Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review

Letter Dentistry, Oral Surgery & Medicine

Eliminating Candida albicans for endodontic treatment purposes during the SARS-CoV-2 pandemic

Kaveh Nasiri et al.

JOURNAL OF DENTAL SCIENCES (2023)

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Review Medicine, General & Internal

Rheumatoid Arthritis - Common Origins, Divergent Mechanisms

Ellen M. Gravallese et al.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Cell Biology

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

Camille Brewer et al.

Summary: This study found that periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anticitrullinated protein antibodies (ACPAs), suggesting a link between oral mucosal inflammation and RA pathogenesis. The researchers also discovered that RA patients with periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of specific monocyte subsets observed in inflamed RA synovia and blood during RA flares. The bacteremia was caused by citrullinated oral bacteria and resulted in activation of ACPA B cells, promoting affinity maturation and epitope spreading to citrullinated human antigens.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Article Health Care Sciences & Services

Association of Oral Health with Risk of Rheumatoid Arthritis: A Nationwide Cohort Study

Yoonkyung Chang et al.

Summary: This study aimed to investigate the associations of periodontitis and oral hygiene status and behaviors with rheumatoid arthritis (RA). The results showed that participants with periodontitis and a higher number of missing teeth had a higher risk of developing RA. In contrast, better oral hygiene behaviors, such as frequent tooth brushing and recent dental scaling, were associated with a lower occurrence of RA.

JOURNAL OF PERSONALIZED MEDICINE (2023)

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Review Biotechnology & Applied Microbiology

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

Zulema Arias et al.

Summary: Apical periodontitis is an inflammatory response caused by pulp infection, leading to bone resorption in the apical and periapical regions of the tooth. Nonsurgical endodontic treatment is the most conservative approach but has reported clinical failure, prompting the need for alternative procedures. This review discusses advanced approaches, such as biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, to improve the success rate of treatment. Further research is needed to understand the molecular mechanisms and validate the clinical application of these alternative approaches.

BIOENGINEERING-BASEL (2023)

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Article Medicine, General & Internal

Cleaning and Disinfecting Oval-Shaped Root Canals: Ex Vivo Evaluation of Three Rotary Instrumentation Systems with Passive Ultrasonic Irrigation

Ying Li et al.

Summary: This study aimed to compare the cleaning and disinfecting efficiency of oval-shaped root canals using XP-endo Shaper (XPS), ProTaper Next (PTN), and HyFlex CM (HCM) in combination with passive ultrasonic irrigation (PUI). Results showed that XPS outperformed PTN and HCM in disinfecting the root canals. However, removing hard tissue debris from the critical apical area remained challenging.

MEDICINA-LITHUANIA (2023)

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Article Medicine, General & Internal

Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjogren's Syndrome

Sanja Vujovic et al.

Summary: Patients with primary Sjogren's syndrome often have oral disorders, which greatly affect their daily lives and well-being. Saliva plays a crucial role in maintaining oral health, so the decrease in saliva quantity and quality leads to chronic oral discomfort and a range of problems. This study aimed to evaluate the oral health of patients with primary Sjogren's syndrome and its impact on their oral health-related quality of life.

MEDICINA-LITHUANIA (2023)

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Letter Rheumatology

Microbiome in Sjogren's syndrome: here we are

Taco A. van der Meulen et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Review Dentistry, Oral Surgery & Medicine

Present status and future directions: Microbiology of endodontic infections

Jose F. Siqueira Jr et al.

Summary: Apical periodontitis is an inflammatory disease caused by microbes, with bacteria being the most prevalent in endodontic infections. Bacterial infection in the root canal system is associated with necrotic pulp or previous treatment. Different types of apical periodontitis show varying microbial compositions, with bacterial interactions influencing the overall virulence of the community.

INTERNATIONAL ENDODONTIC JOURNAL (2022)

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Review Dentistry, Oral Surgery & Medicine

Oral microbiota in human systematic diseases

Xian Peng et al.

Summary: Oral bacteria directly influence dental caries and periodontal diseases, and the dynamic oral microbiota reflects immune and metabolic information and status through communication between the oral cavity and systemic organs. The oral cavity acts as an important interaction window between the human body and the environment, and the microbial composition in different sites is regulated by complex signaling, hosts, and external environmental factors.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

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Review Microbiology

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

Xinyi Li et al.

Summary: The human oral cavity provides a habitat for oral microbial communities, which are influenced by various factors and must maintain a dynamic balance to prevent diseases.

