☆ 4.7 Review

Potential Effects of AIT on Nonspecific Allergic Immune Responses or Symptoms

JOURNAL OF CLINICAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Allergy

Single-cell RNA-Seq identifies precise tolerogenic cellular and molecular pathways induced by depigmented-polymerized grass pollen allergen extract

Janice Layhadi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

添加到收藏夹

Review Allergy

Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma

Mohamed H. Shamji et al.

Summary: Allergen immunotherapy is an effective treatment for allergic rhinitis, inducing long-term clinical tolerance. Recent research has revealed that subcutaneous and sublingual immunotherapy induce immune tolerance through novel cell targets and molecular mechanisms, involving regulatory subsets of innate lymphoid cells and suppression of proinflammatory cells.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

添加到收藏夹

Review Allergy

Mechanisms and biomarkers of successful allergen-specific immunotherapy

Juan-Felipe Lopez et al.

Summary: Allergen-specific immunotherapy is considered the only curative treatment for IgE-mediated allergic diseases. Currently, there are no standardized biomarkers to determine successful responses to AIT, but some studies have found differences between responders and nonresponders.

ASIA PACIFIC ALLERGY (2022)

添加到收藏夹

Review Allergy

Roles of type 1 regulatory T (Tr1) cells in allergen-specific immunotherapy

Masaya Matsuda et al.

Summary: Allergen-specific immunotherapy (AIT) is a causative treatment for allergic diseases that modifies the immune response to allergens. It induces immunotolerance to allergens by generating antigen-specific regulatory T (Treg) cells. Tr1 cells and Foxp3-expressing Treg cells are known subsets of Treg cells. Tr1 cells are considered a distinct subset induced in the periphery during antigen exposure and can produce anti-inflammatory cytokines independently of Foxp3 expression. Research has shown that AIT induces Tr1 cells in the periphery and reactivates them through antigen stimulation, leading to suppression of allergic symptoms.

FRONTIERS IN ALLERGY (2022)

添加到收藏夹

Article Allergy

Comparison of sensitization and prevalence of Japanese cedar pollen and mite-induced perennial allergic rhinitis between 2006 and 2016 in hospital workers in Japan

Masafumi Sakashita et al.

Summary: A study conducted from 2006 to 2016 showed an increasing trend in the prevalence of Japanese cedar pollinosis and mite-induced PAR among staff at the University of Fukui Hospital. The rise in prevalence was attributed to both an increase in new cases and a low rate of remission.

ALLERGOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Allergy

Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy

Andrzej Eljaszewicz et al.

Summary: This study found that AIT treatment can induce changes in the composition and heterogeneity of circulating innate immune cells, bringing them to the level observed in healthy individuals. Monitoring of ILCs, monocytes, and DCs during AIT may serve as a novel biomarker strategy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Letter Allergy

Innate lymphoid cells type 2 in LTP-allergic patients and their modulation during sublingual immunotherapy

Francisca Palomares et al.

ALLERGY (2021)

添加到收藏夹

Article Immunology

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

Korneliusz Golebski et al.

Summary: IL-10(+) ILC2s play a crucial role in modulating grass-pollen allergy, attenuating Th responses, and maintaining epithelial cell integrity. Patients with grass-pollen allergy have lower levels of IL-10(+) KLRG1(+) ILC2s, but this ability to produce IL-10 is restored after immunotherapy treatment. The mechanisms underlying this involve modifications in retinol metabolic pathway, cytokine-cytokine receptor interaction, and JAK-STAT signaling pathways in the ILCs.

IMMUNITY (2021)

添加到收藏夹

Review Immunology

B regulatory cells in allergy

Siyuan Ma et al.

Summary: B cells have long been known for their role in antibody production, but recent research has highlighted their potential as immunoregulatory cells with anti-inflammatory functions. Studies in the field of regulatory B cell research, particularly in the context of allergic inflammation, have been groundbreaking.

IMMUNOLOGICAL REVIEWS (2021)

添加到收藏夹

Review Allergy

Regulatory B cells, A to Z

Kirstin Jansen et al.

Summary: B cells play a central role in the immune system by producing antibodies, and they also have the capacity to regulate immune responses through various mechanisms. Regulatory B cells suppress inflammatory responses in autoimmune diseases, allergies, infections, transplants, and cancer, with key suppressive molecules like cytokines and cell membrane-bound molecules playing important roles. Regulatory B cells can be induced by different stimuli and play a role in altering inflammatory responses in various diseases.

ALLERGY (2021)

添加到收藏夹

Article Allergy

Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy

Hanisah Sharif et al.

Summary: This study aimed to evaluate the role of circulating CXCR5(+)PD-1(+) T follicular helper (cT(FH)) and T follicular regulatory (T-FR) cells in grass pollen allergic patients following different immunotherapy treatments. The findings showed dysregulation of cT(FH) cells in the grass pollen allergic group compared to nonatopic healthy controls, as well as induction of T-FR and IL-101 cT(FH) cells following specific immunotherapy. Changes in chromatin landscape were observed in cT(FH) and T-FR cells post-immunotherapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects

Tetsuya Terada et al.

Summary: The study indicates that 4 years of SLIT is necessary to achieve sustained increases in Foxp3(+) Treg cells, which are closely associated with the efficacy of SLIT.

