期刊
JOURNAL OF CLINICAL MEDICINE
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/jcm12113634
关键词
colorectal cancer; young; pathological feature; prognosis
The aim of this study was to compare the clinicopathologic features and prognosis of young patients with colorectal cancer (CRC) with older patients. The results showed that young patients had more symptoms, aggressive histological features, received more adjuvant chemotherapy and multidrug agents, and had a better prognosis.
Background: The objective of this study was to evaluate clinicopathologic features of young patients with colorectal cancer (CRC) and to compare their prognosis with those of older patients Methods: We retrospectively reviewed the medical records of patients who underwent surgery for stage 0-III CRC at four university-affiliated hospitals between January 2011 and December 2020. The patients were divided into two groups, the young adult group (<= 45 years) and the older group (>45 years). Results: Of 1992 patients, 93 (4.6%) were young adults and 1899 (95.3%) were older patients. Young patients showed more symptoms (p = 0.014) and more poorly or undifferentiated adenocarcinoma (p = 0.047) than older patients. The young adult patients were more likely to receive adjuvant chemotherapy (p < 0.001) and multidrug agents (p = 0.029), and less likely to cease chemotherapy (p = 0.037). The five-year RFS (recurrence-free survival) rate was better in the young adults than in the older patients (p = 0.009). In the multivariable analysis, young age was a significant prognostic factor for better RFS (p = 0.015). Conclusions: Young patients with CRC had more symptoms, aggressive histological features than older patients. They received more multidrug agents and discontinued chemotherapy less often, resulting in better prognosis.
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