4.6 Review

LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

Wei Zhang et al.

Summary: This study reveals the co-localization of ICAM-1 and PD-L1 on exosomes, both of which are upregulated by interferon-y. The adhesion between TEVs and T cells mediated by ICAM-1-LFA-1 is crucial for exosomal PD-L1-mediated immune suppression.

DEVELOPMENTAL CELL (2022)

Review Biochemistry & Molecular Biology

How integrin phosphorylations regulate cell adhesion and signaling

Carl G. Gahmberg et al.

Summary: Cell adhesion is crucial for organ formation, cellular migration, and interaction with target cells and the extracellular matrix. Recent research has revealed the role of integrin phosphorylations in regulating integrin activity and downstream signaling. The SARS-CoV-2 virus receptor ACE2 and potential integrin co-receptors may interact and induce phosphorylation switches and autophagy.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

Article Multidisciplinary Sciences

The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation

Victor Pui-Yan Ma et al.

Summary: T cells defend against cancer and viral infections by binding to specific peptide antigens on target cells. It has been found that the forces transmitted through the LFA-1 /ICAM-1 complex can tune T cell signaling and enhance T cell activation and TCR discrimination.

SCIENCE ADVANCES (2022)

Article Biochemistry & Molecular Biology

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells

Kristoffer H. Johansen et al.

Summary: The study reveals the critical role of RASA3 in T cell migration, homeostasis, and function. RASA3 suppresses the activation of LFA-1 in T cells and its expression is rapidly reduced upon T cell activation. Loss of RASA3 leads to increased Rap1 activation, defective lymph node entry and egress, and impaired responses to T-dependent immunization in mice.

SCIENCE SIGNALING (2022)

Article Medicine, Research & Experimental

LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

Amber Hickman et al.

Summary: The small-molecule activator 7HP349 enhances the localization of tumor-specific T cells to tumors and improves antitumor response, with combinatorial treatment synergizing with neutrophils in inducing cancer regression.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Review Immunology

LFA-1 in T cell priming, differentiation, and effector functions

Audrey Gerard et al.

Summary: The integrin LFA-1 plays a crucial role in T cell entry into lymph nodes and tissues, interactions with antigen-presenting cells, as well as additional functions such as T-T communication and support of T cell memory. Understanding the biology of LFA-1 and its mechanobiology is important for studying immunological synapses and pathologies related to LFA-1 dysregulation.

TRENDS IN IMMUNOLOGY (2021)

Article Biophysics

A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes

Alexander Hornung et al.

BIOPHYSICAL JOURNAL (2020)

Review Biochemistry & Molecular Biology

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

Jeong-Ryul Hwang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Cell Biology

LFA-1 signals to promote actin polymerization and upstream migration in T cells

Nathan H. Roy et al.

JOURNAL OF CELL SCIENCE (2020)

Review Chemistry, Multidisciplinary

The CAR T-Cell Mechanoimmunology at a Glance

Rui Li et al.

ADVANCED SCIENCE (2020)

Article Biochemistry & Molecular Biology

Stuck on sugars - how carbohydrates regulate cell adhesion, recognition, and signaling

Richard D. Cummings

GLYCOCONJUGATE JOURNAL (2019)

Article Multidisciplinary Sciences

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

A. J. Davenport et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

LFA-1 in T Cell Migration and Differentiation

Brandon L. Walling et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Cell Biology

The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse

Nathan H. Roy et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Article Multidisciplinary Sciences

Integrin extension enables ultrasensitive regulation by cytoskeletal force

Jing Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Pontus Nordenfelt et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

Integrin-based therapeutics: biological basis, clinical use and new drugs

Klaus Ley et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

Zhichao Fan et al.

NATURE COMMUNICATIONS (2016)

Article Immunology

T cell migration, search strategies and mechanisms

Matthew F. Krummel et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Immunology

Blocking neutrophil integrin activation prevents ischemia-reperfusion injury

Tadayuki Yago et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Multidisciplinary Sciences

An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding

Sebanti Gupta et al.

