4.6 Review

Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Physiology

Androgen-deprivation therapy with leuprolide increases abdominal adiposity without causing cardiac dysfunction in middle-aged male mice: effect of sildenafil

Lei Xi et al.

Summary: Androgen-deprivation therapy (ADT) is the primary systemic therapy for advanced or metastatic prostate cancer (PCa), but it may cause metabolic and cardiovascular adverse events. In this study, a murine model of ADT was established using a gonadotropin-releasing hormone (GnRH) agonist leuprolide, and the effects on metabolism and cardiac function were investigated. The results showed that long-term ADT with leuprolide increased abdominal adiposity and cardiac injury biomarker levels, and sildenafil did not prevent these adverse changes.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2023)

Article Oncology

Androgen Deprivation Therapy and Risk of Cardiovascular Disease in Patients With Prostate Cancer Based on Existence of Cardiovascular Risk

Alice Dragomir et al.

Summary: This study evaluated the risk of cardiovascular disease (CVD) associated with gonadotropin-releasing hormone (GnRH) agonists versus GnRH antagonist in patients with prostate cancer. The results showed that the use of GnRH antagonist decreased the risk of heart failure in patients with prior CVD, and decreased the risk of ischemic heart disease in patients without prior CVD but increased the risk of arrhythmia.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2023)

Article Endocrinology & Metabolism

Adverse metabolic consequences of androgen deprivation therapy (ADT) on Asian patients with prostate cancer: Primary results from the real-life experience of ADT in Asia (READT) study

Chris H. M. Wong et al.

Summary: This study investigated the adverse effects of androgen deprivation therapy (ADT) on metabolic parameters in an Asian population. The results showed that ADT was associated with changes in glycemic profiles, lipid profiles, and body weight, which could be observed early in treatment and may persist beyond the first year.

PROSTATE (2023)

Article Oncology

Genomic Testing in Localized Prostate Cancer Can Identify Subsets of African Americans With Aggressive Disease

Shivanshu Awasthi et al.

Summary: This study finds that African American men with prostate cancer have a higher risk of genetic risk reclassification compared to non-African American men. Integrating genomic classifiers with clinical risk classification can help identify African American men with localized prostate cancer who have a high genomic risk of early metastatic disease.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2022)

Review Urology & Nephrology

Differential Impact of Gonadotropin-releasing Hormone Antagonist Versus Agonist on Clinical Safety and Oncologic Outcomes on Patients with Metastatic Prostate Cancer: A Meta-analysis of Randomized Controlled Trials

Mohammad Abufaraj et al.

Summary: GnRH antagonists show better safety profiles in terms of overall mortality and cardiovascular events compared to agonists, but have higher rates of injection site reactions.

EUROPEAN UROLOGY (2021)

Article Oncology

Cardiac biomarkers in patients with prostate cancer and cardiovascular disease receiving gonadotrophin releasing hormone agonist vs antagonist

David Margel et al.

Summary: Analysis of prostate cancer patients receiving androgen deprivation therapy (ADT) showed a potential association between increased levels of NTproBNP and hsTn and the development of new cardiovascular (CV) events. This study suggests that the use of cardiac biomarkers may be useful in predicting CV risk in patients receiving ADT, although further validation through larger studies is needed.

PROSTATE CANCER AND PROSTATIC DISEASES (2021)

Article Urology & Nephrology

Cardiovascular risk profiles of GnRH agonists and antagonists: real-world analysis from UK general practice

Patrick Davey et al.

Summary: This study analyzed real-world data from UK primary care setting and found that the GnRH antagonist degarelix had a significantly lower risk of cardiac events compared to GnRH agonists. Patients who received degarelix as first-line treatment switched treatment more frequently to GnRH agonists than those who initiated treatment with a GnRH agonist.

WORLD JOURNAL OF UROLOGY (2021)

Review Oncology

Cardiovascular Toxicities of Androgen Deprivation Therapy

Azariyas A. Challa et al.

