayshwarya Subramanian et al.

NATURE COMMUNICATIONS (2019)

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Article Surgery

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium

Danielle G. Leuning et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

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Article Urology & Nephrology

Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells

Yasuhiro Yoshimura et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

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Article Biochemical Research Methods

Evaluation of variability in human kidney organoids

Belinda Phipson et al.

NATURE METHODS (2019)

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Article Genetics & Heredity

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

Alexander N. Combes et al.

GENOME MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Generation of branching ureteric bud tissues from human pluripotent stem cells

Shin-Ichi Mae et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Cell & Tissue Engineering

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

Stefan M. Czerniecki et al.

CELL STEM CELL (2018)

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Article Cell Biology

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis

Nils O. Lindstrom et al.

DEVELOPMENTAL CELL (2018)

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Review Biochemistry & Molecular Biology

Use and application of 3D-organoid technology

Benedetta Artegiani et al.

HUMAN MOLECULAR GENETICS (2018)

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Article Urology & Nephrology

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning

Nils O. Lindstrom et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Urology & Nephrology

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney

Nils O. Lindstrom et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Urology & Nephrology

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis

Nils O. Lindstrom et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Biochemical Research Methods

Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip

Samira Musah et al.

NATURE PROTOCOLS (2018)

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Review Urology & Nephrology

Advances in predictive in vitro models of drug-induced nephrotoxicity

Joanne Y. -C. Soo et al.

NATURE REVIEWS NEPHROLOGY (2018)

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Article Cell & Tissue Engineering

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

Ioannis Bantounas et al.

STEM CELL REPORTS (2018)

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Article Cell & Tissue Engineering

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

Cathelijne W. van den Berg et al.

STEM CELL REPORTS (2018)

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Article Cell & Tissue Engineering

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

Aneta Przepiorski et al.

STEM CELL REPORTS (2018)

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Article Urology & Nephrology

A CRISP(e)R view on kidney organoids allows generation of an induced pluripotent stem cell-derived kidney model for drug discovery

Cecilia Borestrom et al.

KIDNEY INTERNATIONAL (2018)

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Article Cell & Tissue Engineering

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Shunsuke Tanigawa et al.

STEM CELL REPORTS (2018)

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Article Cell & Tissue Engineering

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

Haojia Wu et al.

CELL STEM CELL (2018)

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Article Multidisciplinary Sciences

3D organoid-derived human glomeruli for personalised podocyte disease model ling and drug screening

Lorna J. Hale et al.

NATURE COMMUNICATIONS (2018)

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Article Biochemical Research Methods

Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells

Ryuji Morizane et al.

NATURE PROTOCOLS (2017)

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Review Urology & Nephrology

Applications of the CRISPR-Cas9 system in kidney research

Yoshiki Higashijima et al.

KIDNEY INTERNATIONAL (2017)

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Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Nelly M. Cruz et al.

NATURE MATERIALS (2017)

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Review Biochemistry & Molecular Biology

Kidney Organoids: A Translational Journey

Ryuji Morizane et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Medicine, General & Internal

Chronic kidney disease

Paola Romagnani et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Engineering, Biomedical

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

Samira Musah et al.

NATURE BIOMEDICAL ENGINEERING (2017)

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Article Cell & Tissue Engineering

Higher-Order Kidney Organogenesis from Pluripotent Stem Cells

Atsuhiro Taguchi et al.

CELL STEM CELL (2017)

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Review Developmental Biology

The hope and the hype of organoid research

Meritxell Huch et al.

DEVELOPMENT (2017)

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Article Urology & Nephrology

Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation

Sazia Sharmin et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

CELL (2016)

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Article Cell & Tissue Engineering

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors

Zhongwei Li et al.

CELL STEM CELL (2016)

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Review Developmental Biology

A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells

Minoru Takasato et al.

DEVELOPMENTAL BIOLOGY (2016)

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Article Biochemical Research Methods

Generation of kidney organoids from human pluripotent stem cells

Minoru Takasato et al.

NATURE PROTOCOLS (2016)

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Review Cell & Tissue Engineering

Insights into kidney stem cell development and regeneration using zebrafish

Bridgette E. Drummond et al.

WORLD JOURNAL OF STEM CELLS (2016)

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Review Engineering, Biomedical

Evolving technology: creating kidney organoids from stem cells

Joseph M. Chambers et al.

AIMS BIOENGINEERING (2016)

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Article Urology & Nephrology

Collecting Duct Intercalated Cell Function and Regulation

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CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Review Developmental Biology

Modeling mouse and human development using organoid cultures

Meritxell Huch et al.

DEVELOPMENT (2015)

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Article Urology & Nephrology

Human Urine-Derived Renal Progenitors for Personalized Modeling of Genetic Kidney Disorders

Elena Lazzeri et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Multidisciplinary Sciences

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Minoru Takasato et al.

NATURE (2015)

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Article Biotechnology & Applied Microbiology

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Ryuji Morizane et al.

NATURE BIOTECHNOLOGY (2015)

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Review Urology & Nephrology

Genetic, environmental, and epigenetic factors involved in CAKUT

Nayia Nicolaou et al.

NATURE REVIEWS NEPHROLOGY (2015)

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Article Multidisciplinary Sciences

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Benjamin S. Freedman et al.

