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Wearable patches for transdermal drug delivery

ACTA PHARMACEUTICA SINICA B (2023)

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Article Engineering, Mechanical

Tip fabrication methods of hollow metal microneedles

Chao-Wei Dong et al.

Summary: Hollow microneedles can penetrate the skin and other biological barriers, making them a promising tool for painless drug delivery and body fluid sensing. A nickel microneedle model with specific dimensions was proposed, and three different manufacturing methods were introduced to construct the microneedle. Penetration capability and structure reliability were verified through experiments on rabbit skin and film puncture. These microneedles can be combined with drug delivery devices to achieve accurate and controllable flow rates. Mechanical tests and solution delivery tests demonstrated the strong mechanical strength and feasibility of the microneedle structure as a drug delivery device.

JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY (2023)

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Article Engineering, Environmental

Flav7+DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors

Huixin Wang et al.

Summary: This study presented a novel microneedle system loaded with the multipurpose small molecule Flav7 for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors, as well as remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Instruments & Instrumentation

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Delly Ramadon et al.

Summary: Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. This article reviews the current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. The use of microneedle technology has shown promising results in improving transdermal delivery systems, with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Programmable and monitorable intradermal vaccine delivery using ultrasound perforation array

Yaxin Hu et al.

Summary: In this study, we introduce a new method of controllable perforation of murine skin using highly-focused ultrasound. By programming ultrasound parameters, the size of the skin perforation area can be varied and monitored using ultrasound pulse-echo imaging. The method enhances local skin expression of heat shock protein 70 and attracts immune cells. The antigen dose delivered by the ultrasound perforation can be effectively modulated via programmable perforation arrays. Compared to traditional intradermal injection, this method shows higher efficacy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Multidisciplinary Sciences

Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

Changwei Yang et al.

Summary: This article describes a transdermal polymeric microneedle patch that achieves glucose-responsive closed-loop insulin and glucagon delivery for glycemic regulation with minimized risk of hypoglycemia. The patch utilizes glucose-responsive phenylboronic acid units to reversibly shift the net charge of the polymeric matrix, allowing dynamic tuning of insulin and glucagon analog release ratio to achieve glycemic homeostasis.

SCIENCE ADVANCES (2022)

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Article Chemistry, Analytical

A wearable electrochemical sensor based on ?-CD functionalized graphene for pH and potassium ion analysis in sweat

Xiaoqing Cui et al.

Summary: In this study, a wearable electrochemical sensor was developed for pH and K+ monitoring in sweat. The sensor consisted of flexible reference electrode, pH response electrode, and K+ selective electrode. The sensor exhibited good stability and accuracy in measuring sweat pH and K+ concentration.

TALANTA (2022)

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Review Engineering, Biomedical

Hydrogel Combined with Phototherapy in Wound Healing

Yinglin Xu et al.

Summary: Combining hydrogels with phototherapy shows great potential for wound healing, overcoming the shortcomings of traditional treatment methods. Phototherapy can effectively treat bacterial infections, while hydrogels provide a moist environment for wound healing.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Multidisciplinary Sciences

Transdermal electroosmotic flow generated by a porous microneedle array patch

Shinya Kusama et al.

Summary: The authors discuss the utilization of porous polymer microneedles combined with electroosmosis powered by enzymatic batteries to deliver small and large molecules across the skin efficiently.

NATURE COMMUNICATIONS (2021)

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Review Pharmacology & Pharmacy

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Ting Liu et al.

Summary: Microneedles play a crucial role in transdermal delivery of protein and peptide drugs, offering advantages over traditional injection methods and promising prospects in conventional therapies.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Battery-Free and Wireless Smart Wound Dressing for Wound Infection Monitoring and Electrically Controlled On-Demand Drug Delivery

Gang Xu et al.

Summary: The battery-free and wireless smart wound dressing integrates near field communication for wireless power harvest and data transmission, on-site signal processing, and drug delivery control. It simultaneously detects wound temperature, pH, and uric acid, and provides on-demand infection treatment through electrically controlled antibiotics delivery. Through experiments, it has been shown to effectively inhibit bacterial growth and accelerate wound healing, demonstrating its effectiveness in wound treatment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

An Intelligent Transdermal Formulation of ALA-Loaded Copolymer Thermogel with Spontaneous Asymmetry by Using Temperature-Induced Sol-Gel Transition and Gel-Sol (Suspension) Transition on Different Sides

Dinglingge Cao et al.

