The Glioma Immune Landscape: A Double-Edged Sword for Treatment Regimens

Article Oncology

Phase IIa Study of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma

Manmeet S. Ahluwalia et al.

Summary: SurVaxM is a peptide vaccine that activates the immune system against glioblastoma cells. The combination of SurVaxM and adjuvant chemotherapy can extend the progression-free survival of newly diagnosed glioblastoma patients.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Multidisciplinary Sciences

Single-cell spatial immune landscapes of primary and metastatic brain tumours

Elham Karimi et al.

Summary: Single-cell technologies have been used to study the tumour microenvironment and reveal cellular diversity in tumour cells and their surroundings. This study used imaging mass cytometry to analyze the immunological landscape of high-grade glioma and brain metastasis tumours. The analysis revealed differences in immune landscapes between primary tumours and brain metastases and identified a unique population of MPO-positive macrophages associated with long-term survival in glioblastoma patients. The findings highlight the importance of integrating spatial resolution into single-cell datasets to understand the microenvironment of cancer.

NATURE (2023)

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Review Oncology

Therapy with oncolytic viruses: progress and challenges

Sophia Z. Shalhout et al.

Summary: This article summarizes the advantages of oncolytic viruses (OVs) as an emerging class of cancer therapeutics, including selective replication in tumor cells, delivery of multiple eukaryotic transgene payloads, induction of immunogenic cell death and promotion of antitumor immunity, and a tolerable safety profile that largely does not overlap with that of other cancer therapeutics. Although four OVs and one non-oncolytic virus have been approved for cancer treatment globally, only T-VEC has been widely approved. However, a better understanding of the biology and pharmacology of OVs is needed to fully exploit their therapeutic potential in patients with cancer.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Article Oncology

NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Yoshihiro Otani et al.

Summary: This study evaluated the impact of NOTCH signaling on virus-induced immunotherapy. The results showed that NOTCH signaling was significantly correlated with myeloid cell infiltration, and NOTCH-activated macrophages promoted the secretion of CCL2 in the tumor microenvironment, leading to the expansion of myeloid-derived suppressor cells. Pharmacologic blockade of NOTCH signaling improved the immunosuppressive tumor microenvironment and activated a CD8-dependent antitumor memory response, resulting in therapeutic benefits.

CLINICAL CANCER RESEARCH (2022)

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Review Oncology

The CD70-CD27 axis in oncology: the new kids on the block

Tal Flieswasser et al.

Summary: The CD70-CD27 axis has been found to play a role in tumor progression and immune suppression, while also participating in co-stimulation in immune responses under normal physiological conditions. In hematological malignancies, co-expression of CD70 and CD27 promotes the stemness, proliferation, and survival of cancer cells. In solid tumors, CD70 expression facilitates immune evasion through CD27 expression in the tumor microenvironment. The CD70-CD27 axis has emerged as a novel target for oncology research and (pre)clinical therapeutic strategies.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Oncology

Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial

E. Antonio Chiocca et al.

Summary: The combination of VDX-regulatable IL-12 gene therapy and nivolumab in recurrent glioblastoma patients has shown promising safety and potential therapeutic effects.

NEURO-ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

Nourhan Abdelfattah et al.

Summary: This study identifies molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and discovers S100A4 as a regulator of immune suppressive T and myeloid cells in GBM. The study reveals extensive spatial and molecular heterogeneity in immune infiltrates and identifies nine distinct myeloid cell subtypes, with five being prognostic indicators of glioma patient survival.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

Vidhya M. Ravi et al.

Summary: The study demonstrates that a subset of myeloid cells in Glioblastomas induce dysfunctional T cells through Interleukin-10 signaling, and inhibiting downstream JAK/STAT pathway could restore the responsiveness of immune therapy. The findings are validated using in vitro and in vivo models, providing further evidence of Interleukin-10 release being a driving force of tumor immune escape. Integrative modeling of single cell and spatial transcriptomics data proves to be a valuable tool for studying the tumor immune microenvironment and may contribute to the development of successful immunotherapies.

NATURE COMMUNICATIONS (2022)

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Review Biotechnology & Applied Microbiology

Engineered cells as glioblastoma therapeutics

Aparna Ramanathan et al.

Summary: Engineered cell therapies for glioblastoma have shown feasibility and safety in clinical trials, with some evidence of activity. Various starting cell types for engineered cell therapies have their own strengths and weaknesses. The future direction is to continue exploring and optimizing this promising modality for glioblastoma therapy.

