Metabolic Support in Acute Respiratory Distress Syndrome: A Narrative Review

Nutritional support for acute respiratory distress syndrome (ARDS) patients shares metabolic notions common to other critically ill conditions. Nevertheless, it generates specific concern regarding the primary limitation of oxygen supply and the complications of carbon dioxide elimination, as well as the significant metabolic alterations due to the body's response to illness. In the present narrative review, after briefly summarizing the pathophysiology of critical illness stress response and patients' metabolic requirements, we focus on describing the characteristics of metabolic and artificial nutrition in patients with acute respiratory failure. In patients with ARDS, several aspects of metabolism assume special importance. The physiological effects of substrate metabolism are described for this setting, particularly regarding energy consumption, diet-induced thermogenesis, and the price of their clearance, transformation, and storage. Moreover, we review the possible direct effects of macronutrients on lung tissue viability during ARDS. Finally, we summarize the noteworthy characteristics of metabolic control in critically ill patients with ARDS and offer a suggestion as to the ideal methods of metabolic support for this problem.

Automated summary

Nutritional support for ARDS patients is important due to the specific metabolic alterations caused by the body's response to illness and the limitations in oxygen supply. This narrative review focuses on the characteristics of metabolic and artificial nutrition in patients with acute respiratory failure, including substrate metabolism, energy consumption, and the effects of macronutrients on lung tissue viability. It also provides suggestions for the ideal methods of metabolic support for critically ill patients with ARDS.