The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5

OTUD5 (OTU Deubiquitinase 5) is a functional cysteine protease with deubiquitinase activity and is a member of the ovarian tumor protease (OTU) family. OTUD5 is involved in the deubiquitination of many key proteins in various cellular signaling pathways and plays an important role in maintaining normal human development and physiological functions. Its dysfunction can affect physiological processes, such as immunity and DNA damage repair, and it can even lead to tumors, inflammatory diseases and genetic disorders. Therefore, the regulation of OTUD5 activity and expression has become a hot topic of research. A comprehensive understanding of the regulatory mechanisms of OTUD5 and its use as a therapeutic target for diseases is of great value. Herein, we review the physiological processes and molecular mechanisms of OTUD5 regulation, outline the specific regulatory processes of OTUD5 activity and expression, and link OTUD5 to diseases from the perspective of studies on signaling pathways, molecular interactions, DNA damage repair and immune regulation, thus providing a theoretical basis for future studies.

Automated summary

OTUD5 is a cysteine protease belonging to the OTU family, which functions as a deubiquitinase. It plays a crucial role in the deubiquitination of key proteins in various cellular signaling pathways, contributing to normal human development and physiological functions. Dysregulation of OTUD5 can result in physiological dysfunctions, including immunity and DNA damage repair, as well as the development of tumors, inflammatory diseases, and genetic disorders. Therefore, understanding and controlling the activity and expression of OTUD5 is of great significance for disease research and therapeutic interventions.