FRONTIERS IN MICROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis

Shuzhi Deng et al.

Summary: This article explores the changes and interactions of microenvironments in Oral Potentially Malignant Disorders (OPMDs) and their relationship with carcinogenesis mechanisms. The authors propose an immuno-metabolic-mechanical-neural interaction network and summarize therapeutic strategies targeting microenvironments. These studies contribute to preventing the carcinogenesis of OPMDs and provide new research directions and clinical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Pamela Pignatelli et al.

Summary: A balanced bacterial ecosystem exists in the oral cavity and can be influenced by various factors. Imbalance of oral bacteria can contribute to the development of oral squamous cell carcinoma through inflammatory responses and changes in the immune system. Certain bacterial profiles detected in saliva samples show potential for noninvasive oral cancer prediction. Additionally, oral lactic acid bacteria can enhance the response to oral cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Letter Dentistry, Oral Surgery & Medicine

Elimination of Enterococcus faecalis in the root canal during the SARS-CoV-2 pandemic

Kaveh Nasiri et al.

JOURNAL OF DENTAL SCIENCES (2022)

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Review Medicine, General & Internal

Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review

Christoph Schaefer et al.

Summary: In recent years, there has been increasing interest in the potential association between lifestyle factors and rheumatoid arthritis (RA). Research has identified smoking, unhealthy diet, obesity, low educational level, and low socioeconomic status as factors that increase the incidence of RA. Additionally, lifestyle habits such as smoking and lack of physical activity can impact the response to treatment for RA. However, methodological challenges make it difficult to draw firm conclusions about the causal role of these factors in the risk and course of RA.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Immunology

Dental Materials for Oral Microbiota Dysbiosis: An Update

Jieyu Zhu et al.

Summary: The balance or dysbiosis of the oral microbiota is crucial for maintaining human health or causing oral diseases. Oral biomaterials play a significant role in regulating the balance of the oral microbiome and treating oral diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

A Glimpse Into the Microbiome of Sjogren's Syndrome

Chuiwen Deng et al.

Summary: Sjogren's syndrome, a common chronic autoimmune disease, is associated with microbial dysbiosis. The alterations in the microbiota correlate with disease severity.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Rheumatology

Oral health-related quality of life in rheumatoid arthritis: a comparative analysis

Amirhossein Parsaei et al.

Summary: Rheumatoid arthritis (RA) has a significant psychological impact on the oral health-related quality of life (OHRQoL) of patients. RA patients exhibit poorer oral function and psychosocial impact. There is a significant correlation between disease activity and oral health factors, with temporomandibular disorders score and number of missing teeth showing positive correlations with increased disease activity.

BMC RHEUMATOLOGY (2022)

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Review Environmental Sciences

Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review

Paula Garcia-Rios et al.

Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with oral manifestations such as oral ulcers, hyposalivation, and pigmentations. However, there is still insufficient research on these oral manifestations.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Medicine, General & Internal

Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review

Sadia Ambreen Niazi et al.

Summary: The "Focal Infection Era in Dentistry" led to widespread tooth extraction and limited progress in endodontics. There is increasing interest in investigating the impact of endodontic disease on general health. Apical periodontitis may negatively affect systemic health, such as cardiovascular diseases, adverse pregnancy outcomes, and diabetic metabolic dyscontrol. Successful root canal treatment can benefit systemic health by reducing inflammation. Further research is needed to support the benefits of endodontic treatment on systemic health.

MEDICINA-LITHUANIA (2022)

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Review Rheumatology

Update on the diagnosis and management of systemic lupus erythematosus

Antonis Fanouriakis et al.

Summary: Systemic lupus erythematosus (SLE) is characterized by clinical heterogeneity, unpredictable course and flares. Diagnosis remains clinical with limited serologic test confirmation, and newer classification criteria offer more accurate classification. Treatment goals focus on patient survival, flare prevention, organ damage prevention, and quality of life optimization. High-intensity immunosuppressive therapy followed by less intensive therapy is typically used to control disease activity in severe cases of SLE.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Dentistry, Oral Surgery & Medicine

A case-control study of oral diseases and quality of life in individuals with rheumatoid arthritis and systemic lupus erythematosus

Brena Rodrigues Manzano et al.

Summary: Individuals with RA have a higher caries index and more frequent periodontal disease, while those with SLE have lower salivary flow and severe xerostomia, impacting their quality of life.