CANCER GENE THERAPY (2022)

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Article Oncology

A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy

Niaz Muhammad et al.

Summary: CAR-T therapy has been proven effective for non-solid tumors, but poses challenges for solid tumors such as glioblastoma. Researchers have developed a new TanCAR that can efficiently kill gliomas and potentially prevent antigen escape and reduce off-target cytotoxicity.

MOLECULAR THERAPY-ONCOLYTICS (2022)

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Article Oncology

Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter

Michael Lim et al.

Summary: The study evaluated the addition of the immune checkpoint inhibitor nivolumab (NIVO) to radiotherapy (RT) + temozolomide (TMZ) in newly diagnosed glioblastoma patients and found that it did not improve survival in these patients.

NEURO-ONCOLOGY (2022)

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Article Oncology

Tumor-Associated Macrophages in Gliomas-Basic Insights and Treatment Opportunities

Johannes K. Andersen et al.

Summary: Glioma is a group of primary brain tumors, among which glioblastoma is the most malignant one. The glioma microenvironment is dominated by tumor-associated macrophages (TAMs), which are immunosuppressive and hinder treatment effectiveness. Shifting TAMs towards a proinflammatory state through new therapeutic strategies is of great therapeutic interest for glioma treatment.

CANCERS (2022)

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Article Biochemistry & Molecular Biology

Intratumoral oncolytic herpes virus G47 increment for residual or recurrent glioblastoma: a phase 2 trial

Tomoki Todo et al.

Summary: A crucial clinical trial demonstrates that repeated tumor-administration of oncolytic herpes virus G47 Increment in residual or recurrent glioblastoma leads to improved survival rates and a safe profile.

NATURE MEDICINE (2022)

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Article Pharmacology & Pharmacy

Integrative multi-omics approach to targeted therapy for glioblastoma

Lynnette Koh et al.

Summary: This review discusses recent technological advances in the treatment of glioblastoma (GBM). Molecular subtypes have been identified within GBM tumors, suggesting that future treatment decisions should consider not only morphological analysis but also molecular and cellular heterogeneity. The use of single-cell technologies has improved our understanding and identification of functional subtypes, which can reveal therapeutic vulnerabilities. The establishment of the Glioportal brain tumor resource provides resources for validating hypotheses based on patient clinical datasets.

PHARMACOLOGICAL RESEARCH (2022)

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Editorial Material Medicine, General & Internal

New mechanistic insights of the pathogenicity of high-risk cytomegalovirus (CMV) strains derived from breast cancer: Hope for new cancer therapy options

Cecilia Soderberg-Nauclera

EBIOMEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Early myeloid-derived suppressor cells accelerate epithelial-mesenchymal transition by downregulating ARID1A in luminal A breast cancer

Guidong Chen et al.

Summary: Highly infiltrated early myeloid-derived suppressor cells (eMDSCs) affect the prognosis of luminal A breast cancer patients by promoting epithelial-mesenchymal transition (EMT) and cell migration and invasion. eMDSCs suppress ARID1A expression in luminal A breast cancer cells, which is closely associated with EMT and serves as an important prognostic factor. This study provides new insights into the development of novel treatment strategies for relapsed luminal A breast cancer after conventional therapies.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

Qu-Jing Gai et al.

Summary: PDGFRA may not be necessary for PDGFA function. The study revealed EPHA2 as a potential receptor of PDGFA and identified that co-upregulation of PDGFA and EPHA2 led to worse patient prognosis and poorer therapeutic effects. Combination inhibitors targeting PDGFRA and EHA2 represent a promising therapeutic strategy for GBM treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Oncology

Immune suppression in gliomas

Matthew M. Grabowski et al.

Summary: Gliomas evade immune detection and destruction through mechanisms such as dysfunctional T cells and NK cells, expansion of regulatory T cells and myeloid-derived suppressor cells, M2 phenotypic transformation in macrophages/microglia, upregulation of immunosuppressive factors, tumor microenvironment hypoxia, and iatrogenic effects of immunosuppressive treatments. Future research should focus on addressing these immunosuppressive mechanisms to develop treatment options with improved survival outcomes.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Review Oncology

Cytotoxic CD8+T cells in cancer and cancer immunotherapy

Hans Raskov et al.

Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.

