☆ 4.7 Review

Research advances in peptide-drug conjugates

ACTA PHARMACEUTICA SINICA B (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pharmacology & Pharmacy

Peptide-drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

Chen Fu et al.

Summary: Peptide-drug conjugates (PDCs) are the next generation of targeted therapeutics that have enhanced cellular permeability and improved drug selectivity. PDCs have been developed for cancer, COVID-19, and metabolic diseases, but face challenges in stability, bioactivity, and long development time. This review summarizes the components and functions of PDCs and discusses strategies for improving their permeability, targeting, and stability. The future direction of PDCs includes coupling with toxin or supramolecular nanostructures. Clinical trials and drug delivery modes for PDCs are also discussed.

ACTA PHARMACEUTICA SINICA B (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells

Alla Pryyma et al.

Summary: This study demonstrates the utility of synthetic amanitins as payloads in peptide drug conjugates (PDCs). The conjugation of octreotate with amatoxins via tailor-built linkers showed target-specific reduction in viability, offering a highly modular synthetic platform for the development of amanitin-based conjugates with various targeting moieties.

RSC CHEMICAL BIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates

Sabine Schuster et al.

Summary: The cleavable GnRH-III bioconjugates showed a growth inhibitory effect on GnRH receptor-expressing A2780 ovarian cancer cells. Furthermore, the antiproliferative activity of the non-cleavable GnRH-III-drug conjugates using cathepsin B-cleavable linker systems was significantly reduced.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis

Tianyue Zhang et al.

Summary: In this study, two peptide-drug conjugates (PDCs) were synthesized by connecting Sinomenine (SIN) with a synovial homing peptide. The cyclic conjugate (C) showed better stability in serum and inflammatory joints, leading to improved therapeutic efficacy and tissue targeting.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Caspase-3 mediated switch therapy of self-triggered and long-acting prodrugs for metastatic TNBC

Ha Rin Kim et al.

Summary: This article describes a tumoral caspase-3 mediated peptide-doxorubicin conjugates (PDC) switch therapy for targeting metastatic triple-negative breast cancer. The therapy utilizes two different caspase-3 cleavable PDCs to induce apoptosis in tumor cells and target tumor sites, resulting in enhanced tumor-specific apoptosis amplification and potent therapeutic efficacy.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Oncology

The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers

Jean-Christophe Currie et al.

Summary: Tumor heterogeneity, drug resistance, and systemic toxicity are major concerns in the treatment of gynecological cancers. This study investigated the anticancer properties of the peptide-docetaxel conjugate TH1902, which targets the SORT1 receptor, in ovarian and endometrial cancers. The results showed that TH1902 had better efficacy and fewer side effects compared to traditional therapies, making it a promising treatment option for SORT1-positive gynecological cancers.

CANCERS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide-Porphyrin Conjugates

Toni Todorovski et al.

Summary: Viral disease outbreaks pose a serious threat to global health, particularly the Zika virus, which can cause severe complications during pregnancy. There is currently no effective treatment, but peptide-porphyrin conjugation shows promise as a strategy for filling this treatment gap.

PHARMACEUTICS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets

Wioletta Brankiewicz et al.

Summary: This study reported five conjugates composed of fluconazole and cell penetrating or antimicrobial peptide, showing high antifungal activity, especially against fluconazole-resistant strains, with low cytotoxicity.

PHARMACEUTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

A designed cyclic peptide based on Trastuzumab used to construct peptide-drug conjugates for its HER2-targeting ability

Jiaqi Zhou et al.

Summary: The newly designed cyclic peptide Cyclo-GCGPep1 shows promising targeting and inhibitory activity against HER2-positive cancers, indicating its potential as a therapeutic agent. Conjugate 1, derived from this peptide, exhibits good anti-proliferative and targeting abilities in cellular assays and tumor spheroid models.

BIOORGANIC CHEMISTRY (2021)

添加到收藏夹

Review Oncology

New drug delivery strategies targeting the GnRH receptor in breast and other cancers

Hany Sadek Ayoub Ghaly et al.

