☆ 4.6 Review

The Role of the Gut Microbiome in Cancer Immunotherapy: Current Knowledge and Future Directions

CANCERS (2023)

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Article Multidisciplinary Sciences

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Katherine M. Kennedy et al.

Summary: The colonization of microbial communities in the human fetus and the prenatal intrauterine environment is still controversial. Recent studies analyzing microbial populations in human fetuses indicate that the detected signals might be due to contamination during sample collection or DNA sequencing processes. The presence of live and replicating microbial populations in healthy fetal tissues contradicts fundamental concepts in immunology and clinical microbiology. This has significant implications for our understanding of human immune development and highlights the challenges in studying microbial communities in low-biomass environments.

NATURE (2023)

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Article Microbiology

Consistent Stool Metagenomic Biomarkers Associated with the Response To Melanoma Immunotherapy

Evgenii I. I. Olekhnovich et al.

Summary: In this study, a list of potentially beneficial bacteria associated with melanoma immunotherapy responsiveness was compiled. Functional biomarkers of immunotherapy responsiveness were also identified and found to be dispersed among different bacterial species. These findings contribute to understanding the relationship between gut microbiome composition and treatment response, and have implications for the development of diagnostic tests and recommendations for gut microbiome correction in cancer immunotherapy.

MSYSTEMS (2023)

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Article Oncology

Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma

Jedd D. Wolchok et al.

Summary: The 6.5-year results of the CheckMate 067 trial demonstrate durable clinical benefits with nivolumab plus ipilimumab or nivolumab monotherapy compared to ipilimumab alone in patients with advanced melanoma.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Microbiology

Microbiome-based therapeutics

Matthew T. Sorbara et al.

Summary: Microbiome-based therapeutics have the potential to reduce disease susceptibility and enhance disease resistance. This review discusses the major bacterial phyla associated with health benefits and explores various microbiome-based therapeutics, including fecal microbiota transplantation, bacterial consortia, engineered symbiotic bacteria, and diet and prebiotics. It also highlights the challenges in therapeutic development and regulatory hurdles for clinical trials and manufacturing.

NATURE REVIEWS MICROBIOLOGY (2022)

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Review Microbiology

Recent Advances in Understanding the Structure and Function of the Human Microbiome

Walaa K. Mousa et al.

Summary: This article discusses the composition of the human microbiome, the relationship between microbiome dysbiosis and diseases, and the opportunities for new microbiome-based therapeutics. Despite significant advances in microbiome research, our understanding is limited due to the personalized nature of the microbiome and its complex interactions with the host.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Immunology

Factors Determining Long-Term Antitumor Responses to Immune Checkpoint Blockade Therapy in Melanoma

Kimberly Loo et al.

Summary: This review aims to explore the long-term survival of melanoma patients treated with immune checkpoint blockade (ICB) therapy and identify prognostic and predictive factors. The review also discusses the use of ICB combinations, retreatment with ICB, and patterns of ICB resistance based on sites of disease.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Effects of Concomitant Antibiotics Use on Immune Checkpoint Inhibitor Efficacy in Cancer Patients

Shuai Jiang et al.

Summary: This study elucidates the relationship between antibiotic treatment and the survival rates of cancer patients receiving immune checkpoint inhibitor therapy. The results indicate that antibiotic treatment is significantly associated with worse progression-free survival and overall survival.

FRONTIERS IN ONCOLOGY (2022)

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Editorial Material Biotechnology & Applied Microbiology

Next steps after 15 stimulating years of human gut microbiome research

Thomas Clavel et al.

Summary: Gut microbiome research has advanced significantly in the past 15 years, but there are still many unanswered questions about enteric microbial ecosystems. In the next 15 years, besides continuing research, organizational measures will also need to be taken to optimize the outcomes of discoveries.

MICROBIAL BIOTECHNOLOGY (2022)

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Article Oncology

Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy

Hirotaka Kawanabe-Matsuda et al.

