Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART

Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we consider the role of the development of mitochondrial dysfunction in the progression of HIV (human immunodeficiency viruses) infection and the onset of AIDS (acquired immunodeficiency syndrome), as well as the direct impact of HIV on mitochondria. In addition, we will touch upon such an important issue as the effect of ART (Antiretroviral Therapy) drugs on mitochondria, since ART is currently the only effective way to curb the progression of HIV in infected patients, and because the identification of potential side effects can help to more consciously approach the development of new drugs in the treatment of HIV infection.

Automated summary

Mitochondrial dysfunction is observed in various chronic and infectious diseases, including HIV infection and AIDS. This review discusses the role of mitochondrial dysfunction in the progression of HIV infection, the impact of HIV on mitochondria, and the effects of Antiretroviral Therapy (ART) drugs on mitochondria.