☆ 4.6 Review

Crosstalk between Autophagy and RLR Signaling

CELLS (2023)

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Review Genetics & Heredity

Autophagy genes in biology and disease

Hayashi Yamamoto et al.

Summary: Macroautophagy and microautophagy are highly conserved cellular processes in eukaryotes that involve the degradation of cellular material in lysosomes. These processes are regulated by autophagy-related proteins and other molecules, with some shared components between the pathways. Recent advancements in technology have allowed for a better understanding of the functions of individual autophagy gene products and their implications in human disorders. Additionally, genome data has shed light on the evolution of autophagy genes and their origins in prokaryotes.

NATURE REVIEWS GENETICS (2023)

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Article Multidisciplinary Sciences

Stimulation of interferon-b responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists

Yasuha Arai et al.

Summary: Patients with severe COVID-19 exhibit elevated levels of cytokines and delayed interferon response. The study finds that SARS-CoV-2 generates excessive small viral RNAs encoding the 50 ends of positive-sense genes, which can stimulate the immune response. It suggests that RIG-I activation by accumulated SARS-CoV-2 50 end svRNAs may contribute to over-exuberant IFN production and the weaker immune response in less pathogenic coronaviruses may be due to lower svRNA production during replication.

ISCIENCE (2023)

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Review Cell Biology

The emerging mechanisms and functions of microautophagy

Liming Wang et al.

Summary: Microautophagy is a type of autophagy that involves the direct engulfment of cytoplasmic components by lysosomes and late endosomes. Although it has only recently emerged as an important cellular process, microautophagy plays a critical role in diseases and provides potential targets for intervention strategies.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

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Review Cell Biology

The mechanisms and roles of selective autophagy in mammals

Jose Norberto S. Vargas et al.

Summary: Autophagy is a process that degrades various intracellular elements, either non-selectively or selectively. Selective autophagy is involved in degrading specific targets such as damaged organelles, aggregated proteins, or invading bacteria, and plays a crucial role in cellular quality control. Recent progress in understanding the mechanisms of selective autophagy in mammals has the potential to enhance cellular quality control capabilities and alleviate pathology.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

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Review Biochemistry & Molecular Biology

Digest it all: the lysosomal turnover of cytoplasmic aggregates

Mario Mauthe et al.

Summary: Aggrephagy is the process of selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. Protein aggregates are polyubiquitinated and sequestered by autophagosomes. Soluble selective autophagy receptors (SARs) play a central role in aggrephagy by physically binding to ubiquitin and the autophagy machinery. Understanding the mechanism of aggrephagy can potentially lead to therapeutic strategies for preventing the buildup of potentially toxic protein aggregates.

TRENDS IN BIOCHEMICAL SCIENCES (2023)

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Review Cell Biology

Autophagic lysosome reformation in health and disease

Randini Nanayakkara et al.

Summary: This review provides an overview of the importance of lysosome reformation in maintaining autophagy function and the role of ALR dysfunction in various diseases.

AUTOPHAGY (2023)

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Article Cell Biology

AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability

Martina Di Rienzo et al.

Summary: The study revealed the critical role of AMBRA1 in controlling PINK1-PRKN mitophagy by interacting with ATAD3A and promoting PINK1 stability. This novel regulatory element may explain changes in PINK1 levels in neuropathological conditions.

AUTOPHAGY (2022)

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Review Cell Biology

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

Sheng Zhang et al.

Summary: Lipophagy is a form of selective autophagy that degrades intracellular lipid droplets, and it plays a significant role in regulating lipid storage, energy balance, and disease development and treatment.

CELL DEATH & DISEASE (2022)

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Article Biochemistry & Molecular Biology

Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense

Weihong Xie et al.

Summary: Our study identifies E3 ubiquitin ligase NEDD4 as a negative regulator of type I interferon signaling by targeting TBK1 for degradation at the late stage of viral infection. Mechanistically, NEDD4 catalyzes the K27-linked poly-ubiquitination of TBK1 at K344, providing a recognition signal for NDP52-mediated selective autophagic degradation. This reveals the regulatory role of NEDD4 in balancing TBK1-centered type I IFN activation and provides insights into the crosstalk between selective autophagy and antiviral signaling.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Cell Biology

Lipophagy at a glance

Micah B. Schott et al.