Summary: This study introduces a novel composite hydrogel formulation utilizing both sol-gel and gel-sol (suspension) transitions for efficient photodynamic therapy of skin diseases. By adjusting the blending ratio, the transition temperatures of the formulation can be easily controlled, allowing for rapid release and improved efficacy. The concept is supported by various experiments including characterization of biomaterials, drug release profiles, cell experiments, in vitro permeation, and in vivo transdermal delivery studies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Materials Science, Multidisciplinary

Photodynamic Bubble-Generating Microneedles for Enhanced Transdermal Cancer Therapy

Xiaoyu Ning et al.

Summary: This research introduces a new technique using the frozen immersion method to load drugs on bubble-generating microneedles, which enhances drug delivery efficiency by producing bubbles to improve drug transportation, combined with sonophoresis to further increase the efficiency of transdermal drug delivery.

ACS APPLIED POLYMER MATERIALS (2021)

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Article Multidisciplinary Sciences

Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels

Chanhyuk Lim et al.

Summary: Hydrogels, composed of a cross-linked polymer network and water molecules, show similar mechanical structures and properties to human tissue, making them ideal for creating tissue-like interfaces between wearable devices and skin. Functionalized hydrogels with high mass-permeability and low impedance play a crucial role in enhancing the performance of wearable bioelectronics by forming a conformal interface on the skin.

SCIENCE ADVANCES (2021)

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Review Nanoscience & Nanotechnology

Portable and wearable self-powered systems based on emerging energy harvesting technology

Chen Xu et al.

Summary: This review focuses on the potential of self-powered systems based on energy harvesting technology for providing power to electronic devices. It introduces portable and wearable self-powered systems with sensing functions, demonstrates their potential in actuation functions, and discusses their development towards intelligent functions supported by information processing and artificial intelligence technologies.

MICROSYSTEMS & NANOENGINEERING (2021)

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Review Biochemistry & Molecular Biology

Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery

Rui Pereira et al.

Summary: Transdermal drug delivery has advantages over conventional routes, but faces challenges due to the skin's natural barrier properties. Amino acid derivatives as permeation enhancers show great potential with high biodegradability and low toxicity, facilitating the delivery of various drugs through the skin.

MEMBRANES (2021)

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Article Chemistry, Multidisciplinary

Electro-Mechanochemical Gating of a Metal-Phenolic Nanocage for Controlled Guest-Release Self-Powered Patches and Injectable Gels

Gyeonghyeon Choi et al.

Summary: The study introduces a facile method to prepare electro-mechanochemically responsive soft gel composites with molecular gatekeeper-based nanocontainers. These composites exhibit self-healing ability and controlled guest molecule release in response to electrical and mechanical stimuli, allowing for remotely controllable drug-delivery applications.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

The Insights of Microbes' Roles in Wound Healing: A Comprehensive Review

Thambirajoo Maheswary et al.

Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.

PHARMACEUTICS (2021)

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Review Engineering, Biomedical

Engineering Micro-Nanomaterials for Biomedical Translation

Yaping Chen et al.

Summary: Different types of engineered nano-bio interfaces, driven by various micro/nanoneedles, nanoparticles, organ-on-chip devices, and nanosubstrates, are advancing scientific and technological progress in biomedical research.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen

Rosa Marti-Centelles et al.

Summary: Transdermal drug delivery is an advantageous approach, but the high impermeability of the stratum corneum presents challenges. A two-component molecular hydrogel platform for transdermal delivery of (S)-naproxen was developed, with promising results shown in terms of drug permeation and localized delivery. The study demonstrates an efficient method for enhancing drug delivery through the skin using this hydrogel platform.

ACS APPLIED BIO MATERIALS (2021)

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Article Engineering, Biomedical

Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

Suyong Kim et al.

BIOMATERIALS (2020)

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Article Biophysics

Oleogel-mediated transdermal delivery of white emitting NaYF4 conjugated with Rose Bengal for the generation of reactive oxygen species through NIR-upconversion

Soumyashree Dhal et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Engineering, Biomedical

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Jicheng Yu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Engineering, Biomedical

Upconversion Nanoparticle Powered Microneedle Patches for Transdermal Delivery of siRNA

Min Wang et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Pharmacology & Pharmacy

Long-acting microneedles: a progress report of the state-of-the-art techniques

Zhongjian Chen et al.