Summary: Prostate cancer is the second leading cause of cancer death in men, with cardiovascular disease being the top cause of death in prostate cancer patients. Studies have shown that GnRH antagonists may have a lower cardiovascular risk compared to agonists. Additionally, racial disparities in cardiovascular outcomes among prostate cancer patients are being explored.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

Review Oncology

Relugolix, an oral gonadotropin-releasing hormone antagonist for the treatment of prostate cancer

Daniel J. George et al.

Summary: Relugolix, a GnRH receptor antagonist, reduces testosterone levels without an initial increase, and has been shown in clinical studies to lower testosterone levels more quickly than leuprolide acetate. Men treated with relugolix also have a lower risk of heart attacks, strokes, and death compared to those treated with leuprolide acetate. This new treatment option offers a faster recovery of testosterone levels post-treatment.

FUTURE ONCOLOGY (2021)

Article Endocrinology & Metabolism

Gonadotropin-releasing hormone antagonist associated with lower cardiovascular risk compared with gonadotropin-releasing hormone agonist in prostate cancer: A nationwide cohort and in vitro study

Dong-Yi Chen et al.

Summary: The study found that compared to patients treated with GnRHa, patients with prostate cancer treated with GnRH antagonists had a lower risk of cardiovascular events, which may be attributed to effects on macrophages.

PROSTATE (2021)

Review Cardiac & Cardiovascular Systems

Cardiovascular Toxicity of Androgen Deprivation Therapy

Julia Boland et al.

Summary: ADT, particularly using GnRH agonists, increases the risk of cardiovascular disease, while GnRH antagonists have relatively fewer cardiovascular adverse effects. Recent phase III clinical trial on the GnRH antagonist, relugolix, suggests its comparative benefit to traditional GnRH agonists in terms of cardiovascular outcomes. Further data with primary cardiovascular outcomes are needed to confirm the potential advantages of GnRH antagonists over GnRH agonists in ADT for PC.

CURRENT CARDIOLOGY REPORTS (2021)

Review Endocrinology & Metabolism

Does Exist a Differential Impact of Degarelix Versus LHRH Agonists on Cardiovascular Safety? Evidences From Randomized and Real-World Studies

Alessandro Sciarra et al.

Summary: The main systemic therapy for hormone-sensitive prostate cancer is androgen deprivation therapy, with LHRH agonists and GnRH antagonists showing differences in inducing castration and impacting cardiovascular risk in patients.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Oncology

Relugolix: a novel androgen deprivation therapy for management of patients with advanced prostate cancer

Fred Saad et al.

Summary: Relugolix, the newest GnRH antagonist, offers rapid and sustained castration without the testosterone surge seen with LHRH agonists, potentially reducing the need for additional anti-androgen therapy. Data from phase III studies also suggest improved cardiovascular safety profile compared to traditional LHRH agonists, indicating a potential new standard of care for prostate cancer management.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

Review Hematology

Cardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer: Contemporary Meta-Analyses

Jiun-Ruey Hu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Article Medicine, General & Internal

Cardiovascular risk with androgen deprivation therapy

Matt T. Rosenberg

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2020)

Article Health Care Sciences & Services

Cardiovascular Risk Profile in Prostate Cancer Patients Treated with GnRH Agonists versus Antagonists: An Italian Real-World Analysis

Valentina Perrone et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2020)

Article Medicine, General & Internal

Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer

Neal D. Shore et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Update on cardiovascular and metabolic risk profiles of hormonal agents used in managing advanced prostate cancer

Celestia S. Higano

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2020)

Article Public, Environmental & Occupational Health

Prostate Cancer Incidence and Survival, by Stage and Race/Ethnicity — United States, 2001–2017

David A. Siegel et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Article Urology & Nephrology

The Long-Term Risks of Metastases in Men on Active Surveillance for Early Stage Prostate Cancer

Martina Maggi et al.