CLINICAL ORAL INVESTIGATIONS (2021)

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Article Dentistry, Oral Surgery & Medicine

Periodontal conditions in patients with Sjo spacing diaeresis gren's syndrome: A meta-analysis

Shih-Yun Wu et al.

Summary: Sjogren's syndrome patients show higher plaque index and gingival index, but similar probing pocket depth and clinical attachment loss compared to healthy controls. However, heterogeneity among studies needs to be considered when interpreting the results.

JOURNAL OF DENTAL SCIENCES (2021)

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Review Dentistry, Oral Surgery & Medicine

Potential application of immunotherapy for modulation of pulp inflammation: opportunities for vital pulp treatment

S. Arora et al.

Summary: Caries can lead to mineral loss and destruction of enamel and dentine, potentially progressing to irreversible pulpitis. Vital pulp therapy aims to preserve the pulp and prevent inflammation progression, but outcomes are not always predictable. Chronic inflammation and prolonged cytokine release may cause irreversible pulp damage and reduced tissue healing capacity.

INTERNATIONAL ENDODONTIC JOURNAL (2021)

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Article Medicine, Research & Experimental

A potential pathogenic association between periodontal disease and Crohn's disease

Jin Imai et al.

Summary: The study found that in patients with ulcerative colitis (UC) and Crohn's disease (CD), the gut microbiome was more similar to the oral microbiome, indicating increased ectopic gut colonization by oral bacteria in IBD patients. Incipient periodontitis did not significantly affect the clinical outcomes of UC and CD patients, but early periodontitis may be associated with worse clinical symptoms in some CD patients.

JCI INSIGHT (2021)

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Review Microbiology

Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

Ling Li et al.

Summary: Periodontitis and chronic kidney disease (CKD) share a strong correlation, with potential mechanisms including periodontal inflammation, elevated serum inflammatory mediators, and oxidative stress. The relationship between these diseases is largely linked by bidirectional associations, and future research will focus on exploring these links to contribute to new treatments for CKD.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

Microbiome of Odontogenic Abscesses

Sebastian Boettger et al.

Summary: Severe odontogenic abscesses are commonly caused by bacteria from the oral microbiome, with errors and lack of growth often seen in bacterial cultures. 16S rRNA gene analysis revealed predominantly anaerobic bacteria in pus, while saliva microbiome resembled that of healthy individuals, suggesting polymicrobial anaerobic infections play a major role in odontogenic infections.

MICROORGANISMS (2021)

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Review Dentistry, Oral Surgery & Medicine

An Update on the Lived Experience of Dry Mouth in Sjogren's Syndrome Patients

Di Ying Joanna Ngo et al.

Summary: This paper provides an updated review of research findings on the impact of dry mouth in Sjogren's Syndrome patients, covering definition, etiology, manifestation, measurement of quality of life, and consequences on patients' physical, emotional, and social well-being.

FRONTIERS IN ORAL HEALTH (2021)

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Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Dentistry, Oral Surgery & Medicine

Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges

Jasmine Wong et al.

Summary: The oral cavity is home to hundreds of microbial taxa coexisting in a unique ecosystem, while the dental pulp is a sterile tissue where microbial invasion indicates pathology. Understanding root canal infections, including microbial composition and host responses, is crucial for effective treatment and prevention strategies. Despite the focus on shaping canals, emphasis should be on cleaning and disinfecting to address the microbial pathogenesis of apical periodontitis.

FRONTIERS IN ORAL HEALTH (2021)

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Article Microbiology

Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture

Elisabetta Caselli et al.

BMC MICROBIOLOGY (2020)

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Review Microbiology

Beyond Risk: Bacterial Biofilms and Their Regulating Approaches

Musa Hassan Muhammad et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Immunology

Phagocytosis: Our Current Understanding of a Universal Biological Process

Eileen Uribe-Querol et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

Sho Kitamoto et al.

CELL (2020)

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Article Primary Health Care

Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu

Nesa Aurlene et al.

JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE (2020)

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Article Environmental Sciences

Association between Periodontal Disease and Subsequent Sjogren's Syndrome: A Nationwide Population-Based Cohort Study

Chien-Yu Lin et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

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Review Biochemistry & Molecular Biology

Association between periodontal pathogens and systemic disease

Fiona Q. Bui et al.

BIOMEDICAL JOURNAL (2019)

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Review Medicine, General & Internal

Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues

Eija Kononen et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Dentistry, Oral Surgery & Medicine

Inflammatory profile of chronic apical periodontitis: a literature review

Paulo Henrique Braz-Silva et al.