Summary: Cancer remains a significant challenge in modern medicine, and targeting GnRH receptors is a potential strategy that efficiently guides anticancer therapeutics, diagnostic agents, and nucleic acids directly to cancer cells. This approach has shown promising results in various types of cancers overexpressing GnRH receptors, highlighting the importance of further research and clinical trials for successful outcomes.

ENDOCRINE-RELATED CANCER (2021)

添加到收藏夹

Article Chemistry, Medicinal

Peptide-Drug Conjugates with Different Linkers for Cancer Therapy

Mona Alas et al.

Summary: Drug conjugates are compounds consisting of chemotherapeutic or cytotoxic agents linked to targeting ligands via a covalent linker, used for cancer treatment. The linker in drug conjugates plays a crucial role in the circulation time and release of the drug at the target site.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy

Chunlei Wu et al.

Summary: Researchers discovered a simplified analogue of Coibamide A and designed two novel peptide-drug conjugates, with one showing better drug release in vitro and significant tumor growth suppression in mice-bearing human tumor xenografts, indicating great potential in cancer drug discovery.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Source and exploration of the peptides used to construct peptide-drug conjugates

Jiaqi Zhou et al.

Summary: Peptide-drug conjugates are novel molecules designed and synthesized for delivering drugs effectively, with the peptide part determining membrane penetration and target specificity. This review focuses on the sources and applications of cell-penetrating peptides and cell-targeting peptides in constructing PDCs, as well as methods for developing and discovering novel peptides. The aim is to help researchers understand the research status of peptides in PDCs and advance the discovery of novel peptides.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell-Penetrative MMP-2-Cleavable Peptide

Dan Hua et al.

Summary: A novel dual-functional nanocomplex drug delivery system, SynB3-PVGLIG-PTX, was developed based on the strategy of peptide-drug conjugates. It exhibited specific inhibition on proliferation, migration, and invasion of GBM cells in vitro through the cleavage of MMP-2 to release PTX.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment

Xin Deng et al.

Summary: A novel PDC was synthesized to intelligently deliver paclitaxel, showing higher cellular uptake and cytotoxicity in experiments, with less toxicity to normal cells and the ability to overcome paclitaxel resistance. The results demonstrated that this new PDC had better in vivo anti-tumor efficacy than paclitaxel.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable click oxime bond tethers and preclinical evaluation against prostate cancer

Eirinaios Vrettos et al.

Summary: In this study, three peptide-drug conjugates were developed with gemcitabine as the cytotoxic unit and D-Lys6-GnRH as the cancer-targeting unit. These conjugates achieved selective targeting of malignant tumor cells through differential drug release rates guided by specific linkers.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer

So Hee Nam et al.

Summary: The designed pH-activatable cell-penetrating peptide dimer LH2 with histidine residues is able to penetrate cells specifically in weak acidic conditions, delivering paclitaxel effectively into triple-negative breast cancer cells. Both non-covalent complexes (PTX-LH2(M)) and covalent conjugates (PTX-LH2(C)) of LH2 show strong antitumor effects in a triple-negative breast cancer grafted mouse model at extremely low dosages, indicating potential for targeted drug delivery and therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A ligand-targeting peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis

Masataka Michigami et al.

Summary: The generation of ligand-targeting peptidedrug conjugates (PDCs) provides a new approach for targeted intracellular drug delivery utilizing receptor-mediated endocytosis. The designed helix-loop-helix (HLH) peptide acts as the drug carrier, forming a ternary complex with VEGF and its receptor, leading to internalization into cells via VEGF receptor-mediated endocytosis. These HLH peptides and their PDCs show great potential as a new modality for targeted molecular therapy.

PLOS ONE (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma

Mingfang Wu et al.