Summary: This article provides an overview of the molecular components of lipid droplets and the mechanisms of lipophagy. It also discusses the implications of impairment in lipophagy for disease states.

JOURNAL OF CELL SCIENCE (2022)

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Review Biochemistry & Molecular Biology

Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy

Ellen A. Goodall et al.

Summary: Selective autophagy plays a crucial role in maintaining cellular health by eliminating damaged or superfluous organelles and proteins through specific mechanisms. The attachment of ubiquitin to cargo is a common mechanism for initiating autophagy and a suite of ubiquitin-binding cargo receptors provide selectivity in cargo capture by recruiting the autophagosome initiation machinery. These emerging mechanisms shed light on how selectivity in cargo degradation is achieved in the field of autophagy research.

MOLECULAR CELL (2022)

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Article Microbiology

Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein

Damien Glon et al.

Summary: This study reveals the role of MT network and its acetylation level in BHRF1-induced evasion of innate immunity. BHRF1 induces MT hyperacetylation, which leads to clustering of mitochondria around the centrosome. ATAT1 interacts with BHRF1 and is necessary for the hyperacetylation and mito-aggresome formation. Dyneins are identified as motors required for mitochondrial clustering. The hyperacetylation of MTs is essential for BHRF1 to block IFN response and inhibit mitophagy.

PLOS PATHOGENS (2022)

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Article Biology

The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast

Houqing Yu et al.

Summary: Autophagy receptor proteins facilitate the destruction of organelles in response to cellular stress. However, the mechanism by which membrane-resident autophagy receptors induce selective autophagy in response to organelle-restricted signals is poorly understood. This study reveals that the ATPase activity of the Pex1/6 complex represses the activation of the pexophagy receptor Atg36 by the casein kinase Hrr25 in yeast cells. In addition, the study identifies a mechanism in which the exportomer complex represses the phosphorylation of Atg36 on Pex3 without the assistance of additional membrane factors. This mechanism prevents the induction of selective autophagy and provides insights into the regulation of organelle homeostasis.

ELIFE (2022)

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Review Microbiology

Targeting Selective Autophagy as a Therapeutic Strategy for Viral Infectious Diseases

Yishan Liu et al.

Summary: Selective autophagy plays a crucial role in host defense against viral infection, but viruses can also exploit this process to facilitate their replication. Understanding the intricate relationship between selective autophagy and viral infection is essential for developing novel antiviral therapeutic strategies.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy

Shan Sun et al.

Summary: Mitophagy, the autophagic clearance of mitochondria, is essential for maintaining mitochondrial homeostasis and cellular quality control. PINK1 and Parkin-mediated mitophagy has been implicated in the pathogenesis of neurodegenerative disorders. This study reveals that PHB2, an inner mitochondrial membrane receptor, is ubiquitinated by Parkin and gains higher affinity to the autophagosome during mitophagy, suggesting a novel model in which PHB2 serves as both a receptor and a ubiquitin-mediated base for efficient autophagosome recruitment.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

ER-phagy: selective autophagy of the endoplasmic reticulum

Keisuke Mochida et al.

Summary: Autophagy is a degradation system in eukaryotic cells that controls the mass and functions of organelles by degrading excess or defective portions. The endoplasmic reticulum (ER) is an organelle with specific functions that dynamically changes its mass and shape to maintain or regulate its functions. Elaborate mechanisms are required for the proper degradation of the ER.

EMBO REPORTS (2022)

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Article Cell Biology

Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

Xiaolian Cai et al.

Summary: OTUD3 plays opposite roles in response to RNA and DNA virus infection by removing distinct types of ubiquitination from RIG-I/MDA5 and cGAS, thereby regulating immune responses. OTUD3 can suppress RNA virus-triggered immunity and enhance DNA virus-triggered immunity.