JOURNAL OF UROLOGY (2020)

Article Cardiac & Cardiovascular Systems

Cardiovascular Complications of Prostate Cancer Therapy

Courtney M. Campbell et al.

CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Cardiovascular Complications of Prostate Cancer Therapy

Courtney M. Campbell et al.

CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE (2020)

Article Oncology

Midlife metabolic factors and prostate cancer risk in later life

Barbra A. Dickerman et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Oncology

The Cardiovascular Toxicity of Abiraterone and Enzalutamide in Prostate Cancer

Roberto Iacovelli et al.

CLINICAL GENITOURINARY CANCER (2018)

Article Cardiac & Cardiovascular Systems

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals

Valerie D. Myers et al.

JAMA CARDIOLOGY (2018)

Article Urology & Nephrology

Cardiovascular Diseases in African Americans: Fostering Community Partnersnips to Stem the Tide

George A. Mensah

AMERICAN JOURNAL OF KIDNEY DISEASES (2018)

Article Oncology

Treatment of men with high-risk prostate cancer based on race, insurance coverage, and access to advanced technology

Robert Steven Gerhard et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2017)

Article Urology & Nephrology

African-American Prostate Cancer Disparities

Zachary L. Smith et al.

CURRENT UROLOGY REPORTS (2017)

Article Oncology

Body size across the life course and prostate cancer in the Health Professionals Follow-up Study

Elisabeth Moller et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Review Peripheral Vascular Disease

Ethnic Minorities and Coronary Heart Disease: an Update and Future Directions

J. Adam Leigh et al.

CURRENT ATHEROSCLEROSIS REPORTS (2016)

Review Oncology

Metabolic syndrome in prostate cancer: impact on risk and outcomes

Fatima H. Karzai et al.

FUTURE ONCOLOGY (2016)

Article Urology & Nephrology

Cardiovascular risk after androgen deprivation therapy for prostate cancer: an Asian perspective

Jeremy Yuen Chun Teoh et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2016)

Article Cardiac & Cardiovascular Systems

Differences in Hypercholesterolemia and Atherogenesis Induced by Common Androgen Deprivation Therapies in Male Mice

Christian Bo Poulsen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Oncology

The effect of smoking on prostate cancer survival: a cohort analysis in Barcelona

Cristiane Murta-Nascimento et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2015)

Article Oncology

Serum Lipid Profile and Risk of Prostate Cancer Recurrence: Results from the SEARCH Database

Emma H. Allott et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

Article Urology & Nephrology

Cardiovascular Morbidity Associated with Gonadotropin Releasing Hormone Agonists and an Antagonist

Peter C. Albertsen et al.

EUROPEAN UROLOGY (2014)

Article Oncology

Genes Associated with Prostate Cancer Are Differentially Expressed in African American and European American Men

Isaac J. Powell et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2013)

Article Biochemistry & Molecular Biology

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c

Leonard C. Edelstein et al.

NATURE MEDICINE (2013)

Article Endocrinology & Metabolism

Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men

Matthias Moehlig et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)

Review Medicine, General & Internal

Association of Androgen Deprivation Therapy With Cardiovascular Death in Patients With Prostate Cancer A Meta-analysis of Randomized Trials

Paul L. Nguyen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Cardiac & Cardiovascular Systems

Community Prevalence of Ideal Cardiovascular Health, by the American Heart Association Definition, and Relationship With Cardiovascular Disease Incidence

Aaron R. Folsom et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Article Oncology

Race, healthcare access and physician trust among prostate cancer patients

Young Kyung Do et al.

CANCER CAUSES & CONTROL (2010)

Article Oncology

Body Size and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Tobias Pischon et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

Article Oncology

Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer

Nancy L. Keating et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

Article Endocrinology & Metabolism

Insulin sensitivity during combined androgen blockade for prostate cancer

MR Smith et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Oncology

Cancer statistics, 2006

A Jemal et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2006)

Article Medicine, General & Internal

Risk of fracture after androgen deprivation for prostate cancer

VB Shahinian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)