期刊
JOURNAL OF CLINICAL MEDICINE
卷 12, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jcm12082939
关键词
osmophobia; primary headaches; migraine; childhood; allodynia; disability
Primary headaches, especially migraines, have a significant impact on the physical and mental health of children and adolescents. Osmophobia can be a potential marker for diagnosing and assessing disability in individuals with migraines. This study found that osmophobia was present in 28.8% of individuals with primary headaches, with a higher prevalence in children suffering from migraines. Migraine patients with osmophobia also showed more severe clinical symptoms, including enhanced disability and psychological distress.
Primary headaches, especially migraines, have a significant impact on physical and mental health, as well as on the scholarly performance and quality of life of children and adolescents. Osmophobia could be a potential diagnostic marker of migraine diagnosis and disability. This multicenter observational cross-sectional study included 645 children, aged 8-15, with a diagnosis of primary headaches. We took into consideration the duration, intensity and frequency of headaches, pericranial tenderness, allodynia and osmophobia. In a subgroup of migraine children, we evaluated the migraine-related disability, Psychiatric Self-Administration Scales for Youths and Adolescents, and the Child Version of the Pain Catastrophizing Scale. Osmophobia was found to be present in 28.8% of individuals with primary headaches, with children suffering from migraines having the highest prevalence (35%). Migraine patients with osmophobia also showed a more severe clinical picture, with enhanced disability, anxiety, depression, pain catastrophizing, and allodynia symptoms (F Roy square 10.47 p < 0.001). The presence of osmophobia could help in identifying a clinical migraine phenotype coherent with an abnormal bio-behavioral allostatic model that is worthy of prospective observations and careful therapeutic management.
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