Summary: A drug delivery system loaded with paclitaxel for hepatocellular carcinoma therapy was developed, showcasing good biocompatibility and strong anticancer efficacy. The nanoparticles, prepared with pH-sensitive coating and targeting peptides, exhibited significant antitumor effects in animal models while demonstrating lower toxicity to normal cells and mice. The results suggest a promising approach for reducing the conflict between multifunctionality and biocompatibility in nanocarriers.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Development of novel bone targeting peptide-drug conjugate of 13-aminomethyl-15-thiomatrine for osteoporosis therapy

Jia Su et al.

Summary: The research developed bone targeting and cathepsin K sensitive peptide-drug conjugates based on M19 to overcome its limitations, showing rapid drug release through cathepsin K digestion and improved stability in biological evaluation studies, with BTM19-2 identified as a promising candidate for further osteoporosis therapy research.

RSC ADVANCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Self-Assembly or Coassembly of Multiresponsive Histidine-Containing Elastin-Like Polypeptide Block Copolymers

Mona Abdelghani et al.

Summary: This study presented a histidine containing elastin-like polypeptide (ELP) diblock copolymer with multiresponsive assembly behavior. The self-assembly into stable nanoparticles can be triggered by the addition of divalent metal ions, especially Zn2+, or by heating the ELPs quickly above the transition temperature. Furthermore, the diblock also exhibits pH-responsiveness.

MACROMOLECULAR BIOSCIENCE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Antibody-drug conjugates: Recent advances in linker chemistry

Zheng Su et al.

Summary: ADCs are gradually revolutionizing clinical cancer therapy, and the linker molecule plays a crucial role in determining their efficacy and safety. An ideal linker should release the cytotoxic payload specifically in the tumor to avoid off-target toxicity. Recent research progress in novel linkers for ADCs has been significant, aiming to improve therapeutic outcomes and minimize adverse effects.

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Quangang Zhu et al.

Summary: Oral administration of proteins and peptides has been a big demand in clinical use, and research has focused on developing new technologies to overcome GI barriers, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, and intestinal microdevices. Some new technologies have been under clinical trials or even on the market.

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Evaluation of a Keratin 1 Targeting Peptide-Doxorubicin Conjugate in a Mouse Model of Triple-Negative Breast Cancer

Azam Saghaeidehkordi et al.

Summary: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC), but it can be toxic to nonmalignant cells and tissues. A study showed that the K1 targeting peptide-Dox conjugate (PDC) had specific toxicity towards TNBC cells and reduced off-target toxicity, resulting in significantly improved antitumor efficacy.

PHARMACEUTICS (2021)

添加到收藏夹

Article Biochemical Research Methods

Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity

Diogo A. Mendonca et al.

Summary: Passing through the blood-brain barrier to treat neurological conditions is a major challenge in modern medicine, and peptide-drug conjugates (PDCs) are seen as a promising therapeutic strategy, particularly for viral neurological disorders.

BIOCONJUGATE CHEMISTRY (2021)

添加到收藏夹

Article Biochemical Research Methods

Targeted Delivery of Cabazitaxel Using Cyclic Cell-Penetrating Peptide and Biomarkers of Extracellular Matrix for Prostate and Breast Cancer Therapy

Shang Eun Park et al.

Summary: Targeted drug delivery for cancer therapy is being explored using cyclic cell-penetrating peptides conjugated with chemotherapeutic agents. The conjugates demonstrated reduced proliferation of cancer cells overexpressing specific biomarkers, while being less toxic to normal cells. This strategy shows potential in enhancing the efficacy and specificity of chemotherapeutic agents.

BIOCONJUGATE CHEMISTRY (2021)

添加到收藏夹

Article Oncology

Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-like Receptor 1 for Cancer Treatment

Tobias F. Fischer et al.

Summary: The innate immune system plays a crucial role in fighting tumors and metastasis, with chemerin inducing immune cells and natural killer cells to cancerous tissue. Treatment with chemerin may counteract immune evasion strategies used by cancer types, making it beneficial for cancer immunotherapy. Synthetic peptides derived from chemerin show promise as cancer therapeutics, being able to deliver chemotherapeutics to tumors expressing CMKLR1 or support the immune system in fighting cancer.

CANCERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development and Characterization of a Novel Peptide-Drug Conjugate with DM1 for Treatment of FGFR2-Positive Tumors

Yayu Wang et al.

Summary: The study identified a novel peptide, LLC2B, with high affinity for the FGFR2 protein, which can precisely target tumor tissues in vitro. LLC2B exhibited high stability and strong anti-proteolytic ability in aqueous solution at room temperature and in human plasma at 37 degrees C. Conjugating LLC2B with DM1 resulted in novel PDCs that inhibited tumor growth and increased the maximum tolerated dose of DM1 in xenografted mice.

BIOMEDICINES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Self-Assembling Peptides: From Design to Biomedical Applications

Sara La Manna et al.

Summary: Self-assembling peptides are a novel class of agents with versatile applications in the biomedical field. They exhibit biocompatibility and molecular recognition capabilities, making them suitable for drug delivery and tissue engineering purposes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)

Bethany M. Cooper et al.

Summary: Peptides offer versatility in oncology drug discovery, with peptide-drug conjugates showing promise in targeting tumors. Despite limitations such as slow progress and limited oral bioavailability, new approaches have enhanced peptide stability, leading to two molecules on the market and various variations in clinical trials.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cancer-Cell-Specific Drug Delivery by a Tumor-Homing CPP-Gossypol Conjugate Employing a Tracelessly Cleavable Linker

Suman Kumar Maity et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

添加到收藏夹

Article Oncology

ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases

Priya Kumthekar et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Biological Evaluation of Naproxen-Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors

Rute Moreira et al.

PHARMACEUTICS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression

Stefanie Wittrisch et al.

MOLECULAR METABOLISM (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain

Emilie Eiselt et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)

添加到收藏夹

Article Chemistry, Medicinal

Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents

Jing Han et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Drug-Bearing Peptide-Based Nanospheres for the Inhibition of Metastasis and Growth of Cancer

Qianqian Zhang et al.

MOLECULAR PHARMACEUTICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential Effect of Extracellular Acidic Environment on IL-1β Released from Human and Mouse Phagocytes

Petra Susjan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Medicine, General & Internal

Melflufen: A Peptide-Drug Conjugate for the Treatment of Multiple Myeloma

Maria-Victoria Mateos et al.

JOURNAL OF CLINICAL MEDICINE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Temperature-triggered micellization of interferon alpha-diblock copolypeptide conjugate with enhanced stability and pharmacology

Zhuoran Wang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Chemistry, Physical

Amphiphilic drug-peptide-polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation onin vitroactivity

Lilla Petho et al.

SOFT MATTER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Naglaa Salem El-Sayed et al.

MOLECULES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin

Jaroslaw Ruczynski et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemical Research Methods

Kiss and Run: Promoting Effective and Targeted Cellular Uptake of a Drug Delivery Vehicle Composed of an Integrin-Targeting Diketopiperazine Peptidomimetic and a Cell-Penetrating Peptide

Lucia Feni et al.

BIOCONJUGATE CHEMISTRY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

The role of molecular simulations in understanding the mechanisms of cell-penetrating peptides

Lauren M. Reid et al.

DRUG DISCOVERY TODAY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer

Shang Eun Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Cyclic Cell-Penetrating Peptides as Efficient Intracellular Drug Delivery Tools

Shang Eun Park et al.

MOLECULAR PHARMACEUTICS (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Imine bond formation: A novel concept to incorporate peptide drugs in self-emulsifying drug delivery systems (SEDDS)

Aida Dizdarevic et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Bombesin receptors as potential targets for anticancer drug delivery and imaging

Deep Pooja et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice

Ivan Randelovic et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy

Shiwei Niu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Recent progress in drug delivery

Chong Li et al.