CELL REPORTS (2022)

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Review Biochemistry & Molecular Biology

Orchestration of selective autophagy by cargo receptors

Elias Adriaenssens et al.

Summary: Selective autophagy is a crucial pathway for the removal of damaged material in cells and plays a key role in various neurodegenerative diseases. Cargo receptors act as multitasking tools in selective autophagy by recognizing cargo, recruiting autophagosome biogenesis machinery, and aligning membranes with cargo. Understanding the mechanisms of action of cargo receptors in the degradation of misfolded, ubiquitinated proteins, and damaged mitochondria can guide the development of future therapies.

CURRENT BIOLOGY (2022)

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Review Immunology

Regulation of the nucleic acid-sensing Toll-like receptors

Nicholas A. Lind et al.

Summary: Activation of nucleic acid-sensing Toll-like receptors is finely tuned to distinguish between self and foreign nucleic acids. The ligands for TLRs are mostly unique to microorganisms, but a subset can recognize nucleic acids present in both host and foreign microorganisms, potentially leading to self-recognition and autoimmune diseases. Research in defining the regulatory mechanisms for proper discrimination between foreign and self-nucleic acids by TLRs has revealed a complex array of mechanisms, categorized into compartmentalization, ligand availability, receptor expression, and signal transduction.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Cell Biology

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy

Wang Ruifang et al.

Summary: IAV infection induces mitophagy, with the PB1-F2 protein playing a key role in this process by translocating to mitochondria and interacting with TUFM and LC3B. PB1-F2-induced mitophagy leads to degradation of MAVS and suppression of type I interferon production, resulting in impaired cellular innate immunity, making it a potential therapeutic target.

AUTOPHAGY (2021)

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Article Cell Biology

Induction of autophagy and suppression of type I IFN secretion by CSFV

Baoming Xie et al.

Summary: The study revealed that CSFV infection inhibits the phosphorylation of MTOR leading to autophagy initiation. The MAPK/ERK signaling pathway is involved in CSFV-induced autophagy. CSFV non-structural protein NS5A induced autophagy through the CAMKK2-PRKAA-MTOR signaling pathway.

AUTOPHAGY (2021)

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Article Cell Biology

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression

Yaoxing Wu et al.

Summary: IRF3, a critical transcription factor in antiviral innate immune signaling, is regulated by CALCOCO2 and PSMD14. CALCOCO2 promotes autophagic degradation of IRF3, while PSMD14 prevents such degradation, maintaining IRF3 activity and fine-tuning immune response against viral infection.

AUTOPHAGY (2021)

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Article Cell Biology

HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation

Juan Liu et al.

Summary: This study identified HFE as a key negative regulator of RLR-mediated type I IFNs signaling during RNA virus infection, revealing a novel role of selective autophagy in innate antiviral immune response regulated by the iron metabolism-related gene Hfe.

AUTOPHAGY (2021)

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Article Cell Biology

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Panpan Hou et al.

Summary: CCDC50 is a newly discovered autophagy receptor that negatively regulates the type I interferon signaling pathway by targeting K63-polyubiquitinated RLRs for autophagic degradation, which enhances viral resistance and survival rates in mouse models.

CELL RESEARCH (2021)

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Review Immunology

Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

Koji Onomoto et al.

Summary: RLRs are RNA sensor molecules that play essential roles in innate antiviral immunity by inducing downstream signaling via interactions with various host and viral factors. The signaling mediated by RLRs is regulated by interactions with endogenous RNAs and host proteins, and deregulation can lead to autoimmune and autoinflammatory disorders.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Cell Biology

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

Guangyan Miao et al.

Summary: ORF3a of the COVID-19 virus SARS-CoV-2 inhibits autophagy activity by blocking fusion of autophagosomes/amphisomes with lysosomes. This leads to accumulation of autophagosomes/amphisomes, impaired lysosome function, and ultimately blocks autophagy process.

DEVELOPMENTAL CELL (2021)

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Review Biochemistry & Molecular Biology

Beyond Autophagy: The Expanding Roles of ATG8 Proteins

Jose L. Nieto-Torres et al.

