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Article
Oncology
Giulia Ferrari et al.
Summary: Bleomycin, a chemotherapy agent, can cause severe pulmonary toxicity when administered systemically. Bleosome, a novel formulation of bleomycin encapsulated in ultra-deformable (UD) liposomes, may be a potential topical chemotherapy for non-melanoma skin cancer. The study found that Bleosome can effectively penetrate through the skin, releasing bleomycin to deeper layers and suggesting its efficacy as a topical treatment warrants further investigation.
Article
Oncology
Sara Zsigrai et al.
Summary: Folic acid has dual role in established neoplasms by participating in DNA synthesis and DNA methylation. The effects of short-term folic acid supplementation on colorectal cancer cells were investigated, showing altered maintenance processes and genetic and epigenetic regulations. The study reveals the importance of considering cell type heterogeneity for effective therapy.
Review
Oncology
Karla V. Torres-Juarez et al.
Summary: The nervous system can participate in cancer development by inducing biochemical, physiological, and cellular modifications associated with the hallmarks of cancer, although its role is still controversial. Despite the need for further research, there is now enough evidence to support these theories and provide hope for finding additional potential treatments.
Article
Oncology
Yonara G. Cordeiro et al.
Summary: This study focused on the use of proteomics and mass spectrometry imaging in canine mammary tumors to investigate cancer heterogeneity and identify potential disease-state markers. The findings suggest that alterations in protein expression may contribute to the development of malignancy and metastasis, indicating the importance of exploring poorly understood proteins as potential early-stage tumor biomarkers. Further validation of key proteins identified in this study could lead to the development of new prognostic markers for human breast cancer patients.
Review
Oncology
Guilherme Ribeiro Romualdo et al.
Summary: Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant neoplasia, with few available anti-HCC drugs. The development of HCC models is essential to understanding the disease and improving diagnostic and therapeutic strategies. Various molecular factors contribute to the pathogenesis of HCC, making the establishment of accurate models crucial for translational research.
Article
Oncology
Jucimara Colombo et al.
Summary: Liquid biopsy has been investigated for its efficacy in detecting gene mutations in the diagnosis and follow-up of women and female dogs with breast cancer (BC). Next Generation Sequencing (NGS) analysis is a complex technique, and the number of genetic variants increases as the disease progresses. Liquid biopsy can be more effective when conducted early in the disease and continued throughout follow-up, aiding clinicians in making decisions for medical intervention.
Article
Oncology
Alessandra Rinah Nogueira Voges et al.
Summary: The study investigated the clinical efficacy, quality of life, and adverse events of poly-ICLC treatment in dogs with advanced cancers. The results showed that the treatment was well tolerated in dogs with some showing clinical benefit and improved quality of life.
Article
Oncology
Fang-Ping Kung et al.
Summary: This study explores the potential of piperlongumine (PL) as a therapeutic candidate for human thyroid cancers by inducing ROS to inhibit cell proliferation and promote apoptosis. PL also suppresses the Akt signaling pathway to induce mitochondria-dependent apoptosis in thyroid cancer cells, demonstrating antitumor activity in vitro and in vivo.
Review
Oncology
Anna Wawruszak et al.
Summary: Breast cancer is the most common malignancy affecting women worldwide, with valproic acid showing promising potential in inhibiting cancer cell proliferation. Studies have demonstrated that VPA, a member of the group of histone deacetylase inhibitors, can modulate multiple signaling pathways and improve the effectiveness of current treatment methods for breast cancer.
Article
Oncology
Igor Piotrowski et al.
Summary: Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer globally, originating from epithelial cells of the upper aerodigestive tract. This study found significant differences in miRNA expression between tumor and healthy tissues, as well as among different tumor locations, suggesting a potential for miRNAs as biomarkers for diagnosis and prognosis of HNSCC.
Article
Oncology
Elaine Zayas Marcelino da Silva et al.
Summary: Head and neck squamous cell carcinoma remains challenging to treat with no improvement in survival rates over the past 50 years. Thus, more reliable therapeutic targets and biomarkers for HNSCC are urgently needed. The serine protease inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI) could potentially inhibit matriptase-dependent squamous cell carcinogenesis by directly blocking kallikreins in epithelial differentiation.