BRITISH JOURNAL OF CANCER (2021)

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Review Oncology

Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor

Kelly M. Hotchkiss et al.

Summary: GBM is difficult to eradicate with immunotherapy and chemotherapy, and different doses and timing of chemotherapy may affect tumor eradication efficacy.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Oncology

Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma

Lakshmi Nayak et al.

Summary: The study showed that pembrolizumab alone or in combination with bevacizumab had limited efficacy in the treatment of recurrent glioblastoma, failing to improve patient survival rates. Tumor immune biomarkers were not reliable predictors of treatment outcomes, while baseline dexamethasone use and certain tumor biomarkers may impact treatment efficacy.

CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Antitumor CD8 T cell responses in glioma patients are effectively suppressed by T follicular regulatory cells

Lenian Lu et al.

Summary: The study found significantly elevated levels of Tfr cells in CD4 T cells infiltrating glioma tumors, and these cells can significantly suppress the proliferation and cytotoxic capacity of CD8 T cells toward glioma cells.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Immunology

The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis

Yu Cheng et al.

Summary: Hypoxia in rheumatoid arthritis (RA) leads to over-expression of PADI4, which plays a role in M1 macrophage activation. The co-polarization of M1 and M2 is influenced by hypoxia, and down-regulating PADI4 expression can alleviate joint swelling and destruction in CIA rats by decreasing M1 macrophages.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Oncology

Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

Maham Farshidpour et al.

Summary: Gastrointestinal cancers are a common malignancy globally, and myeloid-derived suppressor cells (MDSCs) play a significant role in facilitating tumor progression by suppressing immune cells. Understanding the function and mechanism of MDSCs in the tumor microenvironment can potentially lead to the development of novel immune-targeted therapies.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Review Oncology

Immune checkpoint inhibitors in GBM

Eudocia Q. Lee

Summary: Recent updates in immune checkpoint inhibitor therapy for GBM patients have not shown survival benefit in clinical trials, indicating the need for further research in biomarkers and combination therapies.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.

CELL (2021)

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Review Oncology

Diffuse Glioma Heterogeneity and Its Therapeutic Implications

James G. Nicholson et al.

Summary: Diffuse gliomas are characterized by high levels of genetic, epigenetic, and environmental heterogeneity, leading to extreme phenotypic heterogeneity at the cellular level and resistance to various therapies. The intratumoral heterogeneity and malignant cell state plasticity in gliomas pose significant challenges to the development of novel targeted therapies.

CANCER DISCOVERY (2021)

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Review Oncology

Oncolytic virus in gliomas: a review of human clinical investigations

A. B. Carpenter et al.

Summary: Gliomas are challenging to treat due to their resistance to conventional therapies, but immunotherapy, particularly oncolytic viruses, has shown promising results in recent studies. The review provides a comprehensive overview of completed human clinical investigations on oncolytic viruses for glioma treatment.

ANNALS OF ONCOLOGY (2021)

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Review Immunology

Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End

Angeliki Datsi et al.

Summary: Dendritic cell vaccination (DCV) is a promising immunotherapy for treating glioblastomas, with numerous trials showing potential but some controlled studies failing to detect a survival benefit. Further exploration is needed to fully understand the potential of this therapeutic approach.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

MDSC: Markers, development, states, and unaddressed complexity

Samarth Hegde et al.

Summary: MDSCs are a widely discussed biological entity in immunology, commonly describing cells that arise during chronic inflammation with T cell immunosuppressive functions. Currently lacking clear definitions and a unifying framework across pathologies, we propose a framework based on activation signals to classify MDSCs as discrete cell states. Developing this knowledge of myeloid states across pathological conditions may transform how diseases are grouped and treated.

IMMUNITY (2021)

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Article Multidisciplinary Sciences

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Michael Platten et al.

Summary: Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours.

NATURE (2021)

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Review Clinical Neurology

Chimeric Antigen Receptor T Cells for Glioblastoma Current Concepts, Challenges, and Future Perspectives

Philipp Karschnia et al.

Summary: CAR T-cell therapy is a promising approach for glioblastoma, but initial clinical studies showed limited antitumor effects. Factors limiting the efficacy of CAR T-cell therapy in glioblastoma include tumor heterogeneity, antigen loss, and the immunosuppressive tumor microenvironment.