Summary: The ATG8 family proteins are key players in autophagy, participating in cargo recruitment, biogenesis, transport, and fusion with lysosomes. Recent studies have shown their involvement in diverse processes such as vesicle maturation and cargo specification, with complex regulatory mechanisms that are still not fully understood. Individual roles of different ATG8 family members in canonical or non-canonical pathways remain unclear. This review highlights the molecular questions surrounding ATG8s that are only beginning to be explored.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

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Article Microbiology

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng et al.

Summary: The PB1 protein of H7N9 influenza virus was identified as a novel negative regulator that enhances the degradation of MAVS, inhibiting the innate immune antiviral response and facilitating virus replication. This PB1-RNF5-MAVS-NBR1 axis provides insights into flu viruses' evasion strategy involving selective autophagy and innate signaling pathways.

PLOS PATHOGENS (2021)

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Article Multidisciplinary Sciences

The autophagy protein ATG9A enables lipid mobilization from lipid droplets

Elodie Mailler et al.

Summary: ATG9A is a transmembrane protein involved in lipid mobilization, essential for autophagosome expansion, mitochondrial fatty acid import, and beta-oxidation. Depletion of ATG9A inhibits autophagy, increases lipid droplet size/number, and blocks transfer of fatty acids to mitochondria. ATG9A localizes to vesicular-tubular clusters associated with TMEM41B and plays a critical role in lipid mobilization from lipid droplets to autophagosomes and mitochondria.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

Yu-Jie Chen et al.

Summary: The degradation of misfolded proteins from the endoplasmic reticulum is crucial for cellular protein homeostasis. The ER membrane protein PGRMC1 binds to misfolded prohormones and targets them for degradation through the ER-phagy pathway. This finding suggests that PGRMC1 could be a potential therapeutic target for diabetes.

NATURE COMMUNICATIONS (2021)

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Editorial Material Cell Biology

Bidirectional interconversion between PtdIns4P and PtdIns(4,5)P2 is required for autophagic lysosome reformation and protection from skeletal muscle disease

Matthew J. Eramo et al.

Summary: Autophagic lysosome reformation (ALR) is crucial for recycling autophagy membranes to form lysosomes. INPP5K, an enzyme that converts PtdIns(4,5)P-2 to PtdIns4P, plays a key role in this process in skeletal muscle. Mutations in INPP5K can lead to muscular dystrophy by disrupting ALR and lysosome homeostasis in muscles.

AUTOPHAGY (2021)

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Article Multidisciplinary Sciences

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Alexey Stukalov et al.

Summary: The study reports a concurrent multi-omics analysis of SARS-CoV-2 and SARS-CoV, revealing both distinct and common molecular mechanisms between these closely related coronaviruses, as well as their impact on the host cell proteome. The results of this study may provide insights into the design of virus- and host-directed therapies for these coronaviruses.

NATURE (2021)

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Review Biochemistry & Molecular Biology

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

Jaclyn Quin et al.

Summary: Modified bases on cellular RNAs act as markers to distinguish endogenous RNA from foreign RNA, reducing innate immune responses. ADARs and other modified bases play important roles in innate immunity and cancer.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

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Article Microbiology

Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections

Christian K. Pfaller et al.

Summary: C6 deamination of adenosine to inosine in dsRNA is catalyzed by ADARs enzymes encoded by three genes in mammals. Different ADAR1 proteins, p150 and p110, are produced through alternative promoters and splicing, with ADAR2 being a nuclear enzyme. A-to-I editing occurs in both viral and cellular RNAs, with activity dependent on substrate structure and regulatory RNA-binding proteins.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Article Cell Biology

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Yabin Zhang et al.

Summary: The study identified that ORF3a protein of SARS-CoV-2 inhibits autophagic flux by blocking fusion of autophagosomes with lysosomes. This mechanism helps the virus evade degradation, and further research may lead to strategies targeting autophagy to combat the spread of SARS-CoV-2.