NATURE COMMUNICATIONS (2015)

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Review Cell Biology

Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies

Audrey Desgrange et al.

CELLS (2015)

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Review Urology & Nephrology

Collecting Duct Principal Cell Transport Processes and Their Regulation

David Pearce et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Cell & Tissue Engineering

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

Atsuhiro Taguchi et al.

CELL STEM CELL (2014)

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Article Urology & Nephrology

Urine-Concentrating Mechanism in the Inner Medulla: Function of the Thin Limbs of the Loops of Henle

William H. Dantzler et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Proximal Tubule Function and Response to Acidosis

Norman P. Curthoys et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Thick Ascending Limb of the Loop of Henle

David B. Mount

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Homeostasis, the Milieu Interieur, and the Wisdom of the Nephron

Melanie P. Hoenig et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Distal Convoluted Tubule

Arohan R. Subramanya et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Cell Biology

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

M. Takasato et al.

NATURE CELL BIOLOGY (2014)

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Article Biochemical Research Methods

The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells

Yun Xia et al.

NATURE PROTOCOLS (2014)

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Review Pediatrics

Single-gene causes of congenital anomalies of the kidney and urinary tract (CAKUT) in humans

Asaf Vivante et al.

PEDIATRIC NEPHROLOGY (2014)

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Review Multidisciplinary Sciences

Organogenesis in a dish: Modeling development and disease using organoid technologies

Madeline A. Lancaster et al.

SCIENCE (2014)

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Article Cell & Tissue Engineering

Renal stem cell reprogramming: Prospects in regenerative medicine

Elvin E Morales

World Journal of Stem Cells (2014)

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Article Medicine, Research & Experimental

Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer

Qi Li et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2013)

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Article Multidisciplinary Sciences

Cerebral organoids model human brain development and microcephaly

Madeline A. Lancaster et al.

NATURE (2013)

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Article Cell Biology

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells

Yun Xia et al.

NATURE CELL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Johanna F. Dekkers et al.

NATURE MEDICINE (2013)

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Review Urology & Nephrology

Renal progenitors: an evolutionary conserved strategy for kidney regeneration

Paola Romagnani et al.

NATURE REVIEWS NEPHROLOGY (2013)

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Review Urology & Nephrology

When birth comes early: Effects on nephrogenesis

Mary Jane Black et al.

NEPHROLOGY (2013)

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Article Urology & Nephrology

Acute Kidney Injury and Chronic Kidney Disease: It's a Two-Way Street

Jason Kline et al.

RENAL FAILURE (2013)

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Article Physiology

Proximal Nephron

Jia L. Zhuo et al.

COMPREHENSIVE PHYSIOLOGY (2013)

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Article Cell & Tissue Engineering

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

Tokushige Nakano et al.

CELL STEM CELL (2012)

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Review Urology & Nephrology

Acute kidney injury and chronic kidney disease: an integrated clinical syndrome

Lakhmir S. Chawla et al.

KIDNEY INTERNATIONAL (2012)

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Article Cell & Tissue Engineering

Characterization of Renal Progenitors Committed Toward Tubular Lineage and Their Regenerative Potential in Renal Tubular Injury

Maria Lucia Angelotti et al.

STEM CELLS (2012)

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Article Cell Biology

Mammalian Kidney Development: Principles, Progress, and Projections

Melissa H. Little et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Article Multidisciplinary Sciences

Self-organizing optic-cup morphogenesis in three-dimensional culture

Mototsugu Eiraku et al.

NATURE (2011)

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Review Pediatrics

Human nephron number: implications for health and disease

John F. Bertram et al.

PEDIATRIC NEPHROLOGY (2011)

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Article Biochemistry & Molecular Biology

TLR2 plays a role in the activation of human resident renal stem/progenitor cells

Fabio Sallustio et al.

FASEB JOURNAL (2010)

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Review Physiology

Acute kidney injury: a springboard for progression in chronic kidney disease

Manjeri A. Venkatachalam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

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Article Multidisciplinary Sciences

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato et al.

NATURE (2009)

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Article Cell & Tissue Engineering

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Mototsugu Eiraku et al.

CELL STEM CELL (2008)

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Article Urology & Nephrology

Vasopressin directly regulates cyst growth in polycystic kidney disease

Xiaofang Wang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

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Review Urology & Nephrology

The zebrafish pronephros: A model to study nephron segmentation

R. A. Wingert et al.

KIDNEY INTERNATIONAL (2008)

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Article Urology & Nephrology

Regenerative potential of embryonic renal multipotent progenitors in acute renal failure

Elena Lazzeri et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

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Review Genetics & Heredity

Renal abnormalities and their developmental origin

Andreas Schedl

NATURE REVIEWS GENETICS (2007)

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Review Urology & Nephrology

The spectrum of podocytopathies: A unifying view of glomerular diseases

R. C. Wiggins

KIDNEY INTERNATIONAL (2007)

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Review Medicine, General & Internal

Chronic kidney disease: the global challenge

AM El Nahas et al.

LANCET (2005)

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Article Biochemistry & Molecular Biology

Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease

M Koptides et al.

HUMAN MOLECULAR GENETICS (2000)

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