NEUROLOGY (2021)

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Article Oncology

Multicenter, Open-Label, Phase I Study of DSP-7888 Dosing Emulsion in Patients with Advanced Malignancies

Alexander Spira et al.

Summary: The study demonstrated that DSP-7888 was well tolerated in patients with recurrent or advanced malignancies, with no dose-limiting toxicities observed. Furthermore, higher WT1-specific CTL induction activity was noted with intradermal administration, indicating the potential for improved immune response compared to subcutaneous administration.

TARGETED ONCOLOGY (2021)

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Article Genetics & Heredity

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Andrew X. Chen et al.

Summary: This study identified a pro-tumor subpopulation of bone marrow-derived macrophages characterized by MARCO, which is exclusively found in IDH1-wild-type glioblastomas. MARCO expression is associated with worse prognosis and mesenchymal subtype, and significantly altered during treatment with anti-PD1 checkpoint inhibitors, suggesting potential therapeutic targets for preventing their recruitment.

GENOME MEDICINE (2021)

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Article Oncology

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

Joseph S. Durgin et al.

Summary: CAR T-EGFRvIII cells have shown promising results in treating patients with IDH1 wildtype recurrent glioblastoma, with one patient surviving 36 months after disease recurrence. Histopathologic analysis revealed immunosuppressive changes in tumor tissue post-infusion, along with decreased EGFRvIII expression. Serial brain imaging demonstrated reduced rCBV after CAR T treatment, suggesting potential efficacy in recurrent GBM patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

New insights into M1/M2 macrophages: key modulators in cancer progression

Jiuyang Liu et al.

Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.

CANCER CELL INTERNATIONAL (2021)

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Article Immunology

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy

Simon Eschweiler et al.

Summary: Studies have shown the importance of T-FR cells within tumor tissues in enhancing the efficacy of anti-PD-1 therapy. Depleting or blocking T-FR cells can improve the effectiveness of anti-PD-1 treatment and contribute to better survival outcomes in melanoma patients.

NATURE IMMUNOLOGY (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Review Oncology

Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy

Rikke Sick Andersen et al.

Summary: Glioblastoma, the most common and malignant primary brain tumor, has a poor prognosis with limited treatment options. Targeting tumor-associated microglia and macrophages (TAMs) in addition to cancer cells may be a promising therapeutic strategy. Understanding the interactions between TAMs and cancer cells is crucial for developing effective treatment approaches.

CANCERS (2021)

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Review Cell Biology

Single-Cell Omics in Dissecting Immune Microenvironment of Malignant Gliomas-Challenges and Perspectives

Bozena Kaminska et al.

Summary: Single-cell technologies play a crucial role in studying the functional diversity of immune cells in malignant gliomas, allowing precise definition of functional phenotypes under different genetic alterations, which is essential for designing effective immunotherapies. These technologies also identify key cell subpopulations and signaling pathways that influence tumor progression, patient survival, and susceptibility to immunotherapy, paving the way for rational design of oncoimmunotherapeutics.

CELLS (2021)

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Review Cell Biology

Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor-Glioma Therapy?

Ni Tong et al.

Summary: TAMs play a crucial role in the progression of glioma, and treatment strategies targeting TAMs include inhibiting recruitment, reducing viability, and altering phenotype. Research progress has shown the potential effectiveness of anti-tumor therapy targeting TAMs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Multidisciplinary Sciences

AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide

Jing Li et al.

Summary: The study found that AEG-1 is overexpressed in glioma tissues, and its silencing can increase the sensitivity of glioma cells to TMZ and promote DNA damage. Silencing AEG-1 can also reduce M2 polarization of microglia and decrease the secretion of tumor supportive cytokines IL-6 and TGF-beta 1.

SCIENTIFIC REPORTS (2021)

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Article Medicine, Research & Experimental

Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells

Hila Shaim et al.

Summary: Glioblastoma stem cells (GSCs) in the aggressive brain cancer Glioblastoma multiforme (GBM) evade immune responses by impairing the function of tumor-infiltrating NK cells through a direct cell-to-cell contact mechanism mediated by alpha v integrin and TGF-β activation. Treatment with inhibitors of integrin or TGF-β signaling, or with TGFBR2 gene-edited allogeneic NK cells, prevents GSC-induced NK cell dysfunction and tumor growth, suggesting a potential therapeutic strategy for GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biotechnology & Applied Microbiology

Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

Harrison Specht et al.