ACTA ODONTOLOGICA SCANDINAVICA (2019)

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Review Dentistry, Oral Surgery & Medicine

Biofilm model systems for root canal disinfection: a literature review

R. C. D. Swimberghe et al.

INTERNATIONAL ENDODONTIC JOURNAL (2019)

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Review Microbiology

Exploiting the Oral Microbiome to Prevent Tooth Decay: Has Evolution Already Provided the Best Tools?

Jonathon L. Baker et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Food Science & Technology

Oral microbiota: A new view of body health

Maoyang Lu et al.

FOOD SCIENCE AND HUMAN WELLNESS (2019)

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Review Dentistry, Oral Surgery & Medicine

A new system for classifying accessory canal morphology

H. M. A. Ahmed et al.

INTERNATIONAL ENDODONTIC JOURNAL (2018)

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Review Microbiology

The oral microbiota: dynamic communities and host interactions

Richard J. Lamont et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Review Dentistry, Oral Surgery & Medicine

Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology

Brenda Paula Figueiredo de Almeida Gomes et al.

BRAZILIAN ORAL RESEARCH (2018)

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Review Immunology

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Gustavo P. Amarante-Mendes et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Association between a history of periodontitis and the risk of systemic lupus erythematosus in Taiwan: A nationwide, population-based, case-control study

Yi-Da Wu et al.

PLOS ONE (2017)

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Review Immunology

Association between Systemic Lupus Erythematosus and Periodontitis A Systematic Review And Meta-Analysis

Zoe Rutter-Locher et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Rheumatology

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

Adria Aterido et al.

ARTHRITIS RESEARCH & THERAPY (2017)

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Review Cell Biology

An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

Ji-Hyun Jang et al.

MEDIATORS OF INFLAMMATION (2015)

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Article Biochemistry & Molecular Biology

Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts

Ansheng Zhang et al.

MOLECULAR IMMUNOLOGY (2015)

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Review Immunology

On the dynamics of root canal infections-what we understand and what we don't

Matthias Zehnder et al.

VIRULENCE (2015)

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Review Medicine, General & Internal

Management of severe acute dental infections

Douglas P. Robertson et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Review Medicine, General & Internal

Management of severe acute dental infections

Douglas P. Robertson et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

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Article Rheumatology

Prevalence of Hyposalivation in Patients with Systemic Lupus Erythematosus in a Brazilian Subpopulation

Cristhiane Almeida Leite et al.

INTERNATIONAL JOURNAL OF RHEUMATOLOGY (2015)

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Review Dentistry, Oral Surgery & Medicine

Biofilm in endodontics: A review

Kapil Jhajharia et al.

JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY (2015)

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Article Dentistry, Oral Surgery & Medicine

Causes and management of post-treatment apical periodontitis

J. F. Siqueira et al.

BRITISH DENTAL JOURNAL (2014)

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Article Rheumatology

Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy

Cristiana Fabbri et al.

CLINICAL RHEUMATOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

Mature human odontoblasts express virus-recognizing toll-like receptors

V. Paakkonen et al.

INTERNATIONAL ENDODONTIC JOURNAL (2014)

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Review Neurosciences

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer's Disease

Sim K. Singhrao et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

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Article Dentistry, Oral Surgery & Medicine

NOD2 Mediates Odontoblast Differentiation and RANKL Expression

S. -I. Lee et al.

JOURNAL OF DENTAL RESEARCH (2014)

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Article Engineering, Biomedical

Morphologic Classification of Root Canals and Incidence of Accessory Canals in Maxillary First Molar Palatal Roots: Three-Dimensional Observation and Measurements using Micro-CT

Satoru Matsunaga et al.

JOURNAL OF HARD TISSUE BIOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

Managing xerostomia and salivary gland hypofunction Executive summary of a report from the American Dental Association Council on Scientific Affairs

Jacqueline M. Plemons et al.

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION (2014)

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Review Dentistry, Oral Surgery & Medicine

Inflammatory and immune pathways in the pathogenesis of periodontal disease

Ali Cekici et al.

PERIODONTOLOGY 2000 (2014)

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Review Rheumatology

Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions

Clifton O. Bingham et al.

CURRENT OPINION IN RHEUMATOLOGY (2013)

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Review Dentistry, Oral Surgery & Medicine

Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues

J. G. Leprince et al.

INTERNATIONAL ENDODONTIC JOURNAL (2012)

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Review Immunology

Information processing during phagocytosis

David M. Underhill et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Article Orthopedics

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

Sumihisa Orita et al.