SCIENTIFIC REPORTS (2015)

Article Immunology

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Arash Grakoui et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Immunology

Leukocyte Migration into Inflamed Tissues

Sussan Nourshargh et al.

IMMUNITY (2014)

Article Multidisciplinary Sciences

Neutrophils scan for activated platelets to initiate inflammation

Vinatha Sreeramkumar et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

Feng Ye et al.

CURRENT BIOLOGY (2013)

Review Cell Biology

Talins and kindlins: partners in integrin-mediated adhesion

David A. Calderwood et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Cell Biology

Integrin inside-out signaling and the immunological synapse

Timothy A. Springer et al.

CURRENT OPINION IN CELL BIOLOGY (2012)

Article Cell Biology

Talin activates integrins by altering the topology of the β transmembrane domain

Chungho Kim et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Immunology

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels

Young-Min Hyun et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Article Multidisciplinary Sciences

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

David T. Moore et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Pathology

Mechanisms of Leukocyte Transendothelial Migration

William A. Muller

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)

Article Biochemistry & Molecular Biology

Regulation of integrin affinity on cell surfaces

Thomas Schuerpf et al.

EMBO JOURNAL (2011)

Article Allergy

α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin

Hanako Ohmatsu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Review Cell Biology

The final steps of integrin activation: the end game

Sanford J. Shattil et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Cell Biology

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

Sussan Nourshargh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biophysics

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

David R. Critchley

Annual Review of Biophysics (2009)

Review Immunology

The Ins and Outs of Leukocyte Integrin Signaling

Clare L. Abram et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

Nicholas J. Anthis et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium

Joanna C. Porter et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

Nicholas J. Anthis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

LFA-1 Regulates CD8+ T Cell Activation via T Cell Receptor-mediated and LFA-1-mediated Erk1/2 Signal Pathways

Dan Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Immunology

A molecular trio in relapse and remission in multiple sclerosis

Lawrence Steinman

NATURE REVIEWS IMMUNOLOGY (2009)

Review Immunology

T-cell activation through immunological synapses and kinapses

Michael L. Dustin

IMMUNOLOGICAL REVIEWS (2008)

Article Immunology

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo

Natalie A. Bezman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell

Paula Stanley et al.

EMBO JOURNAL (2008)

Article Immunology

Transcellular diapedesis is initiated by invasive podosomes

Christopher V. Carman et al.

IMMUNITY (2007)

Article Biochemistry & Molecular Biology

Structural basis of integrin activation by talin

Kate L. Wegener et al.

Article Immunology

Talin1 regulates TCR-mediated LFA-1 function

William T. N. Simonson et al.

JOURNAL OF IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes

Motomu Shimaoka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Immunology

CD4 T cells integrate signals delivered during successive DC encounters in vivo

S Celli et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Review Immunology

Intracellular signalling controlling integrin activation in lymphocytes

T Kinashi

NATURE REVIEWS IMMUNOLOGY (2005)

Article Multidisciplinary Sciences

Distinct role of lymphocyte fuinction-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes

N Anikeeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Talin binding to integrin β tails:: A final common step in integrin activation

S Tadokoro et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

Structural determinants of integrin recognition by Talin

B Garcia-Alvarez et al.

MOLECULAR CELL (2003)

Article Biochemistry & Molecular Biology

The phosphotyrosine binding-like domain of talin activates Integrins

DA Calderwood et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes

S Fagerholm et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Coupling of the TCR to integrin activation by SLAP-130/Fyb

EJ Peterson et al.

SCIENCE (2001)

Article Multidisciplinary Sciences

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

G Servant et al.

SCIENCE (2000)

Article Cell Biology

Actin machinery: pushing the envelope

GG Borisy et al.

CURRENT OPINION IN CELL BIOLOGY (2000)