Summary: The SCoPE2 technology was developed to improve the accuracy and throughput of single-cell proteomics through automated sample preparation, revealing the gradual differences in the proteome of macrophages during the enhancement of heterogeneity and allowing differentiation of cell states.

GENOME BIOLOGY (2021)

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Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Oncology

Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages

John de Groot et al.

NEURO-ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/beta-catenin signaling pathway

Wei Yang et al.

ONCOGENE (2020)

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Article Biotechnology & Applied Microbiology

Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors

Giulia Golinelli et al.

CANCER GENE THERAPY (2020)

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Article Oncology

Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients

Qian-Ting Wang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Oncology

Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial

David A. Reardon et al.

CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence

Alexandre Teixeira Vessoni et al.

ONCOGENE (2020)

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Article Oncology

A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol

Nicholas F. Brown et al.

BMC CANCER (2020)

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Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

GD2 targeting by dinutuximab beta is a promising immunotherapeutic approach against malignant glioma

Sascha Marx et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Article Oncology

Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner

Defne Bayik et al.

CANCER DISCOVERY (2020)

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Article Oncology

Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils

Anm Nazmul H. Khan et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Review Immunology

The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment

Yajing Mi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Single-Cell Atlas Reveals Complexity of the Immunosuppressive Microenvironment of Initial and Recurrent Glioblastoma

Weilun Fu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma The CheckMate 143 Phase 3 Randomized Clinical Trial

David A. Reardon et al.

JAMA ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Arginase-1+Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression

Juliana H. Azambuja et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Immunology

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression

Tyler J. Alban et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

E. Antonio Chiocca et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Oncology

IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma

Rebekka Weber et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Oncology

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy

Bassel Nazha et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Immunology

Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Shih-Ying Wu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Immunology

Granulocytic Myeloid-Derived Suppressor Cell Exosomal Prostaglandin E2 Ameliorates Collagen-Induced Arthritis by Enhancing IL-10+ B Cells

Xinyu Wu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

MIF-Dependent Control of Tumor Immunity

Jordan T. Noe et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

Chimeric antigen receptor T-cell therapy in glioblastoma: charging the T cells to fight

Craig A. Land et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Review Cell Biology

Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases

Yizhuo Wang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma

Yang Zhang et al.

ONCOIMMUNOLOGY (2020)

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Review Oncology

B cell and B cell-related pathways for novel cancer treatments

Ryuma Tokunaga et al.

CANCER TREATMENT REVIEWS (2019)

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Review Oncology

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

William Tomaszewski et al.

CLINICAL CANCER RESEARCH (2019)

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Article Medicine, Research & Experimental

Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis

Harald Krenzlin et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Timothy F. Cloughesy et al.

NATURE MEDICINE (2019)

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Article Oncology

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

Denis Migliorini et al.

NEURO-ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro

Yoshitaka Tanaka et al.

PLOS ONE (2019)

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Review Immunology

M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

Youhan Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Review Clinical Neurology

Genetic and molecular epidemiology of adult diffuse glioma

Annette M. Molinaro et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Immunology

Clinical Relevance and Immunosuppressive Pattern of Circulating and Infiltrating Subsets of Myeloid-Derived Suppressor Cells (MDSCs) in Epithelial Ovarian Cancer

Karolina Okla et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma

Xin Tang et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

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Article Oncology

Predominance of M2 macrophages in gliomas leads to the suppression of local and systemic immunity

Aurobind Vidyarthi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Clinical Neurology

ATIM-28. PHASE II TRIAL OF AV-GBM-1 (AUTOLOGOUS DENDRITIC CELLS LOADED WITH TUMOR ASSOCIATED ANTIGENS) AS ADJUNCTIVE THERAPY FOLLOWING SURGERY PLUS CONCURRENT CHEMORADIATION IN NEWLY DIAGNOSED GBM PATIENTS

Daniela Bota et al.

NEURO-ONCOLOGY (2019)

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Article Clinical Neurology

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas

Pia S. Zeiner et al.

BRAIN PATHOLOGY (2019)

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Review Oncology

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

Christopher Groth et al.

BRITISH JOURNAL OF CANCER (2019)

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Article Oncology

Glioma exosomes mediate the expansion and function of myeloid-derived suppressor cells through microRNA-29a/Hbp1 and microRNA-92a/Prkar1a pathways

Xiaofan Guo et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Review Oncology

EGFRvIII: An Oncogene with Ambiguous Role

Adrianna Rutkowska et al.

