4.6 Review

Golgi-Targeting Anticancer Natural Products

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Summary: Oxysterol-binding protein-related proteins (ORPs) are a family of intracellular lipid binding/transfer proteins involved in lipid transport within cells. They have the ability to bind phosphatidylinositol polyphosphates (PIPs). Dysregulation of certain ORP family members, such as ORP3, -4, -5, and -8, is implicated in cancer growth through their effects on signaling events, protein interactions, and cellular lipid transport. This review discusses the functional evidence of ORPs in cancer growth and explores the potential of targeting ORPs for anti-cancer therapy.

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Discovery of Anticancer Agents of Diverse Natural Origin

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Ilimaquinone (Marine Sponge Metabolite) Induces Apoptosis in HCT-116 Human Colorectal Carcinoma Cells via Mitochondrial-Mediated Apoptosis Pathway

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Natural products in drug discovery: advances and opportunities

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Maria Podinovskaia et al.

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Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis

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Anticancer Effects and Mechanisms of OSW-1 Isolated From Ornithogalum saundersiae: A Review

Zhixin Zhan et al.

Summary: Cancer has been a long-standing challenge for humanity, but natural compound OSW-1 has shown powerful anticancer activities in various cancers. Despite its unclear anticancer mechanisms, OSW-1 as a potential candidate for anticancer drugs deserves further research.

FRONTIERS IN ONCOLOGY (2021)

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Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism

Fubito Nakatsu et al.

Summary: This article discusses the mechanism of lipid transport within cells, focusing on the role of oxysterol-binding protein (OSBP)-related proteins (ORPs) in lipid transport and their significance in cellular functions.

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Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models

Ryan C. Bensen et al.

Summary: ORP4 is identified as a potential druggable target in ovarian cancer cells, and the natural product compound OSW-1 exhibits high antiproliferative potency by targeting ORP4 and OSBP. The absence of extracellular lipids significantly enhances the cytotoxicity of OSW-1, suggesting a potential synergistic effect in the in vivo ovarian cancer microenvironment when OSBP is also targeted.

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Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer

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Development of Chemical Probes for Functional Analysis of Anticancer Saponin OSW-1

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BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells

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Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy

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Recent Synthesis and Discovery of Brefeldin A Analogs

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Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

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Golgi stress mediates redox imbalance and ferroptosis in human cells

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TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response

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Organelle autoregulation-stress responses in the ER, Golgi, mitochondria and lysosome

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The unfolded protein response: the dawn of a new field

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Fluorescent analog of OSW-1 and its cellular localization

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Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs

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AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

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RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells

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Natural products reveal cancer cell dependence on oxysterol-binding proteins

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