DRUG DISCOVERY TODAY (2020)

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Review Pharmacology & Pharmacy

Ultrasound-Responsive Materials for Drug/Gene Delivery

Xiaowen Cai et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Electroporation-enhanced transdermal drug delivery: Effects of logP, pKa, solubility and penetration time

Xiao Chen et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Engineering, Environmental

Acid-responsive composite hydrogel platform with space-controllable stiffness and calcium supply for enhanced bone regeneration

Ziting Bao et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemical Research Methods

Hollow silicon microneedle fabrication using advanced plasma etch technologies for applications in transdermal drug delivery

Chris J. W. Bolton et al.

LAB ON A CHIP (2020)

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Article Acoustics

CONTROLLED ULTRASOUND EROSION FOR TRANSDERMAL DELIVERY AND HEPATITIS B IMMUNIZATION

Yaxin Hu et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2019)

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Article Engineering, Biomedical

Injectable cell-encapsulating composite alginate-collagen platform with inducible termination switch for safer ocular drug delivery

Francisca Siu Yin Wong et al.

BIOMATERIALS (2019)

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Article Biochemical Research Methods

A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery

Christopher Yeung et al.

BIOMICROFLUIDICS (2019)

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Article Chemistry, Analytical

Controlled transdermal drug delivery using a wireless magnetic microneedle patch: Preclinical device development

V. R. Jayaneththi et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Multidisciplinary Sciences

Printed, Flexible Lactate Sensors: Design Considerations Before Performing On-Body Measurements

Margaret E. Payne et al.

SCIENTIFIC REPORTS (2019)

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Article Engineering, Biomedical

Rapidly separable microneedle patch for the sustained release of a contraceptive

Wei Li et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Article Biochemical Research Methods

A pH-regulated drug delivery dermal patch for targeting infected regions in chronic wounds

Hongjie Jiang et al.

LAB ON A CHIP (2019)

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Article Chemistry, Multidisciplinary

Recent Advances in Wearable Transdermal Delivery Systems

Morteza Amjadi et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization

Jonathan M. Zuidema et al.

ADVANCED MATERIALS (2018)

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Review Dermatology

Recent advances and development in epidermal and dermal drug deposition enhancement technology

Babar Iqbal et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2018)

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Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel

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In Vivo Experimental Study of Noninvasive Insulin Microinjection through Hollow Si Microneedle Array

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MICROMACHINES (2018)

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Separable Microneedles for Near-Infrared Light-Triggered Transdermal Delivery of Metformin in Diabetic Rats

Yang Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Separable Microneedles for Near-Infrared Light-Triggered Transdermal Delivery of Metformin in Diabetic Rats

Yang Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Light-Triggered Drug Release from 3D-Printed Magnetic Chitosan Microswimmers

Ugur Bozuyuk et al.

ACS NANO (2018)

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Multifunctional Chitosan Inverse Opal Particles for Wound Healing

Canwen Chen et al.

ACS NANO (2018)

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Touch-actuated microneedle array patch for closed-loop transdermal drug delivery

Jingbo Yang et al.

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Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine

In-Jeong Choi et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Materials Science, Biomaterials

Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery

Shaohan Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Noninvasive Transdermal Delivery System of Lidocaine Using an Acoustic Droplet-Vaporization Based Wearable Patch

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Selected Medicines Used in Iontophoresis

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Chemical Enhancer: A Simplistic Way to Modulate Barrier Function of the Stratum Corneum

Tasnuva Haque et al.

ADVANCED PHARMACEUTICAL BULLETIN (2018)

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Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Hyunjae Lee et al.

SCIENCE ADVANCES (2017)

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Article Engineering, Biomedical

Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

Sara Bagherifard et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Review Pharmacology & Pharmacy

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Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs

Carl M. Schoellhammer et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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A Commentary on Transdermal Drug Delivery Systems in Clinical Trials

Adam C. Watkinson

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin

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Silk fibroin biomaterials for controlled release drug delivery

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EXPERT OPINION ON DRUG DELIVERY (2011)

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Article Chemistry, Multidisciplinary

Using pH Abnormalities in Diseased Skin to Trigger and Target Topical Therapy

Khalida Rizi et al.

PHARMACEUTICAL RESEARCH (2011)

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Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems

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EXPERT OPINION ON DRUG DELIVERY (2010)

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Sonophoretic enhanced microneedles array (SEMA)-Improving the efficiency of transdermal drug delivery

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SENSORS AND ACTUATORS B-CHEMICAL (2010)

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