JOURNAL OF ONCOLOGY (2019)

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Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Oncology

CD70, a novel target of CAR T-cell therapy for gliomas

Linchun Jin et al.

NEURO-ONCOLOGY (2018)

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Article Oncology

Clinical decision making in the era of immunotherapy for high grade-glioma: report of four cases

Surabhi Ranjan et al.

BMC CANCER (2018)

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Article Oncology

Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

Stephan Lang et al.

CLINICAL CANCER RESEARCH (2018)

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Article Oncology

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

Frederick F. Lang et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment

Wouter B. L. van den Bossche et al.

NEURO-ONCOLOGY (2018)

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Article Medicine, General & Internal

Recurrent Glioblastoma Treated with Recombinant Poliovirus

Annick Desjardins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

Zhenyi An et al.

ONCOGENE (2018)

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Article Biochemistry & Molecular Biology

FHL2 interacts with EGFR to promote glioblastoma growth

Lili Sun et al.

ONCOGENE (2018)

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Article Cell Biology

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Adel Samson et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Immunology

NKG2D: A Master Regulator of Immune Cell Responsiveness

Felix M. Wensveen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Meeting Abstract Oncology

A randomized, multicenter phase 2 study of DSP-7888 dosing emulsion in combination with bevacizumab (Bev) versus Bev alone in patients with recurrent or progressive glioblastoma.

John Frederick De Groot et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Pakawat Chongsathidkiet et al.

NATURE MEDICINE (2018)

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Article Oncology

Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models

Vassilis Genoud et al.

ONCOIMMUNOLOGY (2018)

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Review Oncology

Harnessing the immune system in glioblastoma

Nicholas F. Brown et al.

BRITISH JOURNAL OF CANCER (2018)

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Review Biotechnology & Applied Microbiology

TIM-3, a promising target for cancer immunotherapy

Yayi He et al.

ONCOTARGETS AND THERAPY (2018)

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Review Oncology

NK Cell-Based Glioblastoma Immunotherapy

Irene Golan et al.

CANCERS (2018)

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Article Medicine, Research & Experimental

Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis

Tyler J. Alban et al.

JCI INSIGHT (2018)

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Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Immunology

The diverse functions of the PD1 inhibitory pathway

Arlene H. Sharpe et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Oncology

NKG2D-Based CAR T Cells and Radiotherapy Exert Synergistic Efficacy in Glioblastoma

Tobias Weiss et al.

CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment

Stefanie Keller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Medicine, General & Internal

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma A Randomized Clinical Trial

Roger Stupp et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Review Oncology

Adult Glioblastoma

Brian M. Alexander et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Review Oncology

Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

Song Xue et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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Article Oncology

CD147 and glioma: a meta-analysis

Hui Li et al.

JOURNAL OF NEURO-ONCOLOGY (2017)

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Article Oncology

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Michael Weller et al.

LANCET ONCOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial

Karsten Geletneky et al.

MOLECULAR THERAPY (2017)

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Article Multidisciplinary Sciences

Effective combinatorial immunotherapy for castration-resistant prostate cancer

Xin Lu et al.

NATURE (2017)

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Article Cell Biology

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O'Rourke et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

Jennifer P. Newman et al.

NATURE COMMUNICATIONS (2017)

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Article Oncology

Migration pattern, actin cytoskeleton organization and response to PI3K-, mTOR-, and Hsp90-inhibition of glioblastoma cells with different invasive capacities

Simon Memmel et al.

ONCOTARGET (2017)

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Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

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Article Oncology

HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma A Phase 1 Dose-Escalation Trial

Nabil Ahmed et al.

JAMA ONCOLOGY (2017)

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Article Multidisciplinary Sciences

CD163+ CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

Keigo Kubota et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis

Song Xue et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival

Lijie Zhai et al.

CLINICAL CANCER RESEARCH (2017)

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Review Immunology

The regulation of immune tolerance by FOXP3

Ling Lu et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Review Oncology

Targeting EGFRvIII for glioblastoma multiforme

Ju Yang et al.

CANCER LETTERS (2017)

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Article Oncology

Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy

Orin Bloch et al.

CLINICAL CANCER RESEARCH (2017)

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Review Pharmacology & Pharmacy

Harnessing macrophage plasticity for tissue regeneration

Tim D. Smith et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Article Oncology

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

Kristen A. Batich et al.