BMC MUSCULOSKELETAL DISORDERS (2011)

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Article Biochemistry & Molecular Biology

Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells

Jean-Francois Keller et al.

INNATE IMMUNITY (2011)

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Review Dentistry, Oral Surgery & Medicine

Host-Pathogen Interactions in Progressive Chronic Periodontitis

M. Hernandez et al.

JOURNAL OF DENTAL RESEARCH (2011)

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Article Dentistry, Oral Surgery & Medicine

Up-regulation of Nucleotide-binding Oligomerization Domain 1 in Inflamed Human Dental Pulp

Ya-Yun Lee et al.

JOURNAL OF ENDODONTICS (2011)

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Review Dentistry, Oral Surgery & Medicine

Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis

Tadashi Nakanishi et al.

JAPANESE DENTAL SCIENCE REVIEW (2011)

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Article Immunology

Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells

Jean-Francois Keller et al.

IMMUNOBIOLOGY (2010)

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Article Dentistry, Oral Surgery & Medicine

Synergy of TLR2 and H1R on Cox-2 Activation in Pulpal Cells

C. Park et al.

JOURNAL OF DENTAL RESEARCH (2010)

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Review Immunology

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Taro Kawai et al.

NATURE IMMUNOLOGY (2010)

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Review Microbiology

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Trine H. Mogensen

CLINICAL MICROBIOLOGY REVIEWS (2009)

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Article Dentistry, Oral Surgery & Medicine

A Comparative Study on the Frequency, Location, and Direction of Accessory Canals Filled With the Hydraulic Vertical Condensation and Continuous Wave of Condensation Techniques

Fabiola Ormiga Galvao Barbosa et al.

JOURNAL OF ENDODONTICS (2009)

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Article Rheumatology

The abundant synovial expression of the RANK/RANKL/osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation

Bernard Vandooren et al.

ARTHRITIS AND RHEUMATISM (2008)

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Article Dentistry, Oral Surgery & Medicine

Different roles of odontoblasts and fibroblasts in immunity

M. -J. Staquet et al.

JOURNAL OF DENTAL RESEARCH (2008)

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Review Dentistry, Oral Surgery & Medicine

Oral manifestations of Sjogren's syndrome

S. A. Mathews et al.

JOURNAL OF DENTAL RESEARCH (2008)

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Article Dentistry, Oral Surgery & Medicine

Morphometric study of the apical anatomy of C-shaped root canal systems in mandibular second molars

G. S. P. Cheung et al.

INTERNATIONAL ENDODONTIC JOURNAL (2007)

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Article Rheumatology

Oral health and the masticatory system in juvenile systemic lupus erythematosus

E. G. C. Fernandes et al.

LUPUS (2007)

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Review Medicine, Research & Experimental

Pathophysiology of Sjogren's syndrome

Mario Garcia-Carrasco et al.

ARCHIVES OF MEDICAL RESEARCH (2006)

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Article Dentistry, Oral Surgery & Medicine

Root canal morphology of mandibular incisors in a Jordanian population

A. A. Al-Qudah et al.

INTERNATIONAL ENDODONTIC JOURNAL (2006)

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Article Dentistry, Oral Surgery & Medicine

Expression of toll like receptor 4 in normal human odontoblasts and dental pulp tissue

Hong-Wei Jiang et al.

JOURNAL OF ENDODONTICS (2006)

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Review Dentistry, Oral Surgery & Medicine

On the causes of persistent apical periodontitis: a review

PNR Nair

INTERNATIONAL ENDODONTIC JOURNAL (2006)

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Article Immunology

Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts

Stephanie H. Durand et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Cell Biology

Hypothesis: The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis

ED Rosenstein et al.

INFLAMMATION (2004)

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Article Dentistry, Oral Surgery & Medicine

Evaluation of the root canal configurations of the mandibular and maxillary permanent teeth by gender in the Turkish population

S Sert et al.

JOURNAL OF ENDODONTICS (2004)

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Review Dentistry, Oral Surgery & Medicine

Endodontic infections: Concepts, paradigms, and perspectives

JF Siqueira et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2002)

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Review Endocrinology & Metabolism

Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis

E Romas et al.

BONE (2002)

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Article Dentistry, Oral Surgery & Medicine

Root and canal morphology of Burmese mandibular molars

K Gulabivala et al.

INTERNATIONAL ENDODONTIC JOURNAL (2001)

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Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review

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