4.6 Article

The Challenges of Treating Patients with Breast Cancer and Obesity

期刊

CANCERS
卷 15, 期 9, 页码 -

出版社

MDPI
DOI: 10.3390/cancers15092526

关键词

obesity; breast cancer; systemic treatment; outcomes

类别

向作者/读者索取更多资源

Obesity is associated with worse outcomes in breast cancer patients and presents unique challenges in treatment. Understanding the molecular mechanisms and developing new treatment strategies are essential. Clinical trials focusing on obesity and breast cancer treatment are needed to inform future guidelines.
Obesity is defined as a body mass index (BMI) of 30 kg/m(2) or more and is associated with worse outcomes in patients with breast cancer, resulting in an increased incidence of breast cancer, recurrence, and death. The incidence of obesity is increasing, with almost half of all individuals in the United States classified as obese. Patients with obesity present with unique pharmacokinetics and physiology and are at increased risk of developing diabetes mellitus and cardiovascular disease, which leads to specific challenges when treating these patients. The aim of this review is to summarize the impact of obesity on the efficacy and toxicity of systemic therapies used for breast cancer patients, describe the molecular mechanisms through which obesity can affect systemic therapies, outline the existing American Society of Clinical Oncology (ASCO) guidelines for treating patients with cancer and obesity, and highlight additional clinical considerations for treating patients with obesity and breast cancer. We conclude that further research on the biological mechanisms underlying the obesity-breast cancer link may offer new treatment strategies, and clinicals trials that focus on the treatment and outcomes of patients with obesity and all stages of breast cancer are needed to inform future treatment guidelines.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据