4.6 Article

Toxicity of Asciminib in Real Clinical Practice: Analysis of Side Effects and Cross-Toxicity with Tyrosine Kinase Inhibitors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Hematology

Long-term safety review of tyrosine kinase inhibitors in chronic myeloid leukemia- What to look for when treatment-free remission is not an option

Jeffrey H. Lipton et al.

Summary: The development of BCR::ABL1-targeting tyrosine kinase inhibitors has improved the prognosis of patients with chronic myeloid leukemia. Differences in safety profiles between TKIs allow for personalized treatment plans based on various factors. This review summarizes the safety profiles of currently approved TKIs and their impact on treatment selection, as well as strategies to manage adverse events and comorbidities.

BLOOD REVIEWS (2022)

Review Oncology

Development of asciminib, a novel allosteric inhibitor of BCR-ABL1

Delphine Rea et al.

Summary: This article discusses the mechanism and clinical challenges of chronic myeloid leukemia, as well as the development and potential application of a new drug called Asciminib.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

Article Hematology

An evaluation of asciminib for patients with chronic myeloid leukemia previously treated with ≥2 tyrosine kinase inhibitors

Valentin Garcia-Gutierrez et al.

Summary: This review discusses the potential of a new BCR::ABL1 inhibitor, asciminib, in the treatment of chronic myeloid leukemia (CML) patients. The drug has the ability to overcome resistance/intolerance and has shown promising efficacy in CML patients who have failed at least two TKIs.

EXPERT REVIEW OF HEMATOLOGY (2022)

Article Hematology

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring

Elias Jabbour et al.

Summary: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by a genetic translocation and fusion gene. Tyrosine kinase inhibitors (TKIs) are the frontline therapy, but second-line options are available for patients who develop resistance. Stem cell transplantation and non-TKI agents are recommended for advanced disease and relapse patients.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Article Education, Scientific Disciplines

Management of TKI-resistant chronic phase CML

Timothy P. Hughes et al.

Summary: For chronic phase CML patients who are resistant to multiple TKIs, both dose-modified ponatinib and asciminib are excellent treatment options. Lower doses of ponatinib can reduce the risk of serious vascular occlusive events, while higher doses of both ponatinib and asciminib are critical for patients with the T315I mutation. The choice of the best drug and dose can be challenging in different clinical situations and requires evaluation based on the latest trial evidence.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2022)

Review Oncology

A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase

Valentin Garcia-Gutierrez et al.

Summary: This article discusses the treatment strategies and challenges of using tyrosine kinase inhibitors (TKIs) for patients with chronic myeloid leukemia (CML). It covers treatment choices at initial diagnosis, options after treatment failure, and the importance of treatment-free remission. Additionally, considering the timing of writing during the COVID-19 pandemic, the article addresses global challenges and the advent of newer therapies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Hematology

Real-life analysis on safety and efficacy of asciminib for ponatinib pretreated patients with chronic myeloid leukemia

A. Luna et al.

Summary: Asciminib has shown good efficacy and safety in patients with chronic myeloid leukemia, including those previously treated with ponatinib. However, resistance to asciminib remains a challenge, particularly in patients previously treated with ponatinib.

ANNALS OF HEMATOLOGY (2022)

Review Oncology

Future Directions in Chronic Phase CML Treatment

Nathalie Javidi-Sharifi et al.

Summary: This review focuses on recent and emerging treatment paradigms in chronic phase CML, covering new frontline approaches, second treatment-free remission studies, and refractory disease treatment. Specific treatment methods include immunomodulatory approaches, targeting leukemia stem cells, and BCR-ABL1-intrinsic combination therapy. The challenges remain with regard to deepening initial responses, prolonging treatment-free remission, and providing efficacious and tolerable options for patients with refractory disease and resistance mutations.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2021)

Article Hematology

A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs

Delphine Rea et al.

Summary: Asciminib demonstrated superior efficacy compared to bosutinib in treating patients with CML-CP who are resistant or intolerant to >= 2 prior TKIs, with a favorable safety profile.
Article Pharmacology & Pharmacy

Asciminib: an investigational agent for the treatment of chronic myeloid leukemia

Massimo Breccia et al.

Summary: Tyrosine kinase inhibitors (TKIs) have significantly improved outcomes for CML patients, but resistance and intolerance can still be issues. Asciminib, an allosteric inhibitor, shows promise as a third-line treatment option, particularly for patients with the T315I mutation.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

Review Oncology

Tyrosine Kinase Inhibitors Available for Chronic Myeloid Leukemia: Efficacy and Safety

Valentin Garcia-Gutierrez et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

BCR-ABL Independent Mechanisms of Resistance in Chronic Myeloid Leukemia

Federica Loscocco et al.

FRONTIERS IN ONCOLOGY (2019)

Article Medicine, General & Internal

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure

T. P. Hughes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia

Andreas Hochhaus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Chronic myeloid leukaemia

Jane F. Apperley

LANCET (2015)

Review Pharmacology & Pharmacy

Drug discovery and the human kinome: Recent trends

Richard Eglen et al.

PHARMACOLOGY & THERAPEUTICS (2011)

Review Medical Laboratory Technology

Tyrosine kinase inhibitors in cancer therapy

S Madhusudan et al.

CLINICAL BIOCHEMISTRY (2004)