期刊
JOURNAL OF CLINICAL MEDICINE
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/jcm12103545
关键词
Delphi; consensus; statement; brodalumab; psoriasis
A Delphi consensus document was developed to establish agreement on the use of brodalumab in the treatment of moderate-to-severe psoriasis. Consensus was reached on the key indications for the use of brodalumab based on the opinions of a panel of Italian dermatologists.
Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis with brodalumab. A panel of 32 Italian dermatologists indicated their level of agreement using a 5-point Likert scale (from 1 = strongly disagree to 5 = strongly agree) using an online modified Delphi method. After the first round of voting (32 participants), positive consensus was reached for 15/17 (88.2%) of the proposed statements. Following a face-to-face virtual meeting, the steering committee decided that 5 statements would form main principles and 10 statements formed the final list. After a second round of voting, consensus was reached in 4/5 (80%) of the main principles and 8/10 (80%) for consensus statements. The final list of 5 main principles and 10 consensus statements identify key indications specific to the use of brodalumab in the treatment of moderate-to-severe psoriasis in Italy. These statements aid dermatologists in the management of patients with moderate-to-severe psoriasis.
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