CLINICAL CANCER RESEARCH (2017)

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Review Immunology

Ontogeny and homeostasis of CNS myeloid cells

Marco Prinz et al.

NATURE IMMUNOLOGY (2017)

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Review Pharmacology & Pharmacy

Microglial M1/M2 polarization and metabolic states

Ruben Orihuela et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Oncology

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

Congcong Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Oncology

CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

Daniel Dubinski et al.

NEURO-ONCOLOGY (2016)

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Article Oncology

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

Congcong Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Oncology

MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation

Kavitha Yaddanapudi et al.

CANCER IMMUNOLOGY RESEARCH (2016)

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Article Oncology

Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival

Sabrina Genssler et al.

ONCOIMMUNOLOGY (2016)

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Article Cell Biology

EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation

Yuho Hamaoka et al.

CELLULAR SIGNALLING (2016)

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Article Oncology

Ipilimumab and Bevacizumab in Glioblastoma

T. Carter et al.

CLINICAL ONCOLOGY (2016)

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Article Oncology

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function

Paul R. Gielen et al.

NEURO-ONCOLOGY (2016)

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Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Medicine, General & Internal

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression

A. Ellert-Miklaszewska et al.

ONCOGENE (2016)

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Article Cell & Tissue Engineering

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

Balint Otvos et al.

STEM CELLS (2016)

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Article Oncology

IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway

Ming Tu et al.

TUMOR BIOLOGY (2016)

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Article Oncology

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

Xiaofan Guo et al.

ONCOTARGET (2016)

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Article Cell Biology

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

Robert L. Bowman et al.

CELL REPORTS (2016)

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Meeting Abstract Hematology

DSP-7888, a Novel Cocktail Design of WT1 Peptide Vaccine, and Its Combinational Immunotherapy with Immune Checkpoint-Blocking Antibody Against PD-1

Masashi Goto et al.

BLOOD (2016)

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Meeting Abstract Oncology

Combinatorial targeting of tumor-associated macrophages/ microglia and radiotherapy in gliomas

Leila Akkari et al.

CANCER RESEARCH (2015)

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Article Oncology

Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma

Christine E. Brown et al.

CLINICAL CANCER RESEARCH (2015)

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Review Immunology

Regulatory B Cells: Origin, Phenotype, and Function

Elizabeth C. Rosser et al.

IMMUNITY (2015)

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Article Oncology

Macrophage migration inhibitory factor involvement in breast cancer

Vincent Richard et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Review Medicine, Research & Experimental

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

Stefano Ugel et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Editorial Material Oncology

Cytomegalovirus and glioblastoma; controversies and opportunities

Sean E. Lawler

JOURNAL OF NEURO-ONCOLOGY (2015)

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Article Oncology

Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes

Baisakhi Raychaudhuri et al.

JOURNAL OF NEURO-ONCOLOGY (2015)

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Article Clinical Neurology

Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

Paul R. Gielen et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)

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Article Oncology

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

James Schuster et al.

NEURO-ONCOLOGY (2015)

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Article Medicine, General & Internal

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

Stephen M. Ansell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Multidisciplinary Sciences

Transcriptomic Analysis of Human Polarized Macrophages: More than One Role of Alternative Activation?

Eleonora Derlindati et al.

PLoS One (2015)

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Article Oncology

Glucose-regulated protein 94 is a novel glioma biomarker and promotes the aggressiveness of glioma via Wnt/β-catenin signaling pathway

Tieyi Hu et al.

TUMOR BIOLOGY (2015)

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Review Clinical Neurology

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

Douglas G. Walker et al.

ALZHEIMERS RESEARCH & THERAPY (2015)

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Review Biotechnology & Applied Microbiology

Tim-3 and Tim-4 as the potential targets for antitumor therapy

Lin Cheng et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2015)

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Review Oncology

Molecular heterogeneity in glioblastoma: potential clinical implications

Nicole Renee Parker et al.

FRONTIERS IN ONCOLOGY (2015)

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Review Immunology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray et al.

IMMUNITY (2014)

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Article Immunology

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Jia Xue et al.

IMMUNITY (2014)

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Review Immunology

Transcriptomic analysis of mononuclear phagocyte differentiation and activation

David A. Hume et al.