Summary: This study demonstrated that dietary consumption of exopolysaccharide produced by Lactobacillus can induce CCR6(+) CD8(+) T cells in Peyer's patches, improving the tumor microenvironment and enhancing the therapeutic effects of immune-checkpoint blockade against CCL20-producing tumors.

CANCER DISCOVERY (2022)

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Review Nutrition & Dietetics

The Role of Ketogenic Diet in the Treatment of Neurological Diseases

Damian Dynka et al.

Summary: This paper provides a comprehensive analysis of the role of ketogenic diet in the therapy of neurological diseases, including epilepsy, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and migraine. The study highlights the various mechanisms of action of the ketogenic diet and its effectiveness in the treatment of these diseases.

NUTRIENTS (2022)

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Article Multidisciplinary Sciences

Akkermansia muciniphila phospholipid induces homeostatic immune responses

Munhyung Bae et al.

Summary: This study identifies a lipid molecule from Akkermansia muciniphila's cell membrane that exhibits immunomodulatory activity through the Toll-like receptor TLR2-TLR1 pathway. The findings provide molecular insights into the role of Akkermansia muciniphila in regulating immune balance and its impact on health and disease.

NATURE (2022)

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Article Oncology

Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience

Victoria Serpas Higbie et al.

Summary: This study evaluated the impact of antibiotic exposure on immunotherapy response rates and survival in patients with MSI-H/dMMR colorectal cancer who received ICB. The results showed no association between antibiotic exposure and lower response rates or survival in these patients.

ONCOLOGIST (2022)

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Article

Predicting cancer immunotherapy response from gut microbiomes using machine learning models

Hai Liang et al.

Oncotarget (2022)

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Article Microbiology

Genomic Insight Into Lacticaseibacillus paracasei SP5, Reveals Genes and Gene Clusters of Probiotic Interest and Biotechnological Potential

Despoina Eugenia Kiousi et al.

Summary: This study used genomic tools to further characterize the probiotic and biotechnological potential of Lc. paracasei SP5 strain. Whole genome sequencing and phylogenomic analysis were performed to determine the genomic features of the strain and its range of substrates. The study also identified genes related to stress tolerance and host interactions. Experimental validation confirmed the potential probiotic characteristics of the strain and its application in the food industry.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Presence of Akkermansiaceae in gut microbiome and immunotherapy effectiveness in patients with advanced non-small cell lung cancer

Anna Grenda et al.

Summary: The presence of Akkermansia bacteria, especially Akkermansia mucinifila, in the gut microbiome is being investigated for its potential role as a marker for response to immunotherapy in cancer patients. This study found that NSCLC patients treated with immune checkpoint inhibitors had better treatment response if Akkermansia bacteria were present in their intestines. Furthermore, a higher percentage of Akkermansia bacteria was observed in patients with squamous cell carcinoma compared to adenocarcinoma.

AMB EXPRESS (2022)

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Review Oncology

The Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer

Azin Aghamajidi et al.

Summary: The gut microbiome plays a crucial role in the development of the immune system and can impact the response to systemic treatments like immunotherapy and chemotherapy. This article provides a comprehensive overview of how the gut microbiome interacts with the immune system and cancer, and how it affects anti-tumor immunity and response to immunotherapy. Understanding these mechanisms can lead to better treatment strategies for cancer patients undergoing systemic therapy.

CANCERS (2022)

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Review Pharmacology & Pharmacy

Understanding the functional inflammatory factors involved in therapeutic response to immune checkpoint inhibitors for pan-cancer

Yanmeizhi Wu et al.

Summary: Immune checkpoint inhibitors activate the immune system to fight tumor progression, with inflammatory factors playing a crucial role in this process. The components of the tumor microenvironment also interact with immune factors, affecting the response to immune checkpoint inhibitors. The occurrence of immune-related adverse events is associated with inflammatory factors, serving as a positive feedback loop for better treatment response. Regulating inflammatory factors is therefore important for controlling the anti-cancer response of immune checkpoint inhibitors.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Immunology

The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer

Gauri Mirji et al.

Summary: The gut microbe-derived metabolite TMAO enhances antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) by promoting an immunostimulatory tumor-associated macrophage (TAM) phenotype and activating effector T cell response. TMAO exerts antitumor effects through potentiating the type I interferon pathway.

SCIENCE IMMUNOLOGY (2022)

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Review Oncology

Immune Checkpoint Inhibitors in Cancer Therapy

Yavar Shiravand et al.

Summary: The discovery of immune checkpoint proteins has revolutionized cancer immunotherapy, leading to the successful utilization of targeted monoclonal antibodies in various cancer patients. However, not all patients respond favorably to these drugs, emphasizing the need for biomarkers to predict treatment responses.

CURRENT ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Microbiota in health and diseases

Kaijian Hou et al.

Summary: The role of microbiota in health and disease is significant, contributing to homeostasis and immune regulation. Dysbiosis of microbiota can lead to disease progression, associated with dysregulation of community composition, modulation of host immune response, and induction of chronic inflammation. Clinical approaches utilizing microbiota, such as microbiota modulation and fecal microbial transplantation, can be effective for disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Immunology

Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy

Jii Bum Lee et al.

Summary: Targeting immune evasion through immune checkpoint pathways has revolutionized cancer treatment. This review discusses the historical discovery of CTLA-4 and PD-1 and their potential as anti-cancer therapeutics. It also explores the clinical utility of immune checkpoint inhibitors, particularly in non-small cell lung cancer, and the ongoing research on combination therapy and novel ICIs.

IMMUNE NETWORK (2022)

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Review Immunology

Interferon-γ: teammate or opponent in the tumour microenvironment?

Angela M. Gocher et al.

Summary: IFN gamma plays pleiotropic roles in the tumor microenvironment, acting as both a 'teammate' to promote antitumor immune responses and an 'opponent' promoting tumor growth and suppressing immune responses.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Allergy

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

Charlotte A. Alemao et al.

Summary: The prevalence of chronic immune and metabolic disorders is increasing rapidly, with significant associations found between alterations in the microbiome, diet, and mucous barriers in the onset and progression of these diseases. The interplay between diet, microbiome, and mucous barrier has gained attention in understanding major immune/metabolic disorders.

ALLERGY (2021)

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Review Oncology

Combining immune checkpoint inhibitors with chemotherapy in advanced solid tumours: A review

Mathieu Larroquette et al.

Summary: The combination of immune checkpoint inhibitors and chemotherapy has shown improved overall survival and better objective response rates in certain solid tumors, especially in non-small cell lung cancer and PD1/PD-L1 enriched tumors, indicating potential synergistic effects of this treatment combination. However, the optimal approach between sequential and concomitant administration of chemoimmunotherapy remains controversial in cancer treatment strategies.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

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Editorial Material Biochemistry & Molecular Biology

Cancer Immunoediting and beyond in 2021

Elena Monica Borroni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy

Qin Qiu et al.

Summary: The tumor microenvironment plays a crucial role in tumor development and response to immunotherapy, while the gut microbiome is known to impact cancer progression and treatment efficacy.

FRONTIERS IN IMMUNOLOGY (2021)

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Editorial Material Oncology

Cross-reactivity between cancer and microbial antigens

Laurence Zitvogel et al.

ONCOIMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Gut microbiota: impacts on gastrointestinal cancer immunotherapy

Harry Cheuk Hay Lau et al.

Summary: Recent studies have focused on exploring the association of gut microbiota with gastrointestinal carcinogenesis, revealing the critical roles of commensal microbes in cancer progression. Targeting microbiota to enhance therapeutic effectiveness has become a hot research topic. While the connection between microbial community and chemotherapy efficacy is well-established, more studies are needed to investigate the correlation with immunotherapy.

GUT MICROBES (2021)

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Article Multidisciplinary Sciences

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer et al.

Summary: The study suggests that dietary fiber intake is associated with significantly improved progression-free survival in melanoma patients receiving ICB treatment, especially without the use of probiotics. Preclinical studies demonstrate that a low-fiber diet or probiotics can impair the treatment response to anti-PD-1 therapy, leading to a lower frequency of interferon-gamma-positive cytotoxic T cells in the tumor microenvironment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Review Immunology

Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body

Fernanda Cristofori et al.

Summary: The digestive tract is a key site for microbial colonization, playing a vital role in maintaining host immune homeostasis. The interaction between gut microbiota/probiotics and the immune system can modulate inflammatory responses and prevent unnecessary activation of the immune system, offering potential therapeutic benefits.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Impact of Use of Antibiotics on Response to Immune Checkpoint Inhibitors and Tumor Microenvironment

Uqba Khan et al.

Summary: The study found that using antibiotics during ICB significantly reduces the efficacy of immunotherapy, especially if antibiotics are used in the first 6 weeks after initiating ICB.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2021)

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Article Microbiology

Whole-Genome Sequencing, Phylogenetic and Genomic Analysis of Lactiplantibacillus pentosus L33, a Potential Probiotic Strain Isolated From Fermented Sausages

Odysseas Sotirios Stergiou et al.

Summary: The study analyzed the genome of the potential probiotic strain L. pentosus L33 isolated from fermented sausages, revealing its potential probiotic properties such as sensitivity to antibiotics and biosynthesis of exopolysaccharides. The strain also displayed adhesion properties and the absence of transferable antibiotic resistance genes, indicating its potential for medical and industrial applications.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Fungi of the human gut microbiota: Roles and significance

J. Christian Perez

Summary: Fungi are important components of the gut microbiota and can influence the host's health by affecting immune responses. Further research on the fungi inhabiting the human body is needed to understand how the microbiota contribute to health and disease.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2021)

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Review Oncology

The Gut Microbiome and Cancer Immunotherapy: Can We Use the Gut Microbiome as a Predictive Biomarker for Clinical Response in Cancer Immunotherapy?

Byeongsang Oh et al.

Summary: The gut microbiome plays a significant role in influencing the clinical outcomes of immunotherapy, with potential to predict efficacy and adverse events of ICIs. Further research is needed to explore the modulatory effects of the gut microbiome on ICIs in non-responding patients.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Genomic and Phylogenetic Analysis of Lactiplantibacillus plantarum L125, and Evaluation of Its Anti-Proliferative and Cytotoxic Activity in Cancer Cells

Konstantinos Tegopoulos et al.

Summary: Lactiplantibacillus plantarum is a diverse species with potential probiotic traits, as shown by the genomic analysis and functional studies of strain L125.

BIOMEDICINES (2021)

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Article Microbiology

Metaproteomics-An Advantageous Option in Studies of Host-Microbiota Interaction

Oleg Karaduta et al.

Summary: The gut microbiome plays a crucial role in maintaining host health by contributing to homeostasis, enhancing digestive efficiency, and aiding in the development of the immune system. Therapeutic manipulation of the gut microbiota through dietary changes, prebiotics, probiotics, and fecal microbiome transplantation is being increasingly recognized. Utilizing multi-omics technologies, particularly metaproteomics, is providing new insights into host-microbiota interactions.

MICROORGANISMS (2021)

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Article Oncology

The commensal consortium of the gut microbiome is associated with favorable responses to anti-programmed death protein 1 (PD-1) therapy in thoracic neoplasms

Huihui Yin et al.

Summary: This study investigated the correlation between baseline gut microbiota and clinical treatment efficiency in patients with thoracic neoplasms receiving anti-PD-1 therapy. The abundance of commensal microbes in the gut at diagnosis could potentially serve as a predictor for early response to anti-PD-1 immunotherapy.

CANCER BIOLOGY & MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Problems with the concept of gut microbiota dysbiosis

Harald Brussow

MICROBIAL BIOTECHNOLOGY (2020)

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Article Gastroenterology & Hepatology

Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)

Siew C. Ng et al.

GUT (2020)

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Article Medicine, Research & Experimental

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

Andrea Botticelli et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Oncology

Gut microbial species and metabolic pathways associated with response to treatment with immune checkpoint inhibitors in metastatic melanoma

Thijs T. Wind et al.

MELANOMA RESEARCH (2020)

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Article Oncology

Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei

Georgios Aindelis et al.

CANCERS (2020)

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Review Oncology

Acquired Resistance to Immune Checkpoint Inhibitors

Adam J. Schoenfeld et al.

CANCER CELL (2020)

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Review Cell Biology

Interaction between microbiota and immunity in health and disease

Danping Zheng et al.

CELL RESEARCH (2020)

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Review Immunology

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

Yuhao Jiao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Microbiology

Predictable modulation of cancer treatment outcomes by the gut microbiota

Yoshitaro Heshiki et al.

MICROBIOME (2020)

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Review Biochemical Research Methods

Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota

Yuqiu Wang et al.

JOURNAL OF PROTEOMICS (2020)

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Article Oncology

Relationship between the efficacy of immunotherapy and characteristics of specific tumor mutation genes in non-small cell lung cancer patients

Peng Song et al.

THORACIC CANCER (2020)

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Review Immunology

Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices

Qiang Tang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Microbiology

Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway

Xinjian Xu et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Medicine, General & Internal

Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review

Keisuke Onoi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Microbiology

Assessment of the Immunomodulatory Properties of the Probiotic Strain Lactobacillus paracasei K5 In Vitro and In Vivo

Pelagia Chondrou et al.

MICROORGANISMS (2020)

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Review Immunology

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Immunology

Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice

Zhuo Chen et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

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Review Medicine, General & Internal

Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor

Stefano Bibbo et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Article Oncology

The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

Zhi Peng et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Review Microbiology

Gut Microbiota and Immune System Interactions

Ji Youn Yoo et al.

MICROORGANISMS (2020)

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Review Oncology

Roles of IFN-γ in tumor progression and regression: a review

Dragica Jorgovanovic et al.

BIOMARKER RESEARCH (2020)

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Review Pharmacology & Pharmacy

Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies

Elisabeth Perez-Ruiz et al.

DRUG RESISTANCE UPDATES (2020)

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Review Immunology

Beyond T-Cells: Functional Characterization of CTLA-4 Expression in Immune and Non-Immune Cell Types

Damilola Oyewole-Said et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma

Angelo Limeta et al.

JCI INSIGHT (2020)

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Article Multidisciplinary Sciences

Host variables confound gut microbiota studies of human disease

Ivan Vujkovic-Cvijin et al.

NATURE (2020)

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Review Public, Environmental & Occupational Health

Regulation, risk and safety of Faecal Microbiota Transplant

Blair Merrick et al.

INFECTION PREVENTION IN PRACTICE (2020)

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Review Biotechnology & Applied Microbiology

PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

Yongshuai Jiang et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

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Article Oncology

The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC

Yueping Jin et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Composition of the mucosa-associated microbiota along the entire gastrointestinal tract of human individuals

F. E. R. Vuik et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2019)

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Review Oncology

Exploring the emerging role of the microbiome in cancer immunotherapy

Jessica Fessler et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Immunology

Complementing the Cancer-Immunity Cycle

Ruben Pio et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma

Chune Yu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with updates hepatocellular carcinoma

Yi Zheng et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Nutrition & Dietetics

Mechanisms of Action of Probiotics

Julio Plaza-Diaz et al.

ADVANCES IN NUTRITION (2019)

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Review Oncology

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

Akintunde Akinleye et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Immunology

Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling

Lei Liu et al.

NATURE IMMUNOLOGY (2019)

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Article Genetics & Heredity

Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients

Brandilyn A. Peters et al.

GENOME MEDICINE (2019)

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Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Oncology

The role of the gut microbiome on the efficacy of immune checkpoint inhibitors in Japanese responder patients with advanced non-small cell lung cancer

Yuki Katayama et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2019)

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Review Medical Laboratory Technology

Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS

Ngom Issa Isaac et al.

CLINICAL MASS SPECTROMETRY (2019)

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Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

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Article Oncology

Resveratrol ameliorates Lewis lung carcinoma-bearing mice development, decreases granulocytic myeloid-derived suppressor cell accumulation and impairs its suppressive ability

Yilin Zhao et al.

CANCER SCIENCE (2018)

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Article Oncology

The gut microbiota influences anticancer immunosurveillance and general health

Bertrand Routy et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Multidisciplinary Sciences

The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

Vyara Matson et al.

SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Jotham Suez et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

Niv Zmora et al.

CELL (2018)

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Review Pharmacology & Pharmacy

Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences

Xinyu Yan et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Oncology

Soluble immune checkpoints in cancer: production, function and biological significance

Daqian Gu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Review Medicine, General & Internal

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis

Lynne V. McFarland et al.

FRONTIERS IN MEDICINE (2018)

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Review Oncology

The concept of immune surveillance against tumors. The first theories

Domenico Ribatti

ONCOTARGET (2017)

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Review Medicine, Research & Experimental

Influence of diet on the gut microbiome and implications for human health

Rasnik K. Singh et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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Article Microbiology

Potentially probiotic Lactobacillus strains with anti-proliferative activity induce cytokine/chemokine production and neutrophil recruitment in mice

G. Saxami et al.

BENEFICIAL MICROBES (2017)

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Article Immunology

Butyrate conditions human Dendritic cells to Prime Type 1 regulatory T cells via both histone Deacetylase inhibition and G Protein-coupled receptor 109A signaling

Maria M. M. Kaisar et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Oncology

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

Arthur E. Frankel et al.

NEOPLASIA (2017)

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Article Microbiology

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

Paul W. O'Toole et al.

NATURE MICROBIOLOGY (2017)

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Review Oncology

Hallmarks of response to immune checkpoint blockade

Alexandria P. Cogdill et al.

BRITISH JOURNAL OF CANCER (2017)

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Article Oncology

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

N. Chaput et al.

ANNALS OF ONCOLOGY (2017)

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Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

CELL (2017)

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Article Immunology

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria

D. Rios et al.

MUCOSAL IMMUNOLOGY (2016)

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Review Respiratory System

Immunotherapy for lung cancer

Antonius Steven et al.

RESPIROLOGY (2016)

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Article Gastroenterology & Hepatology

Faecal microbiota transplantation: applications and limitations in treating gastrointestinal disorders

Hani Sbahi et al.

BMJ OPEN GASTROENTEROLOGY (2016)

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Article Multidisciplinary Sciences

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

Ayelet Sivan et al.

SCIENCE (2015)

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Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

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Review Gastroenterology & Hepatology

Application of metagenomics in the human gut microbiome

Wei-Lin Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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Article Gastroenterology & Hepatology

A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and T-reg function

Kiel M. Telesford et al.

GUT MICROBES (2015)

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Article Immunology

Specific Gut Commensal Flora Locally Alters T Cell Tuning to Endogenous Ligands

Pascal Chappert et al.

IMMUNITY (2013)

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Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

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Article Oncology

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8

Masahide Shinnoh et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

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Review Immunology

Antigen sampling in the small intestine

Olga Schulz et al.

TRENDS IN IMMUNOLOGY (2013)

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Article Immunology

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Markus B. Geuking et al.

IMMUNITY (2011)

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Article Multidisciplinary Sciences

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

June L. Round et al.

SCIENCE (2011)

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Article Obstetrics & Gynecology

The role of intestinal bifidobacteria on immune system development in young rats

Ping Dong et al.

EARLY HUMAN DEVELOPMENT (2010)

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Review Immunology

Cancer immunoediting from immune surveillance to immune escape

Ryungsa Kim et al.

IMMUNOLOGY (2007)

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Review Immunology

Cancer despite immunosurveillance: immunoselection and immunosubversion

Laurence Zitvogel et al.

NATURE REVIEWS IMMUNOLOGY (2006)

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Review Immunology

The immunobiology of cancer immunosurveillance and immunoediting

GP Dunn et al.

IMMUNITY (2004)

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Article Biochemistry & Molecular Biology

Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1α nuclear translocation

D Zgouras et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

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