期刊
CANCERS
卷 15, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers15072088
关键词
hepatocellular carcinoma; extracellular vesicles; Wnt signaling
类别
Hepatocellular carcinoma (HCC) is a major type of liver cancer that causes numerous deaths annually. Despite extensive research, the prognosis of HCC remains unclear. Recent studies have focused on extracellular vesicles (EVs) and their involvement in various diseases, including HCC, by regulating cell signaling pathways. This review summarizes the current literature on the regulation of Wnt signaling by EVs in HCC and explores future research directions.
As the primary type of liver cancer, hepatocellular carcinoma (HCC) causes a large number of deaths every year. Despite extensive research conducted on this disease, the prognosis of HCC remains unclear. Recently, research has largely focused on extracellular vesicles (EVs), and they have been found to participate in various ways in the development of various diseases, including HCC, such as by regulating cell signaling pathways. However, recent studies have reported the mechanisms underlying the regulation of Wnt signaling by EVs in HCC, primarily focusing on the regulation of the canonical pathways. This review summarizes the current literature on the regulation of Wnt signaling by EVs in HCC and their underlying mechanisms. In addition, we also present future research directions in this field. This will deepen the understanding of HCC and provide new ideas for its treatment.
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