IMMUNOLOGICAL REVIEWS (2014)

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Article Immunology

Rindopepimut: a promising immunotherapeutic for the treatment of glioblastoma multiforme

Adam M. Swartz et al.

IMMUNOTHERAPY (2014)

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Article Biochemistry & Molecular Biology

Glioma cell-derived placental growth factor induces regulatory B cells

Song Han et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

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Article Biotechnology & Applied Microbiology

A Phase 1 Trial of Oncolytic HSV-1, G207, Given in Combination With Radiation for Recurrent GBM Demonstrates Safety and Radiographic Responses

James M. Markert et al.

MOLECULAR THERAPY (2014)

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Article Clinical Neurology

Wilms tumor 1 gene, CD97, and the emerging biogenetic profile of glioblastoma

Aravind Somasundaram et al.

NEUROSURGICAL FOCUS (2014)

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Article Multidisciplinary Sciences

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

Zineb Belcaid et al.

PLOS ONE (2014)

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Review Immunology

Current Vaccine Trials in Glioblastoma: A Review

LindaW. Xu et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity and Lung Cancer

Leona Mawhinney et al.

MOLECULAR MEDICINE (2014)

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Article Oncology

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α

Gary Kohanbash et al.

CANCER RESEARCH (2013)

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Article Neurosciences

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

Aleksandra Ellert-Miklaszewska et al.

GLIA (2013)

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Article Oncology

Prognostic significance of CD147 in patients with glioblastoma

Min Yang et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

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Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

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Article Multidisciplinary Sciences

Glioma IL13Rα2 Is Associated with Mesenchymal Signature Gene Expression and Poor Patient Prognosis

Christine E. Brown et al.

PLOS ONE (2013)

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Article Oncology

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors

Emilia Mira et al.

ONCOTARGET (2013)

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Article Hematology

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity

Lishomwa C. Ndhlovu et al.

BLOOD (2012)

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Article Oncology

Suppression of Human Glioma Xenografts with Second-Generation IL13R-Specific Chimeric Antigen Receptor-Modified T Cells

Seogkyoung Kong et al.

CLINICAL CANCER RESEARCH (2012)

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Article Oncology

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

Derek A. Wainwright et al.

CLINICAL CANCER RESEARCH (2012)

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Article Biochemistry & Molecular Biology

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

R. Bonavia et al.

ONCOGENE (2012)

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Article Multidisciplinary Sciences

TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression

Xin Gao et al.

PLOS ONE (2012)

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Review Cell Biology

Activating and inhibitory receptors of natural killer cells

Hollie J. Pegram et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

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Article Oncology

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

Janna Paulsson et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Article Oncology

In-vitro effects of the tyrosine kinase inhibitor imatinib on glioblastoma cell proliferation

E. Ranza et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

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Article Medicine, Research & Experimental

Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma

Omar Eton et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2010)

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Article Oncology

TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8(+) T cells glioma patients

Courtney A. Crane et al.

NEURO-ONCOLOGY (2010)

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Review Oncology

Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies

Philip C. De Witt Hamer

NEURO-ONCOLOGY (2010)

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Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

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Article Pharmacology & Pharmacy

Differential Effect of Imatinib and Synergism of Combination Treatment with Chemotherapeutic Agents in Malignant Glioma Cells

Huan Ren et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2009)

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Article Oncology

Arginase I-Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

Paulo C. Rodriguez et al.

CANCER RESEARCH (2009)

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Article Oncology

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

Joannes F. M. Jacobs et al.

NEURO-ONCOLOGY (2009)

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Article Immunology

NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

Nadia Guerra et al.

IMMUNITY (2008)

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Article Oncology

Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma

Jean-Francois Mineo et al.

JOURNAL OF NEURO-ONCOLOGY (2007)

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Article Multidisciplinary Sciences

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

Ana C. Anderson et al.

SCIENCE (2007)

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Review Cell Biology

Malignant astrocytic glioma: genetics, biology, and paths to treatment

Frank B. Furnari et al.

GENES & DEVELOPMENT (2007)

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Article Oncology

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4(+) T cell compartment without affecting regulatory T-cell function

Peter E. Fecci et al.

CLINICAL CANCER RESEARCH (2007)

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Review Pathology

Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression

Kazuki Nabeshima et al.

PATHOLOGY INTERNATIONAL (2006)

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Review Oncology

Physiologic and metabolic magnetic resonance imaging in gliomas

Y Cao et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

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