☆ 4.6 Review

Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge

CANCERS (2023)

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Summary: This study examined the secular trends, age-period-cohort effects, and geographical differences in gastric cancer mortality in Korea. The results showed a decline in gastric cancer mortality among both men and women from 2000 to 2020, mainly attributable to birth cohort effects rather than period effects. Spatial analysis revealed high gastric cancer mortality in the central and eastern regions of Korea.

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Gastric Cancer Risk Was Associated with Dietary Factors Irritating the Stomach Wall: A Case-Control Study in Korea

Sang Young Kim et al.

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NUTRIENTS (2022)

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Yong Lu et al.

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GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists

S. V. S. Deo et al.

Summary: Cancer is becoming a major global public health challenge, with the burden of cancer increasing globally according to the GLOBOCAN 2020 report which estimates the occurrence of 36 cancers in 185 countries. There are global disparities in cancer incidence and mortality in different geographic regions, and the human development index (HDI) also affects cancer incidence and projected global burden. Surgical oncologists play a crucial role in future global cancer control strategies.

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Hung Xuan Le et al.

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Time Trend of Upper Gastrointestinal Cancer Incidence in China from 1990 to 2019 and Analysis Using an Age-Period-Cohort Model

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Sin Hye Park et al.

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Weiwei Zheng et al.

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Population Attributable Fraction of Helicobacter pylori Infection-Related Gastric Cancer in Korea: A Meta-Analysis

Yoon Park et al.

Summary: The study aimed to determine the proportion of gastric cancer attributable to Helicobactor pylori in the Korean population, with men having a higher incidence rate than women. The estimated prevalence of H. pylori infection was 76.4% in men and 71.9% in women, contributing to 34.5% and 33.2% of gastric cancer cases in men and women respectively.

CANCER RESEARCH AND TREATMENT (2021)

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FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma

U. Sahin et al.

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ANNALS OF ONCOLOGY (2021)

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Current treatment and recent progress in gastric cancer

Smita S. Joshi et al.

Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis

Masoud Keikha et al.

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BMC GASTROENTEROLOGY (2021)

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Zhi Peng et al.

Summary: The study reported the efficacy and safety of a novel anti-HER2 antibody RC48 in patients with HER2-overexpressing gastric cancer, showing promising therapeutic activity and manageable safety, suggesting potential application in patients who have previously received at least two lines of chemotherapy.

CANCER COMMUNICATIONS (2021)

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Temporal trend of gastric cancer burden along with its risk factors in China from 1990 to 2019, and projections until 2030: comparison with Japan, South Korea, and Mongolia

Xiaorong Yang et al.

Summary: The study found that while the age-standardized rates of gastric cancer have decreased in most countries, the absolute burden of gastric cancer is gradually increasing, especially in countries like China and Mongolia. Smoking and high-sodium diet have been identified as the main risk factors contributing to gastric cancer occurrence over the past 30 years.

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Chinese and global burdens of gastric cancer from 1990 to 2019

Yuxin He et al.

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CANCER MEDICINE (2021)

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LANCET (2021)

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C. R. Akshatha et al.

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Ngoc-Lan Thi Nguyen et al.

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FRONTIERS IN ONCOLOGY (2021)

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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021

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CANCER COMMUNICATIONS (2021)

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Global Incidence and Mortality of Gastric Cancer, 1980-2018

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JAMA NETWORK OPEN (2021)

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Risk of gastric cancer development after eradication of Helicobacter pylori

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Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease

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Education and cancer incidence in a rural population in south India

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Helicobacter pylori virulence factors in gastric carcinogenesis

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Seroprevalence and ethnic differences in Helicobacter pylori infection among adults in the United States

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