INFLAMMATION RESEARCH (2021)

添加到收藏夹

Article Allergy

IL-10-producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy

Tadech Boonpiyathad et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Allergy

Immunological Responses and Biomarkers for Allergen-Specific Immunotherapy Against Inhaled Allergens

Mohamed H. Shamji et al.

Summary: Allergen immunotherapy leads to decreased IgE-dependent activation of mast cells and tissue eosinophilia, along with changes in regulatory T cells and cytokines, resulting in reduced allergic inflammation. Research also indicates the importance of innate responses and new subsets of regulatory cells induced by immunotherapy in predicting clinical response and developing novel approaches for better efficacy and long-term tolerance.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

添加到收藏夹

Article Allergy

Clinical evaluation of rush immunotherapy using house dust mite allergen in Japanese asthmatics

Takahiro Uchida et al.

Summary: This study aimed to investigate the safety and clinical effectiveness of rush immunotherapy (rush-IT) using standardized house dust mite (HDM) allergen for HDM-sensitive Japanese asthmatics. The study found that rush-HDM-IT can be performed relatively safely in Japanese asthmatics, leading to better asthma treatment and lower doses of inhaled corticosteroids, along with decreased production of HDM-induced type 2 cytokines.

ASIA PACIFIC ALLERGY (2021)

添加到收藏夹

Article Allergy

Dynamic change of anti-inflammatory cytokine IL-35 in allergen immune therapy for Japanese cedar pollinosis

Hideaki Kouzaki et al.

ALLERGY (2020)

添加到收藏夹

Article Immunology

Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis

Hirotaka Kikuoka et al.

CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Review Allergy

Japanese guidelines for allergic rhinitis 2020

Kimihiro Okubo et al.

ALLERGOLOGY INTERNATIONAL (2020)

添加到收藏夹

Article Allergy

Role of IL-35 in sublingual allergen immunotherapy

Mohamed H. Shamji et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Allergy

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

Hideaki Morita et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Article Allergy

Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy

Tadech Boonpiyathad et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

添加到收藏夹

Letter Allergy

Sublingual Immunotherapy for Japanese Cedar Pollinosis Attenuates Asthma Exacerbation

Sayaka Kikkawa et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2019)

添加到收藏夹

Article Allergy

High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers

T. Boonpiyathad et al.

ALLERGY (2017)

添加到收藏夹

Article Allergy

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction

Diamanda Rigas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Article Allergy

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

Mohamed H. Shamji et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Review Allergy

Allergen immunotherapy for allergic asthma: A systematic review and meta-analysis

S. Dhami et al.

ALLERGY (2017)

添加到收藏夹

Article Allergy

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

M. H. Shamji et al.

ALLERGY (2017)

添加到收藏夹

Article Medicine, General & Internal

Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma A Randomized Clinical Trial

J. Christian Virchow et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

添加到收藏夹

Article Allergy

Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge

G. W. Scadding et al.

ALLERGY (2015)

添加到收藏夹

Review Immunology

Regulatory B Cells: Origin, Phenotype, and Function

Elizabeth C. Rosser et al.

IMMUNITY (2015)

添加到收藏夹

Letter Allergy

Seasonal increases in peripheral innatelymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy

Mongkol Lao-Araya et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: A randomized, double-blind, placebo-controlled trial

Holger Mosbech et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation

Abel Suarez-Fueyo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Allergy

IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses

Willem van de Veen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

添加到收藏夹

Article Allergy

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

M. H. Shamji et al.

ALLERGY (2012)

添加到收藏夹

Article Allergy

Responses of CD4+CD25+Foxp3+ and IL-10-secreting type I T regulatory cells to cluster-specific immunotherapy for allergic rhinitis in children

Wei Lou et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2012)

添加到收藏夹

Review Immunology

Follicular Helper CD4 T Cells (T-FH)

Shane Crotty

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

添加到收藏夹

Article Allergy

Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies

Louisa K. James et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mechanism of Immunoglobulin G4 Fab-arm Exchange

Theo Rispens et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

添加到收藏夹

Article Immunology

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Yasutaka Motomura et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Article Allergy

SLIT Improves Cedar Pollinosis by Restoring IL-10 Production from Tr1 and Monocytes~IL-10 Productivity Is Critical for Becoming Allergic~

Kei-ichi Yamanaka et al.

ALLERGOLOGY INTERNATIONAL (2011)

添加到收藏夹

Article Allergy

Long-lasting effects of sublingual immunotherapy according to its duration: A 15-year prospective study

Maurizio Marogna et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

添加到收藏夹

Article Allergy

Allergen Immunotherapy in Asthma: Current Status and Future Perspectives

Makoto Nagata et al.

ALLERGOLOGY INTERNATIONAL (2010)

添加到收藏夹

Article Multidisciplinary Sciences

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

Tomohisa Okamura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Multidisciplinary Sciences

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells

Dat Q. Tran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Allergy

Grass pollen immunotherapy induces Foxp3-expressing CD4+CD25+ cells in the nasal mucosa

Suzana Radulovic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

添加到收藏夹

Article Allergy

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity

James N. Francis et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

添加到收藏夹

Article Allergy

Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma:: 10-year follow-up on the PAT study

L. Jacobsen et al.

ALLERGY (2007)

添加到收藏夹

Article Immunology

Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-β expression

Charles Pilette et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity

KT Nouri-Aria et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Allergy

Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study

V Di Rienzo et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2003)

添加到收藏夹

Article Allergy

Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study)

C Möller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.