Next-Generation Boron Drugs and Rational Translational Studies Driving the Revival of BNCT

BNCT is a high-linear-energy transfer therapy that facilitates tumor-directed radiation delivery while largely sparing adjacent normal tissues through the biological targeting of boron compounds to tumor cells. Tumor-specific accumulation of boron with limited accretion in normal cells is the crux of successful BNCT delivery. Given this, developing novel boronated compounds with high selectivity, ease of delivery, and large boron payloads remains an area of active investigation. Furthermore, there is growing interest in exploring the immunogenic potential of BNCT. In this review, we discuss the basic radiobiological and physical aspects of BNCT, traditional and next-generation boron compounds, as well as translational studies exploring the clinical applicability of BNCT. Additionally, we delve into the immunomodulatory potential of BNCT in the era of novel boron agents and examine innovative avenues for exploiting the immunogenicity of BNCT to improve outcomes in difficult-to-treat malignancies.

Automated summary

BNCT is a high-linear-energy transfer therapy that selectively delivers radiation to tumor cells while sparing normal tissues. The focus is on developing boronated compounds with high selectivity, ease of delivery, and large boron payloads. There is also interest in exploring the immunogenic potential of BNCT and utilizing it to improve outcomes in difficult-to-treat malignancies. This review covers the radiobiological and physical aspects of BNCT, traditional and next-generation boron compounds, as well as translational studies and innovative approaches for leveraging BNCT's immunogenicity.