期刊
CANCERS
卷 15, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers15071978
关键词
biomarker; hepatocellular carcinoma; metastasis; platelet-to-lymphocyte ratio; prognosis; radiation therapy; serum
类别
This study investigated whether serum immune and inflammatory parameters can predict distant metastasis in patients with unresectable hepatocellular carcinoma undergoing radiation therapy. The results showed that posttreatment serum PLR and PNI levels could be used as predictors of distant metastasis. Further research is needed to validate these findings.
Background: We sought to investigate whether serum immune and inflammatory parameters can help to predict distant metastasis (DM) in patients with unresectable hepatocellular carcinoma (HCC) undergoing curative radiation therapy (RT). Methods: A total of 76 RT courses were analyzed. The following variables were included in the analysis: systemic inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), absolute lymphocyte count, lymphocyte-to-monocyte ratio, albumin, albumin-to-alkaline phosphatase ratio, RT-related parameters, and levels of total protein, hemoglobin, a-fetoprotein, and PIVKA-II. Distant control (DC) and overall survival (OS) rates were calculated and compared. Results: The mean age was 61.4 years, and most patients were men (n = 62, 81.6%). The median RT fraction number and fractional doses were 12 (range, 4-30) and 5 (range, 2-12) Gy, respectively. With a median follow-up of 12 (range, 3.1-56.7) months, the 1-year DC and OS rates were 64.4% and 55.2%, respectively. The development of DM significantly deteriorated OS (p = 0.013). In the multivariate analysis, significant independent prognostic indicators for DC and OS rates were the highest posttreatment PLR (= 235.7 vs. >235.7, p = 0.006) and the lowest posttreatment PNI (= 25.4 vs. >25.4, p < 0.001), respectively. Conclusions: Posttreatment serum PLR might be helpfully used as a predictive biomarker of DM in unresectable HCC patients undergoing RT. Future research is necessary to confirm our findings.
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