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Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Lynn Bedford et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Constructing and decoding unconventional ubiquitin chains
Christian Behrends et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
Libin Shang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Stressing the ubiquitin-proteasome system
Nico P. Dantuma et al.
CARDIOVASCULAR RESEARCH (2010)
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
Joo-Yong Lee et al.
EMBO JOURNAL (2010)
The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms
Thomas Landes et al.
EMBO REPORTS (2010)
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis
Muriel Mari et al.
JOURNAL OF CELL BIOLOGY (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
Autophagy in mammalian development and differentiation
Noboru Mizushima et al.
NATURE CELL BIOLOGY (2010)
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases
Cheol-Sang Hwang et al.
NATURE CELL BIOLOGY (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler et al.
NATURE CELL BIOLOGY (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy
Chong-Shan Shi et al.
SCIENCE SIGNALING (2010)
Atg101, a novel mammalian autophagy protein interacting with Atg13
Nao Hosokawa et al.
AUTOPHAGY (2009)
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew et al.
CELL (2009)
Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability
Mi Ran Kang et al.
JOURNAL OF PATHOLOGY (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
The ATG12-conjugating enzyme ATG10 is essential for autophagic vesicle formation in Arabidopsis thaliana
Allison R. Phillips et al.
GENETICS (2008)
Autophagy-physiology and pathophysiology
Yasuo Uchiyama et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2008)
The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function
Keisuke Obara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
Takao Hanada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Autophagosome formation: Core machinery and adaptations
Zhiping Xie et al.
NATURE CELL BIOLOGY (2007)
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
Yang Cao et al.
CELL RESEARCH (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Chengyu Liang et al.
NATURE CELL BIOLOGY (2006)
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Kurt Degenhardt et al.
CANCER CELL (2006)
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules
Lidia M. Duncan et al.
EMBO JOURNAL (2006)
Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue
H Kitamura et al.
HISTOPATHOLOGY (2006)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
G Bjorkoy et al.
JOURNAL OF CELL BIOLOGY (2005)
The pleiotropic role of autophagy: from protein metabolism to bactericide
N Mizushima
CELL DEATH AND DIFFERENTIATION (2005)
The diversity expression of p62 in digestive system cancers
YX Su et al.
CLINICAL IMMUNOLOGY (2005)
Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
M Erkan et al.
ONCOGENE (2005)
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
JJ Lum et al.
CELL (2005)
The proteasome: A suitable antineoplastic target
J Adams
NATURE REVIEWS CANCER (2004)
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
J Okami et al.
CANCER RESEARCH (2004)
Death by design: apoptosis, necrosis and autophagy
AL Edinger et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
ZY Yue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
U Schubert et al.
NATURE (2000)