ACTA PHARMACEUTICA SINICA B (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Blood-Brain Barrier- and Blood-Brain Tumor Barrier-Penetrating Peptide-Derived Targeted Therapeutics for Glioma and Malignant Tumor Brain Metastases

Long Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Article Biochemical Research Methods

Targeting Triple Negative Breast Cancer Cells with Novel Cytotoxic Peptide-Doxorubicin Conjugates

Elmira Ziaei et al.

BIOCONJUGATE CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Physical

Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy

Yue Yuan et al.

NATURE MATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Transferrin Receptor Targeted Cellular Delivery of Doxorubicin Via a Reduction-Responsive Peptide-Drug Conjugate

Songtao Li et al.

PHARMACEUTICAL RESEARCH (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy

Lijun Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Article Chemistry, Medicinal

Development of bioactive gemcitabine-D-Lys6-GnRH prodrugs with linker-controllable drug release rate and enhanced biopharmaceutical profile

Nisar Sayyad et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis, in vitro stability, and antiproliferative effect of d-cysteine modified GnRH-doxorubicin conjugates

Songtao Li et al.

JOURNAL OF PEPTIDE SCIENCE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Diego Tesauro et al.

MOLECULES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Luisa Aguiar et al.

MOLECULES (2019)

添加到收藏夹

Article Materials Science, Biomaterials

Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy

Yongfei Li et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

添加到收藏夹

Review Chemistry, Medicinal

Lutathera®: The First FDA- and EMA-Approved Radiopharmaceutical for Peptide Receptor Radionuclide Therapy

Ute Hennrich et al.

PHARMACEUTICALS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Cleavable linkers in antibody-drug conjugates

Jonathan D. Bargh et al.

CHEMICAL SOCIETY REVIEWS (2019)

添加到收藏夹

Article Chemistry, Medicinal

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug

Nikki A. Thiele et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Recent advances in enzyme-mediated peptide ligation

Silin Xu et al.

CHINESE CHEMICAL LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

A comparative study of the antitumor efficacy of peptide-doxorubicin conjugates with different linkers

Yanqin Liang et al.

JOURNAL OF CONTROLLED RELEASE (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Toxicity of Doxorubicin (Dox) to different experimental organ systems

Arivalagan Pugazhendhi et al.

LIFE SCIENCES (2018)

添加到收藏夹

Article Chemistry, Medicinal

Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis

Lei Lyu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Drug-Bearing Supramolecular MMP Inhibitor Nanofibers for Inhibition of Metastasis and Growth of Liver Cancer

Yujie Ji et al.

ADVANCED SCIENCE (2018)

添加到收藏夹

Article Engineering, Biomedical

Tumor-triggered transformation of chimeric peptide for dual-stage-amplified magnetic resonance imaging and precise photodynamic therapy

Jin Zhang et al.

BIOMATERIALS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Probing the interaction of a quercetin bioconjugate with Bcl-2 in living human cancer cells with in-cell NMR spectroscopy

Alexandra Primikyri et al.

FEBS LETTERS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Improved anticancer efficacy of doxorubicin mediated by human-derived cell-penetrating peptide dNP2

Yucheng Xiang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Cyclic RGD-Peptide-Functionalized Polylipopeptide Micelles for Enhanced Loading and Targeted Delivery of Monomethyl Auristatin E

Min Qiu et al.

MOLECULAR PHARMACEUTICS (2018)

添加到收藏夹

Article Oncology

NGR-hTNF and Doxorubicin as Second-Line Treatment of Patients with Small Cell Lung Cancer

Vanesa Gregorc et al.

ONCOLOGIST (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification

Sabine Schuster et al.

PHARMACEUTICS (2018)

添加到收藏夹

Review Physiology

Cell-Penetrating Peptides: a Useful Tool for the Delivery of Various Cargoes Into Cells

E. Bohmova et al.

PHYSIOLOGICAL RESEARCH (2018)

添加到收藏夹

Article Oncology

iRGD as a tumor-penetrating peptide for cancer therapy

Hong Yin et al.

MOLECULAR MEDICINE REPORTS (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models

Kelly E. Burns et al.