CELL DISCOVERY (2021)

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Review Cell Biology

Membrane supply and remodeling during autophagosome biogenesis

Ruben Gomez-Sanchez et al.

Summary: This review highlights recent advances in understanding the intracellular membrane sources and lipid delivery mechanisms involved in autophagosome biogenesis, emphasizing the importance of vesicular transport and membrane contact sites. Furthermore, it discusses the crucial role of lipid biosynthesis and lipid remodeling events in both phagophore nucleation and expansion.

CURRENT OPINION IN CELL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan

Akihiro Yamada et al.

Summary: FBXO2 acts as a specific substrate receptor for recognizing the GlcNAc side chains of GAS surface carbohydrates and promoting ubiquitin-mediated xenophagy. The SCF components are essential for the ubiquitin-mediated xenophagy against GAS.

EMBO REPORTS (2021)

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Review Cell Biology

Machinery, regulation and pathophysiological implications of autophagosome maturation

Yan G. Zhao et al.

Summary: Autophagosome maturation is a crucial process for maintaining cellular homeostasis and autophagic degradation, involving a variety of regulatory factors working together. Its dysregulation is associated with neurodegenerative disorders, muscle diseases, cancer, and the survival of invading pathogens.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection

Joshua Ames et al.

Summary: The study demonstrates that the autophagy receptor OPTN plays a crucial neuroprotective role during HSV-1 infection by degrading viral proteins, preventing virus spread and neuronal necroptosis. Lack of OPTN leads to cognitive decline and susceptibility to lethal CNS infection in mice, indicating its importance in survival from potentially deadly viral infections.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

The RNA sensor MDA5 detects SARS-CoV-2 infection

Natalia G. Sampaio et al.

Summary: Research has identified MDA5 as a cellular sensor for SARS-CoV-2 infection that induces type I and III IFNs, which can inhibit viral replication, but does not affect the induction of IL6 and TNF.

SCIENTIFIC REPORTS (2021)

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Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Alexiane Decout et al.

Summary: The cGAS-STING signaling pathway plays a crucial role in inflammation in infection, cellular stress, and tissue damage settings. It has the ability to sense and regulate cellular responses to DNA and has the potential to be targeted in the treatment of various inflammatory diseases.

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PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

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Ribosome Abundance Control Via the Ubiquitin-Proteasome System and Autophagy

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Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

Terje Johansen et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Repair or Lysophagy: Dealing with Damaged Lysosomes

Chrisovalantis Papadopoulos et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Autophagosome-Lysosome Fusion

Peter Lorincz et al.

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Article Cell Biology

Dual targeting of RIG-I and MAVS by MARCH5 mitochondria ubiquitin ligase in innate immunity

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ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

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Toll-like Receptors and the Control of Immunity

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Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles

Thomas A. Ryan et al.

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Autophagosome biogenesis: From membrane growth to closure

Thomas J. Melia et al.

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Manipulation of selective macroautophagy by pathogens at a glance

Yingying Cong et al.

JOURNAL OF CELL SCIENCE (2020)

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Autophagosome biogenesis and human health

Tsuyoshi Kawabata et al.

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Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

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Inflammasome activation and regulation: toward a better understanding of complex mechanisms

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Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation

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Microautophagy - distinct molecular mechanisms handle cargoes of many sizes

Sebastian Schuck

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NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes

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The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

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Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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RIG-I-like receptors: their regulation and roles in RNA sensing

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CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation

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ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

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Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses

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The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

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Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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Decoding type I and III interferon signalling during viral infection

Emily Mesev et al.

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Diverse Cellular Roles of Autophagy

Hideaki Morishita et al.

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TEX264 is a major receptor for mammalian reticulophagy

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Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

Maria Zachari et al.

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RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

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A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

Qiyao Chai et al.

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Interferon-Stimulated Genes: What Do They All Do?

John W. Schoggins

ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019 (2019)

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LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation

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Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

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Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

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Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

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Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts

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Subversion of cellular autophagosomal machinery by RNA viruses

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

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Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

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Formation of the ∼350-kDa Apg12-Apg5•Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

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The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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