High-Flow Nasal Therapy in Acute and Chronic Respiratory Failure: Past, Present, and Future

Article Respiratory System

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial

Claudia Crimi et al.

Summary: Among patients with COVID-19 pneumonia and mild hypoxaemia, the use of HFNO did not significantly reduce the likelihood of escalation of respiratory support.

THORAX (2023)

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Review Critical Care Medicine

The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review

Jie Li et al.

Summary: This systematic review examines the effects of flow settings during high-flow nasal cannula (HFNC) therapy. The study finds that flow settings have an impact on the fraction of inspired oxygen (FIO2), positive end-expiratory pressure, and carbon dioxide (CO2) washout. The optimal effect is achieved when the flow exceeds the patient's peak inspiratory flow. However, the impact of flows on different patients is heterogeneous.

CRITICAL CARE (2023)

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Article Respiratory System

ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure

Simon Oczkowski et al.

Summary: This article introduces the use of high-flow nasal cannula (HFNC) in patients with acute respiratory failure and provides corresponding clinical recommendations based on evidence. HFNC is a valuable noninvasive respiratory support intervention that can assist clinicians in choosing the most appropriate treatment method.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Medicine, General & Internal

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19 The RECOVERY-RS Randomized Clinical Trial

Gavin D. Perkins et al.

Summary: Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Review Critical Care Medicine

High-Flow Nasal Cannula and COVID-19: A Clinical Review

Claudia Crimi et al.

Summary: During the COVID-19 pandemic, noninvasive respiratory support, particularly high-flow nasal cannula (HFNC) treatment, has been commonly used for patients with acute hypoxemic respiratory failure. Despite its reported benefits, concerns about the risk of infection transmission to healthcare workers have led to controversial recommendations from different scientific societies.

RESPIRATORY CARE (2022)

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Article Critical Care Medicine

Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD

Kazuma Nagata et al.

Summary: The study found that long-term use of high-flow nasal cannula can reduce the number of exacerbations in patients with chronic obstructive pulmonary disease, improving physiological parameters and quality of life.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Medicine, General & Internal

Long-Term Domiciliary High-Flow Nasal Therapy in Patients with Bronchiectasis: A Preliminary Retrospective Observational Case-Control Study

Claudia Crimi et al.

Summary: This study found that long-term domiciliary HFNT improved the clinical course of patients with bronchiectasis, reducing exacerbations and hospitalizations, and slightly improving pulmonary function.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19 The SOHO-COVID Randomized Clinical Trial

Jean-Pierre Frat et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Review Critical Care Medicine

High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials

N. Ovtcharenko et al.

Summary: The current evidence suggests that in patients with acute hypercapnic respiratory failure, HFNC is not significantly more effective than NIV in reducing mortality, intubation rates, or hospital length of stay, and there is no difference in carbon dioxide pressure change between the two treatments.

CRITICAL CARE (2022)

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Editorial Material Health Care Sciences & Services

Why, whether and how to use high-flow nasal therapy in acute exacerbations of chronic obstructive pulmonary disease

Claudia Crimi et al.

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH (2021)

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Article Medicine, General & Internal

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19 A Randomized Clinical Trial

Gustavo A. Ospina-Tascon et al.

Summary: In a randomized clinical trial conducted in Colombia, it was found that high-flow oxygen therapy through a nasal cannula significantly reduced the need for mechanical ventilation support and shortened time to clinical recovery in patients with severe COVID-19 compared to conventional oxygen therapy.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Respiratory System