MOLECULAR PHARMACEUTICS (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Cell-Penetrating Peptides: From Basic Research to Clinics

Giulia Guidotti et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

添加到收藏夹

Article Medicine, Research & Experimental

A Nanosystem of Amphiphilic Oligopeptide- Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid

Yanqin Liang et al.

THERANOSTICS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

NGR-peptide-drug conjugates with dual targeting properties

Kata Nora Enyedi et al.

PLOS ONE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Peptide-Drug Conjugate: A Novel Drug Design Approach

Liang Ma et al.

CURRENT MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Oncology

Discovery of peptide drug carrier candidates for targeted multi-drug delivery into prostate cancer cells

O. Bashari et al.

CANCER LETTERS (2017)

添加到收藏夹

Article Biochemical Research Methods

Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting

Anne C. Conibear et al.

BIOCONJUGATE CHEMISTRY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

LCST Behavior is Manifested in a Single Molecule: Elastin-Like polypeptide (VPGVG)n

Binwu Zhao et al.

BIOMACROMOLECULES (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Valproic acid induces NET cell growth arrest and enhances tumor suppression of the receptor-targeted peptide-drug conjugate via activating somatostatin receptor type II

Lichun Sun et al.

JOURNAL OF DRUG TARGETING (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation

Nick Cox et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dual-drug RGD conjugates provide enhanced cytotoxicity to melanoma and non-small lung cancer cells

Y. Gilad et al.

BIOPOLYMERS (2016)

添加到收藏夹

Article Chemistry, Medicinal

Double Methotrexate-Modified Neuropeptide Y Analogues Express Increased Toxicity and Overcome Drug Resistance in Breast Cancer Cells

David Boehme et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Controlling toxicity of NPY-drug conjugates by different chemical linker structures

David Böhme et al.

NEUROPEPTIDES (2016)

添加到收藏夹

Article Oncology

Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide

Changjiang Huang et al.

ONCOTARGET (2016)

添加到收藏夹

Article Materials Science, Biomaterials

The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin

Santanu Patra et al.

BIOMATERIALS SCIENCE (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Progress and perspectives on targeting nanoparticles for brain drug delivery

Huile Gao

ACTA PHARMACEUTICA SINICA B (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Activable Cell-Penetrating Peptide Conjugated Prodrug for Tumor Targeted Drug Delivery

Hong Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis, drug release, and biological evaluation of new anticancer drug-bioconjugates containing somatostatin backbone cyclic analog as a targeting moiety

Boris Redko et al.

BIOPOLYMERS (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Colloidal Drug Delivery Systems: Current Status and Future Directions

Tarun Garg et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Brain delivery of insulin boosted by intranasal coadministration with cell-penetrating peptides

Noriyasu Kamei et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Chemistry, Medicinal

Organic Carbamates in Drug Design and Medicinal Chemistry

Arun K. Ghosh et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Drug delivery and release systems for targeted tumor therapy

David Boehme et al.

JOURNAL OF PEPTIDE SCIENCE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cell penetrating peptide TAT can kill cancer cells via membrane disruption after attachment of camptothecin

Jingjing Song et al.

PEPTIDES (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Amino Acid Carbamates As Prodrugs Of Resveratrol

Andrea Mattarei et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Recombinant IFN-α2a-NGR exhibits higher inhibitory function on tumor neovessels formation compared with IFN-α2a in vivo and in vitro

Weina Li et al.

CYTOTECHNOLOGY (2015)

添加到收藏夹

Article Immunology

Cyclization enhances function of linear anti-arthritic peptides

Marina Ali et al.

CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Controlled release of free doxorubicin from peptide-drug conjugates by drug loading

Zhipeng Chen et al.

JOURNAL OF CONTROLLED RELEASE (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cell penetration: scope and limitations by the application of cell-penetrating peptides

Siegmund Reissmann

JOURNAL OF PEPTIDE SCIENCE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel cleavable cell-penetrating peptidedrug conjugates: synthesis and characterization

Marco Lelle et al.

