Quanty-cFOS, a Novel ImageJ/Fiji Algorithm for Automated Counting of Immunoreactive Cells in Tissue Sections

Article Multidisciplinary Sciences

Fos ensembles encode and shape stable spatial maps in the hippocampus

Noah L. Pettit et al.

Summary: Fos-induced cells contribute to accurate, stable and spatially uniform place codes in the hippocampus and Fos itself has a causal role in shaping these place codes.

NATURE (2022)

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Article Computer Science, Interdisciplinary Applications

An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO plus and Light Sheet Fluorescence Microscopy

Johanna Perens et al.

Summary: In recent years, advances in whole-brain immunolabelling and LSFM have led to the development of an optimized digital mouse brain atlas for more accurate and efficient registration of neuronal activity patterns. This atlas has shown to be beneficial in mapping changes in c-Fos expression and evaluating drug effects on whole-brain activity, providing a valuable tool for neuroscience research.

NEUROINFORMATICS (2021)

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Article Biochemical Research Methods

Cellpose: a generalist algorithm for cellular segmentation

Carsen Stringer et al.

Summary: Cellpose is a generalist, deep learning-based segmentation method that can precisely segment cells from various types of images without requiring retraining or parameter adjustments. It was trained on a highly diverse image dataset and supports a three-dimensional extension. Software has been developed to support community contributions to the training data.

NATURE METHODS (2021)

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Article Neurosciences

Repetitive non-invasive prefrontal stimulation reverses neuropathic pain via neural remodelling in mice

Zheng Gan et al.

Summary: Non-invasive, repetitive direct anodal current transcranial stimulation of the prefrontal cortex exerted long-lasting analgesic effects in mice with neuropathic pain, reversing established allodynia and affecting basal activity and responsiveness of distant areas. The study provides valuable insights into the neural mechanisms of prefrontal tDCS in neuropathic pain, highlighting the potential for non-invasive transcranial stimulation paradigms to achieve pain relief in chronic states.

PROGRESS IN NEUROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Democratising deep learning for microscopy with ZeroCostDL4Mic

Lucas von Chamier et al.

Summary: ZeroCostDL4Mic is an entry-level platform that simplifies access to deep learning by leveraging the free, cloud-based computational resources of Google Colab. Researchers can train and apply key deep learning networks for various microscopy tasks without coding expertise. The platform provides quantitative tools for model evaluation and optimization.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences