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Article
Oncology
Chiara Vitale et al.
Summary: Immunotherapies are promising strategies for cancer treatment, but better preclinical tools are needed to predict individual patients' response to therapy. Reliable preclinical models that reproduce the tumor environment while overcoming the limitations of traditional systems are necessary. This review discusses the tumor immune responses, escape mechanisms, and the recent 3D biomaterial-based cancer in vitro models that can be used to study the effects of different immunotherapeutic approaches.
Article
Oncology
Carolyn Shembrey et al.
Summary: Colorectal cancer is the second most common cancer worldwide, and tumor heterogeneity affects treatment outcome. This study presents a multi-color barcoding method for real-time quantification of tumor heterogeneity. The results show limited heterogeneity in traditional cell culture models and better representation of heterogeneity in patient-derived organoids. The optimized imaging protocol allows for real-time tracking of clonal dynamics. In summary, this technique is of great importance for monitoring tumor heterogeneity in cell culture models.
Article
Oncology
Nicola Contessi Negrini et al.
Summary: Development of new therapeutics to treat osteosarcoma is important, and 3D in vitro models are gaining momentum as reproducible and biomimetic tools to study tumor progression and assess new treatments. A 3D printed polyurethane scaffold enriched by in vitro pre-generated bone extracellular matrix was designed to replicate an osteosarcoma model, using osteo-differentiated human mesenchymal stromal cells. This model provides a suitable microenvironment for osteosarcoma cells and can be useful in tumor biology studies and treatment development.
Editorial Material
Oncology
Asbiel Hasbum et al.
Summary: This commentary highlights the potential of using biomaterials combined with patient-derived cancer cells as a 3D in vitro model for cancer research and treatment. While this approach is relatively new and uncommon in clinics, studies have shown promising results in creating 3D models that mimic in vivo tumors. However, there are limitations and challenges, including the need for familiarity with biomaterial scaffolds and the development of easy-to-handle scaffolds for routine assessment.
Article
Oncology
Priyanka Gupta et al.
Summary: Epithelial Ovarian Cancer (EOC) is a deadly gynaecological disease with a low survival rate. In this study, three different 3D in vitro platforms were compared for EOC, and the effect of chemotherapy was assessed. It was found that all three platforms supported EOC growth, but for different time periods. The anti-cancer drug resistance of metastatic EOC cells to Cisplatin varied depending on the structural and biochemical composition of the platform. This study emphasizes the importance of selecting an appropriate 3D platform for in vitro tumour model development, considering the cancer type, experimental time period, and intended application.
Review
Oncology
Lusine Sevinyan et al.
Summary: The aim of this systematic review is to provide an overview of the current research and future applications of in vitro models for ovarian cancer studies, highlighting the importance of using patient-derived cells to create three-dimensional models that can better simulate individual patient characteristics. The review discusses the challenges and advancements in this field and emphasizes the need for more personalized approaches in predicting drug responses and treatment regimens for ovarian cancer patients.
Article
Oncology
Akanksha Tomar et al.
Summary: Tumour progression can be well mimicked in 3D cultures using biodegradable scaffolds, allowing for the study of cancer cells and their growth patterns. These models exhibit real tumour-like characteristics and are valuable for studying gene expression, cellular signaling, angiogenesis, and drug response.
Review
Oncology
Anne M. Hughes et al.
Summary: Breast cancer commonly metastasizes to bone, leading to poor quality of life for patients. Current laboratory models do not fully replicate the human body, but 3D bioprinting technology offers a more realistic environment for studying cancer cell migration and interactions. This technology may also accelerate drug discovery efforts in cancer treatment.
Article
Oncology
Gabrielle Wishart et al.
Summary: Pancreatic cancer poses global health challenges due to non-specific symptoms, low survival rates, and treatment resistance. Tissue engineering is developing animal-free systems to replicate tumor tissue-specific hallmarks and cancer microenvironments for more accurate preclinical assessment of treatment strategies. Specifically, the complex tumor microenvironment of pancreatic cancer plays a significant role in treatment resistance, and new technologies are being developed to mimic these intricate ecosystems for improved therapeutic avenues.
Review
Oncology
Tiziana Fischetti et al.
Summary: This review discusses the use of 3D bioprinting for studying bone cancer, highlighting the challenges and unmet needs in mimicking the complex microenvironment. The potential of 3D technologies in developing predictive models for cancer progression is emphasized, with a focus on the promising role of 3D printing and bioprinting in creating customized and complex structures. Future perspectives and challenges for developing reliable 3D bone models, including the importance of biomaterial selection, are also discussed.
Article
Oncology
Nausika Betriu et al.
Summary: This study demonstrates that EGFR undergoes degradation in response to erlotinib treatment in 3D-cultured cancer cells but not in classic 2D culture systems, highlighting the strong impact of dimensionality on cell drug response. The findings emphasize the importance of more physiological culture platforms to gain mechanistic insights into cell response to chemotherapy.
Article
Engineering, Biomedical
N. Contessi Negrini et al.
Summary: Developmental TE is a novel paradigm aiming to obtain tissues and organs with correct biomorphology and biofunctionality by mimicking the morphogenetic processes leading to the tissue/organ generation in the embryo. Successful applications have been reported for ectodermal appendages such as teeth, hair follicles and glands, with a focus on accurate selection of cell sources, scaffolds, and cell culture configurations to replicate in vivo morphogenetic cues.
MATERIALS TODAY BIO
(2021)
Review
Oncology
Teruki Nii et al.
Article
Engineering, Biomedical
Quynh P. Pham et al.