JOURNAL OF PEPTIDE SCIENCE (2014)

添加到收藏夹

Review Chemistry, Organic

Self-assembly of peptides to nanostructures

Dindyal Mandal et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

添加到收藏夹

Review Pharmacology & Pharmacy

Brain tumor-targeted drug delivery strategies

Xiaoli Wei et al.

ACTA PHARMACEUTICA SINICA B (2014)

添加到收藏夹

Article Biochemical Research Methods

Cellular Uptake and Cytotoxicity of Drug-Peptide Conjugates Regulated by Conjugation Site

Pengcheng Zhang et al.

BIOCONJUGATE CHEMISTRY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biomimetic pseudopolyrotaxane prodrug micelles with high drug content for intracellular drug delivery

Yin Wang et al.

CHEMICAL COMMUNICATIONS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Prodrug Design Targeting Intestinal PepT1 for Improved Oral Absorption: Design and Performance

Youxi Zhang et al.

CURRENT DRUG METABOLISM (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Oral delivery of an anti-diabetic peptide drug via conjugation and complexation with low molecular weight chitosan

Sukyung Ahn et al.

JOURNAL OF CONTROLLED RELEASE (2013)

添加到收藏夹

Review Oncology

Targeted drug delivery for cancer therapy: the other side of antibodies

Michael A. Firer et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeted estrogen delivery reverses the metabolic syndrome

Brian Finan et al.

NATURE MEDICINE (2012)

添加到收藏夹

Article Oncology

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

Y. Bertrand et al.

BRITISH JOURNAL OF CANCER (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock

Udo Conrad et al.

PLANT BIOTECHNOLOGY JOURNAL (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

Chia-Hung Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Elastin-Like Polypeptides: Biomedical Applications of Tunable Biopolymers

Sarah R. MacEwan et al.

BIOPOLYMERS (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Self-Assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials

Honggang Cui et al.

BIOPOLYMERS (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

Youqing Shen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multifunctional Tumor-Targeted Polymer-Peptide-Drug Delivery System for Treatment of Primary and Metastatic Cancers

Pooja Chandna et al.

PHARMACEUTICAL RESEARCH (2010)

添加到收藏夹

Review Chemistry, Multidisciplinary

Self-Organization in Coordination-Driven Self-Assembly

Brian H. Northrop et al.

ACCOUNTS OF CHEMICAL RESEARCH (2009)

添加到收藏夹

Review Pharmacology & Pharmacy

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

Frederic Heitz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

添加到收藏夹

Article Medicine, Research & Experimental

Synthesis, Transport and Pharmacokinetics of 5 '-Amino Acid Ester Prodrugs of 1-beta-D-Arabinofuranosylcytosine

Yongbing Sun et al.

MOLECULAR PHARMACEUTICS (2009)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin

Gene L. Bidwell et al.

BIOCHEMICAL PHARMACOLOGY (2007)

添加到收藏夹

Article Rheumatology

Formatted anti-tumor necrosis factor α VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

Ken Coppieters et al.

ARTHRITIS AND RHEUMATISM (2006)

添加到收藏夹

Review Oncology

Polymer conjugates as anticancer nanomedicines

Ruth Duncan

NATURE REVIEWS CANCER (2006)

添加到收藏夹

Review Reproductive Biology

Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers

A Nagy et al.

BIOLOGY OF REPRODUCTION (2005)

添加到收藏夹

Review Chemistry, Multidisciplinary

Intracellular protein degradation: From a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting - (Nobel lecture)

A Ciechanover

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

添加到收藏夹

Article Biochemical Research Methods

Acetals as pH-sensitive linkages for drug delivery

ER Gillies et al.

BIOCONJUGATE CHEMISTRY (2004)

添加到收藏夹

Article Chemistry, Medicinal

Novel peptide conjugates for tumor-specific chemotherapy

M Langer et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

添加到收藏夹

Review Oncology

Interferon in oncological practice: Review of interferon biology, clinical applications, and toxicities

E Jonasch et al.

ONCOLOGIST (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.