USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis

Article Oncology

YOD1 serves as a potential prognostic biomarker for pancreatic cancer

Zhishuo Zhang et al.

Summary: YOD1 expression is upregulated in pancreatic cancer, associated with poor prognosis, and may impact the development of pancreatic cancer by regulating tumor cell proliferation, metastasis, and the immune microenvironment.

CANCER CELL INTERNATIONAL (2022)

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Review Genetics & Heredity

USP10 as a Potential Therapeutic Target in Human Cancers

Li Tao et al.

Summary: This review summarizes the dual role of deubiquitinating enzyme USP10 in human cancers as well as its downstream substrates and upstream regulators. Additionally, it provides an overview of multiple pharmacological USP10 inhibitors and proposes the development of specific and efficient USP10 inhibitors as a promising therapeutic strategy for cancer treatment.

GENES (2022)

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Article Biochemistry & Molecular Biology

Comprehensive Analysis Reveals USP45 as a Novel Putative Oncogene in Pan-Cancer

Kai Li et al.

Summary: This study investigated the potential oncogenic role of deubiquitinating enzyme USP45 in pan-cancer. The results showed that USP45 is upregulated in most tumors and negatively correlated with overall survival and recurrence-free survival. USP45 was also found to be closely related to tumor stemness, tumor heterogeneity, and tumor immunity. The study provides new insights for further investigation of USP45.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Chemistry, Multidisciplinary

Highlights in USP7 inhibitors for cancer treatment

Rita I. Oliveira et al.

Summary: Ubiquitin-specific protease 7 (USP7) plays a key role in regulating multiple proteins involved in cancer development and immune response. Abnormal expression of USP7 is associated with poor prognosis in various malignant tumors, making it a promising therapeutic target. However, no approved drugs targeting USP7 have entered clinical trials yet, highlighting the need for further research and development efforts. This mini review provides an overview of the role of USP7 as a drug target for cancer therapy and summarizes the characteristics of small molecule inhibitors reported in the literature.

FRONTIERS IN CHEMISTRY (2022)

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Article Oncology

NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer

Bing Li et al.

Summary: The study demonstrated that NLRP7 promotes colorectal cancer progression and induces the polarization of pro-tumor M2-like macrophages. NLRP7 interacts with ubiquitin-specific protease 10 to modulate its stability and protein levels in CRC cells. NLRP7 also promotes NF-kappa B nuclear translocation and activation of C-C motif chemokine ligand 2 transcription in CRC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4

Chao Jing et al.

Summary: JOSD1 is aberrantly expressed in HNSCC, and its overexpression indicates poor clinical outcome in patients. Depletion of JOSD1 significantly inhibits cell proliferation and promotes apoptosis of HNSCC cells. Additionally, the epigenetic regulator BRD4 contributes to the upregulation of JOSD1 in HNSCC.

CANCER CELL INTERNATIONAL (2021)

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Article Health Care Sciences & Services

Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation

Andras Lanczky et al.

Summary: The web-based tool introduced in this study enables univariate and multivariate Cox proportional hazards survival analysis using data from various genomic studies, filling a significant gap in the field where no commonly used spreadsheet software or web server is available for this purpose.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

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Article Biochemistry & Molecular Biology